1. Features of Remyelination after Transplantation of Olfactory Ensheathing Cells with Neurotrophic Factors into Spinal Cord Cysts.
- Author
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Stepanova OV, Fursa GA, Karsuntseva EK, Andretsova SS, Chadin AV, Voronova AD, Shishkina VS, Semkina AS, Reshetov IV, and Chekhonin VP
- Subjects
- Animals, Rats, Humans, Cell Proliferation, Spinal Cord metabolism, Myelin Sheath metabolism, Myelin Sheath physiology, Cells, Cultured, Cell Movement, Cysts pathology, Female, Central Nervous System Cysts surgery, Central Nervous System Cysts pathology, Neurotrophin 3 metabolism, Brain-Derived Neurotrophic Factor metabolism, Brain-Derived Neurotrophic Factor pharmacology, Remyelination physiology, Olfactory Bulb cytology
- Abstract
This paper shows for the first time that co-transplantation of human olfactory ensheathing cells with neurotrophin-3 into spinal cord cysts is more effective for activation of remyelination than transplantation of cells with brain-derived neurotrophic factor and a combination of these two factors. The studied neurotrophic factors do not affect proliferation and migration of ensheathing cells in vitro. It can be concluded that the maximum improvement of motor function in rats receiving ensheathing cells with neurotrophin-3 is largely determined by activation of remyelination., (© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
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