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1. Assessment of Factors Involved in Laser Fiber Degradation with Thulium Fiber Laser

Author: Laurent Berthe, Cyril Gorny, Steeve Doizi, T. Germain, Olivier Traxer, and F. Panthier
Subjects: business.industry, Urology, Physics::Optics, chemistry.chemical_element, Lasers, Solid-State, Lithotripsy, Laser, Laser, Stripping (fiber), Calculi, law.invention, Thulium, chemistry, law, Lithotripsy, Fiber laser, Humans, Laser fiber, Medicine, Degradation (geology), Optoelectronics, Physics::Atomic Physics, Fiber, business
Abstract: OBJETIVES: To assess the effect of various factors on laser fiber tip degradation with the Thulium Fiber Laser (Tm-fiber): fiber stripping, adjustable laser settings (energy, frequency, peak power)...
Published: 2022

2. Oral hygiene in patients with motor neuron disease requires attention

Author: Johannes J. de Soet, Berthe A M Makizodila, Johanna H E van de Wijdeven, Maurits K. A. van Selms, C.M.C. Volgenant, Academic Centre for Dentistry Amsterdam, Preventive Dentistry, and Oral Kinesiology
Subjects: medicine.medical_specialty, Neuromuscular disease, Cross-sectional study, business.industry, Amyotrophic Lateral Sclerosis, Treatment team, Disease, Oral health, medicine.disease, Oral Hygiene, Oral hygiene, stomatognathic diseases, Quality of life (healthcare), Cross-Sectional Studies, Family medicine, medicine, Quality of Life, Humans, In patient, Motor Neuron Disease, business, General Dentistry
Abstract: Aims: Motor Neuron Disease (MND) is a progressive neurodegenerative neuromuscular disease, which can progressively impair arm-hand function. Needs and barriers of MND patients and their caregivers in performing oral hygiene were studied. Methods: An online survey was sent to 706 MND patients. The questions of the survey included self-reliance, self-reported oral health, and oral hygiene. The oral health-related quality of life (GOHAI-NL) and the subjective well-being (ALSAQ-5) were also measured. Results: A total of 259 patients responded (36.7%), of which 71.9% stated not to be informed about the importance of maintaining good oral health by their MND treatment team. Moreover, 40.4% would like to receive help concerning oral hygiene from a dental professional. 19.8% were not satisfied about oral care as conducted by themselves or their caregivers. Patients who do not ask for support with their daily oral care had a significantly worse oral health-related quality of life compared to patients who do ask for support. Conclusions: The support for daily oral hygiene of MND patients and their barriers to requesting support needs more attention from both MND-treatment teams and general dental professionals.
Published: 2022

3. Comparison of Holmium:YAG and Thulium Fiber Lasers on Soft Tissue: An Ex Vivo Study

Author: Steeve Doizi, T. Germain, Eva Compérat, Olivier Traxer, Laurent Berthe, and F. Panthier
Subjects: genetic structures, business.industry, Urology, medicine.medical_treatment, Soft tissue, chemistry.chemical_element, Ablation, Laser, law.invention, Thulium, chemistry, law, Fiber laser, medicine, Coagulation (water treatment), Holmium, business, Ex vivo, Biomedical engineering
Abstract: OBJECTIVE: To assess the fiber-tissue interaction through ablation, coagulation, and carbonization characteristics of the Ho:YAG laser and Super Pulsed Thulium Fiber Laser (TFL) in a non-perfused p...
Published: 2022

4. Impact of Laser Fiber Diameter and Irrigation Fluids on Induced Bubble Stream Dynamics with Thulium Fiber Laser: An In Vitro Study

Author: Olivier Traxer, Laurent Berthe, Steeve Doizi, Cyril Gorny, and F. Panthier
Subjects: Irrigation fluids, business.industry, Urology, medicine.medical_treatment, Bubble, 030232 urology & nephrology, chemistry.chemical_element, Lithotripsy, Laser, law.invention, 03 medical and health sciences, 0302 clinical medicine, Thulium, chemistry, law, 030220 oncology & carcinogenesis, Fiber laser, Laser fiber, Medicine, Optoelectronics, Holmium, business
Abstract: Objectives: The Thulium Fiber Laser (TFL) is studied as an alternative to the holmium:yttrium-aluminium-garnet (Ho:YAG) laser for lithotripsy, with the advantage of an induced bubble stream (IBS). ...
Published: 2021

5. Guilt at Work: An Employee Perspective/La culpabilite au travail: La parole aux salaries/La culpabilidad en el trabajo: el testimonio de los asalariados

Author: Berthe, Benedicte and Chedotal, Camille
Subjects: Work environment -- Analysis, Guilt (Psychology) -- Analysis, Business, general, Business, Economics, Human resources and labor relations
Abstract: Guilt is a common emotion in everyday life. The objective of this research was to study guilt in the context of work. Exploratory research was conducted in order to: 1- identify guilt-inducing situations at work and the effects of this emotion; and 2- determine if guilt inducement is a management strategy to obtain more work from employees. Interviewees are employees with diverse profiles according to age, gender, position, sector of activity, size of company and status. Twenty-eight semi-directive interviews were conducted. The results identify the characteristics of guilt felt at work. It shows that guilt is a familiar emotion, of varying intensity and frequency and which is evolutionary. The analysis of the interviews also revealed eight guilt-inducing situations: absence or delay, perception of work poorly done, unfulfilled requests or promises, inappropriate behaviour or attitude, personal characteristics (status, flaw, lack of competencies), not paying enough attention to a client or to a colleague who is suffering (crying, dismissal), lack of time and the impact of work on private life. This research shows that guilt generates a discomfort for people. Above all, it has positive effects on work carried out by employees. Guilt thus has a beneficial effect on effort at work, except when this emotion is too intense. Guilt-inducement is another important axis of this study. In the event that some managers tried to induce guilt among their employees, the latter considered it ineffective. It was rejected and badly received. This article opens up research perspectives to deepen our understanding of the role and place of this emotion at work and to concentrate upon managerial implications in terms of well-being and performance at work. KEYWORDS: guilt, guilt inducement, emotions at work, effort, well-being at work. La culpabilite est une emotion commune, ressentie au quotidien. Cet article s'interesse a la culpabilite dans le contexte du travail. Il s'agit, par le biais d'une approche exploratoire, d'identifier les situations generatrices de culpabilite au travail et de determiner si la culpabilisation est une strategie de management utilisee en entreprise. Vingt-huit entretiens semi-directifs aupres de salaries ont permis de reveler l'importance de cette emotion au travail. L'apport principal de notre recherche tend a montrer l'effet benefique de cette emotion sur le travail produit par le salarie. Par contre, la culpabilisation en tant que technique de management est, quant a elle, a eviter. Elle a ete massivement rejetee par les salaries interroges. MOTS-CLES: culpabilite, culpabilisation, emotions au travail, effort, bien-etre au travail. La culpabilite est une emotion couramment eprouvee dans la vie quotidienne. L'objectif de cette recherche etait de l'etudier dans le cadre du travail. Une recherche exploratoire a donc ete menee afin, d'une part, d'identifier les situations generant de la culpabilite au travail ainsi que les effets de cette emotion et, d'autre part, de determiner si la culpabilisation est une strategie de management permettant d'obtenir davantage de travail de la part des salaries. Les personnes interviewees sont des salaries aux profils varies selon l'age, le sexe, le poste occupe, le secteur d'activite, la taille de l'entreprise et le statut. Vingt-huit entretiens semi-directifs ont ainsi ete menes. Les resultats identifient les caracteristiques de la culpabilite eprouvee au travail en revelant que cette derniere est familiere, d'intensite et de frequence variables, et evolutive. L'analyse des entretiens revele aussi huit situations generatrices de culpabilite qui sont liees aux phenomenes suivants: une absence ou un retard, la perception d'un travail globalement mal fait, des demandes ou des promesses non suivies, des comportements ou attitudes non corrects, des caracteristiques personnelles (par exemple, un manque de competence), un client ou un collegue qui souffrent et ne peuvent etre aides, un manque de temps ainsi que l'impact du travail sur la vie privee. Cette recherche montre que la culpabilite ressentie genere une gene chez les personnes. Mais elle a, surtout, des effets positifs sur le travail realise par les salaries. La culpabilite a generalement un effet benefique sur les efforts au travail, sauf quand cette emotion est trop intense. La culpabilisation est un autre axe important de cette etude. Si elle est bien constatee par les repondants, il en ressort qu'elle est jugee inefficace lorsqu'elle emane des superieurs. Elle est alors rejetee et mal vecue. Cet article ouvre des perspectives de recherche afin, d'une part, d'approfondir la place et le role de cette emotion et, d'autre part, de developper des implications manageriales en termes de bien-etre au travail et de performance au travail. MOTS-CLES: culpabilite, culpabilisation, emotions au travail, effort, bien-etre au travail. La culpabilidad es una emocion comunmente experimentada en la vida cotidiana. El objetivo de esta investigacion es de estudiar el tema en el campo del trabajo. Se llevo a cabo una investigacion exploratoria con el fin, de un lado, de identificar las situaciones que generan la culpabilidad en el trabajo, asi como los efectos de esta emocion y, de otro lado, de determinar si la culpabilizacion es una estrategia de gestion que permite obtener mas de trabajo por parte de los empleados. Los entrevistados eran empleados asalariados con perfiles variados segun la edad, el sexo, el puesto ocupado, el sector de actividad, el tamano de la empresa y el estatus social. Se realizaron asi veintiocho entrevistas semi-directivas. Los resultados identifican las caracteristicas de la culpabilidad experimentada en el trabajo y nos revelan que esta ultima es familiar, de intensidad y frecuencia variables, y evolutiva. Los analisis de las entrevistas revelan tambien ocho situaciones generadoras de culpabilidad que estan vinculadas a los fenomenos siguientes: una ausencia o un retraso, la percepcion de un trabajo globalmente mal hecho, demandas o promesas no cumplidas, comportamientos o actitudes no correctas, ciertas caracteristicas personales (por ejemplo, falta de competencia), un cliente o un colega que sufre y no puede ser ayudado, falta de tiempo, y tambien el impacto del trabajo sobre la vida privada. Esta investigacion muestra que la culpabilidad resentida genera un bochorno en la persona. Pero ella tiene, sobre todo, efectos positivos en el trabajo realizado por los asalariados. La culpabilidad tiene generalmente un efecto benefico en los esfuerzos en el trabajo, excepto cuando esta emocion es muy intensa. La culpabilizacion es otro eje importante de este estudio. Esta es constatada por los trabajadores entrevistados y es juzgada como ineficaz cuando ella emana de los superiores. Y es, por lo tanto, rechazada y mal soportada. Este articulo abre nuevas perspectivas de investigacion con el objetivo de, por un lado, profundizar el lugar y el rol de esta emocion y, de otro lado, desarrollar ciertas implicaciones de gestion en terminos de bienestar en el trabajo y de rendimiento en el trabajo. PALABRAS CLAVES: culpabilidad, culpabilizacion, emociones en el trabajo, esfuerzo, bienestar en el trabajo., Introduction Les emotions font partie du quotidien et sont egalement ressenties dans le cadre du travail (Cahour et Lancry, 2011; Ribert-Van de Weerdt, 2003; Tran, 2014). Elles peuvent avoir des [...]
Published: 2018

6. Adaptation de l’élevage bovin de l’Ouest du Burkina Faso aux sécheresses récurrentes

Author: André Kiema, Albert Soudré, Téton Habibatou Berthe, Somnoma Nougtara, Guissou, and Laure Sougoti
Subjects: Geography, Livestock farming, business.industry, Pastoralism, Livestock, Forestry, Milk production, business
Abstract: L’élevage est confronté aux difficiles conditions climatiques. Pour s’adapter à cette situation, plusieurs stratégies sont développées. Mais sont-elles efficaces. Pour contribuer à appréhender le phénomène, la présente étude a été conduite. Elle avait pour objectif d’examiner la perception et l’impact des sécheresses récurrentes sur les pratiques pastorales de même que les stratégies d’adaptations développées. Ainsi, elle s’est appuyée sur une enquête individuelle à passage unique auprès de 200 ménages de pasteurs et d’agropasteurs de la province du Noumbiel. Les résultats montrent que l’alimentation du bétail est basée sur le pâturage naturel (100%) qui est soumis aux effets des sécheresses récurrentes. Ces sécheresses apparaissent comme la manifestation majeure du changement climatique. En effet, elle influe le plus négativement sur l’alimentation du bétail (79,5) et sur la production laitière (59%). Pour faire face à cette situation, plusieurs mesures d’adaptation dont la diversification du troupeau (81%), la transhumance nationale (85%), l’achat d’aliments bétail (87%) sont prises par les éleveurs. L’analyse permet de dégager quatre catégories d’acteurs selon leurs capacités d’adaptation. De ces quatre, seule la catégorie C1 représentant 16,5% de l’échantillon, s’adapte le mieux aux effets néfastes des sécheresses. En somme, notre étude démontre que les éleveurs du Noumbiel ont adopté des stratégies d’adaptation pour faire face à l’impact des sécheresses récurrentes sur leurs activités d’élevage. Ils ont cependant des capacités de résilience globalement faibles. English title: Adaptation of cattle breeding in Western Burkina Faso to recurrent droughts Livestock farming is confronted with difficult climatic conditions. To adapt to this situation, several strategies have been developed. But are they effective? To help understand the phenomenon, this study was conducted. The objective of this study was to examine the perception and impact of recurrent droughts on pastoral practices as well as coping strategies developed. Thus, it was based on a one-pass individual survey of 200 pastoralist and agropastoralist households in Noumbiel province. The results show that livestock feed is based on natural grazing (100%) which is subject to the effects of recurrent droughts. These droughts are emerging as the major manifestation of climate change. Indeed, it has the most negative impact on livestock feed (79.5) and milk production (59%). To cope with this situation, several adaptation measures including herd diversification (81%), national transhumance (85%), and the purchase of animal feed (87%) are taken by livestock farmers. The analysis identifies four categories of actors according to their adaptive capacities. Of these four, only category C1, made up of 33 transhumant pastoralists and representing 16.5% of the sample, is best suited to the adverse effects of droughts. In sum, our study shows that pastoralists in Noumbiel have adopted coping strategies to cope with the impact of recurrent droughts on their livestock activities. However, they have globally weak resilience capacities.
Published: 2021

7. Evaluation of mass drug administration for schistosomiasis and soil-transmitted helminths in school-aged children in Bankass, Mali

Author: Adama Berthe, Abdoul Fatao Diabate, Kueshivi Midodji Atsou, Abdallah A. Diallo, Salif Seriba Doumbia, Fatoumata dite Nènè Konipo, Seydou Doumbia, Moussa Brema Sangare, Yaya Ibrahim Coulibaly, Yacouba Sanogo, Modibo Keita, Siaka Y. Coulibaly, Housseini Dolo, Michel Emmanuel Coulibaly, Lamine Diarra, and Lamine Soumaoro
Subjects: Microbiology (medical), Population, Psychological intervention, Helminthiasis, Schistosomiasis, Infectious and parasitic diseases, RC109-216, Mali, Health informatics, Albendazole, Soil, Environmental health, Helminths, medicine, Prevalence, Animals, Humans, Mass drug administration, education, Child, Evaluation, Anthelmintics, education.field_of_study, Schools, business.industry, Soil-transmitted helminths, Reproducibility of Results, General Medicine, medicine.disease, Praziquantel, Infectious Diseases, Cross-Sectional Studies, Community health, Bankass and Mali, School-aged children, business, medicine.drug
Abstract: Background In 2004, Mali implemented mass drug administration (MDA) aimed at controlling schistosomiasis and soil-transmitted helminths. Despite several rounds of MDA, the health district of Bankass reported low coverage (64.8%) for praziquantel and albendazole in 2017, meaning that this district was still facing challenges in accomplishing the targeted 75% coverage. This study aimed to explore the barriers and gaps that hindered MDA implementation in Bankass. Methods A cross-sectional study was performed. Questionnaires were administrated to all school-aged children in randomly selected villages. Technical directors of community health centers and community drug distributors in the selected villages were included in the interviews. Results A total of 2128 children and 52 health workers were interviewed. Coverage rates were 93.51% (1990/2128) for praziquantel and 95.25% (2027/2128) for albendazole. Among the untreated children, 31.63% (31/98) reported being unaware of the campaign and 26.53% (26/98) were unable to reach the distribution points. Most of the health workers suggested increasing incentives. Conclusion The data showed satisfactory coverage >90%, in contrast with lower rates initially reported by the district health information system. These results raise concerns about the reliability of programmatic data and highlight the importance of population-based surveys for the evaluation of control interventions.
Published: 2021

8. Human spaceflight from Guiana Space Center

Author: G. Debas, V. Taponier, J. Bertrand, M. Caporicci, Ch Bonhomme, D. Schmitt, N. Costedoat, Ch. Bonnal, B. Muller, J.-F. Clervoy, E. Louaas, Ph Berthe, I. Quinquis, R. Delage, G. Collange, S. Perezzan, E. Coletti, J. Droz, S. Sandrone, J.-M. Bahu, and P. Marx
Subjects: Engineering, business.industry, Software deployment, Aside, Human spaceflight, Aerospace Engineering, Position (finance), Satellite, Architecture, Space (commercial competition), Adaptation (computer science), business, Telecommunications
Abstract: The use of Space has drastically evolved these last ten years. Tomorrow will see easier and cheaper access to Space, satellite servicing, in-orbit manufacturing, human private spaceflights to ever increasing number of Orbital Stations, road to the Moon, Asteroids, Mars … It seems fundamental to make sure we can rely on robust, reliable, frequent and affordable access to and from LEO with both automatic systems and human missions; such systems are the bricks with which all the future operations in Space will be built. Independent human access to space from Europe for our astronauts is a key to any future in Space. It has been studied in depth since the 80's with Hermes Spaceplane, then through numerous studies, pre-development activities, and demonstrations such as ARD, X38-CRV or IXV, which now allow Europe to reconsider such an endeavor with a much higher confidence. We have worked during one year on every aspect of a European Human spaceflight system aimed at being launched from Guiana Space Center. It would be a logical addition to new orbital infrastructures in LEO which, following the ISS retirement, are already under deployment by governments and commercial entities in the US, Russia, China, India. We found out that Europe could play a very specific role, deploying a “universal” vehicle capable to visit any future LEO architecture; following its historical tradition, Europe would be in a position to cooperate potentially with everyone in LEO! We traded the various types of potential vehicles dealing with the recovery techniques for both nominal and abort cases. The launch with Ariane 6 has been looked at in detail and a particular effort has been devoted to the adaptation of the Guiana Space Center. A cautious examination of the required technologies shows that European industry is fully ready, and that most of these technologies are available. In particular, we have shown the readiness of Human-Rating systems, based on the ATV, Orion ESM and ISS pressurized modules. Even if the capability requires a significant budget, the question is to know if Europe can be left aside in the future? Such a program would release a very strong positive sign for the young generations cradled with the feats of our astronauts; it would give motivating STEM objectives to the next generation of students. As a major space power it is clearly strategic for Europe to develop independent human access to LEO in the current multipolar world.
Published: 2021

9. Understanding the performance of a pan-African intervention to reduce postoperative mortality: a mixed-methods process evaluation of the ASOS-2 trial

