1. 瞠来麟酸钠对类风湿关节炎继发性骨质疏松症患者腰椎骨密度和骨代 谢标志物的影响
- Author
-
陈磊, 张兰玲, 俞登荣, 朱晓俊, 夏云霞, and 万伟
- Subjects
- *
SECONDARY metabolism , *BONE density , *TERIPARATIDE , *ZOLEDRONIC acid , *BONE metabolism , *LUMBAR vertebrae , *CALCITRIOL , *CALCIUM supplements - Abstract
Objective: To retrospectively analyze the changes of bone mineral density (BMD) and bone metabolism in the patients with secondary rheumatoid arthritis osteoporosis treated with zoledronic acid sodium for over 3 times, explore whether long-term use of zoledronic acid sodium could improve and maintain the BMD of the patients for a long time, and also to observe the effects of zoledronic acid sodium on bone metabolism markers of the patients. Methods: 124 patients with secondary rheumatoid arthritis osteoporosis treated with zoledronic acid sodium and hospitalized in Changhai Hospital, Naval Medical University from May 2010 to December 2015 were selected as the treatment group. The patients in the treatment group were treated with 6 g of calcium acetate, qd, Q.25 of cal ci triol, po, qd and 5 mg of zoledronic acid sodium, po, once every 12 months, by ivgtt. Another 124 patients with rheumatoid arthritis but without osteoporosis were selected as the control group and were also trea - ted with calcium acetate and calcitriol in the same way as the treatment group. The BMD values of Li-4 lumbar vertebra and bone metabolism markers of the patients in the two groups were detected and compared before treatment and after treatment for 1,2 and 3 years and a medical followup for over 3 years. Results: The BMD values of lumbar vertebra increased in both groups after treatment. However, the BMD values of the treatment group increased more significantly as compared with those of the co nt rol group (P<0.05). As compared with befo re treatment, the bo ne metabolism markers type I procollagen amino terminal pro peptide (PINP) and 25 hy d ro xy vit am in D (25-0H~D3) all increased significantly (P<0 .05), and p-collagen degradation products ((3-CTX) significantly decreased (PC0 .05). Conclusion: Zoledronic acid sodium combined with calcium and calcitriol could significantly improve the BMD value of lumbar vertebra in the patients with secondary rheumatoid arthritis osteoporosis. However, prolonged use of zoledronic acid sodium (for more than 3 times) is not directly correlated with application frequency. At the same time, this treatment has little effect on bone metabolism/which might effectively inhibit bone resorption and reduce bone turnover rate as well. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF