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Intensity of ascorbate-, NADPH-dependent and spontaneous lipid peroxidation were studied in mice brain and liver tissues after intravenous administration of middle molecular mass peptides, isolated from blood serum of animals with thermic burns. Positive effect of these peptides on lipid peroxidation was detected in tissues of animals with altered rate of lipid peroxidation (strong burns of 10-12% of body surface served as a biological model). The data obtained suggest that individual components of blood serum middle molecular fraction appear to exhibit the regulating effects on lipid peroxidation in animal tissues.

Dynamics of lipid peroxidation was studied in blood serum of patients with burns of various severity and degree. The burns development was accompanied by syndrome of lipid hyperperoxidation, the intensity and duration of which correlated with the disease severity. The procedure of UV-irradiated blood autotransfusion was used to correct the impairments detected. High efficiency of the procedure was demonstrated by reduction of the lipid hyperperoxidation syndrome in patients with burns.