1. Presumed lupus erythematosus cells identified in bronchoalveolar lavage fluid from a Mexican Hairless dog.
- Author
-
Black LJ, Hechler AC, Duffy ME, and Beatty SSK
- Subjects
- Animals, Dog Diseases pathology, Dogs, Lupus Erythematosus, Systemic diagnosis, Lupus Erythematosus, Systemic pathology, Male, Bronchoalveolar Lavage Fluid cytology, Dog Diseases diagnosis, Lupus Erythematosus, Systemic veterinary
- Abstract
A neutered male Mexican Hairless dog was presented for generalized weight loss and weakness. Initial laboratory testing and diagnostic imaging revealed thrombocytopenia and an interstitial to miliary lung pattern affecting all lung fields. Mild joint effusion was found on physical examination affecting the stifle, tarsal, carpal, and elbow joints. Examination of synovial fluid demonstrated an inflammatory polyarthropathy in 3 joints. Cytocentrifuged and direct preparations of the bronchoalveolar lavage (BAL) fluid sample were made and cells consistent with lupus erythematosus (LE) cells and ragocytes were found. Based on these findings, the anti-nuclear antibody (ANA) titer was determined as 1:640. A clinical diagnosis of systemic LE was made based on the satisfaction of 2 major criteria (thrombocytopenia and inflammatory polyarthritis), 4 minor criteria (central nervous system signs, lymphadenopathy, fever of unknown origin, and pleuritis), positive ANA titer, and the identification of presumed LE cells in BAL fluid. This case report highlights a novel finding of LE cells in respiratory secretions and provides a review of diagnostic criteria of systemic LE., (© 2017 American Society for Veterinary Clinical Pathology.)
- Published
- 2017
- Full Text
- View/download PDF