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We review recent works on optomechanics of optically trapped microspheres and nanoparticles in vacuum, which provide an ideal system for studying macroscopic quantum mechanics and ultrasensitive force detection. An optically trapped particle in vacuum has an ultrahigh mechanical quality factor as it is well-isolated from the thermal environment. Its oscillation frequency can be tuned in real time by changing the power of the trapping laser. Furthermore, an optically trapped particle in vacuum may rotate freely, a unique property that does not exist in clamped mechanical oscillators. In this review, we will introduce the current status of optical trapping of dielectric particles in air and vacuum, Brownian motion of an optically trapped particle at room temperature, Feedback cooling and cavity cooling of the Brownian motion. We will also discuss about using optically trapped dielectric particles for studying macroscopic quantum mechanics and ultrasensitive force detection. Applications range from creating macroscopic Schrödinger's cat state, testing objective collapse models of quantum wavefunctions, measuring Casimir force, searching short-range non-Newtonian gravity, to detect gravitational waves. [ABSTRACT FROM AUTHOR]

Brownian motion has played important roles in many different fields of science since its origin was first explained by Albert Einstein in 1905. Einstein's theory of Brownian motion, however, is only applicable at long time scales. At short time scales, Brownian motion of a suspended particle is not completely random, due to the inertia of the particle and the surrounding fluid. Moreover, the thermal force exerted on a particle suspended in a liquid is not a white noise, but is colored. Recent experimental developments in optical trapping and detection have made this new regime of Brownian motion accessible. This review summarizes related theories and recent experiments on Brownian motion at short time scales, with a focus on the measurement of the instantaneous velocity of a Brownian particle in a gas and the observation of the transition from ballistic to diffusive Brownian motion in a liquid. [ABSTRACT FROM AUTHOR]