22 results on '"Schwartz, Marc"'
Search Results
2. Predictors of contralateral prophylactic mastectomy in genetically high risk newly diagnosed breast cancer patients
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Tynan, Mara, Peshkin, Beth N., Isaacs, Claudine, Willey, Shawna, Valdimarsdottir, Heiddis B., Nusbaum, Rachel, Hooker, Gillian, O’Neill, Suzanne C., Jandorf, Lina, Kelly, Scott P., Heinzmann, Jessica, Kelleher, Sarah, Poggi, Elizabeth, and Schwartz, Marc D.
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- 2020
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3. Mediational roles of stress-coping factors in the relationship between patient-perceived communication quality and physical functioning: racial difference between Chinese and Non-Hispanic White American breast cancer survivors.
- Author
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Wang, Judy Huei-yu, Brown, Roger L., Huang, Ellen, and Schwartz, Marc D.
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PHYSICAL mobility ,ZINC oxide ,CANCER survivors ,RACIAL differences ,BREAST cancer ,POST-traumatic stress - Abstract
Purpose: The assumption that patient–provider communication may mediate patients' sense of control over cancer to affect health outcomes has limited evidence. This study examines whether patient-perceived cancer care communication quality (PPCQ) mediates stress appraisal and coping behavior, affecting physical functioning across different racial groups. Methods: Two hundred and twenty Chinese American and 216 non-Hispanic White (NHW) women (ages 28–80) with stage 0–III breast cancer, 1–5 years post-diagnosis, and without recurrence, enrolled and completed a cross-sectional telephone survey. Physical functioning was measured by the NIH-PROMIS short form. Validated measures of PPCQ, patients' evaluation of their socioeconomic well-being, stress appraisal (perceived severity and control), use of coping strategies, treatment-related symptoms, and comorbidities were also assessed. Path analyses were used to examine the mediation for each racial group. Results: Regardless of race, treatment-related symptoms, comorbidities, and socioeconomic well-being were all directly related to physical functioning (p < 0.05). The impact of PPCQ on physical functioning was mediated by perceived control in the Chinese American group (p < 0.05), but not in the NHW group. Perceived severity and coping were not mediators of physical functioning in either group. Conclusions: The mediational pathway from PPCQ to perceived control to physical functioning in Chinese American survivors may be partially explained by their lower socioeconomic well-being and culturally valued conformity to physicians as a medical authority. These sociocultural dynamics reinforce the importance of cancer care communication. For NHW survivors, the impact of treatment-related symptoms and socioeconomic well-being on physical functioning outweighed their PPCQ and perceived control. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Impact of genomic testing and patient-reported outcomes on receipt of adjuvant chemotherapy
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Evans, Chalanda N., Brewer, Noel T., Vadaparampil, Susan T., Boisvert, Marc, Ottaviano, Yvonne, Lee, M. Catherine, Isaacs, Claudine, Schwartz, Marc D., and O’Neill, Suzanne C.
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- 2016
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5. Perceived Risk of Breast Cancer among Latinas Attending Community Clinics: Risk Comprehension and Relationship with Mammography Adherence
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Graves, Kristi D., Huerta, Elmer, Cullen, Jennifer, Kaufman, Elizabeth, Sheppard, Vanessa, Luta, George, Isaacs, Claudine, Schwartz, Marc D., and Mandelblatt, Jeanne
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- 2008
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6. BRCA1/2 test results impact risk management attitudes, intentions, and uptake
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O’Neill, Suzanne C., Valdimarsdottir, Heiddis B., DeMarco, Tiffani A., Peshkin, Beth N., Graves, Kristi D., Brown, Karen, Hurley, Karen E., Isaacs, Claudine, Hecker, Sharon, and Schwartz, Marc D.
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- 2010
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7. Psychosocial impact of proactive rapid genetic counseling following breast cancer diagnosis.
