1. Human herpesvirus 6 (HHV-6) infection in the central nervous system.
- Author
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Yamanishi K, Kondo K, Mukai T, Kondo T, Nagafuji H, Kato T, Okuno T, and Kurata T
- Subjects
- Antibodies, Viral analysis, Antibodies, Viral immunology, Brain Diseases cerebrospinal fluid, Brain Diseases diagnosis, Child, Preschool, Cytopathogenic Effect, Viral immunology, Exanthema Subitum cerebrospinal fluid, Exanthema Subitum microbiology, Fluorescent Antibody Technique, Herpesviridae Infections cerebrospinal fluid, Herpesviridae Infections microbiology, Herpesvirus 6, Human immunology, Humans, In Vitro Techniques, Infant, Seizures, Febrile cerebrospinal fluid, Seizures, Febrile microbiology, Brain Diseases microbiology, Cerebrospinal Fluid microbiology, Exanthema Subitum diagnosis, Herpesviridae Infections diagnosis, Herpesvirus 6, Human isolation & purification, Seizures, Febrile diagnosis
- Abstract
Human herpesvirus 6 (HHV 6) was isolated from patients with exanthema subitum (ES) with a high frequency, and it is now believed that this virus causes ES as a primary infection in childhood. HHV 6 infection is highly prevalent in early childhood and this virus may infect infants through the saliva mainly from mother to child. HHV 6 has a tropism to CD4+ cells and destroys cells in vitro. Although children recover from ES without any sequelae, neurological symptoms associated with exanthema subitum are often observed, and we could detect HHV 6 in the cerebrospinal fluid of ES patients. This result suggests that HHV 6 may invade the central nervous system and cause neurological symptoms.
- Published
- 1992
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