Author: Nicola Vickery, Timothy Stephens, Leon du Toit, Dawid van Straaten, Rupert Pearse, Alexandra Torborg, Lucy Rolt, Mariechen Puchert, Graham Martin, Bruce Biccard, Bruce M. Biccard, Maia Lesosky, Tim Stephens, Landon Myer, Agya BA. Prempeh, Hyla-Louise Kluyts, Akinyinka Omigbodun, Adesoji Ademuyiwa, Muhammed Elhadi, Mohamed Elfagieh, Bernard Mbwele, Mpoki Ulisubisya, Lazaro Mboma, Daniel Z. Ashebir, Mahlet Tesfaye Bahta, Mohammed Hassen, Mikiyas Teferi, Yakob Seman, Eugene Zoumenou, Adam Hewitt-Smith, Janat Tumukunde, Dolly Munlemvo, Atilio Morais, Apollo Basenero, Pisirai Ndarukwa, Nazinigouba Ouerdraogo, Maman Sani Chaibou, Mohyeddine Zarouf, Ahmed Rhassane El Adib, Veekash Gobin, Zimogo Sanogo, Youssouf Coulibaly, Zipporah Ngumi, Tarig Fadalla, Cynthia Iradukunda, Vénérand Barendegere, Isaac O. Smalle, Mustapha Bittaye, Ahmadou Lamin Samateh, Mahmoud Elfiky, Maher Fawzy, Wakisa Mulwafu, Vanessa Msosa, Lygia Lopes, Akwasi Antwi-Kusi, Hamza D. Sama, Patrice Forget, Rupert M. Pearse, Marichen Puchert, Kris Schwebler, Freddy Kabambi, Tebogo Mabotja, Leandys Cobas, Albino Freitas, Maria Antunes, Bartolomeu Cabo, Domingos Paulo, Carlos Camongua, Yvette Avognon, Osseni Marcos, Raymond Kintomonho, Onesime Demahou, Gisèle Hounsa, Hugues Chobli, Elie Fassinou, Aurore Zoglobossou, Blaise Tchaou, Charles Tchegnonsi, Fifame Amadji, Francine Bossa, Ernest Ahounou, Djima Alao, Roushdane Odérémi, Afissatou Montairou, Oswald Gbehade, Romaric Tobome, Adam Boukari, Patrick Bakantieba, Arouna Sambo, Fanou Lionelle, Nounagnon Gilbert, Julien Attinon, Roger Klikpezo, Aumar Dadjo, Dénis Fanou, Gilberte Hounkpe, Bachabi Fafana, Néné Nguilu, Bodourin Dossou-Yovo, Chantal Segla, Mohamed Toko, Evelyne Gnele-Dedewanou, Michel Noukounwoui, Ethienne Yado, Timothé Gouroubéra, Valéry Adjignon, Serge Mewanou, Aïcha Tchomgang, Urielle Agossou, Fernand Soton, Charbel Azanlin, Lidwine Zomahoun, Rawéléguinbasba Armel Flavien Kabore, Salam Savadogo, Fatou Fleur Rosine Sanou, Farid Belém, Victoria Hien, Cheik Tidiane Hafid W. Bougouma, Sie Ahmed Ouattara, Mariam Bambara Kabore, Ouedraogo Nazinigouba, Papougnezambo Bonkoungou, Martin Lankoandé, Mireille Traoré, Patrick Sawadogo, Inès Wenmenga, Boureima Kinda, André Simporé, Christian Sapo, Salah Idriss Traore, Haoua Dipama, Lydie WR. Kaboré, Salifou Napon, Télesphore G. Kaboré, Arouna Louré, Pélagie PP. Tondé, Christian Zoundi, Martin Lankoande, Harouna Sanou, Remy Ndikumana, Carlos Nsengiyumva, Gregory Sund, Alliance Niyukuri, Axel Kwizera, Jean-Claude Niyondiko, Adolphe Manzanza Kilembe, Jean Pierre Mwema Ilunga, Nehema Hailemariam Sarah, Gabriel Mubobo Makeya, Idesbald Mwebe Mwepu, Ted Botawaosenge Likongo, Richard Kapela Mvwala, Raphael Nzau Kapend Mubunda, Noellie Kanka Mukuna, Julie Djondo Pembe, Nicolas Lumuanga Ndaye, Eric Bibonge Amisi, Mike Ilunga Madika, Joe Kembo Lungela, Didier Ndonda Mayemba, Philomene Mamba Diyoyo, Alex Mbo Ngalala, Martin Mamba Mukenga, Patricia Tito Kabuni, Dany Bolimo Mpoto, Herve Inesnku Mole, Louise Keby, Oria Andavo Buti, Anselme Phaka, Belinda Mayenge, Jean Jeacques Kabuley Kalongo, Timothe Kemfuni Mawisa, Rodrigue Tondo Ngwizani, Kuyala Leya, Dieudonne Kisile Sanduku, Timothe Nkemfuni Mawisa, Coco Nseke Mfumu, Mbuta Bolenge, Desire Kinzenzengu Kabuce, Patrick Kintieti, Amelia Mbuluku, Vicky Mahuwa, Tharcice Khonde Mabiala, Guilain Ngoy, Patrick Boloko, Nono Mazangama Mvwama, Jose Kengbanda, Pitchou Mushimbonga, Blaise Kuhapala, Nzosani Marcel, Kienze Guylain, Gerard Mboma, Sandra Zalambo Sagboze, Michel Muteya Manika, Jean Pierre Mumbere Kigayi, Roger Mukanire Cishugi, Placide Buhendwa Mugisho, Roger Baguma, Moïse Kongolo, Michel Mandungu Mbayabu, Crispin Mukendi Muamba, Edmond Banema Kapinga, Vasco Ngolela Kapinga, Guylain Tshimanga Nsumpi, Patrick Kanda Odia, Salomon Bingidimi, Gilbert Kpengbemale, Desire Hubert Bofunga Bosonga Imposo, Patricia Matondo, Servet Lelo, Jeremie Kalambayi, Mohamed Abdel-Ghaffar, Abdelrahman Soliman, Mostafa Abdelrahman, Sameh Shehata, Alia Rabee, Mohamed Abou Heba, Mohamed Rabei Abdelfattah, Tamer Ahmed Maher Ghoniem, Sherif M.K. Shehata, Mohamed Lotfy, Ahmed ElHaddad, Bereket Gebremeskel, Girmay Fisseha, Mebrahtu Abay, Degena Bahrey, Assefa Hika, Abdurezak Ali, Kindie Moges, Jemal Ahmed, Desalegn Abdisa, Abebe Megersa, Wendwosen Abayne, Haftom Berhane, Reiye Esayas, Fitsum Kifle, Kokeb Desita, Abebe Addise, Dagim Shimelash, Shitalem Tadesse, Bezaye Zemedkun, Peniel Kenna, Ayenew Yirdie, Abinet Sisay, Tebikew Gashu, Fassil Mihretu, Yesuf Ahmed, Bekele Debebe, Abdureuf Misgea, Amare Agmas, Rahel Assefa, Abdurahman Gelmo, Seifu Alemu, Brook Damtachew, Merid Mersha, Yaekob Chemere, Samuel Fekadu, Sintayehu Regasa, Bonsa Sileshi, Desalegn Wosen, Rebira Adamu, Gersam Mulugeta, Teshome Bacha, Zewude Gudisa, Kebebe Bekele, Alelign Tasew, Habtamu Gezahegn, Daniel Atlaw, Damtew Solomon, Habtemariam Gebresillasie, Girmaye Tesfaye, Negussie Sarbecha, Biniyam Sahiledengle, Kenbon Seyoum, Gemechu Ganfure, Yohannes Tekalegn, Gosa Tesfaye, Temesgen Ayichew, Shibiru Sendaba, Musefa Redwan, Eyasu Muse, Girma Nina, Bizuneh Sime, Addisalem Tadege, Anbesse Jima, Nugusu Ayalew, Dagmawi Workneh, Daniel Teferi, Momodou T. Nyassi, Landing N. Sanyang, Omar Jallow, Abdoulie Keita, Kitabu Jammeh, Charles Roberts, Patrick Idoko, Kebba Marenah, Masirending Njie, Musa Marena, Karamba Suwareh, Simon Boissey, Fatoumatta Jarjusey, Awa Jah, Awa Sanyang, Dado Jabbi, Kajali Camara, Armando Correa, John Jabang, Lamin Jaiteh, Lamin Dampha, Aminata Manneh, Baboucarr Sowe, Abdoulie Bah, Edrisa Jawo, Victoria Okoje, Momodou Baro, Yaya Bah, Mustapha Njie, Sainabou Mbowe, Ebrima Kanteh, Sarjo Ceesay, Alagie Manneh, Evans Atito-Narh, Adwoa Wilson, Romeo Hussey, Emmanuel Okine, Jemima Kwarteng, Ridge Ntiamoah, Samuel Dadzie, Mark Aseti, Naa Sowah, Akosua Appiah, Charles Bankah, Patrick Mburugu, Thomas Chokwe, Patrick Olang, Vernon Gacii, Susane Nabulindo, Antony Gatheru, Timothy Mwiti, Caroline Mwangi, Julius Muriithi, Daniel Ojuka, Omondi Ogutu, Evans Masitara, Mohamed Chaudhry, Reuben Kamundi, Annmarie Kangangi, Thomas Massaquoi, Stephen Takow, Felister Moraa, Aziz Munubi, Moses Kimani, Adili Wobenjo, Linda Nguu, Vincent Omeddo, Rose Malaba, Ambrose Nabwana, Anita Mwancha, Alexandria Mugaa, John Wamwaki, Joyce Chege, Seymour Sinari, Andrew Ndonga, Rose Shitsinzi, Walter Akello, Winfred Kimani, Elisha Kirwa, Seno Saruni, Andrew Wainaina, Ernest Nshom, Aidah Kenseko, Kizito Shisanya, Purity Wanjiru, Julliah Cherotich, Judy Kimutai, Benson Wahome, Grace Wangui, Dennis Wamalwa, Stephen Mwangi, John Chege, Tabitha Wanjiku, Carolyne Njoki, Wachira Waititu, Conrad Ambani, Samuel Murimi, Sharon Waithira, Nilson Mouti, Collins Kibet, John Kibet, Virginia Sokobe, Beatrice Jeymah, Antony Kamadi, Faith Gichuri, Steve Moses, David Wasike, Favours Adeya, Caesar Bitta, Stephen Ogendo, Killian Kariuki, Hdaya BenAbdalla, Taha Suliaman, Fatima Ali Abokhzam, Mohaned Isa, Mohammed Huwaysh, Asma Bourawi, Kais Alzubaidy, Mohammed Albaraesi, Sumayyah Bahroun, Abdulmueti Alhadi, Ahmed Msherghi, Amira Mohamed, Ala Khaled, Nouran Aljadi, Elham Bareig, Khaled Elgazwi, Adel Elgazwi, Ibrahim El-busife, Safa Owhida, Almahdi Eltwati, Samah Elakeili, Taha Abubaker, Fatima Elkhfeefi, Soha Younis Hasan, Amal Alttaira, Imbarkah Elmraied, Rim Wishah, Omar Abugassa, Hazem Ahmed, Amera Ellafi, Shoukrie Shoukrie, Nawal Aldokali, Aws ElGammudi, Akram Alkaseek, Hoda Elhaddad, Ayyah Alqaarh, Ahlam Brish, Malek Abudsnnuga, Salsabil Albuaishi, Mohammed Albashri, Marwa Morgom, Mohammed Alawami, Eman Shawesh, Abdullah Almabrouk, Moaz Alwarfalli, Nagia Abeid, Anis Buzreg, Ans Malek, Ameerah Abayu, Butaina Abdulhafith, Wedad Abouruwes, Marim Albakuri, Sabria Almuammari, Esam Alsaghair, Fatheia Alreshi, Hassan Badi, Rabiee Alfetoey, Naji Zubia, Bushray Almiqlash, Abdulsalam Alshuhoumi, Rayet Al-islam Ben Jouira, Amaal Dier, Essra Gebril, Mohammed Abdelkabir, Sana Moussa, Marwa Alfitori, Mabroukah Azbeda, Hajar Alamin, Ejmeya Barka, Omlsaad Mosbah, Rema Abdasalam, Miftah Hiyoum, Maryam Abd allateef, Ibrahim Altomi, Mahdi Alsakloul, Ekhlas Karami, Munyah Alriqeeq, Mabruka Omar, Ashraf Samer, Aml Aemeesh, Ahmad Bouhuwaish, Ahmed Elusta, Sultan Ahmeed, Wesal AlFighi Hassan, Mouadah Ali Altayr, Mohamed Addalla, Abrar Geddeda, Kheria Khoja, Doaa Alhaj, Muaad Etturki, Ahmed Elhadi, Ibrahim Ellojli, Anshirah Shuwayyah, Ahmed Elfaghih, Malak Alduwayb, Mohamed Aleiyan, Wedad Aboubreeq, Soliman Alkassem, Sami Ashour, Hayat Ben Hasan, Najat Ben Hasan, Ali Yahya, Palesa Chisala, Edward Kommwa, Lusayo Simwinga, Agness Chalira, Precious Kachitsa, Onias Mtalimanja, Drissa Traoré, Moussa Sissoko, Moussa Camara, Adama Koita, Sekou Koumaré, Omar Sacko, Mahamadou Coulibaly, Lamine Soumaré, Soumaïla Keita, Sidiki Keita, Hamadoun Dicko, Boubacar Diallo, Boureima Bengaly, Mohamed Keita, Siaka Diallo, Drissa Ouattara, Nouhoun Ongoiba, Seydina Beye, Honoré Berthe, Mamadou Diakite, Mamadou Sima, Adégné Togo, Bakary Dembele, Djibo Diango, Moussa Samake, Youssouf Traoré, Louis Traoré, Ongoïba Oumar, Sogoba Gaoussou, Issaga Traoré, Sidy Sangaré, Doua Kanté, Lassana Cissé, Thiam Souleymane, Keita Koniba, Sundaresan Maiyalagan, Julien Chong, Adil Mohit, Khushyant Mungar, Shankaran Vinayagam, Kevin Ramlochun, Jamie Sim, Desai Sneha, Vishaal Kissoon, Yan Tseung, Mohamed Aboobakar, Nitish Fokeerah, Ravi Ramsewak, Jayprakash Gopall, Meetheelesh Abeeluck, Varun Seewoo, Divyanand Jankee, Ashveen Puryag, Senthil Beemadoo, Yashraj Deenoo, Abhisek Goureah, Munawwara Makoon, Hemanshu Rambojan, Beeharry Shanjugsingh, Kevin Viraswami, Shehzaad Joomye, Ashwant Bhugwandass, Bibi Deelawar, Vakil Leelodharry, Luckshmanraj Mungur, Sajid Aungraheeta, Sirsingh Bhajoo, Manpreet Rajcoomar, Rishi Seetaram, Subha Gaya, Gini Batra, Yoshvin Sunnassee, Shailendra Petkar, Sbai Hicham, Labib Smail, Ait Laalim Said, Motaai Youssef, Mouhssine Doumiri, Mustapha Alilou, Nora Farnaoui, Mustapha Bensghir, Abdelghafour Elkoundi, Abdelhamid Jaafari, Abderhmann Elwali, Mohammed Meziane, Walid Atmani, Houssam Rebahi, Hajar Chichou, Safae Zarouf, Abderraouf Soummani, Abou Elhassan Taoufik, Meryem Essafti, Aminata Oumou Traoré, Hamzaoui Hamza, Adnane Berdai, El allani Linda, Salhi Oussama, Nelson Mucopo, Machado Banze, Mouzinho Saide, Tomas Sitoi, Artur Machava, Antonio Carlos, Amilton Guidione, Antonio Saide de Carvalho, Natacha Gemo, Samiro Sema Camal, Arsénio Cuna, Ornelos Madeira, Ladino Assuade, Dercio Amde Fernandes, Dulce Alexandre Machavae Fernandes, Mandua Sebastião, Bernard Sikombe, Matti Kandjimi, Ayoub Shekimweri, Diana Shilomboleni, Mbaundju Kandjii, Leonard Kabongo, Cholastic Hangero, Ike Ndjoze, Ruben Nailonga, Immanuel Uukonga, Uutoni Nakanyala, Lavinia Johannes, Adrian Haruzuvi, Chris Terblanche, Natangwe Shimenda, Delwina Katjipu, Hilma Shalimba, Juliah Kaweendwa, Ali Mbuyi, John Oyedele, Mapumba Mulolo, Peter Njuki, Mutombo Ndaie, Akutu Munyika, Hilma Katangolo, David Tjiyokola, Tawanda Mhene, Archbald Masiambiri, Paidamoyo Mandudzo, Sandra Kapepiso, Haziel Mavesere, Cedia Tjihoto, Daylight Manyere, Charlotte Kauraisa, Learnmore Garanowako, Michael Tune, William DeKlerk, Benvenue Ndolo, Maria Angula, Ndapewoshali Hishekwa, Elizabeth Nandjendja, Elsabe Tsauses, Eunice Mouton, Kudzai Katandawa, Sophia Bruwer, Jaydee Van Staden, Beata Siteketa, Beata Kaholongo, Martha Ntinda, Pueya Nashidengo, Johanna Kandjumbwa, Lahia Lipumbu, Moussa Sirfi, Fouma Djibo, Moutari Mahaman, Abdoulaye Mahaman Bachir, Maikassoua Mamane, Adakal Ousseini, Maman Noury Hamissou Souley, Rabo Oumarou, Rekia Idrissa, Moussa Ichaou, Amina Saley, Abdoulay Seyni, Sahabi Amadou, Mahamane Sani Mahamane Laminou, Issoufou Moustapha Camara, Moussa Gagara, Hadjara Rabiou Daddy, Harissou Adamou, Ibrahim Amadou Magagi, Oumarou Habou, Sabo Ramatou, Saidu Kadas, Rabiu Mohammed, Abubakar Ballah, Tella Olalekan, Kefas Bwala, Mohammed Adamu, Adamu Isa, Ademola Adeyeye, Samuel Fayose, Akinola Akinmade, Taiwo Ajayi, Elizabeth Nwasor, Saidu Yakubu, Euphemia Ugwu, George Mukoro, Muhammed Ahmed, Gideon Akafa, Ahmad Lawal, Daniel Nwoye, Michael Odigbo, Zulaihatu Sarkin-Pawa, Tunde Sholadoye, Benjamin Fomete, Hamisu Yakubu, Abdulkadir Kabiru, Samaila Timothy, Ali Yusuf, Tasiu Saadu, Babangida Mohammed, Abdulghaffar Yunus, Ganiyat Olagunju, Muhammad Aminu, Mohammad Idris, Musliu Tolani, Nasiru Dalhat, Samuel Gana, Talent Adike, Lofty-John Anyanwu, Abdurrahman Sheshe, Sani Aji, Mamuda Atiku, Raphael Attah, Abubakar Muhammed, Rasaki Oseni, Halima Salisu-Kabara, Benjamin Nkemjika, Omotayo Salami, Adekunle Akadri, Bukola Olayinka, Clement Onuoha, Umar Usman Jamaare, Auwalu Saminu Jibrin, Sani Giade Abdullahi, Ibrahim Ishaku, Adenike Odewabi, John Bamigboye, Oladapo Kuforiji, Chidiebere Ogo, Stella Ogunmuyiwa, Abdussemee Abdurrazzaaq, Adebayo Tanimola, Michael Adeyanju, Oluwatimilehin Andero, Temitope Ojo, Olusi Adedotun, Gbadamosi Kehinde, Jimoh Buraimoh, Kabiru Muhammad, Sophia Baidoo, Patrick Okoli, Azeez Adigun, Ekene Ezeonye, Kabir Isa, Yetunde Aremu-Kasumu, Kamil Shoretire, Peter Enesi, Amechi Ezike, Olatunde Olawoye, Emmanuel Ugwu, Christopher Ukah, Abolade Olugbenga, Nwachukwu Chidiebere, Nasiru Abdulraman, Adebiyi Olusegun, Alisa Halisa, Semiat Yusuf, Jamila Salisu, Chidiebube Okoro, Abdul Suleiman, Fabian Onowighose, Aliyu Farinyaro, Suleiman Baba, Umar Abdulmajid, Aisha Abdurrahman, Ogochukwu Obi, Olatunde Alabi, William Adeyemi, Jelili Salau, Jones Taiwo, Nnaemeka Nwafulume, Taiye Ibiyeye, Edith Agu, Ayodeji Danboy, James Abdulazeez, Christopher Ekwunife, Chimaobi Nnaji, Chigozirim Onyekpere, Amara Arunsi, Jude Egwim, Obianuju Nwana, Nnabuike Ojiegbe, Charles Mbamba, Paul Ngwu, Frank Imahigbe, Emmanuel Okoroji, Iloh