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Your search keyword '"Ernst, Marielle S."' showing total 2 results
Start Over Author "Ernst, Marielle S." Topic brain ischemia
2 results on '"Ernst, Marielle S."'

1. Automated Perfusion Calculations vs. Visual Scoring of Collaterals and CBV-ASPECTS : Has the Machine Surpassed the Eye?

Author

Psychogios MN, Sporns PB, Ospel J, Katsanos AH, Kabiri R, Flottmann FA, Menon BK, Horn M, Liebeskind DS, Honda T, Ribo M, Ruiz MR, Kabbasch C, Lichtenstein T, Maurer CJ, Berlis A, Hellstern V, Henkes H, Möhlenbruch MA, Seker F, Ernst MS, Liman J, Tsivgoulis G, and Brehm A

Subjects
Aged, Aged, 80 and over, Automation, Cerebral Angiography, Cerebrovascular Circulation, Female, Humans, Male, Reperfusion, Retrospective Studies, Thrombectomy, Tomography, X-Ray Computed, Treatment Outcome, Vision, Ocular, Brain Ischemia diagnostic imaging, Stroke
Abstract

Purpose: Use of automated perfusion software has gained importance for imaging of stroke patients for mechanical thrombectomy (MT). We aim to compare four perfusion software packages: 1) with respect to their association with 3‑month functional outcome after successful reperfusion with MT in comparison to visual Cerebral Blood Volume - Alberta Stroke Program Early CT Score (CBV-ASPECTS) and collateral scoring and 2) with respect to their agreement in estimation of core and penumbra volume., Methods: This retrospective, multicenter cohort study (2015-2019) analyzed data from 8 centers. We included patients who were functionally independent before and underwent successful MT of the middle cerebral artery. Primary outcome measurements were the relationship of core and penumbra volume calculated by each software, qualitative assessment of collaterals and CBV-APECTS with 3‑month functional outcome and disability (modified Rankin scale >2). Quantitative differences between perfusion software measurements were also assessed., Results: A total of 215 patients (57% women, median age 77 years) from 8 centers fulfilled the inclusion criteria. Multivariable analyses showed a significant association of RAPID core (common odds ratio, cOR 1.02; p = 0.015), CBV-ASPECTS (cOR 0.78; p = 0.007) and collaterals (cOR 0.78; p = 0.001) with 3‑month functional outcome (shift analysis), while RAPID core (OR 1.02; p = 0.018), CBV-ASPECTS (OR 0.77; p = 0.024), collaterals (OR 0.78; p = 0.007) and OLEA core (OR 1.02; p = 0.029) were significantly associated with 3‑month functional disability. Mean differences on core estimates between VEOcore and RAPID were 13.4 ml, between syngo.via and RAPID 30.0 ml and between OLEA and RAPID -3.2 ml., Conclusion: Collateral scoring, CBV-ASPECTS and RAPID were independently associated with functional outcome at 90 days. Core and Penumbra estimates using automated software packages varied significantly and should therefore be used with caution.

Published
2021
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2. Automated Perfusion Calculations vs. Visual Scoring of Collaterals and CBV-ASPECTS

Author

Psychogios, Marios-Nikos, Sporns, Peter B., Ospel, Johanna, Katsanos, Aristeidis H., Kabiri, Reza, Flottmann, Fabian A., Menon, Bijoy K., Horn, Mackenzie, Liebeskind, David S., Honda, Tristan, Ribo, Marc, Ruiz, Manuel Requena, Kabbasch, Christoph, Lichtenstein, Thorsten, Maurer, Christoph J., Berlis, Ansgar, Hellstern, Victoria, Henkes, Hans, Möhlenbruch, Markus A., Seker, Fatih, Ernst, Marielle S., Liman, Jan, Tsivgoulis, Georgios, and Brehm, Alex

Subjects
Aged, 80 and over, Male, Acute ischemic stroke, Collaterals, Perfusion imaging, Brain Ischemia, Cerebral Angiography, Stroke, Automation, Treatment Outcome, Patient selection, Cerebrovascular Circulation, Reperfusion, Humans, Original Article, Female, Tomography, X-Ray Computed, Vision, Ocular, Automated evaluation, Aged, Retrospective Studies, Thrombectomy
Abstract

Purpose Use of automated perfusion software has gained importance for imaging of stroke patients for mechanical thrombectomy (MT). We aim to compare four perfusion software packages: 1) with respect to their association with 3‑month functional outcome after successful reperfusion with MT in comparison to visual Cerebral Blood Volume - Alberta Stroke Program Early CT Score (CBV-ASPECTS) and collateral scoring and 2) with respect to their agreement in estimation of core and penumbra volume. Methods This retrospective, multicenter cohort study (2015–2019) analyzed data from 8 centers. We included patients who were functionally independent before and underwent successful MT of the middle cerebral artery. Primary outcome measurements were the relationship of core and penumbra volume calculated by each software, qualitative assessment of collaterals and CBV-APECTS with 3‑month functional outcome and disability (modified Rankin scale >2). Quantitative differences between perfusion software measurements were also assessed. Results A total of 215 patients (57% women, median age 77 years) from 8 centers fulfilled the inclusion criteria. Multivariable analyses showed a significant association of RAPID core (common odds ratio, cOR 1.02; p = 0.015), CBV-ASPECTS (cOR 0.78; p = 0.007) and collaterals (cOR 0.78; p = 0.001) with 3‑month functional outcome (shift analysis), while RAPID core (OR 1.02; p = 0.018), CBV-ASPECTS (OR 0.77; p = 0.024), collaterals (OR 0.78; p = 0.007) and OLEA core (OR 1.02; p = 0.029) were significantly associated with 3‑month functional disability. Mean differences on core estimates between VEOcore and RAPID were 13.4 ml, between syngo.via and RAPID 30.0 ml and between OLEA and RAPID −3.2 ml. Conclusion Collateral scoring, CBV-ASPECTS and RAPID were independently associated with functional outcome at 90 days. Core and Penumbra estimates using automated software packages varied significantly and should therefore be used with caution. Electronic supplementary material The online version of this article (10.1007/s00062-020-00974-3) contains supplementary material, which is available to authorized users.

Published
2020

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