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1. Development of factor V and thrombin inhibitors in children following bovine thrombin exposure during cardiac surgery: a report of three cases

Author

Lisa, Bomgaars, Kathleen, Carberry, Charles, Fraser, Aaron, West, and Jun, Teruya

Subjects
Blood Coagulation Factor Inhibitors, Thrombin, Factor V, Infant, Hemostatics, Child, Preschool, Prothrombin Time, Animals, Humans, Cattle, Female, Partial Thromboplastin Time, Cardiac Surgical Procedures, Blood Coagulation
Abstract

Factor V and thrombin inhibitors may develop following exposure to bovine thrombin preparations. In patient populations where exposure to bovine thrombin is common, such as children undergoing cardiovascular surgery, the development of such inhibitors should be considered in the evaluation of prolonged prothrombin times. We present three cases of children developing factor V and thrombin inhibitors following repeated exposure during cardiac surgical procedures.

Published
2010

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