Ikenna, Abdulrahman Mohammed, Adebayo Adeniyi, Toluwalope Ariyo, Olajide Gabriel, Tesleem Orewole, Salawu Idris, Idowu Adebara, Abiodun Okunlola, Akinwale Akinbade, Oluwasesan Afolabi, Adewumi Bakare, Olabisi Adeyemo, Benjamin Ugwu, Samuel Nuhu, Henry Embu, Erdoo Isamade, Chinedu Obikili, Amaka Ocheke, Solomon Peter, Donald Orshio, Peter Onuminya, Jack Okopi, Olufemi Bankole, Bosede Afolabi, Dapo Osinowo, Ayodeji Oluwole, Muyiwa Rotimi, Ibironke Desalu, Rufus Ojewola, Bolaji Mofikoya, Kola Owonikoko, Adeolu Adeoye, Temidayo Bobo, Taiwo Akinloye, David Ama, Ebere Okoronkwo, Muhammad Mahmud, Jamiu Adebiyi, Temitope Babalola, Mansur Muhammad, Afeez Aruna, Maryrose Osazuwa, Ayodeji Yusuf, Isiaka Lawal, Bitrus Fidelis, Rephath Pius, Cyril Jomosu, Adebayo Adedayo, Abubakar Aliyu, Adaora Agholor, Abdullateef Abdulazeez, Chabiya Bala, Eziamaka Eze, Elizabeth Ani, Uchenna Okeke, Dominica Adebayo, Okechukwu Ekwunife, Victor Modekwe, Chuka Ugwunne, Chukwuemeka Okoro, Chisom Uche, Simeon Olateju, Fred Ige-Orhionkpaibima, Adedapo Adetoye, Olurotimi Aaron, Jeremiah Abimbola, Folayemi Faponle, Olumuyiwa Ajayeoba, Olusoji Jagun, Oluwabunmi Fatungase, Adeniyi Akiseku, Chigbundu Nwokoro, Ramotalai Shoyemi, Ibukunolu Ogundele, Nankat Joseph, Salihu Bura, Chukwuka Nwezoku, Manu Bwala, Meshach Philips, Abubakar Usman, Emmanuel Filibus, Zara Umate, Nwabuoke Chukwuka, Ahmed Nuhu, Watakiri Ibrahim, James Nggada, Ali Izge, Musa Ismail, Olayinka Eyelade, Tinuola Adigun, Babatunde Osinaike, Olayinka Ogunbode, Olusola Idowu, Taiwo Lawal, Temidayo Ogundiran, Olayiwola Shittu, Omobolaji Ayandipo, Stephen Edino, Zumnan Songden, Olumide Akitoye, Bissallah Ekele, Godwin Akaba, Terkaa Atim, Akitoye Adeleke, Owoicho Okochi, Sunday Akeju, Ernest Ukpoju, Osayomwanbo Osaheni, Ifunanya Obaseki, Lateef Kehinde, Osawemwenze Monday, Stanley Nte, Adesuwa Agboifo, Omajuwa Dawodu, Precious Orhiere, David Atiti, Queeneth Kalu, Felix Effiom, Israel Kolawole, Olawale Ojo, Afusat Olabinjo, Olufemi Ige, Beatrice Ogunyemi, Olusola Oladosu, Kikelomo Adesina, Sulaiman Agodirin, Asimiyu Shittu, Audu Idrisa, Sadiq Adamu, Nuhu Ali, Olayinka Adewunmi, Stephen Nwankwor, Akinwumi Olakanmi, Oluseye Ajayi, Ayotolu Ajayi, Victor Ogunmola, Oluwafunke Olakanmi, Adam Kuranga, Enoch Uche, Chukwuemeka Osuagwu, Chukwudi Ilo, Mesi Matthew, Uko Uko, Ngozi Mba, Olubusola Alagbe-Briggs, Amabra Dodiyi-Manuel, Bisola Onajin-Obembe, Bright Obasuyi, Richard Echem, Ihuoma Mike-Elechi, Job Otokwala, Mark Edubio, Catherine Eyo, Isaac Udo, Aliyu Abdulrahman, A.A. Abdullahi, Ibrahim Galadima Bello, Usman Adinoyin Mohammed, Abidemi Oyaromade, Mohammed Bello, Usman Muhammad, Emeri Mbah, Hyacinth Okereke, Almustapha Aminu, Anthony Ahmadu, Abu Rogers, Peter Samai, Sao Amara, Margaret Yankuba, Mary Josayah, Jayah Swarray Jnr, Alusine Dawo, Peter George, Mustapha Kabba, Mohamed Bah, Charles Mondeh, Ibrahim Kapuwa, Mohamed Sheku, Philip Mattia, Brima Sesay, Jones O.A. Omoshoro-Jones, Motselisi Mbeki, Estie Cloete, Philip Anderson, Busi Mrara, Annemarie Steyn, Tsakani Mhlari, Nic Proctor, Caroline Robertson, Gillian Lamacroft, Usha Singh, Sebenzile Sikhakhane, Kelly Gate, Shepherd Nzenza, John Tshimbalanga Kasonga, Sibongile Ndebele, Patrick Lufuta Kande, Jody Davids, Tino-vito Orlandi, Marischka de Jong, Hugo Stark, Francois Roodt, Jonathan Hall, Ian Nortje, Akanimo Akpakan, Vishendran Govindasamy, Ronisha Sathiram, Mohammad Kathrada, Zane Farina, Lucio Frittella, Charles Kohler, Sibuyiselwe Lubelwana, Sarwat Ikram-Hameed, Adriaan Smit, Muneerah Cassiem, Yvonne Freeman, Saaliha Goga, Larissa Cronje, Constantin Buzdugan, Subash Chirkut, Priyadeshni Singh, Sandhya Jithoo, Vivesh Rughubar, John Arnold, Rishan Bipath, Suman Mewa Kinoo, Ncumisa Khanyisa Msolo, Fleur Ackermans-Deijnen, Tshegofatso Mmasello Emma Boka, Martyn Biccard Greenwood, Shakthi Anand Jayrajh, Devarani Naidoo, Syndrini Reddy, Devandiran Harriraman Rungan, Kylene Subrayen, John Roos, Nina Tredoux, Pascal Plumacher, Anthony Reed, Harald Steinhaus, Mariesa Nock, Paul Ryan Herselman, Gareth Davies, Talitha Harvey, Franklin Muller, Willem Naude, Tania Pretorius, Johan Jochemus Swart, Merryn Walls, Prashant Gokal, Nicolette Rorke, Farzaana Dhoodhat, Precious Dzanibe, Mohammed Yusuf Hussain, Ashmita Junpath, Ameela Maharaj, Hylda Makanisi, Khalid Moosa, Ting Ting Wong, Sean Mould, Trisha Ramsamy, Roel Matos-Puig, Hayley Morgan, Nadeem Nabeebuccas, Ria Devi Naidoo, Viantha Pather, Vasheel Vasheel Bahadur, Renilda Pillay, Zahnne Fullerton, Nicole Bell, Bongisa Grey, Vincent Lorenzo Visentin, Hendrik Adriaan Van Zyl, Terri Anne Killingbeck, Emile Maneveldt, Gerhard Thiart, Magdelena May Venter, Oostewalt Swart, Mariette Grobelaar, Carel Cairns, David Bishop, Christien Steenkamp, Thandekile Khumalo, Noel Naidoo, Ross Murray, Martin Kopieniak, Melusi Sishange, Mxolisi Brian Ndimande, Megan Jaworska, Sarwat Ikram, Bence Rainier, Renier J. Liebenberg, Helena D. Zwiegers, Philip M. Nortje, Kamal Bhagwan, Margot Flint, Robert Dyer, Simone Adams, Yoshua Bwambale, Danny Ngomo, Patrice Kanku, Nivashen Pillay, Alexa de Castro, Atisha Maharaj, Janine Carim, Jenna Leigh Taylor, Karl M. Köhne, Leanne W. Drummond, Leanne Temlett, Lieze Geldenhuys, Yvonne Seilbea, Kathryn Naidoo, Nicola A. Kalafatis, Stefné Verwey, Thulile Biyase, Theroshnie Kisten, Belinda S. Kusel, Timothy Craig Hardcastle, Richard Magagula, Christian Kampik, Kuzolunga Xulu, Sivuyisiwe Solala, Mia Sayed, Basil Enicker, Anil Madaree, Innocent Mukama, Gladmore Madombwe, Nonhlanhla Zulu, Nompumelelo Gasa, Nokuzula Kanjana, Sebenzile Buthelezi, Thembelihle Buthelezi, Andries Brink, Francois Potgieter, Busisiwe Mrara, Zaynab Alexander, Charles Choto, Paula Ima, Zintle Gxagxisa, Baphethuxolo Ningiza, Gillian Lamacraft, Jerome Mogorosi, Nadia du Plessis, Leonie de Man, Suné Thompson, Gerrit van Heerden, Edwin W. Turton, Pieter M. van der Linde, Josephine K. Teme-Pitse, Reitumetse Tladi, Gillian D. Saffy, Ene-Mari Roscher, Kristel Fortune, George Barnard, Tiisetso Makhasane, Evan Bowen, Akangcha Pal, Rachel Moore, Maria Fourtounas, Mary Augusta Adam, Renessa Arumugan, Gabriella Hyman, Jaclyn Jonosky, Maninginingi Makondo, Heveshan Moodley, Phillip Munda, Mzwandile Nyalungu, Victor Olusola, Sohan Zane Pinto, Tristan Pillay, Lucinda Singh, Paul Mwindekuma Wondoh, John Devar, Boitumelo Baloyi-Mnisi, Zach Koto, Matlou Ernest Mabitsela, Sibongile Ruth Ndlovu, Branny Mthelebofu, Colin Beck, Matthew Dold, Alice Fan, Shannon MacQueen, Thembani Matabata, Catherine Mpehle, Charné Kulenkampf, Tsakani McCreath Mhlari, Simangele Cecilia Nyoka-Mokgalong, Felix Thumba Masinge, Randhir Ramnath Gunpath, Maropeng Petrus Pat Mothwa, Jo-Anne Asenath Mothwa, Danai Mhlanga, Jamie-Lyn Colly, Aunel Mallier Peter, Khalid Ben Hameda, Pulane Mokae, Stella Josephine Moumakoe, Kelechi Ekeh, Nezingu Lengo, Marnus Booyens, Inge Louise Seale, Pieter Daniel Theron, Nicolaas Abraham Schuman, Amber Carlyn Sonn, Jacobus Lukas Stander, Nadia Cloete, Marius Cloete, Catherine Ann Makepeace, Ronel van der Westhuizen, Leanne Robyn Messiahs, Amy Ruth Visagie, Fatima Vawda, Frans Christiaan Voster, Deepika Dhilraj, Oliver Smith, Stefan Bolon, Daniel Montwedi, Motsilisi Mbeki, Jayde Wyngaard, Mthunzi Ngcelwane, Thomas Kleyenstuber, Phyllis Phukubye, Liesel Schärf, Grace Laker, Elizabeth Semenya, Reinhard Dembskey, Thomas Tarlton, Tapiwa Jiri, Ngoie Hubert Mushid, Nhlanhla Samuel Ngwenya, Hazel Morongoa Mogodi, Carmen Sinevici, Anthony Osarogie Usenbo, Naledi Fodo, Anesu Chimini, Ntetelelo Sikobi, Sinovuyo Nokwange, Mluleki Noqhamza, Qumba Thembisa, Kajake Anantha Padmanabha Bhat, Rabin Mathew, Katrin Middleton, Abdus-sami Adewunmi, Craig Dickson, Humairah Bulbulia, Bianka Bester, Michelle de Klerk, Christia Benade, Francois Viljoen, Monique Fischer, Khalid Alfaki, Abdalmalik Awad, Abdelsalam Algray, Mohammed Elsiddig, Suha Mohamed, Salih Mahmoud, Muhammed Osman, Asia Elgailany, Mazin Suliman, Hanaa Mohammed, Lina Aljeally, Mohammed Dirar, Mohammed Osman, Mazin Mohamed, Mohamed Elhasan, Abrar Widatalla, Abubakr Abubakr, Eman Mohamed, Alshareef Nour, Ntonto Doris Gama, Dolorosa Khetsiwe Shabangu, Cynthia Iradikunda, Samuel Mkoko, Paul Kisanga, Emmanuel Lema, Benson Lyimo, Mohamed Binde, Alphonce Chandika, Salim Salim, Sylvia Jumbe, Abel Makubi, Vihar Kotecha, Felician Kachinde, Museleta Nyakiroto, Emmanuel Jitambi, Venant Geofrey, Johaphes Josiah, Phinius Makubi, Frank Manumbu, Suzan Mlingwa, Ernest Ibenzi, Peter Mbelle, Kato Peleus, Enid Chiwanga, Nillah Richard, Shoo Leonard, Paulo Sanka, Subira Mushi, Bashir Nyangasa, Mohamed Janabi, Naizihijwa Majani, Pedro Palangyo, Evarist Nyawawa, William Ramadhan, Faraj Lydenge, Gileard Gabriel Masenga, Sakina Rashid, Mubashir Jusabani, Ansbert Ndebea, Jenitha Cheru, Margaret Henjewele, Greyson Kilimanjaro, Sarah Sikimata, Deocles Donatus, Hazina Maduhu, Tumaini Mariro, Given Massasi, Moshi Moshi Shabani, Braison Cholela, Marco Mgeleka, Yohatinus Mbilinyi, Faraja Chiwanga, Bilton Exavery, Caspar Haule, Samson Ndile, Sirili Harya, Julieth Magandi, Deogratius Manyama, Redempta Matindi, Adam Moshi, Daudi Kitwana, Merida Makia, Philip Muhochi, Miriam Herman, Clauda Miombo, Furaha Kahindo, Langtone Kishebuka, Elijah Ussiri, Gloria Kinasa, Patrick Adel, Eric Malaba, Vensesla Sakwari, Sadot Lugereka, Mohamed Mungia, George Mocha, Herman Wella, Cecilia Protas, Patrick Karua, Ahmada Kashagama, Faraja Mwasambugu, Suzana Kajeri, Jacquiline Mchilla, Elibariki Lucumay, Robert Maise, Amon Marti, Beatrice Mahundi, Frederika Jager, Charles Majani, Ludovick Rukeha, Tareeq Mohamed, Nabila Fuad, Winifrida Halinga, Elias Chrisant, Gilbert Msoma, Titus Kihwili, Gadiel Temu, Naima Yusuf, Rashid Saleh, Rashid Inoja, Eva Shang'a, Stella Ibrahim, Hussein Msuma, Edwin Edward, Paul Kilamile, Stephen Mwakyolile, Talkana Adja, Edem Gueouguede, Hafoudhoi Oussene Seddoh, Saliou Adam, Pilakimwe Egbohou, Mawunyo Ahomagnon, Olivier Kadjossou, Abdul-Bassiti Boukari, Mary T. Nabukenya, Ruth Muhindo, Peter Waswa, Peter Kaahwa Agaba, Daphne Kabatoro, Joseph Kayongo, Margaret Naggujja, Nabasiige Rehema, Phiona Nansubuga, Daniel Kavuma, Aggrey Lubikire, Hope Bisilikirwa, Godfrey Ssebaggala, Emmanuel Muwema, Humble Joan Agaba, John Kiconco, Nicholas Wataaka, Bonet Chan, Mary Juliet Nampawu, Fred Bulamba, Emmanuel Bua, Christine Mugala, Caroline Nyakato, John Paul Ochieng, Linda Kyomuhendo Jovia, George Kateregga, Rachel Alum, Lazia Najjuma, Gorret Nampiina, Andrew Kintu, Joshua Sempiira, Luzige Simon, Peter Kayima, Jacob Eyul, Erick Odwar, Rita Nkwine, Christine Namata, Elizabeth Nabakka, Denis Kakaire, Velda Mushangwe-Mtisi, Erisha Munhamo, Celestino Dhege, Juliet Hungwa, Hemish Jasi, Crispin Ntoto, Derek Matsika, Brightson Mutseyekwa, Joseph Zimbovoora, Beaulah Gudyanga, Dennis Mazingi, Chenesa Mbanje, Busisiwe Mlambo, Michael Chiwanga, Harunavamwe N. Chifamba, Sarudzai Zhou, Esta Hove, Shamiso Dende, Beauty Manjengwa, Penias Kapisa, null Mashava, Caritas Chiura, Locadia Katsukunya, Godfrey Muguti, Doreen Mashava, Elton Ndhlovu, Zanele Mangwangwa, and Nombulelo Dube
Subjects: medicine.medical_specialty, Interprofessional Relations, media_common.quotation_subject, Psychological intervention, Fidelity, Postoperative Complications, Surveys and Questionnaires, Intervention (counseling), Humans, Medicine, Postoperative Period, Cooperative Behavior, Nursing management, media_common, Response rate (survey), business.industry, Standard of Care, Odds ratio, Hospitals, Confidence interval, Clinical trial, Anesthesiology and Pain Medicine, Population Surveillance, Africa, Physical therapy, business
Abstract: Background The African Surgical OutcomeS-2 (ASOS-2) trial tested an enhanced postoperative surveillance intervention to reduce postoperative mortality in Africa. We undertook a concurrent evaluation to understand the process of intervention delivery. Methods Mixed-methods process evaluation, including field notes, interviews, and post-trial questionnaire responses. Qualitative analysis used the framework method with subsequent creation of comparative case studies, grouping hospitals by intervention fidelity. A post-trial questionnaire was developed using initial qualitative analyses. Categorical variables were summarised as count (%) and continuous variables as median (inter-quartile range [IQR]). Odds ratios (OR) were used to rank influences by impact on fidelity. Results The dataset included eight in-depth case studies, and 96 questionnaire responses (response rate 67%) plus intervention fidelity data for each trial site. Overall, 57% (n=55/96) of hospitals achieved intervention delivery using an inclusive definition of fidelity. Delivery of the ASOS-2 interventions and data collection presented a significant burden to the investigators, outstripping limited resources. The influences most associated with fidelity were: surgical staff enthusiasm for the trial (OR=3.0; 95% confidence interval [CI], 1.3–7.0); nursing management support of the trial (OR=2.6; 95% CI, 1.1–6.5); performance of a dummy run (OR=2.6; 95% CI, 1.1–6.1); nursing colleagues seeing the value of the intervention(s) (OR=2.1; 95% CI, 0.9–5.7); and site investigators' belief in the effectiveness of the intervention (OR=3.2; 95% CI, 1.2–9.4). Conclusions ASOS-2 has proved that coordinated interventional research across Africa is possible, but delivering the ASOS-2 interventions was a major challenge for many investigators. Future improvement science efforts must include better planning for intervention delivery, additional support to investigators, and promotion of strong inter-professional teamwork. Clinical trial registration ClinicalTrials gov NCT03853824.
Published: 2021

