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The article defines the concept of threat model. Described a list of current security guidelines for the development and administration of web systems. Formed the list of cybersecurity threats, the consequences of their implementation are determined. Described the process of forming a model of cybersecurity threats of web systems. Defined the list of threats based on the recommendations and experience of authoritative organizations in the world and Ukraine. Defined the concepts of risk, risk index and risk status for the security of web systems. Defined the main principles of risk management in software development projects.

Introduction: Due to a high incidence of the novel coronavirus disease (COVID-19) in the Russian Federation in 2020, identification of the regional features of the disease spread has become relevant for understanding of the further development of the development of the epidemic process, organizing and implementing comprehensive preventive measures. Objective. To study regional features of the COVID-19 epidemic process in the Lipetsk Region. Materials and methods. We used data from the Center for Hygiene and Epidemiology in the Lipetsk Region, notifications by healthcare facilities, summary reports on COVID-19 cases in the regions (Form 1076), and the website “стопкоронавирус.рф” (“stopcoronavirus.rf”). Results. Incidence rates indicated a slow development of the epidemic with a growth rate of 0.68 %. Two rises were registered during the year 2020. Female COVID-19 cases prevailed (154.7 0/000 [95 % CI: 150.95–157.10]). The main risk groups included people aged 50–64 years (212.2 0/000 [95 % CI: 206.4–217.7]), 30–49 years (167.9 0/000 [95 % CI: 163.7–172.4]), and 65 years and older (126.2 0/000 [95 % CI: 121.1–131.0]). Among professional groups, high incidence rates were observed among healthcare workers (547.8 0/000 [95 % CI: 520.83–576.52]) and employees of the Ministry of Internal Affairs (257.1 0/000 [95 % CI = 214.65–305.41]). Most people got infected in their home (42.3 ± 0.4 %). We established that moderate (39.8 ± 0.4 %) and mild (31.3 ± 0.4 %) forms of the disease with symptoms similar to those of upper respiratory tract infections (47.4 ± 0.4 %) prevailed. The mortality rate did not exceed the national average (1.6 % and 1.8 %, respectively). In general, timely and consistent implementation of comprehensive measures helped influence the epidemiological situation in the region: the epidemic process was characterized by a moderate intensity of morbidity and mortality and had no explosive nature that could have destroyed the infrastructure of the region. At the same time, further monitoring and analysis of the COVID-19 situation in the Lipetsk Region is important, especially in view of the COVID-19 vaccination campaign and subsequent formation of herd immunity.

The aim of the article is to classify and form strategies of the commercial companies’ and non-commercial organisations’ promotion on the web. The results of analyses. During the analyses of the business models on the web, there were distinguished next possible strategies of the Use of Internet-Marketing instruments: Narrow specialization strategy – this strategy is appropriate for the companies, that want drive narrow specialized traffic to the web-resource. Narrow specialized clicks on the web-resource are specified requests of the user, that could contain professional terms. This kind of user-transitions belong to the people, who understand the subject deeply and can easily form necessary request, using search-engine. Narrow specialization strategy with the elements of reputation instruments – this strategy is appropriate for the companies, that want drive narrow specialized traffic to the web-resource. The main feature of the companies, that use narrow specialization strategy with the elements of reputation instruments, is that they have to have positive reputation, to wake up the interest of the user. Another main feature is that the companies sell the product, that could be freely scaled in a short period of time in comparison with a companies, that have got big productions. It is an element of publicity, that allows to reach first places in new segments. Wide specialization strategy – this strategy is appropriate for the companies, that want to drive more traffic to the web-resource, because this traffic is a source of companies’ income. The aim of the web-site is to answer to the information requests of the users, to encourage them to visit the web-resource and to reach the needed information through the watching of the advertising. Mixed specialization strategy – this strategy is appropriate for the companies, that have to use the large amount of the Internet-Marketing instruments due to the high level of the competition on the market. This type of the strategy requires larger amount of variable-costs, that’s why the level of the profit margin is low or middle. In this case, companies do want to increase their profit, selling their product to the big amount of consumers. This segment has a high level of competition. The synergy of reputation and publicity strategy – this strategy is appropriate for the non-commercial organisations, that have got an aim to educate their target audience or to collect the narrow- specialized information on their web-resource. The costs of the organisation are covered by the donation or by the month-fee. The administration of the organization is interested to support and expand their reputation, to wake up an interest in the larger amount of potential users. Conclusions and perspectives for further research. The classification of the business-models strategies on the web lets commercial companies and non-commercial organisations optimize their marketing processes, save resources, maximize the effectivity of the communication with their audience, in accordance with their aims

