1. Differential Expression of miR-125a-5p and let-7e Predicts the Progression and Prognosis of Non-Small Cell Lung Cancer.
- Author
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Wang-Yu Zhu, Bin Luo, Ji-yuan An, Jian-ying He, Dong-dong Chen, Li-YunXu, Yan-Yan Huang, Xiao-Guang Liu, Han-bo Le, and Yong-Kui Zhang
- Subjects
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GENE expression , *MICRORNA , *CANCER invasiveness , *LUNG cancer prognosis , *REVERSE transcriptase polymerase chain reaction , *BLOOD serum analysis - Abstract
Aberrant expression of various microRNAs (miRNA) has shown diagnostic and prognostic significance in non-small cell lung cancer (NSCLC). qRT-PCR analysis confirmed altered expression of miR-125a-5p, let-7e, miR-30a, miR-30e and miR-30e-3p in 70 paired tissue and serum samples from NSCLC patients. The reduced expression of miR-125a-5p, let-7e and miR-30e was strongly associated with NSCLC dedifferentiation. The lost expression of miR-125a-5p and let-7e was associated with shorter overall survival and let-7e was an independent prognostic factor for NSCLC patients. These five miRNA expressions should be further evaluated as biomarkers for the early detection and prognosis of NSCLC patients. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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