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The authors report a retrospective review o f 70 patients followed up for the presence of incidental, asymptomatic meningiomas. A survey was conducted of primary intracranial tumors diagnosed in Hiroshima Prefectural Hospital between 1995 and 2004. The neuroradiological imaging and clinical studies for asymptomatic meningiomas were performed during the 57.5-month mean follow-up period. Of the asymptomatic 70 meningiomas, 34 (mean age 58.3yrs) were surgically removed just after diagnosis, whereas 36 (mean age 72.1yrs) were treated conservatively. There was no permanent morbidity. Five patients (13%) had the transient operation-related neurological morbidity, which was caused by venous congestion near eloquent area, or operative manipulation at the craniotomy. The transient morbidity in patients over 70 years was 20%, although it was 12% in patients under 70 years. Eight patients (21%) were complained of chronic pain at the wound and 5 of them had medication. In 11(30.6%) of these 36 cases treated conservatively, the tumor size increased by mean 0.24 cm/year. Three of them had operation. The tumor growth rate was 0.33 cm/year in the operative group, whereas it was 0.09 cm/year in the conservative group. Histological grading of 3 cases revealed WHO grade I meningiomas. The absence of calcification and high intensity on T2 weighted-imaging were significantly associated with the higher growth rate (p<0.05). We should decide the strategy for treatment, paying attention to the radiological features, the tumor growth rate, age and operative difficulty. In addition that, we should keep in mind that over 20% patients were suffered from postoperative painful wound.

A 74-year-old man presented with a rare metastatic leiomyosarcoma of the brain manifesting as subacute development of multiple cerebral hemorrhages. Cerebral angiography demonstrated no tumor staining or vascular malformation. Whole body computed tomography revealed abnormal masses in the liver, left adrenal gland, and duodenum. Histological examination of an open biopsy specimen identified the lesion as metastatic leiomyosarcoma. Whole brain irradiation controlled the intracranial lesions, but the patient's general condition progressively deteriorated and he died of pneumonia. Metastatic leiomyosarcoma is a very uncommon tumor in the central nervous system with a poor response to existing treatment options. Consequently, new approaches to the treatment of this disease are needed.