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Background: Overweight and obesity are also found among persons with type 1 diabetes., Objective: The present study examined which nutrients predict the body mass index (BMI), the waist-to-hip ratio (WHR) and the waist circumference (WC) of European persons with type 1 diabetes., Design: Cross-sectional, clinic-based study (EURODIAB Complications Study)., Subjects and Methods: Nutrient intakes (assessed by a 3-day dietary record) predicting measures of body weight (BMI, WHR and WC) were determined by stepwise forward regression analysis in 1458 males and 1410 females with type 1 diabetes (P< or =0.05 for inclusion)., Results: In men, a higher carbohydrate intake was a significant independent predictor for lower levels of BMI, WHR and WC, an increased saturated fat intake and a lower intake of cereal fibre predicted a higher WHR, a higher monounsaturated fat intake and a lower glycaemic index of the diet determined lower levels of WHR and WC, and a moderate consumption of alcohol determined an increased WC. In women, a higher carbohydrate intake predicted a lower BMI and a thinner WC, no alcohol consumption determined a lower BMI, and an increased intake of saturated fat and a lower consumption of cereal fibre were significant independent predictors for a higher WHR., Conclusions: A modified fat intake, an increase of carbohydrate and cereal fibre intake and a preferred consumption of low glycaemic index foods are independently related to lower measures of body weight in European persons with type 1 diabetes.

Background: Restrained Eating, i.e. the tendency to restrict dietary intake to control body-weight, often emerges during adolescence and may result in changes in circadian eating patterns. Objective: The objective of the present investigation was to determine the cross-sectional relevance of restrained eating for characteristics of circadian eating pattern in adolescents and whether changes in restrained eating are accompanied by concurrent changes in circadian eating pattern over the course of adolescence. Methods: Two questionnaires assessing restrained eating (Score 0–30) with parallel 3-day weighed dietary records from two different time points were available from 209 (♂:101, ♀:108) 11–18 year old adolescents of the DONALD study. Mixed linear regression models were used to analyze whether restrained eating was associated with eating occasion frequency, snack frequency and morning and evening energy intake [in % of daily energy intake, %E]. Linear regression models were used to examine whether changes in restrained eating were associated with changes in the mentioned variables. Results: Among girls, greater restrained eating was cross-sectionally associated with higher morning energy intake (p = 0.03). Further, there was a tendency towards lower evening energy intake with higher levels of restrained eating for the whole sample (p = 0.06). No cross-sectional associations were found with eating occasion or snack frequency. Each one-point increase in restrained eating during adolescence was related to a concurrent decrease in eating occasion frequency by 0.04 (95% CI -0.08; -0.01, p = 0.02) and in evening energy intake by 0.36%E (95% CI -0.70; -0.03, p = 0.04). A tendency towards decreasing snack frequency with increasing restrained eating was observed (β = -0.03, 95% CI -0.07; 0.00, p = 0.07). No association was found between changes in restrained eating and concurrent changes in morning energy intake. Conclusion: We found indications for cross-sectional and prospective associations between restrained eating and chronobiological aspects of food intake in adolescents. Our results suggest that restrained eating should be considered a relevant determinant of circadian eating patterns. [ABSTRACT FROM AUTHOR]

Early life, adiposity rebound, and puberty represent critical growth periods when food choices could have long-term relevance for cancer risk. We aimed to relate dietary patterns during these periods to the growth hormone-insulin-like-growth-factor (GH-IGF) axis, insulin resistance, and body fatness in adulthood. Data from the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) Study participants with outcome data at 18–37 years, and ≥2 dietary records during early life (1–2 yr;n= 128), adiposity rebound (4–6 years,n= 179), or puberty (girls 9–14, boys 10–15 yr;n= 213) were used. Dietary patterns at these ages were derived by 1) reduced rank regression (RRR) to explain variation in adult IGF-I, IGF-binding protein-3 (IGFBP-3), homoeostasis model assessment for insulin resistance (HOMA-IR) and fat-mass index; 2) principal component analysis (PCA). Regarding RRR, the patterns “cake/canned fruit/cheese & eggs” (early life), “sweets & dairy” (adiposity rebound) and “high-fat foods” (pubertal boys) were independently associated with higher adult HOMA-IR. Furthermore, the patterns “favorable carbohydrate sources” (early life), “snack & convenience foods” (adiposity rebound), and “traditional & convenience carbohydrates” (pubertal boys) were related to adult IGFBP-3 (Ptrend < 0.01). PCA identified “healthy” patterns for all periods, but none was associated with the outcomes (Ptrend > 0.1). In conclusion, dietary patterns during sensitive growth periods may be of long-term relevance for adult insulin resistance and IGFBP-3. [ABSTRACT FROM PUBLISHER]