Background. Breast cancer (BC) is distinguished with its biological tumour subtypes as luminal A, B, HER2-positive and triple-negative. The current clinical guidelines of the Russian Ministry of Health prescribe neoadjuvant targeted chemotherapy as combined treatment in the HER2-positive cancer subtype. An adequate model for treatment efficacy prediction in such patients had been missing to date.Aim. Development of a mathematical model and its computer realisation for complete morphological regression estimation in patients with primary operable HER2-positive breast cancer.Materials and methods. Statistically significant predictors were estimated with the treatment outcome data on 103 HER2- positive breast cancer cases with neoadjuvant targeted chemotherapy. A binary logistic regression model was developed to account for a dichotomous variable dependency on certain predictors.Results and discussion. Multivariate analysis laid out a mathematical model and software “Complete morphological regression estimation in primary operable EGFR-expressing breast cancer under neoadjuvant chemotherapy”. Our results attest that the program correctly automates a systematic estimation of complete morphological regression achieved prior to neoadjuvant targeted chemotherapy and is clinically justified for optimising treatment regimens in primary operable HER2-positive BC.Conclusion. The mathematical model and computer program developed estimate the rate of complete morphological regression achieved prior to neoadjuvant targeted chemotherapy with a high 92 % sensitivity, 97.33 % specificity and 93.21% accuracy.

The stability of periodical domain structure during high-temperature annealing was studied in MgO doped lithium niobate single crystals by analysis of efficiency and homogeneity of the seco...

The article is devoted to the development of the financial monitoring system in the context of a pandemic. The issues of organizational, legal and methodological support, departmental interaction and international cooperation, automation of the activities of bodies are considered.

This paper discusses the problems of ethical systems in the context of the post-non-classical paradigm of scientific rationality and the development of artificial intelligence technologies in the taxation area. A brief analysis of modern methods and approaches of artificial intelligence in the taxation area is carried out, the need to include ethical contexts and principles in the processes of designing and developing these technologies to ensure international stability and security is justified. The basic approaches of the post-nonclassical ethical system for the formation of harmonious environments of interdisciplinary research are proposed. Ethical imperatives for the development of AI in the taxation area are formulated, the methodological framework of the problems of moral values of technological processes is outlined.

Purpose The purpose of this paper is to review and analyze how the development and utilization of artificial intelligence (AI) technologies for social responsibility are defined in the national AI strategies of the USA, Russia and China. Design/methodology/approach The notion of responsibility concerning AI is currently not legally defined by any country in the world. The authors of this research are going to use the methodology, based on Luciano Floridi’s Unified framework of five principles for AI in society, to determine how social responsibility is implemented in the AI strategies of the USA, Russia and China. Findings All three strategies for the development of AI in the USA, Russia and China, as evaluated in the paper, contain some or other components aimed at achieving public responsibility and responsible use of AI. The Unified framework of five principles for AI in society, developed by L. Floridi, can be used as a viable assessment tool to determine at least in general terms how social responsibility is implied and implemented in national strategic documents in the field of AI. However, authors of the paper call for further development in the field of mutually recognizable ethical models for socially beneficial AI. Practical implications This study allows us to better understand the linkages, overlaps and differences between modern philosophy of information, AI-ethics, social responsibility and government regulation. The analysis provided in this paper can serve as a basic blueprint for future attempts to define how social responsibility is understood and implied by government decision-makers. Originality/value The analysis provided in the paper, however general and empirical it may be, is a first-time example of how the Unified framework of five principles for AI in society can be applied as an assessment tool to determine social responsibility in AI-related official documents.

To increase the reliability of diagnosing tractor engines, a dynamic loading mode is proposed under bench conditions. The loading modes are substantiated from the point of view of diagnostics of the input action and the most informative mode of engine operation.

