1. A STUDY ON EXPRESSION PROFILE OF BASAL MARKER CD44 AND LUMINAL MARKER CK20 IN UROTHELIAL NEOPLASM AND ITS CORRELATION WITH WHO GRADING AND STAGING OF TUMOUR
- Author
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Gopinath Barui, Krishnendubikas Bag, and Anish kumar Rakshit
- Subjects
Pathology ,medicine.medical_specialty ,biology ,business.industry ,CD44 ,Urothelial Neoplasm ,Correlation ,03 medical and health sciences ,Basal (phylogenetics) ,0302 clinical medicine ,030220 oncology & carcinogenesis ,biology.protein ,Medicine ,030212 general & internal medicine ,business ,Grading (tumors) - Abstract
Aim: Histomorphological study of urothelial carcinoma on TRBT and Cystectomy specimen and its categorization on the basis of WHO grading & pTNM staging and to nd out the correlation between CK20 and CD44 exprression with tumour grade, pTNM staging. Material And Method: This descriptive cross sectional prospective study was conducted in the Department of Pathology, R G Kar Medical College & Hospital Kolkata in collaboration with Department of Urosurgery, R G Kar Medical College & Hospital, Kolkata, West Bengal. The present study is intended to nd out over expression of CD44 & CK20 in Urothelial Carcinoma of Bladder and correlate with tumour grade and clinical features. Result: There is strong association between CD44, CK20 expression and Stage of Urothelial Carcinoma cases and had a strong association between CD44 expressions and grade Urothelial Carcinoma cases. Conclusion: CK20 overexpression was seen more signicantly in High Grade tumours HGPUC (p < 0.05) as well as advanced stage pT2 and CD44 overexpression was more signicantly in lower grade tumours LGPUC (p
- Published
- 2021