10. Pneumococcal Carriage in Burkina Faso After 13-Valent Pneumococcal Conjugate Vaccine Introduction: Results From 2 Cross-sectional Population-Based Surveys

Author: Bertrand Meda, Edouard Betsem, Lesley McGee, Seydou Yaro, Flavien Aké, Félix Tarbangdo, Berthe Marie Njanpop-Lafourcade, Brice Bicaba, Jennifer C. Moïsi, Cynthia G. Whitney, Srinivasan Velusamy, Alain Gervaix, Lassané Kaboré, Chris A. Van Beneden, Soumeya Ouangraoua, Bradford D Gessner, and Tolulope Adebanjo
Subjects: Male, Serotype, Pneumococcal carriage, medicine.medical_specialty, Serogroup, medicine.disease_cause, Pneumococcal Infections, Pneumococcal conjugate vaccine, Pneumococcal Vaccines, Vaccine Impact, Nasopharynx, Internal medicine, Burkina Faso, Streptococcus pneumoniae, Humans, Immunology and Allergy, Medicine, survey, Serotyping, carriage, Vaccines, Conjugate, business.industry, Infant, Newborn, Infant, medicine.disease, Confidence interval, pneumococcal conjugate vaccine, Vaccination, Cross-Sectional Studies, AcademicSubjects/MED00290, serotypes, Infectious Diseases, Carriage, Child, Preschool, Population Surveillance, Carrier State, Female, business, Meningitis, medicine.drug
Abstract: Background Burkina Faso, a country in Africa’s meningitis belt, introduced 13-valent pneumococcal conjugate vaccine (PCV13) in October 2013, with 3 primary doses given at 8, 12 and 16 weeks of age. To assess whether the new PCV13 program controlled pneumococcal carriage, we evaluated overall and serotype-specific colonization among children and adults during the first 3 years after introduction. Methods We conducted 2 population-based, cross-sectional, age-stratified surveys in 2015 and 2017 in the city of Bobo-Dioulasso. We used standardized questionnaires to collect sociodemographic, epidemiologic, and vaccination data. Consenting eligible participants provided nasopharyngeal (all ages) and oropharyngeal (≥5 years only) swab specimens. Swab specimens were plated onto blood agar either directly (2015) or after broth enrichment (2017). Pneumococci were serotyped by conventional multiplex polymerase chain reaction. We assessed vaccine effect by comparing the proportion of vaccine-type (VT) carriage among colonized individuals from a published baseline survey (2008) with each post-PCV survey. Results We recruited 992 (2015) and 1005 (2017) participants. Among children aged Conclusion Within 3 years of PCV13 implementation in Burkina Faso, we documented substantial reductions in the percentage of pneumococcal carriers with a VT among children aged
Published: 2021

11. Enhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2): a cluster-randomised controlled trial

Author: Bruce M Biccard, Leon du Toit, Maia Lesosky, Tim Stephens, Landon Myer, Agya BA Prempeh, Nicola Vickery, Hyla-Louise Kluyts, Alexandra Torborg, Akinyinka Omigbodun, Adesoji Ademuyiwa, Muhammed Elhadi, Mohamed Elfagieh, Bernard Mbwele, Mpoki Ulisubisya, Lazaro Mboma, Daniel Z Ashebir, Mahlet Tesfaye Bahta, Mohammed Hassen, Mikiyas Teferi, Yakob Seman, Eugene Zoumenou, Adam Hewitt-Smith, Janat Tumukunde, Dolly Munlemvo, Atilio Morais, Apollo Basenero, Pisirai Ndarukwa, Nazinigouba Ouerdraogo, Maman Sani Chaibou, Mohyeddine Zarouf, Ahmed Rhassane El Adib, Veekash Gobin, Zimogo Sanogo, Youssouf Coulibaly, Zipporah Ngumi, Tarig Fadalla, Cynthia Iradukunda, Vénérand Barendegere, Isaac O Smalle, Mustapha Bittaye, Ahmadou Lamin Samateh, Mahmoud Elfiky, Maher Fawzy, Wakisa Mulwafu, Vanessa Msosa, Lygia Lopes, Akwasi Antwi-Kusi, Hamza D Sama, Patrice Forget, Dawid van Straaten, Rupert M Pearse, Marichen Puchert, Lucy Rolt, Kris Schwebler, Freddy Kabambi, Tebogo Mabotja, Leandys Cobas, Albino Freitas, Maria Antunes, Bartolomeu Cabo, Domingos Paulo, Carlos Camongua, Yvette Avognon, Osseni Marcos, Raymond Kintomonho, Onesime Demahou, Gisèle Hounsa, Hugues Chobli, Elie Fassinou, Aurore Zoglobossou, Blaise Tchaou, Charles Tchegnonsi, Fifame Amadji, Francine Bossa, Ernest Ahounou, Djima Alao, Roushdane Odérémi, Afissatou Montairou, Oswald Gbehade, Romaric Tobome, Adam Boukari, Patrick Bakantieba, Arouna Sambo, Fanou Lionelle, Nounagnon Gilbert, Julien Attinon, Roger Klikpezo, Aumar Dadjo, Dénis Fanou, Gilberte Hounkpe, Bachabi Fafana, Néné Nguilu, Bodourin Dossou-Yovo, Chantal Segla, Mohamed Toko, Evelyne Gnele-Dedewanou, Michel Noukounwoui, Ethienne Yado, Timothé Gouroubéra, Valéry Adjignon, Serge Mewanou, Aïcha Tchomgang, Urielle Agossou, Fernand Soton, Charbel Azanlin, Lidwine Zomahoun, Rawéléguinbasba Armel Flavien Kabore, Salam Savadogo, Fatou Fleur Rosine Sanou, Farid Belém, Victoria Hien, Cheik Tidiane Hafid W Bougouma, Sie Ahmed Ouattara, Mariam Bambara Kabore, Ouedraogo Nazinigouba, Papougnezambo Bonkoungou, Martin Lankoandé, Mireille Traoré, Patrick Sawadogo, Inès Wenmenga, Boureima Kinda, André Simporé, Christian Sapo, Salah Idriss Traore, Haoua Dipama, Lydie WR Kaboré, Salifou Napon, Télesphore G Kaboré, Arouna Louré, Pélagie PP Tondé, Christian Zoundi, Harouna Sanou, Remy Ndikumana, Carlos Nsengiyumva, Gregory Sund, Alliance Niyukuri, Axel Kwizera, Jean-Claude Niyondiko, Adolphe Manzanza Kilembe, Jean Pierre Mwema Ilunga, Nehema Hailemariam Sarah, Gabriel Mubobo Makeya, Idesbald Mwebe Mwepu, Ted Botawaosenge Likongo, Richard Kapela Mvwala, Raphael Nzau Kapend Mubunda, Noellie Kanka Mukuna, Julie Djondo Pembe, Nicolas Lumuanga Ndaye, Eric Bibonge Amisi, Mike Ilunga Madika, Joe Kembo Lungela, Didier Ndonda Mayemba, Philomene Mamba Diyoyo, Alex Mbo Ngalala, Martin Mamba Mukenga, Patricia Tito Kabuni, Dany Bolimo Mpoto, Herve Inesnku Mole, Louise Keby, Oria Andavo Buti, Anselme Phaka, Belinda Mayenge, Jean Jeacques Kabuley Kalongo, Timothe Kemfuni Mawisa, Rodrigue Tondo Ngwizani, Kuyala Leya, Dieudonne Kisile Sanduku, Timothe Nkemfuni Mawisa, Coco Nseke Mfumu, Mbuta Bolenge, Desire Kinzenzengu Kabuce, Patrick Kintieti, Amelia Mbuluku, Vicky Mahuwa, Tharcice Khonde Mabiala, Guilain Ngoy, Patrick Boloko, Nono Mazangama Mvwama, Jose Kengbanda, Pitchou Mushimbonga, Blaise Kuhapala, Nzosani Marcel, Kienze Guylain, Gerard Mboma, Sandra Zalambo Sagboze, Michel Muteya Manika, Jean Pierre Mumbere Kigayi, Roger Mukanire Cishugi, Placide Buhendwa Mugisho, Roger Baguma, Moïse Kongolo, Michel Mandungu Mbayabu, Crispin Mukendi Muamba, Edmond Banema Kapinga, Vasco Ngolela Kapinga, Guylain Tshimanga Nsumpi, Patrick Kanda Odia, Salomon Bingidimi, Gilbert Kpengbemale, Desire Hubert Bofunga Bosonga Imposo, Patricia Matondo, Servet Lelo, Jeremie Kalambayi, Mohamed Abdel-Ghaffar, Abdelrahman Soliman, Mostafa Abdelrahman, Sameh Shehata, Alia Rabee, Mohamed Abou Heba, Mohamed Rabei Abdelfattah, Tamer Ahmed Maher Ghoniem, Sherif M.K. Shehata, Mohamed Lotfy, Ahmed ElHaddad, Bereket Gebremeskel, Girmay Fisseha, Mebrahtu Abay, Degena Bahrey, Assefa Hika, Abdurezak Ali, Kindie Moges, Jemal Ahmed, Desalegn Abdisa, Abebe Megersa, Wendwosen Abayne, Haftom Berhane, Reiye Esayas, Fitsum Kifle, Kokeb Desita, Abebe Addise, Dagim Shimelash, Shitalem Tadesse, Bezaye Zemedkun, Peniel Kenna, Ayenew Yirdie, Abinet Sisay, Tebikew Gashu, Fassil Mihretu, Yesuf Ahmed, Bekele Debebe, Abdureuf Misgea, Amare Agmas, Rahel Assefa, Abdurahman Gelmo, Seifu Alemu, Brook Damtachew, Merid Mersha, Yaekob Chemere, Samuel Fekadu, Sintayehu Regasa, Bonsa Sileshi, Desalegn Wosen, Rebira Adamu, Gersam Mulugeta, Teshome Bacha, Zewude Gudisa, Kebebe Bekele, Alelign Tasew, Habtamu Gezahegn, Daniel Atlaw, Damtew Solomon, Habtemariam Gebresillasie, Girmaye Tesfaye, Negussie Sarbecha, Biniyam Sahiledengle, Kenbon Seyoum, Gemechu Ganfure, Yohannes Tekalegn, Gosa Tesfaye, Temesgen Ayichew, Shibiru Sendaba, Musefa Redwan, Eyasu Muse, Girma Nina, Bizuneh Sime, Addisalem Tadege, Anbesse Jima, Nugusu Ayalew, Dagmawi Workneh, Daniel Teferi, Momodou T Nyassi, Landing N Sanyang, Omar Jallow, Abdoulie Keita, Kitabu Jammeh, Charles Roberts, Patrick Idoko, Kebba Marenah, Masirending Njie, Musa Marena, Karamba Suwareh, Simon Boissey, Fatoumatta Jarjusey, Awa Jah, Awa Sanyang, Dado Jabbi, Kajali Camara, Armando Correa, John Jabang, Lamin Jaiteh, Lamin Dampha, Aminata Manneh, Baboucarr Sowe, Abdoulie Bah, Edrisa Jawo, Victoria Okoje, Momodou Baro, Yaya Bah, Mustapha Njie, Sainabou Mbowe, Ebrima Kanteh, Sarjo Ceesay, Alagie Manneh, Evans Atito-Narh, Adwoa Wilson, Romeo Hussey, Emmanuel Okine, Jemima Kwarteng, Ridge Ntiamoah, Samuel Dadzie, Mark Aseti, Naa Sowah, Akosua Appiah, Charles Bankah, Patrick Mburugu, Thomas Chokwe, Patrick Olang, Vernon Gacii, Susane Nabulindo, Antony Gatheru, Timothy Mwiti, Caroline Mwangi, Julius Muriithi, Daniel Ojuka, Omondi Ogutu, Evans Masitara, Mohamed Chaudhry, Reuben Kamundi, Annmarie Kangangi, Thomas Massaquoi, Stephen Takow, Felister Moraa, Aziz Munubi, Moses Kimani, Adili Wobenjo, Linda Nguu, Vincent Omeddo, Rose Malaba, Ambrose Nabwana, Anita Mwancha, Alexandria Mugaa, John Wamwaki, Joyce Chege, Seymour Sinari, Andrew Ndonga, Rose Shitsinzi, Walter Akello, Winfred Kimani, Elisha Kirwa, Seno Saruni, Andrew Wainaina, Ernest Nshom, Aidah Kenseko, Kizito Shisanya, Purity Wanjiru, Julliah Cherotich, Judy Kimutai, Benson Wahome, Grace Wangui, Dennis Wamalwa, Stephen Mwangi, John Chege, Tabitha Wanjiku, Carolyne Njoki, Wachira Waititu, Conrad Ambani, Samuel Murimi, Sharon Waithira, Nilson Mouti, Collins Kibet, John Kibet, Virginia Sokobe, Beatrice Jeymah, Antony Kamadi, Faith Gichuri, Steve Moses, David Wasike, Favours Adeya, Caesar Bitta, Stephen Ogendo, Killian Kariuki, Hdaya BenAbdalla, Taha Suliaman, Fatima Ali Abokhzam, Mohaned Isa, Mohammed Huwaysh, Asma Bourawi, Kais Alzubaidy, Mohammed Albaraesi, Sumayyah Bahroun, Abdulmueti Alhadi, Ahmed Msherghi, Amira Mohamed, Ala Khaled, Nouran Aljadi, Elham Bareig, Khaled Elgazwi, Adel Elgazwi, Ibrahim El-busife, Safa Owhida, Almahdi Eltwati, Samah Elakeili, Taha Abubaker, Fatima Elkhfeefi, Soha Younis Hasan, Amal Alttaira, Imbarkah Elmraied, Rim Wishah, Omar Abugassa, Hazem Ahmed, Amera Ellafi, Shoukrie Shoukrie, Nawal Aldokali, Aws ElGammudi, Akram Alkaseek, Hoda Elhaddad, Ayyah Alqaarh, Ahlam Brish, Malek Abudsnnuga, Salsabil Albuaishi, Mohammed Albashri, Marwa Morgom, Mohammed Alawami, Eman Shawesh, Abdullah Almabrouk, Moaz Alwarfalli, Nagia Abeid, Anis Buzreg, Ans Malek, Ameerah Abayu, Butaina Abdulhafith, Wedad Abouruwes, Marim Albakuri, Sabria Almuammari, Esam Alsaghair, Fatheia Alreshi, Hassan Badi, Rabiee Alfetoey, Naji Zubia, Bushray Almiqlash, Abdulsalam Alshuhoumi, Rayet Al-islam Ben Jouira, Amaal Dier, Essra Gebril, Mohammed Abdelkabir, Sana Moussa, Marwa Alfitori, Mabroukah Azbeda, Hajar Alamin, Ejmeya Barka, Omlsaad Mosbah, Rema Abdasalam, Miftah Hiyoum, Maryam Abd allateef, Ibrahim Altomi, Mahdi Alsakloul, Ekhlas Karami, Munyah Alriqeeq, Mabruka Omar, Ashraf Samer, Aml Aemeesh, Ahmad Bouhuwaish, Ahmed Elusta, Sultan Ahmeed, Wesal AlFighi Hassan, Mouadah Ali Altayr, Mohamed Addalla, Abrar Geddeda, Kheria Khoja, Doaa Alhaj, Muaad Etturki, Ahmed Elhadi, Ibrahim Ellojli, Anshirah Shuwayyah, Ahmed Elfaghih, Malak Alduwayb, Mohamed Aleiyan, Wedad Aboubreeq, Soliman Alkassem, Sami Ashour, Hayat Ben Hasan, Najat Ben Hasan, Ali Yahya, Palesa Chisala, Edward Kommwa, Lusayo Simwinga, Agness Chalira, Precious Kachitsa, Onias Mtalimanja, Drissa Traoré, Moussa Sissoko, Moussa Camara, Adama Koita, Sekou Koumaré, Omar Sacko, Mahamadou Coulibaly, Lamine Soumaré, Soumaïla Keita, Sidiki Keita, Hamadoun Dicko, Boubacar Diallo, Boureima Bengaly, Mohamed Keita, Siaka Diallo, Drissa Ouattara, Nouhoun Ongoiba, Seydina Beye, Honoré Berthe, Mamadou Diakite, Mamadou Sima, Adégné Togo, Bakary Dembele, Djibo Diango, Moussa Samake, Youssouf Traoré, Louis Traoré, Ongoïba Oumar, Sogoba Gaoussou, Issaga Traoré, Sidy Sangaré, Doua Kanté, Lassana Cissé, Thiam Souleymane, Keita Koniba, Sundaresan Maiyalagan, Julien Chong, Adil Mohit, Khushyant Mungar, Shankaran Vinayagam, Kevin Ramlochun, Jamie Sim, Desai Sneha, Vishaal Kissoon, Yan Tseung, Mohamed Aboobakar, Nitish Fokeerah, Ravi Ramsewak, Jayprakash Gopall, Meetheelesh Abeeluck, Varun Seewoo, Divyanand Jankee, Ashveen Puryag, Senthil Beemadoo, Yashraj Deenoo, Abhisek Goureah, Munawwara Makoon, Hemanshu Rambojan, Beeharry Shanjugsingh, Kevin Viraswami, Shehzaad Joomye, Ashwant Bhugwandass, Bibi Deelawar, Vakil Leelodharry, Luckshmanraj Mungur, Sajid Aungraheeta, Sirsingh Bhajoo, Manpreet Rajcoomar, Rishi Seetaram, Subha Gaya, Gini Batra, Yoshvin Sunnassee, Shailendra Petkar, Sbai Hicham, Labib Smail, Ait Laalim Said, Motaai Youssef, Mouhssine Doumiri, Mustapha Alilou, Nora Farnaoui, Mustapha Bensghir, Abdelghafour Elkoundi, Abdelhamid Jaafari, Abderhmann Elwali, Mohammed Meziane, Walid Atmani, Houssam Rebahi, Hajar Chichou, Safae Zarouf, Abderraouf Soummani, Abou Elhassan Taoufik, Meryem Essafti, Aminata Oumou Traoré, Hamzaoui Hamza, Adnane Berdai, El allani Linda, Salhi Oussama, Nelson Mucopo, Machado Banze, Mouzinho Saide, Tomas Sitoi, Artur Machava, Antonio Carlos, Amilton Guidione, Antonio Saide de Carvalho, Natacha Gemo, Samiro Sema Camal, Arsénio Cuna, Ornelos Madeira, Ladino Assuade, Dercio Amde Fernandes, Dulce Alexandre Machavae Fernandes, Mandua Sebastião, Bernard Sikombe, Matti Kandjimi, Ayoub Shekimweri, Diana Shilomboleni, Mbaundju Kandjii, Leonard Kabongo, Cholastic Hangero, Ike Ndjoze, Ruben Nailonga, Immanuel Uukonga, Uutoni Nakanyala, Lavinia Johannes, Adrian Haruzuvi, Chris Terblanche, Natangwe Shimenda, Delwina Katjipu, Hilma Shalimba, Juliah Kaweendwa, Ali Mbuyi, John Oyedele, Mapumba Mulolo, Peter Njuki, Mutombo Ndaie, Akutu Munyika, Hilma Katangolo, David Tjiyokola, Tawanda Mhene, Archbald Masiambiri, Paidamoyo Mandudzo, Sandra Kapepiso, Haziel Mavesere, Cedia Tjihoto, Daylight Manyere, Charlotte Kauraisa, 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Zulaihatu Sarkin-Pawa, Tunde Sholadoye, Benjamin Fomete, Hamisu Yakubu, Abdulkadir Kabiru, Samaila Timothy, Ali Yusuf, Tasiu Saadu, Babangida Mohammed, Abdulghaffar Yunus, Ganiyat Olagunju, Muhammad Aminu, Mohammad Idris, Musliu Tolani, Nasiru Dalhat, Samuel Gana, Talent Adike, Lofty-John Anyanwu, Abdurrahman Sheshe, Sani Aji, Mamuda Atiku, Raphael Attah, Abubakar Muhammed, Rasaki Oseni, Halima Salisu-Kabara, Benjamin Nkemjika, Omotayo Salami, Adekunle Akadri, Bukola Olayinka, Clement Onuoha, Umar Usman Jamaare, Auwalu Saminu Jibrin, Sani Giade Abdullahi, Ibrahim Ishaku, Adenike Odewabi, John Bamigboye, Oladapo Kuforiji, Chidiebere Ogo, Stella Ogunmuyiwa, Abdussemee Abdurrazzaaq, Adebayo Tanimola, Michael Adeyanju, Oluwatimilehin Andero, Temitope Ojo, Olusi Adedotun, Gbadamosi Kehinde, Jimoh Buraimoh, Kabiru Muhammad, Sophia Baidoo, Patrick Okoli, Azeez Adigun, Ekene Ezeonye, Kabir Isa, Yetunde Aremu-Kasumu, Kamil Shoretire, Peter Enesi, Amechi Ezike, Olatunde Olawoye, Emmanuel Ugwu, 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Onajin-Obembe, Bright Obasuyi, Richard Echem, Ihuoma Mike-Elechi, Job Otokwala, Mark Edubio, Catherine Eyo, Isaac Udo, Aliyu Abdulrahman, A.A. Abdullahi, Ibrahim Galadima Bello, Usman Adinoyin Mohammed, Abidemi Oyaromade, Mohammed Bello, Usman Muhammad, Emeri Mbah, Hyacinth Okereke, Almustapha Aminu, Anthony Ahmadu, Abu Rogers, Peter Samai, Sao Amara, Margaret Yankuba, Mary Josayah, Jayah Swarray Jnr, Alusine Dawo, Peter George, Mustapha Kabba, Mohamed Bah, Charles Mondeh, Ibrahim Kapuwa, Mohamed Sheku, Philip Mattia, Brima Sesay, Jones O.A. Omoshoro-Jones, Motselisi Mbeki, Estie Cloete, Philip Anderson, Busi Mrara, Annemarie Steyn, Tsakani Mhlari, Nic Proctor, Caroline Robertson, Gillian Lamacroft, Usha Singh, Sebenzile Sikhakhane, Kelly Gate, Shepherd Nzenza, John Tshimbalanga Kasonga, Sibongile Ndebele, Patrick Lufuta Kande, Jody Davids, Tino-vito Orlandi, Marischka de Jong, Hugo Stark, Francois Roodt, Jonathan Hall, Ian Nortje, Akanimo Akpakan, Vishendran Govindasamy, Ronisha Sathiram, Mohammad Kathrada, Zane Farina, Lucio Frittella, Charles Kohler, Sibuyiselwe Lubelwana, Sarwat Ikram-Hameed, Adriaan Smit, Muneerah Cassiem, Yvonne Freeman, Saaliha Goga, Larissa Cronje, Constantin Buzdugan, Subash Chirkut, Priyadeshni Singh, Sandhya Jithoo, Vivesh Rughubar, John Arnold, Rishan Bipath, Suman Mewa Kinoo, Ncumisa Khanyisa Msolo, Fleur Ackermans-Deijnen, Tshegofatso Mmasello Emma Boka, Martyn Biccard Greenwood, Shakthi Anand Jayrajh, Devarani Naidoo, Syndrini Reddy, Devandiran Harriraman Rungan, Kylene Subrayen, John Roos, Nina Tredoux, Pascal Plumacher, Anthony Reed, Harald Steinhaus, Mariesa Nock, Paul Ryan Herselman, Gareth Davies, Talitha Harvey, Franklin Muller, Willem Naude, Tania Pretorius, Johan Jochemus Swart, Merryn Walls, Prashant Gokal, Nicolette Rorke, Farzaana Dhoodhat, Precious Dzanibe, Mohammed Yusuf Hussain, Ashmita Junpath, Ameela Maharaj, Hylda Makanisi, Khalid Moosa, Ting Ting Wong, Sean Mould, Trisha Ramsamy, Roel Matos-Puig, Hayley Morgan, Nadeem Nabeebuccas, Ria Devi Naidoo, Viantha Pather, Vasheel Vasheel Bahadur, Renilda Pillay, Zahnne Fullerton, Nicole Bell, Bongisa Grey, Vincent Lorenzo Visentin, Hendrik Adriaan Van Zyl, Terri Anne Killingbeck, Emile Maneveldt, Gerhard Thiart, Magdelena May Venter, Oostewalt Swart, Mariette Grobelaar, Carel Cairns, David Bishop, Christien Steenkamp, Thandekile Khumalo, Noel Naidoo, Ross Murray, Martin Kopieniak, Melusi Sishange, Mxolisi Brian Ndimande, Megan Jaworska, Sarwat Ikram, Bence Rainier, Renier J Liebenberg, Helena D Zwiegers, Philip M Nortje, Kamal Bhagwan, Margot Flint, Robert Dyer, Simone Adams, Yoshua Bwambale, Danny Ngomo, Patrice Kanku, Nivashen Pillay, Alexa de Castro, Atisha Maharaj, Janine Carim, Jenna Leigh Taylor, Karl M Köhne, Leanne W Drummond, Leanne Temlett, Lieze Geldenhuys, Yvonne Seilbea, Kathryn Naidoo, Nicola A Kalafatis, Stefné Verwey, Thulile Biyase, Theroshnie Kisten, Belinda S Kusel, Timothy Craig Hardcastle, Richard Magagula, Christian Kampik, Kuzolunga Xulu, Sivuyisiwe Solala, Mia Sayed, Basil Enicker, Anil Madaree, Innocent Mukama, Gladmore Madombwe, Nonhlanhla Zulu, Nompumelelo Gasa, Nokuzula Kanjana, Sebenzile Buthelezi, Thembelihle Buthelezi, Andries Brink, Francois Potgieter, Busisiwe Mrara, Zaynab Alexander, Charles Choto, Paula Ima, Zintle Gxagxisa, Baphethuxolo Ningiza, Gillian Lamacraft, Jerome Mogorosi, Nadia du Plessis, Leonie de Man, Suné Thompson, Gerrit van Heerden, Edwin W Turton, Pieter M van der Linde, Josephine K Teme-Pitse, Reitumetse Tladi, Gillian D Saffy, Ene-Mari Roscher, Kristel Fortune, George Barnard, Tiisetso Makhasane, Evan Bowen, Akangcha Pal, Rachel Moore, Maria Fourtounas, Mary Augusta Adam, Renessa Arumugan, Gabriella Hyman, Jaclyn Jonosky, Maninginingi Makondo, Heveshan Moodley, Phillip Munda, Mzwandile Nyalungu, Victor Olusola, Sohan Zane Pinto, Tristan Pillay, Lucinda Singh, Paul Mwindekuma Wondoh, John Devar, Boitumelo Baloyi-Mnisi, Zach Koto, Matlou Ernest Mabitsela, Sibongile Ruth Ndlovu, Branny Mthelebofu, Colin Beck, Matthew Dold, Alice Fan, Shannon MacQueen, Thembani Matabata, Catherine Mpehle, Charné Kulenkampf, Tsakani McCreath Mhlari, Simangele Cecilia Nyoka-Mokgalong, Felix Thumba Masinge, Randhir Ramnath Gunpath, Maropeng Petrus Pat Mothwa, Jo-Anne Asenath Mothwa, Danai Mhlanga, Jamie-Lyn Colly, Aunel Mallier Peter, Khalid Ben Hameda, Pulane Mokae, Stella Josephine Moumakoe, Kelechi Ekeh, Nezingu Lengo, Marnus Booyens, Inge Louise Seale, Pieter Daniel Theron, Nicolaas Abraham Schuman, Amber Carlyn Sonn, Jacobus Lukas Stander, Nadia Cloete, Marius Cloete, Catherine Ann Makepeace, Ronel van der Westhuizen, Leanne Robyn Messiahs, Amy Ruth Visagie, Fatima Vawda, Frans Christiaan Voster, Deepika Dhilraj, Oliver Smith, Stefan Bolon, Daniel Montwedi, Motsilisi Mbeki, Jayde Wyngaard, Mthunzi Ngcelwane, Thomas Kleyenstuber, Phyllis Phukubye, Liesel Schärf, Grace Laker, Elizabeth Semenya, Reinhard Dembskey, Thomas Tarlton, Tapiwa Jiri, Ngoie Hubert Mushid, Nhlanhla Samuel Ngwenya, Hazel Morongoa Mogodi, Carmen Sinevici, Anthony Osarogie Usenbo, Naledi Fodo, Anesu Chimini, Ntetelelo Sikobi, Sinovuyo Nokwange, Mluleki Noqhamza, Qumba Thembisa, Kajake Anantha Padmanabha Bhat, Rabin Mathew, Katrin Middleton, Abdus-sami Adewunmi, Craig Dickson, Humairah Bulbulia, Bianka Bester, Michelle de Klerk, Christia Benade, Francois Viljoen, Monique Fischer, Khalid Alfaki, Abdalmalik Awad, Abdelsalam Algray, Mohammed Elsiddig, Suha Mohamed, Salih Mahmoud, Muhammed Osman, Asia Elgailany, Mazin Suliman, Hanaa Mohammed, Lina Aljeally, Mohammed Dirar, Mohammed Osman, Mazin Mohamed, Mohamed Elhasan, Abrar Widatalla, Abubakr Abubakr, Eman Mohamed, Alshareef Nour, Ntonto Doris Gama, Dolorosa Khetsiwe Shabangu, Cynthia Iradikunda, Samuel Mkoko, Paul Kisanga, Emmanuel Lema, Benson Lyimo, Mohamed Binde, Alphonce Chandika, Salim Salim, Sylvia Jumbe, Abel Makubi, Vihar Kotecha, Felician Kachinde, Museleta Nyakiroto, Emmanuel Jitambi, Venant Geofrey, Johaphes Josiah, Phinius Makubi, Frank Manumbu, Suzan Mlingwa, Ernest Ibenzi, Peter Mbelle, Kato Peleus, Enid Chiwanga, Nillah Richard, Shoo Leonard, Paulo Sanka, Subira Mushi, Bashir Nyangasa, Mohamed Janabi, Naizihijwa Majani, Pedro Palangyo, Evarist Nyawawa, William Ramadhan, Faraj Lydenge, Gileard Gabriel Masenga, Sakina Rashid, Mubashir Jusabani, Ansbert Ndebea, Jenitha Cheru, Margaret Henjewele, Greyson Kilimanjaro, Sarah Sikimata, Deocles Donatus, Hazina Maduhu, Tumaini Mariro, Given Massasi, Moshi Moshi Shabani, Braison Cholela, Marco Mgeleka, Yohatinus Mbilinyi, Faraja Chiwanga, Bilton Exavery, Caspar Haule, Samson Ndile, Sirili Harya, Julieth Magandi, Deogratius Manyama, Redempta Matindi, Adam Moshi, Daudi Kitwana, Merida Makia, Philip Muhochi, Miriam Herman, Clauda Miombo, Furaha Kahindo, Langtone Kishebuka, Elijah Ussiri, Gloria Kinasa, Patrick Adel, Eric Malaba, Vensesla Sakwari, Sadot Lugereka, Mohamed Mungia, George Mocha, Herman Wella, Cecilia Protas, Patrick Karua, Ahmada Kashagama, Faraja Mwasambugu, Suzana Kajeri, Jacquiline Mchilla, Elibariki Lucumay, Robert Maise, Amon Marti, Beatrice Mahundi, Frederika Jager, Charles Majani, Ludovick Rukeha, Tareeq Mohamed, Nabila Fuad, Winifrida Halinga, Elias Chrisant, Gilbert Msoma, Titus Kihwili, Gadiel Temu, Naima Yusuf, Rashid Saleh, Rashid Inoja, Eva Shang'a, Stella Ibrahim, Hussein Msuma, Edwin Edward, Paul Kilamile, Stephen Mwakyolile, Talkana Adja, Edem Gueouguede, Hafoudhoi Oussene Seddoh, Saliou Adam, Pilakimwe Egbohou, Mawunyo Ahomagnon, Olivier Kadjossou, Abdul-Bassiti Boukari, Mary T Nabukenya, Ruth Muhindo, Peter Waswa, Peter Kaahwa Agaba, Daphne Kabatoro, Joseph Kayong, Margaret Naggujja, Nabasiige Rehema, Phiona Nansubuga, Daniel Kavuma, Aggrey Lubikire, Hope Bisilikirwa, Godfrey Ssebaggala, Emmanuel Muwema, Humble Joan Agaba, John Kiconco, Nicholas Wataaka, Bonet Chan, Mary Juliet Nampawu, Fred Bulamba, Emmanuel Bua, Christine Mugala, Caroline Nyakato, John Paul Ochieng, Linda Kyomuhendo Jovia, George Kateregga, Rachel Alum, Lazia Najjuma, Gorret Nampiina, Andrew Kintu, Joshua Sempiira, Luzige Simon, Peter Kayima, Jacob Eyul, Erick Odwar, Rita Nkwine, Christine Namata, Elizabeth Nabakka, Denis Kakaire, Velda Mushangwe-Mtisi, Erisha Munhamo, Celestino Dhege, Juliet Hungwa, Hemish Jasi, Crispin Ntoto, Derek Matsika, Brightson Mutseyekwa, Joseph Zimbovoora, Beaulah Gudyanga, Dennis Mazingi, Chenesa Mbanje, Busisiwe Mlambo, Michael Chiwanga, Harunavamwe N Chifamba, Sarudzai Zhou, Esta Hove, Shamiso Dende, Beauty Manjengwa, Penias Kapisa, null Mashava, Caritas Chiura, Locadia Katsukunya, Godfrey Muguti, Doreen Mashava, Elton Ndhlovu, Zanele Mangwangwa, and Nombulelo Dube
Subjects: Adult, medicine.medical_specialty, Standard of care, business.industry, Psychological intervention, MEDLINE, Standard of Care, General Medicine, Articles, Hospitals, Hospitalization, Intervention (counseling), Relative risk, Emergency medicine, Africa, medicine, Humans, In patient, Female, Cluster randomised controlled trial, Postoperative Period, business, Surgical patients
Abstract: Summary Background Risk of mortality following surgery in patients across Africa is twice as high as the global average. Most of these deaths occur on hospital wards after the surgery itself. We aimed to assess whether enhanced postoperative surveillance of adult surgical patients at high risk of postoperative morbidity or mortality in Africa could reduce 30-day in-hospital mortality. Methods We did a two-arm, open-label, cluster-randomised trial of hospitals (clusters) across Africa. Hospitals were eligible if they provided surgery with an overnight postoperative admission. Hospitals were randomly assigned through minimisation in recruitment blocks (1:1) to provide patients with either a package of enhanced postoperative surveillance interventions (admitting the patient to higher care ward, increasing the frequency of postoperative nursing observations, assigning the patient to a bed in view of the nursing station, allowing family members to stay in the ward, and placing a postoperative surveillance guide at the bedside) for those at high risk (ie, with African Surgical Outcomes Study Surgical Risk Calculator scores ≥10) and usual care for those at low risk (intervention group), or for all patients to receive usual postoperative care (control group). Health-care providers and participants were not masked, but data assessors were. The primary outcome was 30-day in-hospital mortality of patients at low and high risk, measured at the participant level. All analyses were done as allocated (by cluster) in all patients with available data. This trial is registered with ClinicalTrials.gov , NCT03853824 . Findings Between May 3, 2019, and July 27, 2020, 594 eligible hospitals indicated a desire to participate across 33 African countries; 332 (56%) were able to recruit participants and were included in analyses. We allocated 160 hospitals (13 275 patients) to provide enhanced postoperative surveillance and 172 hospitals (15 617 patients) to provide standard care. The mean age of participants was 37·1 years (SD 15·5) and 20 039 (69·4%) of 28 892 patients were women. 30-day in-hospital mortality occurred in 169 (1·3%) of 12 970 patients with mortality data in the intervention group and in 193 (1·3%) of 15 242 patients with mortality data in the control group (relative risk 0·96, 95% CI 0·69–1·33; p=0·79). 45 (0·2%) of 22 031 patients at low risk and 309 (5·6%) of 5500 patients at high risk died. No harms associated with either intervention were reported. Interpretation This intervention package did not decrease 30-day in-hospital mortality among surgical patients in Africa at high risk of postoperative morbidity or mortality. Further research is needed to develop interventions that prevent death from surgical complications in resource-limited hospitals across Africa. Funding Bill & Melinda Gates Foundation and the World Federation of Societies of Anaesthesiologists. Translations For the Arabic, French and Portuguese translations of the abstract see Supplementary Materials section.
Published: 2021