We present a method of minimally invasive transcutaneous insertion of screws using a prefabricated extracorporeal navigation system using additive technologies (based on primary data obtained from the DICOM package in multi-detector computed tomography of the affected spine segment) according to the principle of personalized medicine. The method was tested on 10 dogs of different breeds with generally similar mechanism of trauma and typical consequences that led to fracture and dislocation of one of the lumbar vertebrae. In all animals, a positive treatment outcome of different degrees was achieved. Regression of the neurological deficit without significant postoperative inflammatory reaction was noted. The proposed method of treatment reduces the risk of malposition in pedicular and interbody pins and reduces radiation intraoperative exposure.

Postmortem changes occurring in human carotid body were simulated on the Wistar rat model. It was shown that light, dark, and pyknotic (progenitor) subtypes of human carotid body cells are an artifact and cannot be used in clinical practice to study the characteristics of various human diseases. The differences between the control group of healthy individuals and individuals with the various pathologies are most likely due to the different levels of premortal hypoxia that the tissue had been exposed to. Moreover, widespread antigens used in practice were divided into 2 groups by their tolerance to autolysis: stable and unstable ones. This can be useful for the development of immunohistochemical test algorithms for the diagnostics on autopsy material.

Magnetoelectric (ME) effects in composite ferromagnet-piezoelectric (FM/PE) heterostructures realize the mutual transformation of alternating magnetic and electric fields, and are used to create magnetic field sensors, actuators, inductors, gyrators, and transformers. The ME effect in composite structures is excited by an alternating magnetic field, which is created using volumetric electromagnetic coils. The coil increases the size, limits the operating frequencies, and complicates the manufacture of devices. In this work, we propose to excite the ME effect in composite heterostructures using a new coil-free excitation system, similar to a “magnetic capacitor”. The system consists of parallel electrodes integrated into the heterostructure, through which an alternating current flows. Modeling and measurements have shown that the excitation magnetic field is localized mainly between the electrodes of the magnetic capacitor and has a fairly uniform spatial distribution. Monolithic FM/PE heterostructures of various designs with FM layers of amorphous Metglas alloy or nickel-zinc ferrite and PE layers of lead zirconate titanate piezoceramic were fabricated and investigated. The magnitude of the ME effect in such structures is comparable to the magnitude of the ME effect in structures excited by volumetric coils. However, the low impedance of the coil-free excitation system makes it possible to increase the operating frequency, reducing the size of ME devices and the power consumption. The use of coil-free excitation opens up the possibility of creating planar ME devices, and accelerates their integration into modern electronics and microsystem technology.

Introduction. The cells in adrenal medulla, carotid body and the organ of Zuckerkandl have the common origin from the neural crest. Nevertheless, despite the similarity in both histological and biochemical characteristics of these organs, contemporary scientific paradigm contrasts the carotid body with the adrenal gland and the organ of Zuckerkandl. The adrenal gland and the organ of Zuckerkandl are considered to function as endocrine glands whereas carotid body is thought to be a chemoreceptor organ. The endocrine function of the carotid body is still in question. The aim of the work was to evaluate the possibility of the presence of endocrine function by the carotid body in the embryonic, prefetal and early fetal period of human development by immunohistochemistry and compare it with the function of the organ of Zuckerkandl and the adrenal medulla. Materials and methods. The study was performed on 5 fetal autopsies (gestational age 8–20 weeks) using immunoperoxidase labeling with antibodies to bIII-tubulin, tyrosine hydroxylase, synaptophysin and PGP9.5. Results. In all samples of the carotid body, the organ of Zuckerkandl and the adrenal medulla, the cells showed a positive reaction to all the markers. All carotid bodies showed very high TH/bIII ratio approaching unity. The organ of Zuckerkandl in all fetus showed much higher TH/bIII ratio than that inthe carotid body. In the adrenal glands at 11–20 weeks of gestation TH/bIII ratio was even greater. In the adrenal gland in 8-week embryo this ratio was lower than in the carotid body. Conclusion. We have showed that the number of TH-positive cells in the carotid body in the embryonic and early fetal periods is much higher than in postnatal period. Our data may indicate endocrine function of the carotid body during the antenatal period of development. Thus, the carotid body is likely to synthesize catecholamines while the adrenal medulla is functionally immature and cannot support the body’s homeostasis. Keywords: sympathoadrenal system, human development, carotid body, organ of Zuckerkandl, adrenal gland.

