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Gayet Wernicke encephalopathy (EGW) is a neurological emergency secondary to thiamine deficiency (vitamin B1). This is more often secondary to chronic alcoholism. The purpose of this study is to remind clinicians of some clinical signs different from ethylism, suggesting EGW as well as to report four cases characterized by different types of anomalies shown by MRI. The average age of patients was 40 years (2 females 2 males). The neurological picture was characterized by disorders of vigilance in all patients, oculomotor disorders in 2 cases, and cerebellar ataxia in one patient. Chronic vomiting was reported in two cases, prolonged fasting in the first case and alcoholism in the second case. MRI of the brain showed anomalies suggesting EGW in all patients with contrast enhancement in one case. Thiamin deficiency was confirmed in two patients. In our context EGW seems to be more frequent in pathological circumstances other than chronic alcoholism (chronic vomiting, severe malnutrition, severe starvation, and chemotherapy...). The clinical signs can suggest other pathologies such as cerebral venous thrombosis, stroke, or other metabolic disorders but MRI excluded them and allowed the diagnosis of EGW. MRI of the brain has an essential role in the diagnosis of EGW. Absence or delay in treatment may influence the prognosis., Competing Interests: Les auteurs ne déclarent aucun conflit d´intérêts., (Copyright: Siham Bouchal et al.)

Creutzfeldt-jakob disease (CJD) is a very rare and fatal disease affecting the central nervous system. It is characterized by mental deterioration leading to progressive dementia, pyramidal and extrapyramidal symptoms as well as myoclonus. Early diagnosis is essential to prevent human-to-human transmission. We here report the case of a 62-year old patient in whom the diagnosis of sporadic CJD was retained based on his clinical status including dementia-related deterioration with myoclonus preceded by behavioral disorders, hallucinations and depression and on brain MRI data showing hyperintensities at the level of the striatum and the cortex on FLAIR and diffusion-weighted imaging sequences., Competing Interests: Les auteurs ne déclarent aucun conflit d'intérêts.