12. Does the Addition of Upper Thoracic Manipulation to Proprioceptive Training Improve Cervicocephalic Joint Position Sense and Forward Head Posture in Asymptomatic College Students?

Author: Berthe Hanna-Boutros, Grace Battal, Nibal Ali, and Rima Chamoun
Subjects: medicine.medical_specialty, Physical medicine and rehabilitation, Proprioception, business.industry, Forward head posture, Joint position sense, Training (meteorology), Medicine, medicine.symptom, business, Asymptomatic
Published: 2021

13. ART initiation among women newly diagnosed with HIV in a contraceptive trial in sub-Saharan Africa

Author: Shannon Evans, Ivana Beesham, Maricianah Onono, Rodal Issema, Lunga Dlamini, Thesla Palanee-Phillips, Margaret P Kasaro, Khatija Ahmed, Renee Heffron, Berthe Yankurije, Jennifer Deese, Joanne Batting, Mags Beksinska, and Katherine K. Thomas
Subjects: Adult, Counseling, Pediatrics, medicine.medical_specialty, Health (social science), Sub saharan, Adolescent, Social Psychology, Referral, Anti-HIV Agents, Art initiation, Human immunodeficiency virus (HIV), HIV Infections, Hiv testing, Newly diagnosed, medicine.disease_cause, Young Adult, 03 medical and health sciences, Sexually active, 0302 clinical medicine, Contraceptive Agents, medicine, Humans, 030212 general & internal medicine, Africa South of the Sahara, 030505 public health, business.industry, Public Health, Environmental and Occupational Health, Clinical trial, Female, 0305 other medical science, business
Abstract: Current guidelines recommend starting antiretroviral therapy (ART) as soon as possible after HIV diagnosis to reduce morbidity, mortality and onward HIV transmission. We examined factors influencing ART initiation by women who seroconverted during the Evidence for Contraceptive Options and HIV Outcomes (ECHO) Trial. ECHO, conducted between 2015 and 2018, enrolled HIV-negative, sexually active women, aged 16-35 years, from four African countries. Follow-up was 12-18 months, with quarterly HIV testing. Women with incident HIV infection received extensive counselling by trial staff and referral to local facilities for HIV care. Of 304 women with ≥90 days follow-up time since HIV diagnosis, 186(61.2%) initiated ART within 90 days, 69(22.7%) initiated after 90 days, and 49(16.1%) had not initiated by the end of the study. There were no statistically significant differences in characteristics among women who initiated ART ≤90 days versus those who did not. Frequent reasons for delayed or non-initiation of ART included not feeling ready to start ART and being newly diagnosed. In a large clinical trial, ART initiation was modest within 90 days of HIV diagnosis and grew to 84% with longer observation. Despite extensive counselling on the importance of early ART initiation, personal barriers delayed some women from starting ART.
Published: 2021

14. THE KLEINE-LEVIN SYNDROME: A RARE DISEASE WITH OFTEN DELAYED DIAGNOSIS—A REPORT OF TWO CASES IN THE DEPARTMENT OF NEUROLOGY OF THE UNIVERSITY HOSPITAL OF COCODY (CÔTE D'IVOIRE)

Author: Mohamed Ben Allaoui Baby, Berthe Assi, Constance Yapo-Ehounoud, Evelyne Aka-Diarra, Christian Tanoh, and Muriel Amon-Tanoh
Subjects: Pediatrics, medicine.medical_specialty, Neurology, business.industry, Cote d ivoire, Case Report, Disease, Delayed diagnosis, medicine.disease, University hospital, lcsh:RC346-429, 03 medical and health sciences, 0302 clinical medicine, Kleine–Levin syndrome, mental disorders, Medicine, Hypersexuality, 030212 general & internal medicine, medicine.symptom, General Agricultural and Biological Sciences, business, 030217 neurology & neurosurgery, lcsh:Neurology. Diseases of the nervous system, Rare disease
Abstract: TheKleine-Levin syndrome (KLS)is classied among rare diseases[1, 2]. It belongs to the central hypersomnias said to be recurrent and dened according to the International Classication of Sleepiness Disorders, 3rd version (ICSD-3), revised in 2014. For the ICSD-3, the Kleine-Levin syndrome is a disorder characterized by recurrent episodes of hypersomnia andhyperphagia (rapidconsumptionof a large amountoffood),usually with onset in early adolescence inmales but occasionally in laterlife and in women.Amonosymptomatic form of the disorder with hypersomnia only can occur with- out binge eating or hypersexuality [1]. Usually affecting adolescent males, episodes normally last up to a few weeks and terminate with total and spontaneous recovery. Possibly rst reported by Brierre de Bosmont in 1862, the condition however received its name from Willi Kleinewho,in1925,reporteda seriesof casesofperiodichypersomnia and also Max Levin who described a case of periodic hypersomnia and excessive appetite in1930[2].The exactprevalence remainsunknown.But it seems very rare: around one to two cases per million. All cases are not published. A review of the inter- national literature of language between 1962and2004,byArnulf et al.[2], estimatedthenumberofpublishedcases at186.Accordingtotheseauthors,theannualincidencewas2.7in1970,3.5 in 1980, and 5.8 in the 1990s. For these authors, this growth would rather correspond to the extension ofthe globalscientic communication than an actual increase in the prevalence of the syndrome. Patients were described aroundtheworld,includingAsiaandAfrica,withcuriouslyone-sixthofthe world's cases described in Israel [1, 2]. Its etiology remains unknown. The genetic trail was discussed in the presence of familial cases [1, 2]. The diseasemainlyaffectsyoungmales[1,2].Itsdiagnosisisclinical[1,3,4].
Published: 2022

15. Motion-compensated FDG PET/CT for oesophageal cancer

Author: Francine E.M. Voncken, Berthe M.P. Aleman, Johanna W. van Sandick, Erik Vegt, Jolanda M. van Dieren, Cecile Grootscholten, Steven L. Takken, Jan-Jakob Sonke, Jeroen B. van de Kamer, and Annemarieke Bartels-Rutten
Subjects: Four-Dimensional Computed Tomography, business.industry, medicine.medical_treatment, Cancer, Standardized uptake value, medicine.disease, 030218 nuclear medicine & medical imaging, Radiation therapy, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, medicine, Radiology, Nuclear Medicine and imaging, Fdg pet ct, Tomography, Lymph, business, Nuclear medicine, Lymph node
Abstract: PurposeRespiratory-induced motion of oesophageal tumours and lymph nodes can influence positron emission tomography/computed tomography (PET/CT). The aim was to compare standard three-dimensional (3D) and motion-compensated PET/CT regarding standardized uptake value (SUV), metabolic tumour volume (MTV) and detection of lymph node metastases. MethodsThis prospective observational study (NCT02424864) included thirty-seven newly diagnosed oesophageal cancer patients. Diagnostic PET/CT was reconstructed in 3D and motion-compensated PET/CT. MTVs of the primary tumour were calculated using an automated region-growing algorithm with SUV thresholds of 2.5 (MTV2.5) and ≥50% of SUVmax (MTV50%). Blinded for reconstruction method, a nuclear medicine physician assessed all lymph nodes showing 18F-fluorodeoxyglucose uptake for their degree of suspicion. ResultsThe mean (95% CI) SUVmax of the primary tumour was 13.1(10.6-15.5) versus 13.0(10.4-15.6) for 3D and motion-compensated PET/CT, respectively. MTVs were also similar between the two techniques. Bland-Altman analysis showed mean differences between both measurements (95% limits of agreement) of 0.08(-3.60 - 3.75), -0.26(-2.34 – 1.82), 4.66(-29.61 – 38.92)cm3 and -0.95(-19.9 – 18.0)cm3 for tumour SUVmax, lymph node SUVmax, for MTV2.5 and MTV50%, respectively. Lymph nodes were classified as highly suspicious (30/34 nodes), suspicious (20/22) and dubious (66/59) for metastases on 3D/motion-compensated PET/CT. No additional lymph node metastases were found on motion-compensated PET/CT. SUVmax of the most intense lymph nodes was similar for both scans: mean (95% CI) 6.6(4.3-8.8) and 6.8(4.5-9.1) for 3D and motion-compensated, respectively.ConclusionsSUVmax of the primary oesophageal tumour and lymph nodes was comparable on 3D and motion-compensated PET/CT. The use of motion-compensated PET/CT did not improve lymph node detection. Trial registration(www.clinicaltrials.gov: NCT02424864)
Published: 2021

16. Prevalence of Tinnitus in an Aging Population and Its Relation to Age and Hearing Loss

Author: Berthe C Oosterloo, Robert J. Baatenburg de Jong, Pauline H. Croll, M. Kamran Ikram, André Goedegebure, Otorhinolaryngology and Head and Neck Surgery, Epidemiology, Radiology & Nuclear Medicine, and Neurology
Subjects: Male, Population ageing, medicine.medical_specialty, Otology and Neurotology, Aging, Hearing loss, Audiology, 03 medical and health sciences, Tinnitus, 0302 clinical medicine, Age related, Epidemiology, medicine, otorhinolaryngologic diseases, Prevalence, Humans, 030223 otorhinolaryngology, Hearing Loss, Aged, Aged, 80 and over, business.industry, Age Factors, Middle Aged, age related, Cross-Sectional Studies, Otorhinolaryngology, Surgery, epidemiology, Female, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract: Objectives: Tinnitus is a common hearing-related disorder, which may have a large impact on daily life. With aging populations worldwide, it is important to gain insight in the occurrence of tinnitus at older ages and to understand its relationship with age-related hearing loss. We investigated the prevalence of tinnitus among a general aging population, across age strata and hearing status. Study Design: Cross-sectional. Setting: The population-based Rotterdam Study. Methods: A total of 6098 participants underwent tinnitus assessment, and 4805 had additional hearing assessment. We determined tinnitus prevalence per 5-year age groups. Hearing impairment was defined as ≥25–dB HL worse ear pure tone average (0.5, 1, 2, 4 kHz). We investigated with multivariable logistic regression the association between hearing impairment and tinnitus. Tinnitus handicap was assessed in 663 participants with daily tinnitus via the Tinnitus Handicap Inventory–screening version (THI-s). Results: Tinnitus was prevalent in 21.4% (n = 1304). Prevalent tinnitus was evenly distributed over 5-year age groups. Participants with hearing impairment were more likely to have tinnitus (odds ratio, 2.27; 95% CI, 1.92-2.69) as compared with those without hearing impairment. The median THI-s score was 4 (interquartile range, 0-10), indicating a slight handicap, and 14.6% of the participants reported a moderate or severe handicap (THI-s ≥16). Conclusions: In a general elderly population, 1 in 5 persons has tinnitus. Of those with tinnitus, for 1 per 10 persons, the presence of tinnitus interfered with daily life. Participants with hearing impairment were twice as likely to have tinnitus. Despite the age-dependent occurrence of hearing impairment, no such age dependency was found for tinnitus.
Published: 2021

17. Trans oral endoscopic thyroidectomy (TOETVA): First French experience in 90 patients

Author: A. Anuwong, G. Deroide, A. Berthe, H. Richa, F. Branger, C. Cussac-Pillegand, and I. Honigman
Subjects: medicine.medical_specialty, Hypoparathyroidism, medicine.medical_treatment, Graves' disease, 03 medical and health sciences, 0302 clinical medicine, Hematoma, medicine, Humans, Mouth, Palsy, business.industry, Thyroid, Thyroidectomy, Endoscopy, General Medicine, medicine.disease, Chin, Surgery, Axilla, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, business, Neck
Abstract: Summary Objective Thyroidectomy techniques using extracervical approaches have grown in popularity for about 20 years and their feasibility has now been demonstrated. We wanted to evaluate one of these new approaches: the anterior vestibular endoscopic approach (TOETVA). The aim of this study was to evaluate the results of an initial series patients who underwent an anterior trans-vestibular endoscopic oral thyroidectomy. Methods From February 2018 to September 2020, this technique was offered to patients aged 18 to 70, ASA I or II, who presented with an indication for thyroid surgery and who wished to avoid cervical scars. The approach was through the anterior vestibule of the mouth and the specimen was extracted either transorally or via the axilla depending on its size. Apart from the first ten cases, all patients underwent recurrent nerve neuromonitoring. The patients were operated on by two surgeons experienced in thyroid surgery. All the patients had follow-up visits on D15, D30 and at 2 months. The pre- and intra-operative data, length of stay and complications were evaluated. Results A total of 90 consecutive patients (87 women) aged 46 ± 12.4 years (18 to 69) with a mean BMI of 24.4 ± 4 were included. The indications for surgery included 11 papillary cancers, 5 oncocytic nodules, 15 toxic nodules, 13 cases of Graves disease and 46 symptomatic goiters and/or nodules. The mean pre-operative diameter of the nodules was 3.61 ± 1.99 (0.44 to 7.3) cm. The interventions performed were 44 lobo-isthmectomies, 41 total thyroidectomies and 5 isthmectomies. The mean operating time was 134 ± 45 min (40 to 255). On D1, the post-operative ionized calcium was 1.09 ± 0.11 mmol/L (4.3685 ± 0.44 mg/dL) (normal 0.8–1.15 mmol/L) (3.206–4.609 mg/dL)) and the total serum calcium was 2.07 ± 0.11 mmol/L 8.296 ± 0.44 mg/dL (normal 2.2–2.5 mmol/L) (8.817–10.019 mg/dL). Five patients underwent conversion from endoscopic to open cervical approach (5.5%). The complications were seven cases of transient recurrent nerve palsy (7.8%), eight cases of hypoparathyroidism (19%) including six transient and two permanent, one skin burn and 26 cases of transient chin numbness related to the electrocautery (29%). Ten patients (11%) presented with transient post-operative skin ecchymosis that resolved within 7–10 days. A spontaneous pneumo-mediastinum was observed on chest CT in three patients and evolved favorably. No hematoma, or surgical site infection, or complications related to axillary extraction were observed. All the patients declared themselves satisfied post-operatively and at the end of the follow-up. Conclusion The TOETVA route of entry is a safe and reliable technique in well-selected patients wishing to avoid a cervical scar.
Published: 2021

18. Van Hove Singularities and Trap States in Two-Dimensional CdSe Nanoplatelets

Author: Nathali Alexandra Franchina Vergel, Christophe Delerue, Iwan Moreels, Dominique Deresmes, Bruno Grandidier, Y. Lambert, Nemanja Peric, Ali Hossain Khan, Shalini Singh, Maxime Berthe, Zeger Hens, Louis Biadala, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Physique - IEMN (PHYSIQUE - IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Universiteit Gent = Ghent University [Belgium] (UGENT), Plateforme de Caractérisation Multi-Physiques - IEMN (PCMP - IEMN), This study was financially supported by the European Community’s H2020 Program (Grant No. PITN-GA-2016-722176, 'Indeed' Project), the EQUIPEX program Excelsior (Grant No. ANR-11-EQPX-0015), the RENATECH network, the Agence National de la Recherche (Grant No. ANR-19-CE09-0022, 'TROPICAL' Project), and I-SITE ('PRIVET' project). This project has also received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 714876 PHOCONA). We also acknowledge the TEM facility of the Nematology Research Unit, member of the UGent TEM-Expertise Centre (life sciences)., Renatech Network, PCMP PCP, ANR-11-EQPX-0015,Excelsior,Centre expérimental pour l'étude des propriétés des nanodispositifs dans un large spectre du DC au moyen Infra-rouge.(2011), European Project: 722176,H2020, H2020-MSCA-ITN-2016,INDEED(2017), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), and Universiteit Gent = Ghent University (UGENT)
Subjects: Nanostructure, Flatness (systems theory), Scanning tunneling spectroscopy, Bioengineering, 02 engineering and technology, dimensionality, CdSe, quantum confinement, Tight binding, nanocrystals, General Materials Science, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, Quantum well, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], Condensed matter physics, business.industry, Mechanical Engineering, nanoplatelets, General Chemistry, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Semiconductor, Quantum dot, Density of states, 0210 nano-technology, business
Abstract: International audience; Semiconductor nanoplatelets, which offer a compelling combination of the flatness of two-dimensional semiconductors and the inherent richness brought about by colloidal nanostructure synthesis, form an ideal and general testbed to investigate fundamental physical effects related to the dimensionality of semiconductors. With low temperature scanning tunnelling spectroscopy and tight binding calculations, we investigate the conduction band density of states of individual CdSe nanoplatelets. We find an occurrence of peaks instead of the typical steplike function associated with a quantum well, that rule out a free in-plane electron motion, in agreement with the theoretical density of states. This finding, along with the detection of deep trap states located on the edge facets, which also restrict the electron motion, provides a detailed picture of the actual lateral confinement in quantum wells with finite length and width.
Published: 2021