An experiment on measuring the equivalent dose rate over the Shelter object after the completion of the construction of the New Safe Confinement is described. Measurements of the gamma radiation were performed in the time of commissioning of the New Safe Confinement with the help of the sensor installed on its Main Cranes System. The carriage with a sensor was moved by a chaotic trajectory so the method of missing data interpolation was proposed. As a result, a cartogram of the distribution of the gamma field at the level of movement of the bogies of the Main Cranes System of the New Safe Confinement is provided in this paper.

The authors address the problem of development of urban waterfront territories. Therefore the focus is on the basic principles of the organization of public recreational areas. The relevance of the interest is generally stipulated by the following reasons. Firstly, due to the analysis of the domestic and overseas waterfront design experience it seems reasonable to point out that the quality of urban living depends directly on the viability of open public spaces. The waterfront area proves to be a major element of urban tissue that can be related as the city image. Secondly, it can be reasonable to outline a range of issues that are extremely important for many cities in Russia such as the lack of land improvement, comfortable living environment and architectural-aesthetic identity in terms of the image of waterfront areas. The article aims to reveal basic principles of spatial organization of urban waterfront areas. The study is carried out on the material of the domestic and overseas experience in design solu-tions and existing public recreational areas. This implies the analysis and comparison of the following cases: waterfront revival in great cities and suburban towns within Russia as well as overseas experi-ence on regeneration of abandoned waterfront areas. Furthermore, there is the description of the main methods, principles, prospective directions in design management and architectural-aesthetic features of each considering design solution. The methodological basis of the research incorporates architectur-al, art, historical and cultural approaches. In terms of key results of the research we consider highlighting such principles of the organiza-tion of urban waterfronts as multilayer communication structure which are the priority for pedestrian circulation and multilevel waterfront environment; the ability to access water bodies, the addition of focal points, viable and barrier-free environment. Moreover, one of the most important factors is the concentration of urban recreational areas with diverse multifunctional zones that can be used both in summer and winter seasons. The preservation of ecological framework and maintenance of biodiversi-ty, the reliance on water protection zones as well as the appliance of eco-materials are also considered to be a range of inalienable measures in urban waterfront design. Waterfronts cannot be designed sepa-rately from adjacent urban bodies that, for example, can represent historical value. Architectural-aesthetic image of urban waterfronts should meet the modern tendencies in architecture, urban plan-ning and design or emphasize historical identity of urban development. The overall statements are supported by the analysis of the following design solutions: the embankment of Zaryadye Park in Moscow; the design of the waterfront regeneration in Divnogorsk in Krasnoyarsk region; the design of Riga waterfront in Latvia, the design of Seine quayside reinvention in Paris; the East River waterfront in New York; the waterfront arear HafenCity in Hamburg. Overall, due to the results of our research the organization of urban waterfronts incorporates a variety of crucial factors (in terms of architecture, urban planning and design, imageability, ecology, economy etc) which add the complexity to the designing process. Nevertheless, the implementation of the basic principles of design provides waterfronts with the high level of diversity and comfort for cities’ inhabitants.

The article deals with the features of the development and formation of the digital economy as a new era and the conditions for the functioning of modern companies. The digital economy is a new way and functioning mode of the market which competition has become even more toughened, and methods have become more diverse and high-tech. The authors substantiate the need to form a strategy for the development of companies taking into account new digital concepts and tools. The authors proposed the concept and structure of media space, highlighted the elements of macro-and mesosphere of the company. Also, a study was conducted to identify the basic requirements that consumers impose when choosing a company for further interaction in the search media space. Before ordering products (services, works), future customers carefully study information about the company on the Internet, analyze web-site, read reviews, blogs that affect the decision to buy. The results can be used in the formation of the concept of development of the company's strategy, both in the field of material production and in the field of services and the provision of various works.

