1. Escorting α-globin to eNOS: α-globin-stabilizing protein paves the way.
- Author
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Straub, Adam C. and Gladwin, Mark T.
- Subjects
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ENDOTHELIAL cells , *NITRIC-oxide synthases , *BLOOD pressure , *VASCULAR smooth muscle , *GLOBIN genes , *GENE expression , *ANIMAL experimentation , *COMPARATIVE studies , *ENDOTHELIUM , *EPITHELIAL cells , *HEMOGLOBINS , *RESEARCH methodology , *MEDICAL cooperation , *MICE , *MOLECULAR chaperones , *OXIDOREDUCTASES , *RESEARCH , *EVALUATION research - Abstract
In the vascular wall, endothelial nitric oxide synthase (eNOS) produces NO to regulate peripheral vascular resistance, tissue perfusion, and blood pressure. In resistance arteries, eNOS couples with α-globin and, through chemical reactions, modulates NO diffusion needed for vascular smooth muscle relaxation. While α-globin protein alone is known to be unstable, the mechanisms that enable α-globin protein expression remain elusive. Here, Lechauve et al. report that arterial endothelium expresses α hemoglobin-stabilizing protein, which acts as a critical chaperone protein for α-globin expression and vascular function. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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