1. Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging
- Author
-
Yu Shang, Ting Li, and Guoqiang Yu
- Subjects
Physiology ,Biomedical Engineering ,Biophysics ,01 natural sciences ,Article ,Diffusion ,010309 optics ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,0103 physical sciences ,Animals ,Humans ,Medicine ,Tomography ,Spectroscopy, Near-Infrared ,business.industry ,Near-infrared spectroscopy ,Hemodynamics ,Blood flow ,Diffuse correlation spectroscopy ,Diffuse optical imaging ,Therapeutic monitoring ,body regions ,Blood Circulation ,High temporal resolution ,business ,030217 neurology & neurosurgery ,Preclinical imaging ,Biomedical engineering - Abstract
OBJECTIVE Blood flow is one such available observable promoting a wealth of physiological insight both individually and in combination with other metrics. APPROACH Near-infrared diffuse correlation spectroscopy (DCS) and, to a lesser extent, diffuse correlation tomography (DCT), have increasingly received interest over the past decade as noninvasive methods for tissue blood flow measurements and imaging. DCS/DCT offers several attractive features for tissue blood flow measurements/imaging such as noninvasiveness, portability, high temporal resolution, and relatively large penetration depth (up to several centimeters). MAIN RESULTS This review first introduces the basic principle and instrumentation of DCS/DCT, followed by presenting clinical application examples of DCS/DCT for the diagnosis and therapeutic monitoring of diseases in a variety of organs/tissues including brain, skeletal muscle, and tumor. SIGNIFICANCE Clinical study results demonstrate technical versatility of DCS/DCT in providing important information for disease diagnosis and intervention monitoring.
- Published
- 2017