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Objectives: We performed data collection concerning the coronavirus disease 2019 (COVID-19) pandemic-related delay in the diagnosis of cancers to individuate proper corrective procedures.Methods: A comparison was made among the number of first pathologic diagnoses of malignancy made from weeks 11 to 20 of 2018, 2019, and 2020 at seven anatomic pathology units serving secondary care hospitals in northern-central Italy.Results: Cancer diagnoses fell in 2020 by 44.9% compared with the average number recorded in 2018 and 2019. Melanoma and nonmelanoma skin cancer represented 56.7% of all missing diagnoses. The diagnostic decrease in colorectal (-46.6%), prostate (-45%), and bladder (-43.6%) cancer was the most relevant among internal malignancies; for prostate, however, high-grade tumors were only moderately affected (-21.7%).Conclusions: Diagnosis of cutaneous malignancies was mostly affected by the lockdown; among internal malignancies, corrective actions were mostly needed for colorectal cancer and invasive bladder cancer. [ABSTRACT FROM AUTHOR]

An 82-year-old man, with 6-year history of radical prostatectomy followed by radiotherapy performed for prostatic carcinoma, underwent transurethral resection of a papillary tumor of the bladder lateral walls. Histologically, the lesion displays 2 distinct components: epithelial and stromal. The epithelial component was composed of a noninvasive papillary urothelial carcinoma, predominantly low grade and focally high grade. The stromal component exhibited extensive myxoid changes with increased cellularity but lacking cellular atypia and mitoses. The epithelial component was immunoreactive for pan-cytokeratins and negative for smooth muscle actin (SMA) and vimentin. The stromal component exhibited focal positivity for pan-cytokeratins and SMA, and diffuse immunoreactivity for vimentin. The ki67 reached 70% in the epithelial component and 20% in the stromal component. Papillary intraurothelial carcinoma following radiotherapy may be associated with pseudosarcomatous stromal proliferation. The clinical history and the lack of cellular atypia and mitoses point toward the correct diagnosis. [ABSTRACT FROM PUBLISHER]