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Kritzik, Rachel, Usoro, Edidiong, Peshkin, Beth N., Isaacs, Claudine, Valdimarsdottir, Heiddis B., Willey, Shawna, O'Neill, Suzanne, DeMarco, Tiffani, Nusbaum, Rachel, Jandorf, Lina, Kelleher, Sarah, and Schwartz, Marc D.
- Abstract
Objective: As germline genetic referral becomes increasingly routine as part of the care of newly diagnosed breast cancer patients, it is important to understand the psychosocial impact of genetic counseling at the time of diagnosis. We examined the psychosocial and quality of life (QOL) impact of providing proactive rapid genetic counseling and testing (RGCT) in the immediate aftermath of a breast cancer diagnosis. Methods: We randomized 330 patients in a 2:1 ratio to proactive rapid genetic counseling (RGCT; N = 222) versus usual care (UC; N = 108). Participants completed a baseline telephone survey before randomization and definitive surgery and a follow‐up survey at 1‐month post‐randomization. We evaluated the impact of RGCT versus UC on breast cancer genetic knowledge, distress, QOL, and decisional conflict. Given that 43% of UC participants and 86% of RGCT participants completed genetic counseling prior to the 1‐month assessment, we also evaluated the impact of genetic counseling participation over and above group assignment. Results: The RGCT intervention led to increased breast cancer genetic knowledge relative to UC but did not differentially impact other study outcomes. Across groups patients who participated in genetic counseling had significantly increased knowledge and improved QOL compared to those who did not participate in genetic counseling. Conclusions: While prior research has documented the impact of genetic counseling and testing on surgical decisions, these results confirm that participation in genetic counseling at the time of diagnosis can yield improvements in knowledge and QOL in the short‐term. [ABSTRACT FROM AUTHOR]
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- 2022
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8. Development of an Interactive Decision Aid for Female BRCA1/BRCA2 Carriers
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Kaufman, Elizabeth M., Peshkin, Beth N., Lawrence, William F., Shelby, Rebecca, Isaacs, Claudine, Brown, Karen, Rispoli, Jessica, O'Neill, Suzanne, Hurley, Karen, DeMarco, Tiffani, Brogan, Barbara, Grumet, Sherry, Jandorf, Lina, McKenna, Kristine, Valdimarsdottir, Heiddis, and Schwartz, Marc D.
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- 2003
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9. Psychological distress in women seeking genetic counseling for breast-ovarian cancer risk: The contributions of personality and appraisal
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Audrain, Janet, Schwartz, Marc D., Lerman, Caryn, Hughes, Chanita, Peshkin, Beth N., and Biesecker, Barbara
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- 1997
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10. Gail model breast cancer risk components are poor predictors of risk perception and screening behavior
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Daly, Mary B., Lerman, Caryn L., Ross, Eric, Schwartz, Marc D., Sands, Colleen Burke, and Masny, Agnes
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- 1996
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11. Process evaluation of a culturally targeted video for Latinas at risk of hereditary breast and ovarian cancer.
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Hurtado‐de‐Mendoza, Alejandra, Gómez‐Trillos, Sara, Graves, Kristi D., Carrera, Pilar, Campos, Claudia, Anderson, Lyndsay, Gronda, Andrés, Orellana, Halyn, Peshkin, Beth N., Schwartz, Marc D., Cupertino, Paula, Ostrove, Nancy, Luta, George, Gonzalez, Nathaly, and Sheppard, Vanessa B.