Aim: To compare the safety and prophylactic efficacy of Cytovir-3 and Arbidol in an open-label randomized clinical trial in children at seasonal risk of infectious respiratory disease.Methods: This study was performed in the period preceding a seasonal outbreak of acute respiratory viral infections (ARVI) and influenza. The study enrolled apparently healthy children aged 6 to 18 years without contra-indications to either Cytovir-3 or Arbidol. Cytovir-3 was given as 1 capsule per day, each day in a fasted state for 12 days. Arbidol was taken as a 100 mg capsule twice a week for three weeks. Following dosing, subjects were followed-up for a further three weeks. Overall health and presence of symptoms of either ARVI or influenza were monitored daily in all subjects. The level of sIgA in saliva was baselined before treatment and measured at the end of the follow-up period.Results: Most subjects did not exhibit any change in overall health status during the dosing and follow-up periods. The first two cases of illness in subjects receiving Cytovir-3 were diagnosed at the end of the third week after completion of dosing. In those subjects receiving Arbidol the first cases of illness were reported at the end of the second week following the end of prophylactic dosing. All patients displayed a significant increase in sIgA level at the end of the dosing period, but this was more pronounced in the Cytovir-3 group. Conclusion: The results of this comparative randomized clinical trial confirmed the safety and tolerability of both medications, and that the prophylactic efficacy of Cytovir-3 is equal to that of Arbidol.

A monolithic magnetoelectric (ME) resonator for applications in magnetic field sensors was manufactured and investigated. The resonator contains a piezoelectric lead zirconate titanate plate of dimensions 20 mm × 4 mm × 0.2 mm with Ag electrodes, located between two layers of a magnetostrictive amorphous ferromagnet FeBSiC, each of which is 25 μ m thick. Planar acoustic oscillations with a frequency of 74 kHz in the resonator were excited by a magnetic field of linear alternating current I = 0–100 mA flowing through conductive copper strips that are 20 μ m thick, deposited on both external surfaces of the resonator. The voltage u generated by the ME resonator depends linearly on the tangential dc magnetic field in the range H = 0–130 Oe. The excitation efficiency of the resonator with a linear current reached u / I = 1.5 V/A. The use of strips with a current, instead of electromagnetic coils, to excite ME resonators will allow reduction of the size and increase the frequency of the resonators, expand the range of operating magnetic fields, and, by order of magnitude, reduce the power required to excite the resonators.

Goal: Because of the outbreak of coronavirus infection, healthcare systems are faced with the lack of medical professionals. We present a system for the differential diagnosis of coronavirus disease, based on deep learning techniques, which can be implemented in clinics. Methods: A recurrent network with a convolutional neural network as an encoder and an attention mechanism is used. A database of about 3000 records of coughing was collected. The data was collected through the Acoustery mobile application in hospitals in Russia, Belarus, and Kazakhstan from April 2020 to October 2020. Results: The model classification accuracy reaches 85%. Values of precision and recall metrics are 78.5% and 73%. Conclusions: We reached satisfactory results in solving the problem. The proposed model is already being tested by doctors to understand the ways of improvement. Other architectures should be considered that use a larger training sample and all available patient information.

The evolutionary and ontogenetic development of the carotid body is still understudied. Research aimed at studying the comparative morphology of the organ at different periods in the individual development of various animal species should play a crucial role in understanding the physiology of the carotid body. However, despite more than two centuries of study, the human carotid body remains poorly understood. There are many knowledge gaps in particular related to the antenatal development of this structure. The aim of our work is to study the morphological and immunohistochemical characteristics of the human carotid body in the antenatal and postnatal periods of development. We investigated the human carotid bodies from 1 embryo, 20 fetuses and 13 adults of different ages using samples obtained at autopsy. Immunohistochemistry revealed expression of βIII-tubulin and tyrosine hydroxylase in the type I cells and nerve fibers at all periods of ontogenesis, synaptophysin and PGP9.5 in the type I cells in some of the antenatal cases and all of the postnatal cases, 200 kDa neurofilaments in nerve fibers in some of the antenatal cases and all of the postnatal cases, and GFAP and S100 in the type II cells and Schwann cells in some of the antenatal cases and all of the postnatal cases. A high level of tyrosine hydroxylase in the type I cells was a distinctive feature of the antenatal carotid bodies. On the contrary, in the type I cells of adults, the expression of tyrosine hydroxylase was significantly lower. Our data suggest that the human carotid body may perform an endocrine function in the antenatal period, while in the postnatal period of development, it loses this function and becomes a chemosensory organ.

