1. Maternal peripheral blood CD34+ cells for prediction of fetal kidney malformations: results from a case-control analysis.
- Author
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Giordano, Domenico, Cernaro, Valeria, Scilipoti, Mariagrazia, Cosentino, Sonia, Inferrera, Ramona, Fresta, Jlenia, Andreucci, Michele, Conti, Giovanni, Buemi, Michele, D'Anna, Rosario, and Coppolino, Giuseppe
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BLOOD cells ,BLOOD cell count ,HUMAN abnormalities ,KIDNEYS ,KIDNEY development ,CASE-control method ,CORD blood ,QUESTIONNAIRES - Abstract
Purpose: To evaluate the relation between CD34+ cells count in maternal blood and potential development of fetal congenital renal abnormalities.Materials and Methods: We enrolled 16 women that gave birth to newborns carrying congenital renal malformations over a 3-year period and 48 women with uncomplicated pregnancies (controls) in a 1:3 ratio (three controls per case).Results: CD34+ cells in the maternal peripheral blood were significantly lower in the group of women who gave birth to newborns carrying congenital renal malformations compared to the controls (pā<ā.0001).Conclusions: CD34+ cells in maternal blood could be validated as a potential marker to predict the development of possible kidney malformations. [ABSTRACT FROM AUTHOR]- Published
- 2021
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