- Abstract
This paper presents a process evaluation of a culturally targeted narrative video about hereditary breast and ovarian cancer (HBOC) for Latina women at risk for HBOC. Spanish‐speaking Latina women at risk for HBOC participated in a single arm study (n = 40). Participants watched the video developed by the authors and responded to surveys. We used mixed methods to assess theoretical constructs that are hypothesized mediators of narrative interventions (i.e., transportation or engagement, identification with characters, emotions) and implementation outcomes (e.g., acceptability). Descriptive statistics summarized theoretical constructs and implementation outcomes. We conducted Mann–Whitney U tests to assess the differences in theoretical and implementation outcomes between participants who were affected versus. unaffected and participants with different levels of education and health literacy. We used the consensual qualitative research framework to analyze qualitative data. Participants' mean age was 47.1 years (SD = 9.48). Most participants were high school graduates or less (62.5%). Acceptability of the video was extremely high (Md = 10.0, IQR = 0.2, scale 1–10). Most (82.5%) suggested video dissemination be through social media. Participants were highly engaged (Md = 5.7, IQR = 1.5, scale 1–7), strongly identified with the main character (Md = 8.7, IQR = 2.6, scale 1–10), and reported experiencing mostly positive emotions (Md = 9.5, IQR = 2.8, scale 1–10). Participants with low health literacy and affected participants reported a significantly higher identification with the main character (p<.05). Qualitative data reinforced the quantitative findings. Women reported gaining knowledge, correcting misconceptions, and feeling empowered. Our culturally targeted video is highly acceptable and targets mechanisms of behavior change for narrative interventions. The video is easily disseminable and can be used as an education tool for patients including affected and unaffected women and patients with different education and health literacy levels. Future studies should test the impact of the video in enhancing genetic counseling and testing uptake. [ABSTRACT FROM AUTHOR]
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- 2021
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12. Characteristics Associated with Participation in ENGAGED 2 – A Webbased Breast Cancer Risk Communication and Decision Support Trial.
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Wernli, Karen J., Bowles, Erin A., Knerr, Sarah, Leppig, Kathleen A., Ehrlich, Kelly, Hongyuan Gao, Schwartz, Marc D., and O’Neill, Suzanne C.
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MAGNETIC resonance mammography ,BREAST cancer ,RISK communication ,VOICE mail systems - Abstract
Purpose: We evaluated demographic and clinical characteristics associated with participation in a clinical trial testing the efficacy of an online tool to support breast cancer risk communication and decision support for risk mitigation to determine the generalizability of trial results. Methods: Eligible women were members of Kaiser Permanente Washington aged 40-69 years with a recent normal screening mammogram, heterogeneously or extremely dense breasts and a calculated risk of > 1.67% based on the Breast Cancer Surveillance Consortium 5-year breast cancer risk model. Trial outcomes were chemoprevention and breast magnetic resonance imaging by 12-months post-baseline. Women were recruited via mail with phone follow-up using plain language materials notifying them of their density status and higher than average breast cancer risk. Multivariable logistic regression calculated independent odds ratios (ORs) for associations between demographic and clinical characteristics with trial participation. Results: Of 2,569 eligible women contacted, 995 (38.7%) participated. Women with some college (OR = 1.99, 95% confidence interval [CI] 1.34-2.96) or college degree (OR = 3.35, 95% CI 2.29-4.90) were more likely to participate than high schooleducated women. Race/ethnicity also was associated with participation (African-American OR = 0.50, 95% CI 0.29-0.87; Asian OR = 0.22, 95% CI 0.12-0.41). Multivariate adjusted ORs for family history of breast/ovarian cancer were not associated with trial participation. Discussion: Use of plain language and potential access to a website providing personal breast cancer risk information and education were insufficient in achieving representative participation in a breast cancer prevention trial. Additional methods of targeting and tailoring, potentially facilitated by clinical and community outreach, are needed to facilitate equitable engagement for all women. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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13. Endocrine therapy initiation, discontinuation and adherence and breast imaging among 21-gene recurrence score assay-eligible women under age 65.
