11 results on '"Brain, Kate"'
Search Results
2. Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial
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Burton, Maria, Lifford, Kate J., Wyld, Lynda, Armitage, Fiona, Ring, Alistair, Nettleship, Anthony, Collins, Karen, Morgan, Jenna, Reed, Malcolm W. R., Holmes, Geoffrey R., Bradburn, Mike, Gath, Jacqui, Green, Tracy, Revell, Deirdre, Brain, Kate, Edwards, Adrian, Harder, Helena, Ward, Susan, Richards, Paul, Martin, Charlene, Chater, Tim, Pemberton, Kirsty, Murray, Christopher, Walters, Stephen, Herbert, Esther, Robinson, Thompson, Cheung, Kwok Leung, and Audisio, Riccardo
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Medicine (General) ,medicine.medical_specialty ,Decision support system ,Bridging (networking) ,media_common.quotation_subject ,Psychological intervention ,Medicine (miscellaneous) ,Fidelity ,Breast Neoplasms ,Disease cluster ,Intervention implementation ,Process evaluation ,Older women ,03 medical and health sciences ,Breast cancer ,R5-920 ,0302 clinical medicine ,Intervention (counseling) ,medicine ,Humans ,Pharmacology (medical) ,030212 general & internal medicine ,Shared decision-making ,Aged ,media_common ,Data collection ,business.industry ,Research ,medicine.disease ,Decision support ,030220 oncology & carcinogenesis ,Family medicine ,Female ,business ,Decision Making, Shared - Abstract
Background The Bridging the Age Gap in Breast Cancer research programme sought to improve treatment decision-making for older women with breast cancer by developing and testing, in a cluster randomised trial (n = 1339 patients), two decision support interventions (DESIs). Both DESIs were used in the intervention arm and each comprised an online risk prediction model, brief decision aid and information booklet. One DESI supported the decision to have either primary endocrine therapy (PET) or surgery with adjuvant therapies and the second supported the decision to have adjuvant chemotherapy after surgery or not. Methods Sixteen sites were randomly selected to take part in the process evaluation. Multiple methods of data collection were used. Medical Research Council (MRC) guidelines for the evaluation of complex interventions were used. Results Eighty-two patients, mean age 75.5 (range 70–93), provided data for the process evaluation. Seventy-three interviews were completed with patients. Ten clinicians from six intervention sites took part in telephone interviews. Dose: Ninety-one members of staff in the intervention arm received intervention training. Reach: The online tool was accessed on 324 occasions by 27 clinicians. Reasons for non-use of the online tool were commonly that the patient had already made a decision or that there was no online access in the clinic. Of the 32 women for whom there were data available, fifteen from the intervention arm and six from the usual care arm were offered a choice of treatment. Fidelity: Clinicians used the online tool in different ways, with some using it during the consultation and others checking the online survival estimates before the consultation. Adaptation: There was evidence of adaptation when using the DESIs. A lack of infrastructure, e.g. internet access, was a barrier to the use of the online tool. The brief decision aid was rarely used. Mediators: Shared decision-making: Most patients felt able to contribute to decision-making and expressed high levels of satisfaction with the process. Participants’ responses to intervention: Six patients reported the DESIs to be very useful, one somewhat useful and two moderately useful. Conclusions Clinicians who participated were mainly supportive of the interventions and had attempted some adaptations to make the interventions applicable, but there were practical and engagement barriers that led to sub-optimal adoption in routine practice. Trial registration ISRCTN46099296. Registered on 11 August 2016—retrospectively registered
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- 2021
3. Efficient development and usability testing of decision support interventions for older women with breast cancer
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Lifford, Kate J, Edwards, Adrian, Burton, Maria, Harder, Helena, Armitage, Fiona, Morgan, Jenna, Caldon, Lisa, Balachandran, Kirsty, Ring, Alastair, Collins, Karen, Reed, Malcolm, Wyld, Linda, and Brain, Kate
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RC0254 ,lcsh:R5-920 ,decision support ,breast cancer ,Patient Preference and Adherence ,RC0280.B8 ,shared decision-making ,RC0266 ,patient decision aids ,lcsh:Medicine (General) ,older patients - Abstract
Kate J Lifford,1 Adrian Edwards,1 Maria Burton,2 Helena Harder,3 Fiona Armitage,4 Jenna L Morgan,4 Lisa Caldon,5 Kirsty Balachandran,6 Alistair Ring,7 Karen Collins,2 Malcolm Reed,8 Lynda Wyld,4 Kate Brain1 1Division of Population Medicine, Cardiff University, Cardiff, UK; 2Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, UK; 3Sussex Health Outcomes Research and Education in Cancer, Brighton and Sussex Medical School, University of Sussex, Brighton, UK; 4Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK; 5Department of General Surgery, The Rotherham NHS Foundation Trust, Rotherham, UK; 6Department of Medical Oncology, Imperial College London, London, UK; 7Breast Unit, Royal Marsden Hospital NHS Foundation Trust, Sutton, UK; 8Brighton and Sussex Medical School, Brighton, UK Background: Around one-third of breast cancers diagnosed every year in the UK are in women aged≥70 years. However, there are currently no decision support interventions (DESIs) for older women who have a choice between primary endocrine therapy and surgery followed by adjuvant endocrine therapy (surgery+endocrine therapy), or who can choose whether or not to have chemotherapy following surgery. There is also little evidence-based guidance specifically on the management of these older patients. A large UK cohort study is currently underway to address this lack of evidence and to develop two DESIs to facilitate shared decision-making with older women about breast cancer treatments. Here, we present the development and initial testing of these two DESIs. Methods: An initial prototype DESI was developed for the choice of primary endocrine therapy or surgery+endocrine therapy. Semi-structured interviews with healthy volunteers and patients explored DESI acceptability, usability, and utility. A framework approach was used for analysis. A second DESI for the choice of having chemotherapy or not was subsequently developed based on more focused development and testing. Results: Participants (n=22, aged 75–94 years, 64% healthy volunteers, 36% patients) found the primary endocrine therapy / surgery+endocrine therapy DESI acceptable, and contributed to improved wording and illustrations to address misunderstandings. The chemotherapy DESI (tested with 14 participants, aged 70–87 years, 57% healthy volunteers, 43% patients) was mostly understandable, however, suggestions for rewording sections were made. Most participants considered the DESIs helpful, but highlighted the importance of complementary discussions with clinicians. Conclusion: It was possible to use a template DESI to efficiently create a second prototype for a different treatment option (chemotherapy). Both DESIs were acceptable and considered helpful to support/augment consultations. Development of acceptable additional DESIs for similar target populations using simplified methods may be an efficient way to develop future DESIs. Further research is needed to test the effectiveness of the DESIs. Keywords: patient decision aids, decision support, shared decision-making, breast cancer, older patients
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- 2019
4. Health economics and genetic service development: a familial cancer genetic example
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Cohen, David, Barton, Garry, Gray, Jonathon, and Brain, Kate
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- 2004
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5. Understanding emotional responses to breast/ovarian cancer genetic risk assessment: An applied test of a cognitive theory of emotion.
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Phelps, Ceri, Bennett, Paul, and Brain, Kate
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CANCER in women ,EMOTIONS & cognition ,BREAST cancer ,OVARIAN cancer ,RISK assessment - Abstract
This study explored whether Smith and Lazarus' (1990, 1993) cognitive theory of emotion could predict emotional responses to an emotionally ambiguous real-life situation. Questionnaire data were collected from 145 women upon referral for cancer genetic risk assessment. These indicated a mixed emotional reaction of both positive and negative emotions to the assessment. Hierarchical regression analyses revealed that the hypothesised models explained between 20% and 33% of the variance of anxiety, hope and gratitude scores, but only 10% of the variance for challenge scores. For the previously unmodelled emotion of relief, 31% of the variance was explained by appraisals and core relational themes. The findings help explain why emotional responses to cancer genetic risk assessment vary and suggest that improving the accuracy of individuals' beliefs and expectations about the assessment process may help subsequent adaptation to risk information. [ABSTRACT FROM AUTHOR]
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- 2008
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6. Does dispositional optimism predict psychological responses to counseling for familial breast cancer?
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Norman, Paul and Brain, Kate
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BREAST cancer , *CANCER in women , *COUNSELING , *OPTIMISM - Abstract
Abstract: Objective: The present study sought to assess the ability of dispositional optimism to predict the psychological responses of women with a family history of breast cancer who had been referred to counseling for familial breast cancer. Methods: Women completed questionnaires prior to (n=735), immediately after (n=655), and 9 months after (n=545) attending counseling. Breast cancer risk status was assessed and communicated to the women in the clinics. Results: Dispositional optimism was found to predict lower levels of anxiety and breast cancer worries immediately following counseling as well as lower levels of anxiety and perceived risk at 9-month follow-up, controlling for corresponding baseline scores. In addition, risk status moderated the optimism-perceived risk relationship, such that optimism was only predictive of lower risk perceptions among women at high risk. Conclusions: Low levels of dispositional optimism may be considered to be a risk factor for adverse reactions to high breast cancer risk information. The implications of the findings for the clinical management of such reactions are discussed. [Copyright &y& Elsevier]
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- 2007
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7. The information needs of men with breast cancer.
