1. Effective exosomes in breast cancer: focusing on diagnosis and treatment of cancer progression.
- Author
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Abdullaev B, Rasyid SA, Ali E, Al-Dhalimy AMB, Mustafa YF, Fenjan MN, Misra N, Al-Musawi SG, Alawadi A, and Alsalamy A
- Subjects
- Female, Humans, Signal Transduction, Cell Communication, Tumor Microenvironment, Breast Neoplasms therapy, Breast Neoplasms drug therapy, Exosomes metabolism, Extracellular Vesicles metabolism
- Abstract
Breast cancer (BC) is the most prevalent aggressive malignant tumor in women worldwide and develops from breast tissue. Although cutting-edge treatment methods have been used and current mortality rates have decreased, BC control is still not satisfactory. Clarifying the underlying molecular mechanisms will help clinical options. Extracellular vesicles known as exosomes mediate cellular communication by delivering a variety of biomolecules, including proteins, oncogenes, oncomiRs, and even pharmacological substances. These transferable bioactive molecules can alter the transcriptome of target cells and affect signaling pathways that are related to tumors. Numerous studies have linked exosomes to BC biology, including therapeutic resistance and the local microenvironment. Exosomes' roles in tumor treatment resistance, invasion, and BC metastasis are the main topics of discussion in this review., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Competing interests Authors declare no conflict of interests., (Copyright © 2023 Elsevier GmbH. All rights reserved.)
- Published
- 2024
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