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O'Neill, Suzanne C., Isaacs, Claudine, Lynce, Filipa, Graham, Deena Mary Atieh, Chao, Calvin, Sheppard, Vanessa B., Yingjun Zhou, Chunfu Liu, Selvam, Nandini, Schwartz, Marc D., Potosky, Arnold L., Zhou, Yingjun, and Liu, Chunfu
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HORMONE therapy ,PEPTIDES ,CYTOKINES ,DRUG receptors ,BREAST cancer ,AGE distribution ,BREAST tumors ,COMBINED modality therapy ,DRUGS ,PATIENT compliance ,RESEARCH funding ,TUMOR classification ,DISEASE relapse ,GENE expression profiling ,KAPLAN-Meier estimator ,ODDS ratio - Abstract
Background: Aside from chemotherapy utilization, limited data are available on the relationship between gene expression profiling (GEP) testing and breast cancer care. We assessed the relationship between GEP testing and additional variables and the outcomes of endocrine therapy initiation, discontinuation and adherence, and breast imaging exams in women under age 65 years.Methods: Data from five state cancer registries were linked with claims data and GEP results. We assessed variables associated with survivorship care outcomes in an incident cohort of 5014 commercially insured women under age 65 years, newly diagnosed with stage I or II hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2) non-positive breast cancer from 2006 to 2010.Results: Among tested women, those with high Oncotype DX® Breast Recurrence Score® (RS) were significantly less likely to initiate endocrine therapy than women with low RS tumors (OR 0.40 (95% CI 0.20 to 0.81); P = 0.01). Among all test-eligible women, receipt of Oncotype DX testing was associated with a greater likelihood of endocrine therapy initiation (OR 2.48 (95% CI 2.03 to 3.04); P <0.0001). The odds of initiation were also significantly higher for tested vs. untested women among women who did not initiate chemotherapy within six months of diagnosis (OR 3.25 (95% CI 2.53 to 4.16)), with no effect in women who received chemotherapy. Discontinuation and adherence and breast imaging exams were unrelated to tested status or RS.Conclusions: Lower endocrine therapy initiation rates among women with high RS tumors and among untested women not receiving chemotherapy are concerning, given its established efficacy. Additional research is needed to suggest mechanisms to close this gap. [ABSTRACT FROM AUTHOR]- Published
- 2017
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14. American BRCA Outcomes and Utilization of Testing (ABOUT) Study: A Pragmatic Research Model that Incorporates Personalized Medicine/Patient-Centered Outcomes in a Real World Setting.
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Armstrong, Joanne, Toscano, Michele, Kotchko, Nancy, Friedman, Sue, Schwartz, Marc, Virgo, Katherine, Lynch, Kristian, Andrews, James, Aguado Loi, Claudia, Bauer, Joseph, Casares, Carolina, Teten, Rachel, Kondoff, Matthew, Molina, Ashley, Abdollahian, Mehrnaz, Brand, Lana, Walker, Gregory, and Sutphen, Rebecca
- Abstract
Research to date regarding identification and management of hereditary breast and ovarian cancer syndrome (HBOC) in the U.S. has been confined primarily to academic center-based studies with limited patient engagement. To begin to understand and address the current gaps and disparities in delivery of services for the appropriate identification and optimal risk management of individuals with HBOC, we designed and have initiated the American BRCA Outcomes and Utilization of Testing (ABOUT) Study. ABOUT relies on a collaborative patient advocacy, academic and industry partnership to recruit and engage U.S. individuals who are at increased risk for HBOC and investigate their experiences, decisions and outcomes. It utilizes an extensive research infrastructure, including an interactive web-based data system and electronic interfaces for secure online participation and automated data exchange. We describe the novel recruitment approach that was designed for collaboration with a national commercial health plan partner to identify all individuals for whom a healthcare provider orders a BRCA test and mail to each individual an invitation to participate and study packet. The study packet contains detailed information about the study, a baseline questionnaire and informed consent for participation in the study, for release of relevant medical and health plan records and for ongoing research engagement. This approach employs patient-reported, laboratory-reported and health plan-reported outcomes and facilitates longitudinal engagement. We believe that the type of innovative methodology and collaborative framework we have developed for ABOUT is an ideal foundation for a patient-powered research network. This approach can make substantial contributions to identifying current and best practices in HBOC, leading to improved strategies for clinical care and optimal health outcomes among individuals with high inherited risk for cancer. [ABSTRACT FROM AUTHOR]
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- 2015
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15. Conveying genomic recurrence risk estimates to patients with early-stage breast cancer: oncologist perspectives.
