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In this study, a new fractional-order model for human skull heat conduction is tackled by using a neural network, and the results were further modified by using the hybrid cuckoo search algorithm. In order to understand the temperature distribution, we introduced memory effects into our model by using fractional time derivatives. The objective function was constructed in such a way that the L 2 − error remained at a minimum. The fractional order equation was then calculated by using the proposed biogeography-based hybrid cuckoo search (BHCS) algorithm to approximate the solution. When compared to earlier simulations based on integer-order models, this method enabled us to examine the fractional-order (FO) cases, as well as the integer order. The results are presented in the form of figures and tables for the different case studies. The results obtained for the various parameters were validated numerically against the available literature, where our proposed methodology showed better performance when compared to the least squares method (LSM). [ABSTRACT FROM AUTHOR]