10 results on '"BACKER, LORRAINE C."'
Search Results
2. Initial Evaluation of the Effects of Aerosolized Florida Red Tide Toxins (Brevetoxins) in Persons with Asthma
- Author
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Fleming, Lora E., Kirkpatrick, Barbara, Backer, Lorraine C., Bean, Judy A., Wanner, Adam, Dalpra, Dana, Tamer, Robert, Zaias, Julia, Cheng, Yung Sung, Pierce, Richard, Naar, Jerome, Abraham, William, Clark, Richard, Zhou, Yue, Henry, Michael S., Johnson, David, Van De Bogart, Gayl, Bossart, Gregory D., Harrington, Mark, and Baden, Daniel G.
- Published
- 2005
3. Overview of Aerosolized Florida Red Tide Toxins: Exposures and Effects
- Author
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Fleming, Lora E., Backer, Lorraine C., and Baden, Daniel G.
- Published
- 2005
4. Exposure and Effect Assessment of Aerosolized Red Tide Toxins (Brevetoxins) and Asthma
- Author
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Fleming, Lora E., Bean, Judy A., Kirkpatrick, Barbara, Cheng, Yung Sung, Pierce, Richard, Naar, Jerome, Nierenberg, Kate, Backer, Lorraine C., Wanner, Adam, Reich, Andrew, Zhou, Yue, Watkins, Sharon, Henry, Mike, Zaias, Julia, Abraham, William M., Benson, Janet, Cassedy, Amy, Hollenbeck, Julie, Kirkpatrick, Gary, Clarke, Tainya, and Baden, Daniel G.
- Published
- 2009
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5. Reported Respiratory Symptom Intensity in Asthmatics During Exposure to Aerosolized Florida Red Tide Toxins.
- Author
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Milian, Alexyz, Nierenberg, Kate, Fleming, Lora E., Bean, Judy A., Wanner, Adam, Reich, Andrew, Backer, Lorraine C., Jayroe, David, and Kirkpatrick, Barbara
- Subjects
ASTHMATICS ,RED tide ,ALGAL toxins ,AEROSOLS ,PULMONARY function tests - Abstract
Florida red tides are naturally occurring blooms of the marine dinoflagellate, Karenia brevis. K. brevis produces natural toxins called brevetoxins. Brevetoxins become part of the marine aerosol as the fragile, unarmored cells are broken up by wave action. Inhalation of the aerosolized toxin results in upper and lower airway irritation. Symptoms of brevetoxin inhalation include: eye, nose, and throat irritation, coughing, wheezing, chest tightness, and shortness of breath. Asthmatics appear to be more sensitive to the effects of inhaled brevetoxin. This study examined data from 97 asthmatics exposed at the beach for 1 hour during K. brevis blooms, and on separate occasions when no bloom was present. In conjunction with extensive environmental monitoring, participants were evaluated utilizing questionnaires and pulmonary function testing before and after a 1-hour beach walk. A modified Likert scale was incorporated into the questionnaire to create respiratory symptom intensity scores for each individual pre- and post-beach walk. Exposure to Florida red tide significantly increased the reported intensity of respiratory symptoms; no significant changes were seen during an unexposed period. This is the first study to examine the intensity of reported respiratory symptoms in asthmatics after a 1-hour exposure to Florida red tide. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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6. Aerosolized Red-Tide Toxins (Brevetoxins) and Asthma.
- Author
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Fleming, Lora E., Kirkpatrick, Barbara, Backer, Lorraine C., Bean, Judy A., Wanner, Adam, Reich, Andrew, Zaias, Julia, Yung Sung Cheng, Pierce, Richard, Naar, Jerome, Abraham, William M., and Baderi, Daniel G.
- Subjects
ASTHMA ,RED tide ,TOXINS ,SYMPTOMS ,RESPIRATION - Abstract
The article discusses a study which examined the association between exposures to Florida red-tide toxin aerosols and the incidence of asthma. Participants in the study were significantly more likely to report respiratory symptoms after Karenia brevis red-tide aerosol exposure than before exposure. The subjects showed small, but statistically significant decreases in forced expiratory volume, midexpiratory phase of forced expiratory flow and peak expiratory flow after exposure.
- Published
- 2007
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7. Recreational exposure to aerosolized brevetoxins during Florida red tide events
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Backer, Lorraine C., Fleming, Lora E., Rowan, Alan, Cheng, Yung-Sung, Benson, Janet, Pierce, Richard H., Zaias, Julia, Bean, Judy, Bossart, Gregory D., Johnson, David, Quimbo, Raul, and Baden, Daniel G.
