Search

In the MagLIF ICF scheme, a cylindrical gas volume is laser heated before the walls of the cylinder are driven radially inward to compress the heated gas. Exploring the effects of material from the walls and the laser entrance window mixing into the heated region are important considerations for MagLIF experiments 1 , 2 , 3 ,. The addition of these materials into the heated gas can potentially have detrimental effects, radiatively cooling the gas fill and degrading the yield 4 . The NIF has been used to drive gas-pipe experiments where a tracer element (Ti) is placed on the LEH window or where strips of Ti and Sc are attached to the wall. Spatially and temporally resolved spectroscopic measurements of the Ti and Sc emission indicate the spatial location of these materials at various times during the interaction, assisting future predictions and mitigations of their propagation into the gas-pipe.

To assess whether BIO 300, a synthetic genistein nanosuspension, improves the therapeutic index in prostate cancer treatment by preventing radiation-induced erectile dysfunction (ED) without reducing tumor radiosensitivity.Male Sprague-Dawley rats were exposed to 25 Gy of 220-kV prostate-confined x-rays. Animals were randomized to receive sham radiation therapy (RT), RT alone, RT with daily BIO 300 at 2 experimental dosing regimens, or RT with daily genistein. Erectile response was evaluated over time. Penile shaft tissue was harvested for histologic analyses. Murine xenograft studies using prostate cancer cell lines determined the effects of BIO 300 dosing on RT efficacy.Prostate-confined RT significantly decreased apomorphine-induced erectile response (P.05 vs sham RT). Erection frequency in animals receiving prophylactic treatment with BIO 300 starting 3 days before RT was similar to sham controls after RT. Treatment with synthetic genistein did not mitigate loss in erectile frequency. At week 14, post-RT treatment with BIO 300 resulted in significantly higher quality of erectile function compared with both the RT arm and the RT arm receiving genistein starting 3 days before irradiation (P.05). In hormone-sensitive and insensitive prostate tumor-bearing mice, BIO 300 administration did not negatively affect radiation-induced tumor growth delay.BIO 300 prevents radiation-induced ED, measured by erection frequency, erectile function, and erection quality, when administered 3 days before RT and continued daily for up to 14 weeks. Data also suggest that BIO 300 administered starting 2 hours after RT mitigates radiation-induced ED. Data provide strong nonclinical evidence to support clinical translation of BIO 300 for mitigation of ED while maintaining treatment response to RT.

There are no FDA-approved drugs that can be administered prior to ionizing radiation exposure to prevent hematopoietic–acute radiation syndrome (H-ARS). A suspension of synthetic genistein nanoparticles was previously shown to be an effective radioprotectant against H-ARS when administered prior to exposure to a lethal dose of total body radiation. Here we aimed to determine the time to protection and the duration of protection when the genistein nanosuspension was administered by intramuscular injection, and we also investigated the drug’s mechanism of action. A single intramuscular injection of the genistein nanosuspension was an effective radioprotectant when given prophylactically 48 h to 12 h before irradiation, with maximum effectiveness occurring when administered 24 h before. No survival advantage was observed in animals administered only a single dose of drug after irradiation. The dose reduction factor of the genistein nanosuspension was determined by comparing the survival of treated and untreated animals following different doses of total body irradiation. As genistein is a selective estrogen receptor beta agonist, we also explored whether this was a central component of its radioprotective mechanism of action. Mice that received an intramuscular injection of an estrogen receptor antagonist (ICI 182,780) prior to administration of the genistein nanosuspension had significantly lower survival following total body irradiation compared with animals only receiving the nanosuspension (P < 0.01). These data define the time to and duration of radioprotection following a single intramuscular injection of the genistein nanosuspension and identify its likely mechanism of action.

Misunderstanding is an integral and unavoidable element of communication. This article links misunderstanding theoretically to message interpretation and conflict, then presents the results of a study that examined relationships among misunderstanding, channel of communication, and three forms of perspective-taking. Participants ( n = 98) responded to scaled items and described experiences of misunderstanding. Results showed that face-to-face misunderstandings are more serious than those that occur in computer-mediated communication. Dispositional perspective-taking, situational perspective-taking, and partner’s situational perspective-taking were correlated with features such as frequency of misunderstanding, use of integrative strategies, open communication, humor, personal offense, and communication satisfaction. In about two thirds of the reported misunderstandings, the problem occurred because of the tone of the message, an interlocutor took personal offense, and open communication was used to resolve it. The findings are consistent with predictions concerning perspective-taking and extend understanding of misunderstanding. Recommendations include examining misunderstanding, especially in CMC, in greater depth.