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Late-onset seizures are frequently caused by cerebrovascular disease, head trauma, degenerative disorders or CNS tumors. In one-third of cases, the etiology remains obscure. In only 60-70% of adult-onset epilepsy is antiepileptic drug treatment successful. Although seizures are a well-known symptom of Hashimoto's encephalopathy, it is rarely taken into consideration as differential diagnosis in epilepsy. We describe a 74-year-old patient with seizures and slowly progressive cognitive deterioration. Previous therapeutic attempts with carbamazepine, lamotrigine and topiramate had not been effective. We suspected Hashimoto's encephalopathy, which was treated with prednisolone 100 mg/d over 6 months. This regimen led to a cessation of the complex partial seizures and cognitive improvement. We conclude that Hashimoto's encephalopathy is a possible differential diagnosis in epilepsy in the elderly. Glucocorticoid treatment should be considered if there are no important contraindications.