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Objective To investigate the expression and clinical significance of CD68 and vascular endothelial growth factor ( VEGF) in breast cancer tissues. Methods Immunohistochemistry was used to detect the expression of CD68 and VEGF in 230 cases of breast cancer tissues and the corresponding adjacent tissues. The relationship of the expression of two proteins with the clinicopathological parameters and the recurrence of breast cancer was analyzed. Meanwhile, the correlation between the two proteins was also analyzed. Results The positive rates of CD68 and VEGF in the breast cancer tissues were significantly higher than those in the adjacent tissues ( both P <0. 01 ). The positive rate of CD68 protein in the breast cancer was closely related to the clinical stage, lymph node metastasis, and ER status of breast cancer patients ( P < 0. 05). The positive rate of VEGF protein in the breast cancer was closely related to the ER status of breast cancer patients (P <0. 05 ). The positive rates of CD68 and VEGF proteins in the recurrent patients were significantly higher than those in the non recurrent patients ( both P <0. 05 ). The expression of CD68 protein was positively correlated with the expression of VEGF (rs =0.397, P<0.01). Conclusion The expression of CD68 protein and VEGF protein increase in the breast cancer tissues, and they may be involved in the occurrence, development, and recurrence of breast cancer. [ABSTRACT FROM AUTHOR]

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