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Iredale, Rachel, Williams, Buddug, Brain, Kate, France, Elizabeth, and Gray, Jonathan
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BREAST cancer ,MEN ,GENDER ,INFORMATION resources ,NURSES - Abstract
The information needs of men with breast cancer are under-researched. This article uses questionnaire data from 161 men with breast cancer, and in-depth interview data from a sample of 30 of these men, to explore perceptions of information needs and how best to meet these needs. These men typically received verbal information or written information in the form of leaflets or booklets. Generally this information was helpful, was pitched at about the right level and contained the right amount of information, but was of variable relevance given that it had not been developed specifically for men. Men with breast cancer would benefit from receiving gender-specific information, given the limitations of existing information sources. Of all healthcare professionals, breast care nurses were described as being most helpful in terms of providing both information and practical support. [ABSTRACT FROM AUTHOR]
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- 2007
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8. The experiences of men with breast cancer in the United Kingdom
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Iredale, Rachel, Brain, Kate, Williams, Buddug, France, Elizabeth, and Gray, Jonathon
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BREAST cancer patients , *CANCER in men , *SELF-perception , *BODY image , *SOCIAL stigma , *SOCIAL services - Abstract
Abstract: To investigate the experiences of men with breast cancer across the United Kingdom, a multi-phase study using: (a) focus groups (n =4) with men and women with breast cancer and with healthcare professionals; (b) questionnaires to men with breast cancer (n =161); (c) follow-up interviews with these men (n =30) and (d) reconvening the focus groups (n =2) for the men and women with breast cancer. The majority of men (84%, n =135) reported their symptoms early, but were shocked to receive a breast cancer diagnosis. Disclosure of the diagnosis was commonly made to partners (80%, n =129) and other close family and was influenced by perceptions of embarrassment, stigma and altered body image. Very little information was available to participants; that which was available was often inappropriate as it was intended for women. Over half the sample wanted much more information (56%, n =90). This study also demonstrated low utilisation of formal support services and initiatives are needed to improve the information and support provided to men with breast cancer after diagnosis and treatment. Increasing the profile of breast cancer in men generally amongst healthcare professionals and the public is also needed. [Copyright &y& Elsevier]
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- 2006
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9. An application of an extended health belief model to the prediction of breast self-examination among women with a family history of breast cancer.
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Norman, Paul and Brain, Kate
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BREAST self-examination , *MEDICAL self-examination , *BREAST cancer , *CANCER in women , *WOMEN'S health - Abstract
Objectives. This study reports an application of the health belief model (HBM) to the prediction of breast self‐examination (BSE) among women with a family history of breast cancer. The study also considered the influence of breast cancer worries and past behaviour. Methods. Eight hundred and thirty‐three women completed questionnaires, based on the HBM, to assess their beliefs about breast cancer and BSE. Of these women, 567 were followed‐up at 9 months when BSE frequency was assessed. Results. Discriminant function analysis was employed to discriminate among infrequent, appropriate and excessive BSE. Two functions were calculated which were predictive of group membership. The first function maximally discriminated between the infrequent BSE group and the other two groups, with infrequent self‐examiners reporting a greater number of self‐efficacy and emotion barriers, fewer benefits and less frequent BSE at Time 1. The second function maximally discriminated between the excessive BSE group and the appropriate BSE group, with excessive self‐examiners reporting higher levels of breast cancer worries and perceived severity and fewer self‐efficacy barriers. Conclusions. The results highlight the importance of focusing on excessive as well as infrequent BSE. Interventions designed to enhance women's confidence in their ability to perform BSE, coupled with attempts to reduce breast cancer worries, may encourage more appropriate and effective BSE. [ABSTRACT FROM AUTHOR]
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- 2005
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10. A model protocol evaluating the introduction of genetic assessment for women with a family history of breast cancer.
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Gray, Jonathon, Brain, Kate, Norman, Paul, Anglim, Cathy, France, Liz, Barton, Garry, Branston, Lucy, Parsons, Evelyn, Clarke, Angus, Sampson, Julian, Roberts, Elizabeth, Newcombe, Robert, Cohen, David, Rogers, Cerilan, Mansel, Robert, and Harper, Peter
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- 2000
11. Breast cancer in men.
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Iredale, Rachel, Williams, Buddug, Brain, Kate, and France, Elizabeth
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LETTERS to the editor ,BREAST cancer ,MEN'S health - Abstract
Presents a letter to the editor regarding an article which was previously published in the "British Medical Journal" and discussed breast cancer in men.
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- 2003
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