More then 50 years Photomultiplier Tubes (PMT’s) fills the area of low photon flux detection practically without alternative (Hammamatsu Photonics K.K., 2006), despite the fact that is very well known many disadvantages of this devices. Concerning modern semiconductor structures for the photon detection, few options were investigated for the detecting of the low photon flux, but main critical problem to develop the semiconductor device was the relative high level of thermal noise of semiconductor detector structure and associated frontend electronics. One of the solutions, overcome this problem is Visible Light Photon Counter (VLPC) (Atac, 1993). This device is semiconductor avalanche structure operated at the temperature of 4K, for the suppression of thermal noise. The results was successful possibility to detect low photon flux up to single photon, but operational conditions are to complicated to be acceptable for wide area application, cryostat for the 4K temperature up to now is challenge even in the laboratory conditions. Development of the modern detection structures for the low photon flux Si was initiated at the beginning of 90’th from studies of Silicon Metal Oxide Semiconductor (MOS) structures with avalanche breakdown mode operation for the detecting of single visible light photons [Gasanov et al., 1989]. The results were positive, but strong limitation was the necessity to include external recharge circuits for the discharge the detector structure after charging the MOS structure during the photons detection. Next step was implementation of special resistive layer instead oxide layers, Metal Resistive Semiconductor (MRS) structures, which gives the possibility to recharge the structure after photon detection and in addition to control the breakdown avalanche process by quenching. Such structures had very high and stable amplification characteristics for photons detection, in comparison to conventional avalanche photodetector structures, but limited sensitive area. The idea of Silicon Photomultiplier or more precisely Silicon Photoelectron Multipliers was created for overcoming problem of above mentioned structures as small sensitive area due to nonstability of amplification over large area, low dynamic range, improving the resolution. It was decided create the fine metal resistor semiconductor structure with local space distributed pn-junctions (micro-cells) and common output. The result was fascinated, first time clear single photon spectra was detected on the semiconductor structure at room temperature. Results of study such structures was presented on the 9th European semiconductor conference in 1995 (Saveliev, 1995). Source: Advances in Optical and Photonic Devices, Book edited by: Ki Young Kim, ISBN 978-953-7619-76-3, pp. 352, January 2010, INTECH, Croatia, downloaded from SCIYO.COM

Capacitive proximity sensors allow detecting the presence of nearby objects without any physical contact with them, as well as in poor visibility conditions in the presence of dust or smoke. Tactile sensors in robotic devices provide additional information about the environment to the robot control system, and particularly serve as a feedback element for an object gripping system or a robot's coordination and gait system. In this work, tactile sensors were used to determine the distance from the object to the sensor and to recognize the type of object material. An array of capacitive sensors of four cells was used. We tested the effectiveness of seven machine learning methods (support vector machine (SVM), decision tree, naive Bayesian classifier (NBC), random forest, k-nearest neighbors method, gradient boosting, neural network model (Keras, ReLU activation function) in the problem of determining the distance to an object, as well as its type of material. According to the results of the experiment, the most accurate method for recognizing the type of object material was the k-nearest neighbors method (96.9%), and the most accurate method for determining the distance to an object based on the output signal of capacitive sensors and the object material was a random forest (78.7%).

PEACH is an important tool for evaluation of children's hearing development, used in age 2-7 years. It is also appropriate for amplification outcomes measurements. PEACH scale includes 13 questions. Parents fill the questionnaire after week observation of child's hearing behavior in different situations. The goal of the study was validation of Russian version of PEACH scale. Translation and cross-cultural adaptation were performed following international guidelines. 50 children with normal hearing and 50 hearing impaired children were involved in the validation process. All of the hearing-impaired children used hearing aids or cochlear implants. PEACH scores of the children with normal hearing have strong correlation with data of original version (ρ=0.998;Опросник PEACH является важным инструментом оценки слухоречевого развития детей от 2 до 7 лет, применяемым в том числе для определения эффективности проводимых реабилитационных мероприятий. Опросник включает 13 вопросов, заполняется родителями по результатам недельного наблюдения за реакциями ребенка на звуки в различных ситуациях.Валидация русскоязычной версии опросника PEACH.Согласно международным рекомендациям, выполнен перевод и произведена кросс-культурная адаптация опросника. В процессе валидации участвовали 50 детей с нормальным слухом и 50 детей с различной степенью тугоухости, использующих слуховые аппараты или кохлеарные импланты.По результатам обследования детей с нормальным слухом получены нормативные значения русскоязычной версии PEACH, которые коррелируют с данными разработчиков оригинальной версии (Показана высокая воспроизводимость опросника, а также подтверждена возможность его применения у детей с различными состояниями слуховой функции.