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Spellman, Elizabeth, Sulayman, Nadiyah, Eggly, Susan, Peshkin, Beth N., Isaacs, Claudine, Schwartz, Marc D., and O'Neill, Suzanne C.
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BREAST cancer patients ,BREAST cancer treatment ,ONCOLOGISTS ,GENOMICS ,EARLY detection of cancer ,MEDICAL education - Abstract
Objective The development and increased use of genomic profiling has led to refinement of breast cancer treatment. This study sought to examine medical and surgical oncologists' perceptions of factors related to the translation and integration of Onco type DX® (Genomic Health, Inc., Redwood City, CA, USA) into routine clinical care. Methods Twenty oncologists (10 medical and 10 surgical oncologists) participated in qualitative interviews. Questions centered on the following themes: oncologists' perceptions about the clinical utility of testing, the impact of patient preferences on the decision to test and use results to inform treatment decisions, methods of communicating risk associated with test results to patients, and benefits of and barriers to incorporating testing into multidisciplinary care settings. Results Oncologists found Onco type DX test results useful in their practice but had concerns as well. These included that some oncologists either used testing inappropriately or placed undue emphasis on the results at the expense of other clinical information. The use of intermediate test results, which have less clear clinical implications, incorporating results with patient treatment preferences, and the use of testing in multidisciplinary teams were noted as specific challenges. Conclusion Oncologists noted several benefits of testing and also many challenges, despite wide dissemination and common use. Education for health providers should include specific training in how to interpret and communicate the uncertainty inherent in genomic tests while integrating patient preferences to inform treatment decision making. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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16. BRCA1/2 test results impact risk management attitudes, intentions, and uptake.
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O'Neill, Suzanne, Valdimarsdottir, Heiddis, DeMarco, Tiffani, Peshkin, Beth, Graves, Kristi, Brown, Karen, Hurley, Karen, Isaacs, Claudine, Hecker, Sharon, and Schwartz, Marc
- Abstract
Women who receive positive or uninformative BRCA1/2 test results face a number of decisions about how to manage their cancer risk. The purpose of this study was to prospectively examine the effect of receiving a positive versus uninformative BRCA1/2 genetic test result on the perceived pros and cons of risk-reducing mastectomy (RRM) and risk-reducing oophorectomy (RRO) and breast cancer screening. We further examined how perceived pros and cons of surgery predict intention for and uptake of surgery. 308 women (146 positive, 162 uninformative) were included in RRM and breast cancer screening analyses. 276 women were included in RRO analyses. Participants completed questionnaires at pre-disclosure baseline and 1-, 6-, and 12-months post-disclosure. We used linear multiple regression to assess whether test result contributed to change in pros and cons and logistic regression to predict intentions and surgery uptake. Receipt of a positive BRCA1/2 test result predicted stronger pros for RRM and RRO ( P < 0.001), but not perceived cons of RRM and RRO. Pros of surgery predicted RRM and RRO intentions in carriers and RRO intentions in uninformatives. Cons predicted RRM intentions in carriers. Pros and cons predicted carriers' RRO uptake in the year after testing ( P < 0.001). Receipt of BRCA1/2 mutation test results impacts how carriers see the positive aspects of RRO and RRM and their surgical intentions. Both the positive and negative aspects predict uptake of surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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17. Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast cancer risk.
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Ricks-Santi, Luisel J., Sucheston, Lara E., Yang Yang, Freudenheim, Jo L., Isaacs, Claudine J., Schwartz, Marc D., Dumitrescu, Ramona G., Marian, Catalin, Jing Nie, Vito, Dominica, Edge, Stephen B., and Shields, Peter G.
