1. The HLA-A03 supertype and several Pan species' MHC-A allotypes share a preference for binding positively charged residues in the F pocket: implications for controlling retroviral infections.
- Author
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de Groot, Natasja G., Heijmans, Corrine M. C., de Ru, Arnoud H., Otting, Nel, Koning, Frits, van Veelen, Peter A., and Bontrop, Ronald E.
- Subjects
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RETROVIRUS diseases , *BONOBO , *CHIMPANZEES , *POPULATION , *MAJOR histocompatibility complex , *SPECIES - Abstract
The major histocompatibility complex (MHC) class I region of humans, chimpanzees (Pan troglodytes), and bonobos (Pan paniscus) is highly similar, and orthologues of HLA-A, -B, and -C are present in both Pan species. Based on functional characteristics, the different HLA-A allotypes are classified into different supertypes. One of them, the HLA A03 supertype, is widely distributed among different human populations. All contemporary known chimpanzee and bonobo MHC class I A allotypes cluster genetically into one of the six HLA A families, HLA-A1/A3/A11/A30. We report here that the peptide-binding motif of the Patr-A*05:01 allotype, which is commonly present in a cohort of Western-African chimpanzees, has a strong preference for binding peptides with basic amino acids at the carboxyl terminus. This phenomenon is shared with the family members of the HLA A03 supertype. Based on the chemical similarities in the peptide-binding pocket, we inferred that the preference for binding peptides with basic amino acids at the carboxyl terminus is widely present among the human, chimpanzee, and bonobo MHC-A allotypes. Subsequent in silico peptide-binding predictions illustrated that these allotypes have the capacity to target conserved parts of the HIV-1/SIVcpz proteome. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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