In this paper the development of structure and circuit solution for a bidirectional wireless power transmission system is presented, based on current fed push-pull inverter. Existing solutions are analyzed, as well their structures and characteristics. The principle of operation of the developed circuit solution is described in receiving/transmitting mode, an electrical principal circuit is given with respective ratios calculated. The SPICE modeling of the system was performed, and the theoretically calculated dependency of energy transmission efficiency from the transmitted power was obtained. The developed structure includes a step-up DC-DC converter, which enables to obtain the output voltage of the system, active in receiving mode, being equal or higher than the voltage of the power supply of energy-transmitting system. Therefore, the proposed bidirectional wireless power transmitting system can be utilized within a swarm robotic system with unified robots, having identical power supply batteries. Practical application of the proposed solution is relevant for energy transmission among autonomous robots, energy transmission from power supply source to robot and in reverse direction.

The development of laser industry and the increase in the intensity of laser radiation make the problem of protecting the vision organs and photosensitive sensors from high-intensity laser radiation more relevant. This paper presents the results for optical characteristics of phthalocyanine J-type dimeric complexes of Mg (phtMg) dissolved in dimethylformamide (DMF). Coherent Chameleon Ultra laser system was used as a source of laser radiation. The pulse duration was 140 fs, the pulse repetition rate was 80 MHz, and the wavelength was 810 nm. The studied solution didn’t exhibit nonlinear absorption properties (in contrast to the case of exposure by nanosecond radiation); the sample transmission remained unchanged with the increase in the intensity of the incident radiation. However, with the increase in the radiation power above 20 mW, an expansion of the beam was observed with the formation of a diffraction rings pattern due to spatial self-phase modulation induced by nonlinear refraction. The expansion of the laser beam allows the intensity of the laser radiation to be reduced by increasing the beam radius. Moreover, the addition of a diaphragm to the optical scheme, which "cuts off" a part of the incident radiation with an increase in the beam radius, makes it possible to reduce the radiation power getting in the sensor. This makes phthalocyanine complexes of Mg dissolved in DMF a promising material for use not only as a limiter of femtosecond pulsed radiation, but also as a nonlinear optical switcher for signal control in optical communication systems.

A traction-driven tillage tool with low traction resistance has been developed. A decrease in the tractive resistance of the implement is achieved by transferring the main share of the power consumed by the implement to the process of loosening the soil through the tractor power take-off shaft (PTO) to the drive needle discs, which in turn create a pushing force. The efficiency of the technological process of soil cultivation depends on the kinematic mode of operation of each row of disk working bodies of the tractiondrive tillage implements. To optimize their kinematic mode of operation, a multifactorial experiment was carried out, which made it possible to establish the optimal values of such factors as the kinematic parameters of the 1st and 2nd rows of needle disks at the set operating speed of the unit.

Finding hidden champions in Ukraine was not easy. Many business leaders have decided not to be hidden and have invested in corporate brand promotion. On the other hand, most company-related information is private. Also, the domestic market is relatively large. Therefore, many successful companies are still operating within their own range. The key advantage of the Ukrainian hidden champions is their narrow specialization that renders the domestic market too small. These companies have no other choice but to compete on a global scale. Ukrainian hidden champions produce high added value and export hi-tech products.

This paper presents a study related to human psychophysiological activity estimation based on a smartphone camera and sensors. In recent years, awareness of the human body, as well as human mental states, has become more and more popular. Yoga and meditation practices have moved from the east to Europe, the USA, Russia, and other countries, and there are a lot of people who are interested in them. However, recently, people have tried the practice but would prefer an objective assessment. We propose to apply the modern methods of computer vision, pattern recognition, competence management, and dynamic motivation to estimate the quality of the meditation process and provide the users with objective information about their practice. We propose an approach that covers the possibility of recognizing pictures of humans from a smartphone and utilizes wearable electronics to measure the user&rsquo, s heart rate and motions. We propose a model that allows building meditation estimation scores based on these parameters. Moreover, we propose a meditation expert network through which users can find the coach that is most appropriate for him/her. Finally, we propose the dynamic motivation model, which encourages people to perform the practice every day.