- Subjects
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RED tide , *TOXINS , *WHEEZE - Abstract
During two separate Karenia brevis red tide events, we measured the levels of brevetoxins in air and water samples, conducted personal interviews, and performed pulmonary function tests on people before and after they visited one of two Florida beaches. One hundred and twenty-nine people participated in the study, which we conducted during red tide events in Sarasota and Jacksonville, FL, USA. Exposure was categorized into three levels: low/no exposure, moderate exposure, and high exposure. Lower respiratory symptoms (e.g. wheezing) were reported by 8% of unexposed people, 11% of the moderately exposed people, and 28% of the highly exposed people. We performed nasal–pharyngeal swabs on people who experienced moderate or high exposure, and we found an inflammatory response in over 33% of these participants. We did not find any clinically significant changes in pulmonary function test results; however, the study population was small. In future epidemiologic studies, we plan to further investigate the human health impact of inhaled brevetoxins. [Copyright &y& Elsevier]
- Published
- 2003
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8. Review of Florida red tide and human health effects
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Fleming, Lora E., Kirkpatrick, Barbara, Backer, Lorraine C., Walsh, Cathy J., Nierenberg, Kate, Clark, John, Reich, Andrew, Hollenbeck, Julie, Benson, Janet, Cheng, Yung Sung, Naar, Jerome, Pierce, Richard, Bourdelais, Andrea J., Abraham, William M., Kirkpatrick, Gary, Zaias, Julia, Wanner, Adam, Mendes, Eliana, Shalat, Stuart, and Hoagland, Porter
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RED tide , *TOXIC algae , *EFFECT of environment on human beings , *PUBLIC health , *POISONOUS shellfish , *COASTS - Abstract
Abstract: This paper reviews the literature describing research performed over the past decade on the known and possible exposures and human health effects associated with Florida red tides. These harmful algal blooms are caused by the dinoflagellate, Karenia brevis, and similar organisms, all of which produce a suite of natural toxins known as brevetoxins. Florida red tide research has benefited from a consistently funded, long-term research program, that has allowed an interdisciplinary team of researchers to focus their attention on this specific environmental issue—one that is critically important to Gulf of Mexico and other coastal communities. This long-term interdisciplinary approach has allowed the team to engage the local community, identify measures to protect public health, take emerging technologies into the field, forge advances in natural products chemistry, and develop a valuable pharmaceutical product. The review includes a brief discussion of the Florida red tide organisms and their toxins, and then focuses on the effects of these toxins on animals and humans, including how these effects predict what we might expect to see in exposed people. [Copyright &y& Elsevier]
- Published
- 2011
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9. Environmental exposures to Florida red tides: Effects on emergency room respiratory diagnoses admissions
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Kirkpatrick, Barbara, Fleming, Lora E., Backer, Lorraine C., Bean, Judy A., Tamer, Robert, Kirkpatrick, Gary, Kane, Terrance, Wanner, Adam, Dalpra, Dana, Reich, Andrew, and Baden, Daniel G.
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RED tide , *SHELLFISH , *TOXINS , *ASTHMATICS , *OBSTRUCTIVE lung diseases - Abstract
Abstract: Human exposure to Florida red tides formed by Karenia brevis, occurs from eating contaminated shellfish and inhaling aerosolized brevetoxins. Recent studies have documented acute symptom changes and pulmonary function responses after inhalation of the toxic aerosols, particularly among asthmatics. These findings suggest that there are increases in medical care facility visits for respiratory complaints and for exacerbations of underlying respiratory diseases associated with the occurrence of Florida red tides. This study examined whether the presence of a Florida red tide affected the rates of admission with a respiratory diagnosis to a hospital emergency room in Sarasota, FL. The rate of respiratory diagnoses admissions were compared for a 3-month time period when there was an onshore red tide in 2001 (red tide period) and during the same 3-month period in 2002 when no red tide bloom occurred (non-red tide period). There was no significant increase in the total number of respiratory admissions between the two time periods. However, there was a 19% increase in the rate of pneumonia cases diagnosed during the red tide period compared with the non-red tide period. We categorized home residence zip codes as coastal (within 1.6km from the shore) or inland (>1.6km from shore). Compared with the non-red tide period, the coastal residents had a significantly higher (54%) rate of respiratory diagnoses admissions than during the red tide period. We then divided the diagnoses into subcategories (i.e. pneumonia, bronchitis, asthma, and upper airway disease). When compared with the non-red tide period, the coastal zip codes had increases in the rates of admission of each of the subcategories during the red tide period (i.e. 31, 56, 44, and 64%, respectively). This increase was not observed seen in the inland zip codes. These results suggest that the healthcare community has a significant burden from patients, particularly those who live along the coast, needing emergency medical care for both acute and potentially chronic respiratory illnesses during red tide blooms. [Copyright &y& Elsevier]
- Published
- 2006
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10. Inland transport of aerosolized Florida red tide toxins
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Kirkpatrick, Barbara, Pierce, Richard, Cheng, Yung Sung, Henry, Michael S., Blum, Patricia, Osborn, Shannon, Nierenberg, Kate, Pederson, Bradley A., Fleming, Lora E., Reich, Andrew, Naar, Jerome, Kirkpatrick, Gary, Backer, Lorraine C., and Baden, Daniel
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KARENIA brevis , *DINOFLAGELLATES , *NEUROTOXIC agents , *FISH kills , *SEA birds , *MARINE mammals , *LIQUID chromatography , *MASS spectrometry - Abstract
Abstract: Florida red tides, an annual event off the west coast of Florida, are caused by the toxic dinoflagellate, Karenia brevis. K. brevis produces a suite of potent neurotoxins, brevetoxins, which kill fish, sea birds, and marine mammals, as well as sickening humans who consume contaminated shellfish. These toxins become part of the marine aerosol, and can also be inhaled by humans and other animals. Recent studies have demonstrated a significant increase in symptoms and decrease in lung function in asthmatics after only one hour of beach exposure during an onshore Florida red tide bloom. This study constructed a transect line placing high volume air samplers to measure brevetoxins at sites beginning at the beach, moving approximately 6.4km inland. One non-exposure and 2 exposure studies, each of 5 days duration, were conducted. No toxins were measured in the air during the non-exposure period. During the 2 exposure periods, the amount of brevetoxins varied considerably by site and by date. Nevertheless, brevetoxins were measured at least 4.2km from the beach and/or 1.6km from the coastal shoreline. Therefore, populations sensitive to brevetoxins (such as asthmatics) need to know that leaving the beach may not discontinue their environmental exposure to brevetoxin aerosols. [Copyright &y& Elsevier]
- Published
- 2010
- Full Text
- View/download PDF
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