1. Red Grape Seed Extract Improves Lipid Profiles and Decreases Oxidized Low-Density Lipoprotein in Patients with Mild Hyperlipidemia.
- Author
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Razavi, Seyed-Mostafa, Gholamin, Sharareh, Eskandari, Ali, Mohsenian, Nakta, Ghorbanihaghjo, Amir, Delazar, Abbas, Rashtchizadeh, Nadereh, Keshtkar-Jahromi, Maryam, and Argani, Hassan
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ATHEROSCLEROSIS prevention , *HYPERLIPIDEMIA , *ALTERNATIVE medicine , *CHOLESTEROL , *CROSSOVER trials , *GRAPES , *HIGH density lipoproteins , *LOW density lipoproteins , *OXIDATION-reduction reaction , *STATISTICAL sampling , *SEEDS , *TRIGLYCERIDES , *PLANT extracts , *RANDOMIZED controlled trials , *PRE-tests & post-tests , *BLIND experiment , *DESCRIPTIVE statistics , *PREVENTION - Abstract
Hyperlipidemia can lead to atherosclerosis by lipoprotein deposition inside the vessel wall and oxidative stress induction that leads to the formation of atherosclerotic plaque. Oxidized low-density lipoprotein particles (Ox-LDL) have a key role in the pathogenesis of atherosclerosis. The lipid-lowering properties and antioxidants of the grape seed can be beneficial in atherosclerosis prevention. We conducted a randomized double-blind placebo-controlled crossover clinical trial. Fifty-two mildly hyperlipidemic individuals were divided into two groups that received either 200 mg/day of the red grape seed extract (RGSE) or placebo for 8 weeks. After an 8-week washout period, the groups were crossed over for another 8 weeks. Lipid profiles and Ox-LDL were measured at the beginning and the end of each phase. RGSE consumption reduced total cholesterol (−10.68±26.76 mg/dL, P=.015), LDL cholesterol (−9.66±23.92 mg/dL, P=.014), and Ox-LDL (−5.47±12.12 mg/dL, P=.008). While triglyceride and very low-density lipoprotein cholesterol were decreased and high-density lipoprotein cholesterol was increased by RGSE, the changes were not statistically significant. RGSE consumption decreases Ox-LDL and has beneficial effects on lipid profile-consequently decreasing the risk of atherosclerosis and cardiovascular disorders-in mild hyperlipidemic individuals. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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