1. The Role of MicroRNA in Graft-Versus-Host-Disease: A Review.
- Author
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Pitea, Martina, Canale, Filippo Antonio, Porto, Gaetana, Verduci, Chiara, Utano, Giovanna, Policastro, Giorgia, Alati, Caterina, Santoro, Ludovica, Imbalzano, Lucrezia, and Martino, Massimo
- Subjects
HOMEOSTASIS ,HEMATOPOIETIC stem cell transplantation ,BLOOD diseases ,GRAFT versus host disease ,MICRORNA ,STEM cell transplantation - Abstract
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a clinically challenging modality for the treatment of many hematologic diseases such as leukemia, lymphoma, and myeloma. Graft-versus-host disease (GVHD) is a common complication after allo-HSCT and remains a major cause of morbidity and mortality, limiting the success of a potentially curative transplant. Several microRNAs (miRNAs) have recently been shown to impact the biology of GVHD. They are molecular regulators involved in numerous processes during T-cell development, homeostasis, and activation, and contribute to the pathological function of T-cells during GvHD. Here, we review the key role of miRNAs contributing to the GvHD; their detection might be an interesting possibility in the early diagnosis and monitoring of disease [ABSTRACT FROM AUTHOR]
- Published
- 2023
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