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Aim: Brucellosis may affect the eye to varying degrees. The aim of this study was to investigate the ocular involvement of brucellosis and highlight key points., Material and Methods: Published literature in English language on the ocular involvement of brucellosis within last 30 years was evaluated. The PubMed international database was screened using certain keywords., Results: The study included 27 publications evaluating a total of 159 cases. The most common types of ocular involvement were uveitis (52.2%) and conjunctivitis (17.6%). Most cases had concomitant systemic brucellosis (27.7%), and the most commonly used diagnostic method was a serological test (92.4%). Of all the patients, 37.1% recovered with sequelae., Conclusion: Brucellosis may cause a wide range of ophthalmic manifestations, and an overlooked or late diagnosis may also lead to the development of sequelae or loss of vision. A routine ophthalmologic examination should be performed in all patients with systemic brucellosis.

Objective: There are insufficient data in the literature concerning whether cellular changes in tissue are reflected in blood circulation in granulomatous infections, such as zoonotic brucellosis. In this study, we compared laboratory parameters between patients with brucella (BEO) and non-brucella epididymo-orchitis (NBEO). Materials and Methods: This retrospective study included 84 patients with BEO and 92 with NBEO who presented to six medical centers between 2017 and 2021. Results: The median age of the patients was 41 (interquartile range: 27-61) years. In the multivariate analysis, the presence of abdominal pain (p=0.003), the percentage of lymphocytes (p=0.012) and the percentage of monocytes (p=0.029) were significantly higher in the BEO group than in the NBEO group. In addition, the percentage of neutrophils (p=0.001) was significantly lower in the BEO group than in the NBEO group. In the receiver operating characteristic analysis, the percentage of lymphocytes had an area under the curve (AUC) value of 0.808 at a cut-off point of >22.1%, the percentage of monocytes had an AUC value of 0.745 at a cut-off point of >7.7%, and the percentage of neutrophils had an AUC value of 0.746 at a cut-off point of <66.8%. Conclusion: To the best of our knowledge, there is no other study comparing the percentages of lymphocytes, monocytes, and neutrophils between patients with BEO and NBEO. The percentages of mononuclear leukocytes (monocytes and lymphocytes) and neutrophils may be useful for the prediagnosis of BEO in endemic areas. [ABSTRACT FROM AUTHOR]

Objective: Brucellosis is one of the most frequent zoonotic infectious diseases and is a global public health concern, particularly in developing countries. Brucellosis causes systemic symptoms and can affect different parts of the body. Brucellar pericarditis is a rare involvement of the cardiovascular system. This study aimed to investigate the clinical outcomes of Brucella pericarditis cases. Methods: A pooled analysis study was conducted by searching four international online databases with the terms "Brucella" and "pericarditis" and their synonyms. The full texts or abstracts were screened using these keywords. The publications were examined in terms of the age and gender of cases, publication year and country, additional diagnosis, diagnostic methods, treatments, and outcomes. Results: The study included 25 cases (14 males, 56%), with a mean age of 38.84 ± 9.7 (12-79) years. Systemic findings were present in 17 (68%) patients, and 17 (68%) had a cardiac presentation. 10 (40%) patients had retrosternal pain/ chest pain, 10 (40%) patients had pericardial frontman, and five (%10) cases had tachycardia. The most commonly used diagnostic method was a serological test (96%), and a positive blood culture result was determined in 64%. The Rose Bengal test was performed in seven cases, of which six had positive results. Complete recovery was reported for 22 cases, and death in two patients. Conclusion: Although brucellosis is less common in many developed countries, it should be keep in mind differential diagnosis in endemic areas. Brucellosis is a rare cause of pericarditis and requires specific treatment. Standard tube agglutination tests are highly sensitive and specific in the diagnosis of brucellosis. This non-invasive, practical test should be used in the differential diagnosis of pericarditis [ABSTRACT FROM AUTHOR]