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This study was designed to assess the effects of fasting during Ramadan on weight, blood pressure, metabolic control and plasma lipoproteins in diabetic patients. This study was conducted in December 2000 (Ramadan 1421) when the length of fasting was 12 hours a day. It included 38 type 2 diabetic patients (20 males and 18 females). Mean patient age was 51.410.5 years and mean body mass index (BMI) 28.94.7kg/m2. Three patients were treated with diet and 35 with oral hypoglycemic agents. Clinical and biochemical parameters were evaluated during three periods: three weeks before Ramadan (T0), at the fourth week of Ramadan (T1) and three weeks after the end of Ramadan (T2). During the month of Ramadan, a decrease in weight (0.52kg) and no change in blood pressure were observed. No metabolic complication occurred in our patients. A significant effect of Ramadan fasting was observed on glycemic control and lipoprotein levels. In patients whose fructosamine level before Ramadan was higher than 340micromol/l, plasma fasting glucose and serum fructosamine increased during Ramadan (p

Nous avons analysé les effets métaboliques, en particulier les variations du cholestérol HDL, du jeûne du mois de ramadan chez 25 diabétiques de type 2 bien équilibrés traités par le régime ou les antidiabétiques oraux. Nos patients ont été évalués trois semaines avant le ramadan, durant la quatrième semaine du mois de ramadan et trois semaines aprés le mois de ramadan. Cette évaluation a comporté une enquête clinique, une enquête nutritionnelle et des analyses biologiques. Le jeûne du mois de ramadan n’a pas eu d’influence sur le poids, la tension artérielle, la glycémie, la fructosamine et l’hémoglobine A1c. Nous avons trouvé une relation négative entre les variations du cholestérol HDL et la consommation alimentaire de cholestérol. Le cholestérol HDL a augmenté de 13 % à la fin du jeûne et de 23 % trois semaines après la fin du jeûne chez les diabétiques ayant eu une consommation alimentaire de cholestérol inférieure à 400 mg/j

We assessed the effects of Ramadan fasting on metabolic control, particularly change of HDL-cholesterol in 25 type 2 diabetic patients treated with diet or oral agents, with good metabolic control. Clinical and biochemical parameters and food intake were evaluated 3 weeks before Ramadan, in the fourth week of Ramadan and 3 weeks after Ramadan.There were no changes in body weight and blood pressure nor any metabolic complications. The mean plasma fasting glucose, serum fructosamin and haemoglobin A1c did not change. We found a negative relation between cholesterol intake during Ramadan and the change of HDL-cholesterol. When cholesterol intake was lower than 400 mg/day, plasma HDL-cholesterol increased by 13% at the end of Ramadan and by 23% 3 weeks after Ramadan.