1. Bone marrow uptake of thallium-201 before and after therapy in multiple myeloma.
- Author
-
Ishibashi M, Nonoshita M, Uchida M, Kojima K, Tomita N, Matsumoto S, Tanaka K, and Hayabuchi N
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Humans, Lumbar Vertebrae diagnostic imaging, Lumbar Vertebrae pathology, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Myeloma drug therapy, Multiple Myeloma pathology, Radionuclide Imaging, Bone Marrow diagnostic imaging, Multiple Myeloma diagnostic imaging, Thallium Radioisotopes
- Abstract
We describe a patient with multiple myeloma who was found to have diffuse bone marrow uptake of 201Tl. Magnetic resonance (MR) imaging of the lumbar spine demonstrated abnormal low signal intensity on T1-weighted images and abnormal high signal intensity on T2-weighted images. The bone marrow consisted of 68% plasma cells, and the serum immunoglobulin (Ig)G concentration was 7900 mg/dL. After receiving chemotherapy, the percentage of plasma cells and serum IgG concentration declined and there was a decrease in the bone marrow uptake of 201Tl. However, the MR abnormalities in the lumbar spine showed no change after chemotherapy. This patient illustrates a limitation of the use of MR imaging for evaluation of disease state in patients with multiple myeloma, and demonstrates the potential usefulness of 201Tl imaging in these patients.
- Published
- 1998