1. Effect of Pregnancy Sera on Isolated Lysosomes
- Author
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Karl H. Hempel, Linda A. Fernandez, and Robert H. Persellin
- Subjects
Pregnancy ,Multidisciplinary ,business.industry ,Physiology ,Gestational Age ,medicine.disease ,Pathogenesis ,Blood ,Organelle ,medicine ,Animals ,Humans ,Female ,Rabbits ,Lysosomes ,business ,Human Females ,Hydrocortisone ,medicine.drug - Abstract
INFLAMMATORY diseases, notably rheumatoid arthritis1, frequently subside during the last 3 months of pregnancy and recur several weeks after parturition. Evidence implicating lysosomes in the pathogenesis of inflammation2 suggested that the subsidence of this phenomenon in pregnant human females could be mediated by an effect on these subcellular organelles. We present here evidence that serum from pregnant females stabilizes leucocyte lysosomes. In addition, we have data suggesting that hydrocortisone is not responsible for the stabilizing activity observed.
- Published
- 1970
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