1. Engaging a polylactide copolymer in oral tissue regeneration: first validation of Suprathel
- Author
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Cristian Dinu, Ileana Mitre, Winfried Kretschmer, Dan Gheban, Gabriel Armencea, Simion Bran, Grigore Baciut, Horatiu Alexandru Colosi, Sergiu Vacaras, Septimiu Toader, Horia Opris, Mihaela Baciut, Avram Manea, Mihaela Hedesiu, and Daiana Opris
- Subjects
FDBA – frozen-dried bone allograft ,Male ,Pathology ,medicine.medical_specialty ,Bone Regeneration ,PLGA – poly-lactide-co-glycolide ,Polyesters ,CPB – porcine bone ,PLA – poly-lactic acid ,Neovascularization, Physiologic ,Biocompatible Materials ,Bone healing ,Suprathel® ,Matrix (biology) ,Bone and Bones ,Epithelium ,socket preservation ,Osteogenesis ,Regeneration in humans ,PVA – polyvinyl alcohol ,Medicine ,Animals ,Regeneration ,Oral mucosa ,Dental alveolus ,Socket preservation ,Mouth ,Wound Healing ,oral mucosa ,business.industry ,Guided Tissue Regeneration ,Regeneration (biology) ,Mouth Mucosa ,Biomaterial ,General Medicine ,PGA – poly-glycolic acid ,rhBMP-2 – recombinant human morphogenetic protein-2 ,GBR –Guided bone regeneration ,medicine.anatomical_structure ,PCL – polycaprolactone ,Cancellous Bone ,Original Article ,Rabbits ,bone healing ,business - Abstract
The present study investigated the capacity of Suprathel® (a copolymer membrane, so far validated for skin regeneration) to also regenerate oral tissue – mucosa and bone, by comparing this biomaterial, in a split-mouth rabbit model, to Mucoderm®, a xenogeneic collagen matrix certified for keratinized oral mucosa healing. The clinical reason behind this experimental animal model was to determine whether the benefits of this advanced skin regeneration product (Suprathel®) could be conveyed for future evaluation in clinical trials of oral tissue regeneration in humans. The outcomes of this study validated the use of Suprathel®, a terpolymer of polylactide with trimethylene carbonate and ε-caprolactone, for stimulation of oral epithelium and alveolar bone regeneration in rabbits. Both Suprathel® and Mucoderm® exhibited comparable results and the null hypothesis stating a comparable regenerating effect of these two materials could not be rejected.
- Published
- 2021