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1. Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line--derived neurotrophic factor in patients with Parkinson's disease. Report of two cases and technical considerations.

Author

Mendez I, Dagher A, Hong M, Hebb A, Gaudet P, Law A, Weerasinghe S, King D, Desrosiers J, Darvesh S, Acorn T, and Robertson H

Subjects
Aged, Cell Count, Cell Line, Cell Survival, Dihydroxyphenylalanine analogs & derivatives, Dopamine metabolism, Feasibility Studies, Fluorine Radioisotopes, Follow-Up Studies, Humans, Male, Mesencephalon cytology, Mesencephalon drug effects, Mesencephalon embryology, Middle Aged, Neuroglia, Putamen surgery, Radiopharmaceuticals, Substantia Nigra cytology, Substantia Nigra embryology, Substantia Nigra transplantation, Tissue Preservation, Tomography, Emission-Computed, Treatment Outcome, Tyrosine 3-Monooxygenase analysis, Brain Tissue Transplantation pathology, Fetal Tissue Transplantation pathology, Graft Survival, Nerve Growth Factor therapeutic use, Parkinson Disease surgery, Substantia Nigra drug effects
Abstract

The authors have studied the ability of glial cell line-derived neurotrophic factor (GDNF) to promote survival of human fetal dopaminergic tissue after a storage period of 6 days and subsequent implantation into the human putamen. The results indicate that GDNF promotes survival of stored dopaminergic cells. Cells stored without GDNF had a 30.1% decrease in survival time compared with those exposed to GDNF. Two patients with Parkinson's disease received bilateral putaminal implants of fetal dopaminergic cells exposed to GDNF for 6 days and showed enhancement of graft survival as assessed by positron emission tomography scanning. A mean increase of 107% in putaminal fluorodopa uptake from baseline values was observed 12 months postgrafting.

Published
2000
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