1. Association between n-3 polyunsaturated fatty acids in erythrocytes and metabolic syndrome in Chinese men and women.
- Author
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Dai, Xiao-wei, Chen, Yu-ming, Zeng, Fang-fang, Sun, Li-li, Chen, Cao-gang, and Su, Yi-xiang
- Subjects
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ERYTHROCYTES , *CHI-squared test , *CONFIDENCE intervals , *GAS chromatography , *INTERVIEWING , *NUTRITIONAL assessment , *OMEGA-3 fatty acids , *PROBABILITY theory , *QUESTIONNAIRES , *RESEARCH funding , *T-test (Statistics) , *DOCOSAHEXAENOIC acid , *EICOSAPENTAENOIC acid , *METABOLIC syndrome , *BODY mass index , *LIFESTYLES , *DATA analysis software , *DESCRIPTIVE statistics , *ODDS ratio , *MANN Whitney U Test , *ALPHA-linolenic acid - Abstract
Purpose: Evidence of an association between n-3 polyunsaturated fatty acids (PUFAs) and metabolic syndrome (MS) is limited and inconsistent. We investigated the association between n-3 PUFAs in erythrocytes and the presence of MS in Chinese adults. Methods: The levels of α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) in erythrocytes were measured using gas chromatography in 3072 participants (900 men and 2172 women) aged 30-75 years from Guangzhou, China. Cardiometabolic factors were determined, and MS was defined using the updated Adult Treatment Panel III criteria. Other covariates were collected via interviewer-administered questionnaires. Results: After adjusting for age and other confounders, higher levels of marine-derived n-3 PUFAs, including EPA, DPA, and DHA, were associated with a lower presence of metabolic syndrome in both men and women. The odds ratios (95 % confidence interval) for MS obtained by comparing extreme quartiles were 0.55 (0.35-0.88) (EPA), 0.54 (0.34-0.87) (DPA), 0.45 (0.27-0.73) (DHA), and 0.52 (0.32-0.84) (total n-3 PUFAs) in men ( p trend <0.05 for all results); and 0.74 (0.56-0.99) (EPA), 0.73 (0.55-0.98) (DPA), 0.75 (0.56-1.02) (DHA), and 0.71 (0.53-0.96) (total n-3 PUFAs) in women, respectively. No significant association of ALA with MS was observed ( p trend > 0.05). Conclusion: Higher levels of total n-3 PUFAs, EPA, DPA, and DHA, but not of ALA, in erythrocyte membranes are associated with a lower presence of metabolic syndrome in Chinese adults. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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