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2 results on '"Tolsurf Investigators"'

1. Surfactant status and respiratory outcome in premature infants receiving late surfactant treatment

Author

Ballard, Philip L, Keller, Roberta L, Truog, William E, Chapin, Cheryl, Horneman, Hart, Segal, Mark R, Ballard, Roberta A, and Tolsurf Investigators

Subjects
Paediatrics, Biomedical and Clinical Sciences, Infant Mortality, Preterm, Low Birth Weight and Health of the Newborn, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Clinical Research, Lung, Neonatal Respiratory Distress, Birth Weight, Bronchopulmonary Dysplasia, Drug Administration Schedule, Female, Humans, Infant, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Male, Phospholipids, Pulmonary Surfactant-Associated Protein B, Pulmonary Surfactants, Respiration, Tolsurf Investigators, Paediatrics and Reproductive Medicine, Public Health and Health Services, Pediatrics
Abstract

BackgroundMany premature infants with respiratory failure are deficient in surfactant, but the relationship to occurrence of bronchopulmonary dysplasia (BPD) is uncertain.MethodsTracheal aspirates were collected from 209 treated and control infants enrolled at 7-14 days in the Trial of Late Surfactant. The content of phospholipid, surfactant protein B, and total protein were determined in large aggregate (active) surfactant.ResultsAt 24 h, surfactant treatment transiently increased surfactant protein B content (70%, p

Published
2019

2. Surfactant status and respiratory outcome in premature infants receiving late surfactant treatment

Author

Roberta A. Ballard, Hart F. Horneman, Cheryl J. Chapin, William E Truog, Tolsurf Investigators, Mark R. Segal, Roberta L. Keller, and Philip L. Ballard

Subjects
Male, Diseases, Infant, Premature, Diseases, Low Birth Weight and Health of the Newborn, Pediatrics, chemistry.chemical_compound, 0302 clinical medicine, Pulmonary surfactant, Infant Mortality, Birth Weight, Respiratory system, Lung, Phospholipids, Bronchopulmonary Dysplasia, Pediatric, Pulmonary Surfactant-Associated Protein B, Respiration, 3. Good health, Public Health and Health Services, Female, Infant, Premature, medicine.medical_specialty, Phospholipid, Tolsurf Investigators, Article, Drug Administration Schedule, Neonatal Respiratory Distress, Paediatrics and Reproductive Medicine, 03 medical and health sciences, Preterm, Clinical Research, 030225 pediatrics, Internal medicine, medicine, Humans, Pulmonary surfactant-associated protein B, Premature, business.industry, Infant, Newborn, Infant, Pulmonary Surfactants, Metabolism, Perinatal Period - Conditions Originating in Perinatal Period, Newborn, medicine.disease, Endocrinology, Respiratory failure, Bronchopulmonary dysplasia, chemistry, Pediatrics, Perinatology and Child Health, business, 030217 neurology & neurosurgery
Abstract

BACKGROUND:Many premature infants with respiratory failure are deficient in surfactant, but the relationship to occurrence of bronchopulmonary dysplasia (BPD) is uncertain. METHODS:Tracheal aspirates were collected from 209 treated and control infants enrolled at 7-14 days in the Trial of Late Surfactant. The content of phospholipid, surfactant protein B, and total protein were determined in large aggregate (active) surfactant. RESULTS:At 24 h, surfactant treatment transiently increased surfactant protein B content (70%, p

Published
2018
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