1. The significance of bone marrow cell morphology and its correlation with cytogenetic features in the diagnosis of MDS-RA patients.
- Author
-
Liu D, Chen Z, Xue Y, Lu D, Zhou Y, Gong J, Wu W, Liang J, Ma Q, Pan J, Wu Y, Wang Y, Zhang J, and Shen J
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Diagnosis, Differential, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Retrospective Studies, Anemia, Refractory pathology, Bone Marrow Cells pathology, Chromosome Aberrations, Myelodysplastic Syndromes pathology
- Abstract
Besides cytopenia, dysplasia is crucial characteristic of MDS-RA. To summarize the morphological features that contribute to the diagnosis of MDS-RA, 48 RA patients with abnormal karyotype were analyzed for the features of morphological and cytogenetical abnormalities and the relationships between them. 46 MDS-RA patients with normal karyotype and 207 patients with non-MDS anemia were enrolled into control groups. More conspicuous and diverse dysplasia can be found in abnormal karyotype MDS-RA than those in control groups (P<0.05). Apparent dysplasia in granulocyte and megakaryocytoid lineages may provide valuable evidence for the diagnosis. Dysplasia occurred more frequently in patients with severe chromosome abnormalities.
- Published
- 2009
- Full Text
- View/download PDF