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3 results on '"Branagan, Aoife"'

1. Proceedings of the 13th International Newborn Brain Conference: Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring.

Author

Abend N, Adams E, Al Balushi A, Alburaki W, Appendino J, Barbosa VS, Birca A, Bonifacio S, Branagan A, Chang T, Chowdhury R, Christou H, Chu C, Cilio MR, Comani S, Corsi-Cabrera M, Croce P, Cubero-Rego L, Dawoud F, de Vries L, Dehaes M, Devane D, Duncan A, El Ters N, El-Dib M, Elshibiny H, Esser M, Fairchild K, Finucane E, Franceschini MA, Gallagher A, Ghosh A, Glass H, Venkata SKRG, Baillet TH, Herzberg E, Hildrey E, Hurley T, Inder T, Jacobs E, Jefferies K, Jermendy A, Khazaei M, Kilmartin K, King G, Lauronen L, Lee S, Leijser L, Lind J, Llaguno NS, Machie M, Magalhães M, Mahdi Z, Maluomi J, Marandyuk B, Massey S, McCulloch C, Metsäranta M, Mikkonen K, Mohammad K, Molloy E, Momin S, Munster C, Murthy P, Netto A, Nevalainen P, Nguyen J, Nieves M, Nyman J, Oliver N, Peeters C, Pietrobom RFR, Pijpers J, Pinchefksy E, Ping YB, Quirke F, Raeisi K, Ricardo-Garcell J, Robinson J, Rodrigues DP, Rosati J, Scott J, Scringer-Wilkes M, Shellhaas R, Smit L, Soul J, Srivastava A, Steggerda S, Sunwoo J, Szakmar E, Tamburro G, Thomas S, Toiviainen-Salo S, Toma AI, Vanhatalo S, Variane GFT, Vein A, Vesoulis Z, Vilan A, Volpe J, Weeke L, Wintermark P, Wusthoff C, Zappasodi F, Zein H, and Zempel J

Subjects
Electroencephalography, Humans, Infant, Newborn, Monitoring, Physiologic, Brain, Seizures therapy
Published
2022
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2. Neuroprotective therapies in the NICU in term infants: present and future.

Author

Molloy, Eleanor J, El-Dib, Mohamed, Juul, Sandra E, Benders, Manon, Gonzalez, Fernando, Bearer, Cynthia, Wu, Yvonne W, Robertson, Nicola J, Hurley, Tim, Branagan, Aoife, Michael Cotten, C, Tan, Sidhartha, Laptook, Abbot, Austin, Topun, Mohammad, Khorshid, Rogers, Elizabeth, Luyt, Karen, Bonifacio, Sonia, Soul, Janet S, Gunn, Alistair J, and Newborn Brain Society Guidelines and Publications Committee

Subjects
Newborn Brain Society Guidelines and Publications Committee, Humans, Brain Injuries, Hypoxia-Ischemia, Brain, Infant, Newborn, Diseases, Neuroprotective Agents, Hypothermia, Induced, Child, Infant, Infant, Newborn, Intensive Care Units, Neonatal, Neuroprotection, Pediatric, Neurosciences, Neurodegenerative, Physical Injury - Accidents and Adverse Effects, Brain Disorders, Infant Mortality, Perinatal Period - Conditions Originating in Perinatal Period, Reproductive health and childbirth, Good Health and Well Being, Paediatrics and Reproductive Medicine, Public Health and Health Services, Pediatrics
Abstract

Outcomes of neonatal encephalopathy (NE) have improved since the widespread implementation of therapeutic hypothermia (TH) in high-resource settings. While TH for NE in term and near-term infants has proven beneficial, 30-50% of infants with moderate-to-severe NE treated with TH still suffer death or significant impairments. There is therefore a critical need to find additional pharmacological and non-pharmacological interventions that improve the outcomes for these children. There are many potential candidates; however, it is unclear whether these interventions have additional benefits when used with TH. Although primary and delayed (secondary) brain injury starting in the latent phase after HI are major contributors to neurodisability, the very late evolving effects of tertiary brain injury likely require different interventions targeting neurorestoration. Clinical trials of seizure management and neuroprotection bundles are needed, in addition to current trials combining erythropoietin, stem cells, and melatonin with TH. IMPACT: The widespread use of therapeutic hypothermia (TH) in the treatment of neonatal encephalopathy (NE) has reduced the associated morbidity and mortality. However, 30-50% of infants with moderate-to-severe NE treated with TH still suffer death or significant impairments. This review details the pathophysiology of NE along with the evidence for the use of TH and other beneficial neuroprotective strategies used in term infants. We also discuss treatment strategies undergoing evaluation at present as potential adjuvant treatments to TH in NE.

Published
2023

3. Neuroprotective therapies in the NICU in term infants: present and future

Author

Molloy, Eleanor J, El-Dib, Mohamed, Juul, Sandra E, Benders, Manon, Gonzalez, Fernando, Bearer, Cynthia, Wu, Yvonne W, Robertson, Nicola J, Hurley, Tim, Branagan, Aoife, Michael Cotten, C, Tan, Sidhartha, Laptook, Abbot, Austin, Topun, Mohammad, Khorshid, Rogers, Elizabeth, Luyt, Karen, Bonifacio, Sonia, Soul, Janet S, Gunn, Alistair J, and Newborn Brain Society Guidelines and Publications Committee

Subjects
Physical Injury - Accidents and Adverse Effects, Diseases, Hypothermia, Reproductive health and childbirth, Neurodegenerative, Pediatrics, Paediatrics and Reproductive Medicine, Neonatal, Hypoxia-Ischemia, Infant Mortality, Humans, Child, Pediatric, Induced, Neurosciences, Brain, Infant, Perinatal Period - Conditions Originating in Perinatal Period, Newborn, Neuroprotection, Brain Disorders, Intensive Care Units, Neuroprotective Agents, Good Health and Well Being, Brain Injuries, Public Health and Health Services, Newborn Brain Society Guidelines and Publications Committee
Abstract

Outcomes of neonatal encephalopathy (NE) have improved since the widespread implementation of therapeutic hypothermia (TH) in high-resource settings. While TH for NE in term and near-term infants has proven beneficial, 30-50% of infants with moderate-to-severe NE treated with TH still suffer death or significant impairments. There is therefore a critical need to find additional pharmacological and non-pharmacological interventions that improve the outcomes for these children. There are many potential candidates; however, it is unclear whether these interventions have additional benefits when used with TH. Although primary and delayed (secondary) brain injury starting in the latent phase after HI are major contributors to neurodisability, the very late evolving effects of tertiary brain injury likely require different interventions targeting neurorestoration. Clinical trials of seizure management and neuroprotection bundles are needed, in addition to current trials combining erythropoietin, stem cells, and melatonin with TH. IMPACT: The widespread use of therapeutic hypothermia (TH) in the treatment of neonatal encephalopathy (NE) has reduced the associated morbidity and mortality. However, 30-50% of infants with moderate-to-severe NE treated with TH still suffer death or significant impairments. This review details the pathophysiology of NE along with the evidence for the use of TH and other beneficial neuroprotective strategies used in term infants. We also discuss treatment strategies undergoing evaluation at present as potential adjuvant treatments to TH in NE.

Published
2022

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