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GENETIC polymorphisms ,DNA repair ,GENETIC mutation ,BREAST cancer ,LYMPHOCYTES - Abstract
Background: Inter-individual variation in DNA repair capacity is thought to modulate breast cancer risk. The phenotypic mutagen sensitivity assay (MSA) measures DNA strand breaks in lymphocytes; women with familial and sporadic breast cancers have a higher mean number of breaks per cell (MBPC) then women without breast cancer. Here, we explore the relationships between the MSA and the Rad51 gene, which encodes a DNA repair enzyme that interacts with BRCA1 and BRCA2, in BRCA1 mutation carriers and women with sporadic breast cancer. Methods: Peripheral blood lymphoblasts from women with known BRCA1 mutations underwent the MSA (n = 138 among 20 families). BRCA1 and Rad51 genotyping and sequencing were performed to identify SNPs and haplotypes associated with the MSA. Positive associations from the study in high-risk families were subsequently examined in a population-based case-control study of breast cancer (n = 1170 cases and 2115 controls). Results: Breast cancer diagnosis was significantly associated with the MSA among women from BRCA1 families (OR = 3.2 95%CI: 1.5-6.7; p = 0.004). The Rad51 5'UTR 135 C>G genotype (OR = 3.64; 95% CI: 1.38, 9.54; p = 0.02), one BRCA1 haplotype (p = 0.03) and in a polygenic model, the E1038G and Q356R BRCA1 SNPs were significantly associated with MBPC (p = 0.009 and 0.002, respectively). The Rad51 5'UTR 135C genotype was not associated with breast cancer risk in the population-based study. Conclusions: Mutagen sensitivity might be a useful biomarker of penetrance among women with BRCA1 mutations because the MSA phenotype is partially explained by genetic variants in BRCA1 and Rad51. [ABSTRACT FROM AUTHOR]
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- 2011
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18. Knowledge, Cultural, and Attitudinal Barriers to Mammography Screening Among Nonadherent Immigrant Chinese Women.
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Wang, Judy H., Mandelblatt, Jeanne S., Wenchi Liang, Bin Yi, Ma, I.-Jung, and Schwartz, Marc D.
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MAMMOGRAMS ,BREAST cancer ,MEDICAL screening ,BREAST exams ,SURVEYS - Abstract
The article focuses on the impact of knowledge, cultural views and health beliefs on intentions to obtain mammography among Chinese women. Chinese-American women have much lower mammography screening rates than the general population. A survey of Chinese women were conducted to measure variables of interest of the Chinese women. It was concluded that understanding cultural patterns and health beliefs in Chinese women is critical to changing their screening behavior.
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- 2009
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19. Cognitive and Emotional Factors Predicting Decisional Conflict Among High-Risk Breast Cancer Survivors Who Receive Uninformative BRCA1/2 Results.
- Author
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Rini, Christine, O'Neill, Suzanne C., Valdimarsdotti, Heiddis, Goldsmith, Rachel E., Jandorf, Lina, Brown, Karen, DeMarco, Tiffani A., Peshkin, Beth N., and Schwartz, Marc D.
- Abstract
Objective: To investigate high-risk breast cancer survivors' risk reduction decision making and decisional conflict after an uninformative BRCA1/2 test. Design: Prospective, longitudinal study of 182 probands undergoing BRCA1/2 testing, with assessments 1-, 6-, and 12-months postdisclosure. Measures: Primary predictors were health beliefs and emotional responses to testing assessed 1-month postdisclosure. Main outcomes included women's perception of whether they had made a final risk management decision (decision status) and decisional conflict related to this issue. Results: There were four patterns of decision making, depending on how long it took women to make a final decision and the stability of their decision status across assessments. Late decision makers and nondecision makers reported the highest decisional conflict; however, substantial numbers of women--even early and intermediate decision makers--reported elevated decisional conflict. Analyses predicting decisional conflict 1- and 12-months postdisclosure found that, after accounting for control variables and decision status, health beliefs and emotional factors predicted decisional conflict at different timepoints, with health beliefs more important 1 month after test disclosure and emotional factors more important 1 year later. Conclusion- Many of these women may benefit from decision making assistance. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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20. Prospective Association Between Distress and Mammography Utilization Among Women with a Family History of Breast Cancer.
