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3 results on '"Tribl, Florian"'

1. The HUPO Brain Proteome project wish list--summary of the 9(th) HUPO BPP Workshop 9-10 January 2008, Barbados.

Author

Hamacher M, Eisenacher M, Tribl F, Stephan C, Marcus K, Hardt T, Wiltfang J, Martens L, Desiderio D, Gutstein H, Park YM, and Meyer HE

Subjects
Barbados, Biochemistry methods, Biomarkers, Computational Biology methods, Humans, Models, Genetic, Pituitary Gland metabolism, Proteome, Brain metabolism, Brain Chemistry, Proteomics instrumentation, Proteomics methods
Abstract

The Human Brain Proteome Project (HUPO BPP) aims at advancing knowledge and the understanding of neurodiseases and aging with the purpose of identifying prognostic and diagnostic biomarkers, as well as to push new diagnostic approaches and medications. The participating groups meet in semi-annual workshops to discuss the progress, as well as the needs, within the field of proteomics. The 9(th) HUPO BPP workshop took place in Barbados from 9-10 January, 2008. Discussing the future HUPO BPP Roadmap, the attendees drafted the so called HUPO BPP wish list containing timelines, suggestions and missions. This wish list will be updated regularly and will serve as a guideline for the next phase.

Published
2008
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2. Streptozotocin-intracerebroventricularly treated rats: behavioral, neurochemical and structural resembling to the human sporadic type of Alzheimer's disease

Author

Salkovic-Petrisic, Melita, Tribl, Florian, Osmanovic, Jelena, Schmidt, Manuela, Hoyer, Siegfried, Riederer, Peter, and Iqbal K, Winblad B

Subjects
streptozotocin, Alzheimer's disease, brain, Akt/PKB, GSK-3
Abstract

Streptozotocin-intracerebroventricularly treated rats (STZ-icv) have become an experimental model of sporadic Alzheimer's disease, and demonstrate resembling in cognitive deficits, alterations of Akt/PKB and GSK-3 enzymes of insulin receptor signaling cascade in the brain, as well as alterations of tau protein and accumulation of beta amyloid like aggregates in the brain.

Published
2006

3. Analysis of organelles within nervous system: impact on brain and organelle functions.

Author

Tribl, Florian, Meyer, Helmut E., and Marcus, Katrin

Subjects
ORGANELLES, NERVOUS system, GENE expression, PROTEOMICS, LYSOSOMES, MELANINS
Abstract

Currently, neuroproteomic approaches aimed at the profiling of total brain areas generally mirror the expression of the most abundant proteins, but fail to uncover less abundant proteins. By contrast, the focus on typical brain subproteomes, (e.g., synaptic vesicles, synaptic terminal membranes or the postsynaptic density), may give a more specific insight into brain function. Subproteomes are accessible via several strategies, including subcellular fractionation or affinity-based pull-down approaches. Combined with mass spectrometric quantification approaches, subcellular proteomics is expected to reveal differences in the protein constitution of related cellular organelles. Focusing on novel functions and mechanistic models, we review recent data on the analysis of brain-derived organelles and subproteomes, including presynaptic termini, synaptic vesicles, neuronal plasma membranes, postsynaptic density and neuromelanin granules, which were identified as novel lysosome-related organelles within the human brain. [ABSTRACT FROM AUTHOR]

Published
2008
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