The objective of the study was searching for surface antigen expression that could predict presence of translocation t(12;21)(p13;q22)/ETV6RUNX1 in pediatric B-cell precursor acute lymphoblastic leukemia patients.Results . ETV6-RUNX1 fusion gene transcript was revealed in 118 (22.4 %) out of 526 children with B-cell precursor acute lymphoblastic leukemia. Leukemic blast cells in ETV6-RUNX1-positive patients more frequently had high CD10 expression, myeloid markers co-expression , including CD13, CD33, CD117, and absence of CD20 than in ETV6-RUNX1-negative ones. Nevertheless diagnostic test performance characteristics of each single parameter was not strong enough for predicting the presence of translocation t(12;21)(p13;q22)/ETV6-RUNX1.Conclusion . Thus application of conventional set of immunological markers does not allow reliable distinguishing this patients’ subgroup. However antibodies panel enlargement, high degree of flow cytometry standardization and additional analytical methods can potentially improve applicability of antigen profile analysis for separation of patients with translocation t(12;21)(p13;q22)/ETV6-RUNX1.

The paraganglionic system is one of the least studied systems of the body, closely interacting with the autonomous nervous system. The carotid body is an essential part of the paraganglionic system. The carotid body is a small organ located in the area of the common carotid artery bifurcation. The review summarizes more than 250-year history of studying the morphology and physiology of carotid body, considers its anatomical, histological, ultrastructural and immunohistochemical features. Being a peripheral chemoreceptor, the carotid body responds to the changes in pH-blood, partial pressure of arterial oxygen and carbon dioxide. The organ affects the functions of the respiratory and cardiovascular systems by complex reflexes, regulating the frequency and depth of breathing, the tone of the smooth muscles of the bronchi, the frequency and strength of heart contractions. Due to the complex interactions between the paraganglionic and autonomic nervous systems, this organ can be targeted in the treatment of diseases such as bronchial asthma, chronic obstructive pulmonary disease, and arterial hypertension. Despite significant successes in the study of the organ, there are still contradictions and difficulties faced by scientists and practitioners. So, there is still no final answer about the effect of carotid body on the motility of the bronchi and arterial vessels. It makes difficult to create the theory of its role in the pathogenesis of bronchial asthma and hypertension. The synaptogenesis and proliferation of carotid body cells have not been studied in normal and pathological conditions. There is practically no data on the embryonic development of the human carotid body. Further research should be aimed to create the theories that will describe the work of this organ in the whole organism and will not be limited to description of the group of molecules secreted by it in response to certain stimuli. Key words: carotid body, paraganglionic system, chemoreception, bronchial asthma, COPD, arterial hypertension

The compact linear accelerator for research and applications (CLARA) is an ultrabright electron beam test facility being developed at STFC Daresbury Laboratory. The ultimate aim of CLARA is to test advanced free electron laser (FEL) schemes that can later be implemented on existing and future short-wavelength FELs. In addition, CLARA is a unique facility to provide a high-quality electron beam to test novel concepts and ideas in a wide range of disciplines and to function as a technology demonstrator for a future United Kingdom x-ray FEL facility. CLARA is being built in three phases; the first phase, or front end (FE), comprises an S-band rf photoinjector, a linac, and an S-bend merging with the existing versatile electron linear accelerator beam line; the second phase will complete the acceleration to full beam energy of 250 MeV and also incorporate a separate beam line for use of electrons at 250 MeV; and the third phase will include the FEL section. The CLARA FE was commissioned during 2018, and the facility was later made available for user experiments. Significant advancements have been made in developing high-level software and a simulation framework for start-to-end simulations. The high-level software has been successfully used for unmanned rf conditioning and for characterization of the electron beam. This paper describes the design of the CLARA FE, performance of technical systems, high-level software developments, preliminary results of measured beam parameters, and plans for improvements and upgrades. © 2020 authors. Published by the American Physical Society.