1. Risk factor analysis for inaccurate pre-operative MRI staging in rectal cancer
- Author
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Zerong Cai, Yufeng Chen, Zexian Chen, Yifeng Zou, Wuteng Cao, Ping Lan, Xiaojian Wu, Khamis Salem Saeed Saad, and Xiaoyu Xie
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Colorectal cancer ,Lower risk ,Gastroenterology ,lcsh:RC254-282 ,Surgical oncology ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Genetics ,Medicine ,Humans ,Stage (cooking) ,Risk factor ,Rectal cancer ,Neoplasm Staging ,Retrospective Studies ,TNM stage ,business.industry ,Rectal Neoplasms ,Middle Aged ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Adenocarcinoma, Mucinous ,Magnetic Resonance Imaging ,Bowel obstruction ,Oncology ,T-stage ,Adenocarcinoma ,Female ,business ,Factor Analysis, Statistical ,Follow-Up Studies ,Research Article ,MRI - Abstract
Background Various tumor characteristics might lead to inaccurate local MRI-defined stage of rectal cancer and the purpose of this study was to explore the clinicopathological factors that impact on the precision pre-treatment MRI-defined stage of rectal cancer. Methods A retrospectively analysis was conducted in non-metastatic rectal cancer patients who received radical tumor resection without neoadjuvant treatment during 2007–2015 in the Sixth Affiliated Hospital of Sun Yat-sen University. Clinical T stage and N stage defined by pelvic enhanced MRI and pathological stage were compared and patients were subdivided into accurate-staging, over-staging and under-staging subgroups. Logistic regressions were used to explore risk factors for over-staging or under-staging. Results Five hundred fifty-one cases of patients were collected. Among them, 109 cases (19.4%) of patients were over-T-staged and 50 cases (8.9%) were under-T-staged, while 78 cases (13.9%) were over-N-staged and 75 cases (13.3%) were under-N-staged. Logistic regression suggested that pre-operative bowel obstruction was risk factor for over-T-staging (OR = 3.120, 95%CI: 1.662–5.857, P P P P = 0.024) and higher risk for over-N-staging (OR = 1.434, 95%CI: 1.223–1.680, P Conclusion Bowel obstruction, mucinous adenocarcinoma and tumor size might have impact on the pre-operative MRI T staging or N staging of rectal cancer. Our results reminded clinicians to assess clinical stage individually in such rectal cancer patients.
- Published
- 2020