Objectives:To examine whether maximal velocities of weight, height and fat mass during potentially critical periods of growth were associated with body composition in young adulthood.Subjects/methods:Analyses were performed on 277 female and 271 male participants of the DOrtmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study with anthropometric measurements in young adulthood (18-25 years) as well as early life (0-2 years), mid-childhood (3-8 years) or puberty (9-15 years). Maximum growth velocities were calculated using the SuperImposition by Translation And Rotation (SITAR) routine or polynomial functions and related to adult fat mass index (FMI) and fat-free mass index (FFMI).Results:In early life, faster weight gain was associated with a moderately higher FMI and FFMI in young adulthood in women only (Ptrend=0.01). In mid-childhood and puberty, weight and fat mass velocities were related to adult FMI and FFMI in both sexes (Ptrend⩽0.002): relative differences between the highest and lowest tertiles of these growth velocities ranged 33-69% for adult FMI and 6-12% for adult FFMI. A higher mid-childhood height velocity was related to a modestly higher adult FMI in women only (Ptrend=0.0005).Conclusions:Faster gain in weight and body fat during mid-childhood and puberty appear to be particularly relevant for adult fat mass. [ABSTRACT FROM AUTHOR]

Primary school years seem to represent a critical period for the development of overweight and obesity. However, only a few studies have analysed the prospective relationship between dietary patterns and weight status in children. The aims of the present study were to identify dietary patterns at the beginning of and during the primary school period and to examine their relevance to the development of body composition. Nutritional and anthropometric data from 371 participants of the Dortmund Nutritional and Longitudinally Designed (DONALD) Study at the beginning (ages 6 and 7 years) and end (ages 10 and 11 years) of the primary school period were used. Principal component analyses (PCA) were conducted to identify dietary patterns, which were regressed on changes in BMI and fat mass index (FMI) between ages 6 and 7 years and ages 10 and 11 years. Reduced rank regression (RRR) was used to directly extract patterns explaining variation in changes in BMI and FMI between ages 6 and 7 years and ages 10 and 11 years. PCA yielded interpretable patterns of dietary changes at the beginning of and during the primary school period, which were not related to changes in body composition. Conversely, RRR allowed identifying predictive patterns: higher baseline intakes of white bread and lower baseline intakes of whole-grain products as well as increases in the consumption of savoury snacks, sausages and cheese during primary school years independently predicted increases in BMI and FMI during the primary school period. In conclusion, selection of unfavourable carbohydrate sources at the beginning of the primary school period and increases in the consumption of processed savoury foods during primary school years may adversely affect the development of body composition during the course of primary school. [ABSTRACT FROM PUBLISHER]

Objective: To examine, whether overweight in adolescents can be predicted from the body mass index (BMI) category, at the age of 6, the mother's education level and mother's obesity and to quantify the proportion of overweight at the age of 14 that can be explained by these predictors. Method: Pooled data from three German cohorts providing anthropometric and other relevant data to a total of 1 287 children. We used a classification and regression tree (CART) approach to identify the contribution of BMI category at the age of 6 (obese: BMI>97th percentile (P97); overweight: P90P90) at the age of 14. Results: While 4.8% [95%CI: 3.2;7.0] of 651 boys and 4.1% [95%CI: 2.6;6.2] of 636 girls with a BMIP97 (similar results for girls). BMI≥P75 at the age of 6 explained 63.5% [95%CI: 51.1;74.5]) and 72.0% [95%CI: 60.4;81.8] of overweight/obesity at the age of 14 in boys and girls, respectively. Conclusions: Overweight/obesity in adolescence can be predicted by BMI category at the age of 6 allowing for parent counselling or risk guided interventions in children with BMI≥P75, who accounted for >2/3 of overweight/obesity in adolescents. [ABSTRACT FROM AUTHOR]

