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In this paper, we consider the inverse problem for identifying the initial value problem of the time–space fractional nonlinear diffusion equation. The uniqueness of the solution is proved by taking the fixed point theorem of Banach compression, and the ill-posedness of the problem is analyzed through the exact solution. The quasi-boundary regularization method is chosen to solve the ill-posed problem, and the error estimate between the regularization solution and the exact solution is given. Moreover, several numerical examples are chosen to prove the effectiveness of the quasi-boundary regularization method. Finally, our method can be used to solve high dimensional time–space fractional nonlinear diffusion equation, especially in cylindrical and spherical symmetric regions. [ABSTRACT FROM AUTHOR]