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Schwartz, Marc D., Taylor, Kathryn L., and Willard, Kristen S.
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MAMMOGRAMS , *PSYCHOLOGICAL distress , *BREAST cancer , *WORRY - Abstract
In this study we sought to evaluate the prospective association between psychological distress and mammography utilization among women with a family history of breast cancer. We evaluated the association of cancer worry, cancer-specific distress, and general distress with mammography utilization after controlling for potential confounders. The results revealed that 74% of our sample had obtained a mammogram within 12 months of the baseline assessment. Logistic regression models revealed that after controlling for potential confounding variables, cancer worry and general distress were independent predictors of mammography utilization. Specifically, women who reported higher levels of worry and/or distress at baseline were less likely to report having received a mammogram in the 12 months following the baseline assessment. These results are in contrast to the only other prospective study in this population. Additional research is needed to determine the prospective association between distress and adherence and to identify potential mechanisms for such an association. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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21. A Randomized Trial of Breast Cancer Risk Counseling: The Impact on Self-Reported Mammography Use.
- Author
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Schwartz, Marc D., Rimer, Barbara K., Daly, Mary, Sands, Colleen, and Lerman, Caryn
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BREAST cancer , *MAMMOGRAMS , *COUNSELING , *HEALTH education , *HEALTH attitudes , *MULTIVARIATE analysis - Abstract
Objectives. We evaluated the impact of individualized breast cancer risk counseling on mammography use among women at risk for breast cancer. Methods. Participants (n = 508) were randomized to the breast cancer risk counseling intervention or a general health education control intervention, and 85% completed follow-up. Results. In multivariate modeling, a significant group-by-education interaction demonstrated that among less-educated participants, breast, cancer risk counseling led to reduced mammography use. There was no intervention effect among the more-educated participants. Conclusions. These results suggest that standard breast cancer risk counseling could have an adverse impact on the health behaviors of less-educated women. [ABSTRACT FROM AUTHOR]
- Published
- 1999
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22. A web-based personalized risk communication and decision-making tool for women with dense breasts: Design and methods of a randomized controlled trial within an integrated health care system.
- Author
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Knerr, Sarah, Wernli, Karen J., Leppig, Kathleen, Ehrlich, Kelly, Graham, Amanda L., Farrell, David, Evans, Chalanda, Luta, George, Schwartz, Marc D., and O’Neill, Suzanne C.
- Subjects
- *
MAMMOGRAMS , *INTEGRATED health care delivery , *RANDOMIZED controlled trials , *MEDICAL decision making , *HEALTH counseling - Abstract
Background Mammographic breast density is one of the strongest risk factors for breast cancer after age and family history. Mandatory breast density disclosure policies are increasing nationally without clear guidance on how to communicate density status to women. Coupling density disclosure with personalized risk counseling and decision support through a web-based tool may be an effective way to allow women to make informed, values-consistent risk management decisions without increasing distress. Methods/design This paper describes the design and methods of Engaged, a prospective, randomized controlled trial examining the effect of online personalized risk counseling and decision support on risk management decisions in women with dense breasts and increased breast cancer risk. The trial is embedded in a large integrated health care system in the Pacific Northwest. A total of 1250 female health plan members aged 40–69 with a recent negative screening mammogram who are at increased risk for interval cancer based on their 5-year breast cancer risk and BI-RADS® breast density will be randomly assigned to access either a personalized web-based counseling and decision support tool or standard educational content. Primary outcomes will be assessed using electronic health record data (i.e., chemoprevention and breast MRI utilization) and telephone surveys (i.e., distress) at baseline, six weeks, and twelve months. Discussion Engaged will provide evidence about whether a web-based personalized risk counseling and decision support tool is an effective method for communicating with women about breast density and risk management. An effective intervention could be disseminated with minimal clinical burden to align with density disclosure mandates. Clinical Trials Registration Number: NCT03029286 . [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
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