Objective:To analyse the influence of habitual protein intake in early childhood on age and body mass index (BMI) at adiposity rebound (AR), a potential critical period for the development of obesity.Subjects:A total of 313 children (161 boys, 152 girls) participating in the Dortmund Nutritional and Anthropometric Longitudinally Designed Study.Methods:Weighted summary indices were created reflecting habitual, energy-adjusted protein intake (expressed as % of energy) and protein intake per kg reference body weight per day (g/kg RBW/day) between the age of 12 and 24 months. Body mass index standard deviation scores (BMI-SDS), age at AR and covariates (mother's BMI, gestational age, breastfeeding and siblings) were included in the final models.Results:After adjusting for potential confounders, girls in the highest tertile (T3) of habitual energy-adjusted protein intake had a significantly higher BMI-SDS at AR than those in T1 (T1: −0.61 (95% CI: −0.90; −0.31), T2: −0.49 (−0.79; −0.20), T3: −0.08 (−0.36; 0.20), P for difference=0.01). A comparable association existed with habitual protein intake expressed as g/kg RBW/day (T1: −0.64 (−0.93; −0.36), T2: −0.22 (−0.52; 0.09), T3: −0.25 (−0.54; 0.04), P=0.04). In boys, there were no differences in BMI-SDS at AR between tertiles of habitual protein intake (% of energy or g/kg RBW/day) (P>0.05). Boys in the lowest tertile of habitual energy-adjusted protein intake tended to experience a later AR (T1: 6.0 (5.6; 6.4), T2: 5.5 (5.1; 5.9), T3: 5.4 (5.0; 5.9) years, P=0.07). But neither in girls nor in boys was age at AR significantly different between tertiles of habitual protein intake (% of energy or g/kg RBW/day) (P>0.05).Conclusion:A higher habitual protein intake between the age of 12 and 24 months was associated with a higher BMI-SDS at AR in girls, but not in boys. There was no consistent relation between habitual protein intake in early childhood and timing of AR.International Journal of Obesity (2006) 30, 1072–1079. doi:10.1038/sj.ijo.0803288; published online 7 March 2006 [ABSTRACT FROM AUTHOR]

This study first examined whether urinary C-peptide (UCP), stored at -20 degrees C, remains stable over the long term, and second, whether the dietary glycemic index (GI) and the glycemic load (GL: GI x g carbohydrates) are related to the 24-h UCP excretion of healthy children. Participants in the Dortmund Nutrition and Anthropometric Longitudinally Designed Study with 24-h urine collections and a simultaneously completed weighed dietary record were included. From these, 3 comparable groups of 7- to 8-y-old children (n = 40 each) from 1990, 1996, and 2002 were randomly selected (total n = 120). C-peptide was measured with a 1-site ELISA. A GI value was assigned to all recorded foods containing carbohydrates (CHO). Statistical equivalence tests corroborated that UCP excretion in the 3 sampling periods was equivalent when corrected for body weight and protein intake (P < 0.05). UCP excretion was associated with the GL after adjustment for body weight, protein, and fiber intake [mean UCP (95% CI) in GL tertiles 1-3: 6.19 (5.37, 7.14) vs. 7.82 (6.77, 9.02) vs. 7.76 (6.71, 8.97) nmol/d, P for difference 0.04]. GI was not significantly related to UCP excretion [adjusted means (95% CI): 7.27 (6.28, 8.41) vs. 6.51 (5.64, 7.51) vs. 7.94 (6.86, 9.18), P for difference 0.2]. In conclusion, UCP retrospectively measured with a 1-site ELISA remained stable for up to 12 y (from 1990 until 2002). The observed positive relation of UCP with GL appears to result largely from its association with the amount of CHO, whereas dietary GI may be relevant only at higher intake levels. [ABSTRACT FROM AUTHOR]