19. Long-term effects of adjuvant treatment for breast cancer on carotid plaques and brain perfusion

Author: Meike W. Vernooij, Berthe M.P. Aleman, M. Arfan Ikram, Flora E. van Leeuwen, Sanne B. Schagen, Kimberly D. van der Willik, Vincent Koppelmans, Banafsheh Arshi, Maryam Kavousi, Brein en Cognitie (Psychologie, FMG), Psychology Other Research (FMG), Epidemiology, and Radiology & Nuclear Medicine
Subjects: Cancer Research, medicine.medical_specialty, Epidemiology, Intima-media thickness, medicine.medical_treatment, Population, Breast Neoplasms, Perfusion scanning, 030204 cardiovascular system & hematology, Carotid Intima-Media Thickness, 03 medical and health sciences, Rotterdam Study, Breast cancer, 0302 clinical medicine, Brain perfusion, SDG 3 - Good Health and Well-being, Risk Factors, Internal medicine, medicine, Chemotherapy, Humans, Carotid plaques, education, education.field_of_study, Radiotherapy, business.industry, Brain, Cancer, medicine.disease, Perfusion, Radiation therapy, Carotid Arteries, Oncology, Cerebral blood flow, 030220 oncology & carcinogenesis, Cardiology, Female, business
Abstract: Purpose Breast cancer treatment has been associated with vascular pathology. It is unclear if such treatment is also associated with long-term cerebrovascular changes. We studied the association between radiotherapy and chemotherapy with carotid pathology and brain perfusion in breast cancer survivors. Methods We included 173 breast cancer survivors exposed to radiotherapy and chemotherapy, assessed ± 21.2 years after cancer diagnosis, and 346 age-matched cancer-free women (1:2) selected from the population-based Rotterdam Study. Outcome measures were carotid plaque score, intima-media thickness (IMT), total cerebral blood flow (tCBF), and brain perfusion. Additionally, we investigated the association between inclusion of the carotid artery in the radiation field (no/small/large part), tumor location, and these outcome measures within cancer survivors. Results Cancer survivors had lower tCBF (− 19.6 ml/min, 95%CI − 37.3;− 1.9) and brain perfusion (− 2.5 ml/min per 100 ml, 95%CI − 4.3;− 0.7) than cancer-free women. No statistically significant group differences were observed regarding plaque score or IMT. Among cancer survivors, a large versus a small part of the carotid artery in the radiation field was associated with a higher IMT (0.05, 95%CI0.01;0.09). Also, survivors with a right-sided tumor had lower left carotid plaque score (− 0.31, 95%CI − 0.60;− 0.02) and higher brain perfusion (3.5 ml/min per 100 ml, 95%CI 0.7;6.2) than those with a left-sided tumor. Conclusions On average two decades post-diagnosis, breast cancer survivors had lower tCBF and brain perfusion than cancer-free women. Also, survivors with a larger area of the carotid artery within the radiation field had a larger IMT. Future studies should confirm if these cerebrovascular changes underlie the frequently observed cognitive problems in cancer survivors.
Published: 2021

20. Hydrological Characterization of Water Resources Used for Sugarcane Production in the Sugar Complexes of Ferkessedougou (North of Côte d’Ivoire)

Author: Arona Diedhiou, Sampah Georges Eblin, Kouakou Lazare Kouassi, Affoué Berthe Yao, Bi Crépin Péné, Do Ange Désiré Soro, and Gla Blaise Ouede
Subjects: Return period, Hydrology, Water resources, Resource (biology), Flood myth, business.industry, Climate change, Environmental science, Sediment, business, Water scarcity, Renewable energy
Abstract: Water resources, although renewable, are limited and threatened by climate change and anthropic activities. Assessment and forecasting of these resources can provide valuable information for water resource planners. This study aims to quantify the surface water resources used for sugarcane production in sugar complexes of Ferkessedougou. This is based on the morphological characterization of the river Morrison and Lopkoho dams and on extreme daily flow probability of occurrence estimation using frequency analysis method. The bathymetric survey showed that the Morrison Dam impoundment had a maximum depth of 11.98 m; a water capacity of 11,656,735.5 m3. For the Lokpoho dam, the reservoir had a maximum depth of 8.82 m, which corresponds to a water volume of 4,354,531.5 m3. Nevertheless, the water capacity of these reservoirs is greatly reduced by a large volume of sediment estimated at 1,013,058.96 m3 for Morrison and 599,740 m3 for Lokpoho. Statistical analysis of maximum daily flows shows that flows between 73.9 and 100 m3/s have the potential to occur every five years at the Route Korhogo Badikaha hydrometric station. The recurrence of the decennial (298 m3) and quinquenal (248 m3) flows shows the importance of the flood flows of the Bandama River. It also shows that the low water levels of the Bandama are very pronounced. The minimum flow that SUCAF-CI water managers should expect every five years is 1.36 m3/s and the ten-year low flow is 2.10 m3/s. These results are indicators of water scarcity risks and could guide decision making in the Ferkessedougou sugar complexes.
Published: 2021

21. Risk of heart failure after systemic treatment for early breast cancer: results of a cohort study

Author: Flora E. van Leeuwen, Margreet H.A. Baaijens, Gabe S. Sonke, Emiel J. Th. Rutgers, Michael Schaapveld, Judy N. Jacobse, Michael Hauptmann, Maartje J. Hooning, Naomi B. Boekel, Nicola S. Russell, Agnes Jager, Berthe M.P. Aleman, Medical Oncology, and Radiotherapy
Subjects: 0301 basic medicine, Cancer Research, medicine.medical_specialty, Anthracycline, business.industry, Proportional hazards model, Hazard ratio, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Breast cancer, Oncology, SDG 3 - Good Health and Well-being, Trastuzumab, 030220 oncology & carcinogenesis, Internal medicine, Cohort, Medicine, Cumulative incidence, business, medicine.drug, Cohort study
Abstract: Purpose: Anthracyclines and trastuzumab can increase the risk of heart failure (HF), but long-term cardiotoxicity data in breast cancer (BC) patients treated at younger ages are limited. Furthermore, it is unknown whether aromatase inhibitors are associated with HF risk. Methods: HF risk was studied in a multicenter cohort of BC survivors treated during 2000–2009, at age < 61 years. Information on treatment and cardiovascular disease incidence was collected through medical records, general practitioners and cardiologists. Analyses included multivariable Cox regression and cumulative incidence curves. Results: In total, 10,209 women with a median age at BC diagnosis of 50.3 years and a median follow-up of 8.9 years were enrolled in the study. Anthracycline-based chemotherapy was associated with HF (hazard ratio [HR] 2.18, 95% confidence interval [CI] 1.41–3.39) and risk increased with increasing cumulative anthracycline dose. For trastuzumab, HF risk was highest within the first 2 years after treatment (HR0–2 years: 13.06, 95% CI 5.70–29.92) and decreased thereafter (HR2–4 years: 4.84, 95% CI 1.99–11.75 and HR≥4 years: 0.64, 95% CI 0.23–1.81). The 10-year cumulative incidence of HF was 4.8% (95% CI 3.2–6.8) among patients treated with anthracyclines and trastuzumab. One-third of patients who developed HF after trastuzumab had long-term impaired cardiac function. Patients treated with aromatase inhibitors alone also had higher HF risk (HR 2.18, 95% CI 1.24–3.82) compared to patients not receiving endocrine therapy. Conclusions: Our results stress the importance of considering anthracycline-free regimens in BC patients who need trastuzumab-containing treatment. The association between aromatase inhibitors and HF needs confirmation.
Published: 2021

22. Using 'Water Evaluation and Planning' (WEAP) Model to Simulate Water Demand in Lobo Watershed (Central-Western Cote d’Ivoire)

Author: Eblin Sampah Georges, Bi Tié Albert Goula, Oi Mangoua Jules Mangoua, Alioune Kane, and Affoué Berthe Yao
Subjects: education.field_of_study, Watershed, business.industry, Population, Integrated water resources management, Water supply, WEAP, Water resources, Sustainability, Watershed Central, Environmental science, Water resource management, business, education
Abstract: Climate change continues to pose a threat to the sustainability of water resources while, water need is increasing. In spite of the efforts made by the state authorities to build water infrastructure, a large majority of the population is not having access to drinking water. In this study, Water Evaluation and Planning (WEAP) model was used to model the current situation of water supply and demands, to create scenarios for future water demands and supply. The results show that, in contrast to the livestock sector, which has a zero DNS, huge deficits are observed in reference scenario. These unsatisfied demands (DNS) are dominated by deficits in rice irrigation. The analysis of the evolution of demand according to the growth scenarios has shown that the deficits already observed in the reference scenario will reach 100.45 × 106 m3 in 2040. To mitigate the effects of such deficits, water management optimization measures have been proposed. Strengthening the water supply to urban centers from the creation of dams could considerably reduce the observed deficits. These results are an important decision support tool for sustainable water resource management in the Lobo watershed. However, these strategies to improve access to water depend on the government’s political will on water and economic opportunities.
Published: 2021

23. Pulmonary tuberculosis co-infection and COVID-19 in Senegal

Author: Adama Berthe, Agbogbenkou Tevi Déla-dem Lawson, and Fulgence Abdou Faye
Subjects: Coronavirus disease 2019 (COVID-19), business.industry, Pulmonary tuberculosis, Medicine, business, Virology, Co infection
Abstract: New Coronavirus Disease (SARS-CoV-2) is responsible for the severe acute respiratory syndrome. Appeared in Wuhan, China, in December 2019, it affects more than 188 countries around the world to date. Africa is not spared by this pandemic (COVID-19), which is on the rise. Tuberculosis (TB), a disease endemic in Africa with a fatality of 1.5 million people per year , like COVID-19, is transmitted mainly by the respiratory route and affects the lungs[1,2]. In the literature, few studies have demonstrated the association and interactions between these two pathologies. However, the fragmented data reveal that tuberculosis with pulmonary localization must be considered as a potential risk factor for aggravation or complication of the disease. COVID-19, especially since the lung damage is significant, therefore In the fight against the COVID-19 pandemic, we must not forget to suspect and appropriately manage tuberculosis [2]. We report here the case of 3 patients who presented with COVID-19-Tuberculosis co-infection, treated at the level of the Epidemic Treatment Center (CTE) of the Thiès regional hospital in Senegal and whose evolution is favorable under early and adequate treatment.
Published: 2020

24. Engineering a Robust Flat Band in III–V Semiconductor Heterostructures

Author: Xavier Wallart, Daniel Vanmaekelbergh, Gilles Patriarche, David Troadec, Guillaume Fleury, Bruno Grandidier, Christophe Delerue, Nathali Alexandra Franchina Vergel, Maxime Berthe, Ludovic Desplanque, C. Coinon, Yannick Lambert, Tao Xu, François Vaurette, Davide Sciacca, Dmitri A. Yarekha, L. Christiaan Post, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Debye Institute for Nanomaterials Science, Utrecht University [Utrecht], Laboratoire de Chimie des Polymères Organiques (LCPO), Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Team 4 LCPO : Polymer Materials for Electronic, Energy, Information and Communication Technologies, Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies (C2N), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Sino-European School of Technology, University of Shanghai [Shanghai], Physique - IEMN (PHYSIQUE - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Centrale de Micro Nano Fabrication - IEMN (CMNF - IEMN), EPItaxie et PHYsique des hétérostructures - IEMN (EPIPHY - IEMN), Dutch Research Council (NWO Chemistry - Toppunt 'Superficial superstructures'), Natural Science Foundation of Shanghai (19ZR1419500), Renatech Network, PCMP PCP, ANR-16-CE24-0007,Dirac-III-V,Super-réseau d'antipoints de Dirac pour les électrons dans les semiconducteurs III-V(2016), ANR-11-EQPX-0015,Excelsior,Centre expérimental pour l'étude des propriétés des nanodispositifs dans un large spectre du DC au moyen Infra-rouge.(2011), ANR-17-CE09-0021,GERMANENE,Croissance de germanene sur substrats à bande interdite(2017), European Project: FIRST STEP, Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Physique-IEMN (PHYSIQUE-IEMN), and Centrale de Micro Nano Fabrication - IEMN (CMNF-IEMN)
Subjects: Materials science, tight binding calculations, quantum well, flat band, Scanning tunneling spectroscopy, band engineering, Bioengineering, 02 engineering and technology, Electron, Lattice constant, General Materials Science, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], Electronic band structure, Lithography, ComputingMilieux_MISCELLANEOUS, Quantum well, block copolymer lithography, business.industry, Mechanical Engineering, Heterojunction, disorder, General Chemistry, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Two-dimensional lattice, Quantum dot, scanning tunneling spectroscopy, Optoelectronics, III−V semiconductor, 0210 nano-technology, business
Abstract: Electron states in semiconductor materials can be modified by quantum confinement. Adding to semiconductor heterostructures the concept of lateral geometry offers the possibility to further tailor the electronic band structure with the creation of unique flat bands. Using block copolymer lithography, we describe the design, fabrication, and characterization of multiorbital bands in a honeycomb In0.53Ga0.47As/InP heterostructure quantum well with a lattice constant of 21 nm. Thanks to an optimized surface quality, scanning tunnelling spectroscopy reveals the existence of a strong resonance localized between the lattice sites, signature of a p-orbital flat band. Together with theoretical computations, the impact of the nanopatterning imperfections on the band structure is examined. We show that the flat band is protected against the lateral and vertical disorder, making this industry-standard system particularly attractive for the study of exotic phases of matter.
Published: 2020

25. Travailler dans un groupement d'employeurs

Author: Berthe, Bénédicte, Berthe , Bénédicte, Gury, Nicolas, Héas , Franck, Martin , Dominique Philippe, Podevin , Gérard, Thery , Michel, and Berthe, Bénédicte
Subjects: économie sociale et solidaire, travail salarié, BUS000000, Economics, Business
Abstract: Depuis les années quatre-vingt, le modèle de l’emploi stable à temps plein exercé dans un lieu unique pour une durée indéterminée est remis en cause. Les employeurs ont besoin de flexibilité mais les salariés ont besoin de sécurité. C’est dans ce contexte qu’émergent les groupements d’employeurs (GE) multisectoriels qui permettent la mise en application du temps partagé. Les groupements d’employeurs, en développement, suscitent de nombreux questionnements. Quels sont les véritables impacts sur les salariés, sur leur travail et sur les pratiques de management ? Quelles sont les innovations juridiques, économiques et managériales ? Les auteurs étudient particulièrement les répercussions des GE sur les relations professionnelles, les rapports au travail, la rémunération et la formation. Ils dénouent ainsi les fils de la complexité tissés dans cette relation tripartite qui unit le salarié, le groupement d’employeurs et l’entreprise adhérente. Ils mettent aussi en lumière l’individualisation des relations de travail qui, paradoxalement, en découle. L’étude s’appuie sur une enquête quantitative et qualitative menée auprès des salariés et des directeurs de plusieurs GE sur le territoire breton.
Published: 2020

26. Human Immunodeficiency Virus Continuum of Care in 11 European Union Countries at the End of 2016 Overall and by Key Population: Have We Made Progress?

Author: Vourli, G., Noori, T., Pharris, A., Porter, K., Axelsson, M., Begovac, J., Cazein, F., Costagliola, D., Cowan, S., Croxford, S., Monforte, A. D., Delpech, V., Diaz, A., Girardi, E., Gunsenheimer-Bartmeyer, B., Hernando, V., Leierer, G., Lot, F., Nunez, O., Obel, N., Op de Coul, E., Paraskeva, D., Patrinos, S., Reiss, P., Schmid, D., Sonnerborg, A., Suligoi, B., Supervie, V., van Sighem, A., Zangerle, R., Touloumi, G., Egle, A., Kanatschnig, M., Ollinger, A., Rieger, A., Schmied, B., Wallner, E., Dewasurendra, D., Gisinger, M., Kitchen, M., Plattner, A., Rieser, E., Sarcletti, M., Greil, R., Schachner, M., Skocic, M., Muller, M., Aichwalder, R., Chromy, D., Grabmeier-Pfstershammer, K., Skoll, M., Touzeau, V., Cichon, P., Wolf-Nussmuller, S., Laferl, H., Zoufaly, A., Genger-Hackl, C., Kapper, A., Schneeberger, T., Trattner, E., Schober, G., Atzl, M., Hartmann, B., Puchhammer-Stockl, E., Berg, J., Appoyer, H., Rappold, M., Strickner, S., Schindelwig, K., Ledergerber, B., Fatkenheuer, G., Gerstof, J., Kronborg, G., Pedersen, C., Larsen, C. S., Pedersen, G., Mohey, R., Nielsen, L., Weise, L., Kvinesdal, B., Jensen, J., Abgrall, S., Bernard, L., Billaud, E., Boue, F., Boyer, L., Cabie, A., Caby, F., Canestri, A., Cotte, L., de Truchis, P., Duval, X., Duvivier, C., Enel, P., Fischer, H., Gasnault, J., Gaud, C., Grabar, S., Khuong-Josses, M. A., Launay, O., Marchand, L., Mary-Krause, M., Matheron, S., Melica-Gregoire, G., Melliez, H., Meynard, J. L., Nacher, M., Pavie, J., Piroth, L., Poizot-Martin, I., Pradier, C., Reynes, J., Rouveix, E., Simon, A., Slama, L., Tattevin, P., Tissot-Dupont, H., Biga, J., Kurth, T., Jacquemet, N., Guiguet, M., Leclercq, S., Lievre, L., Marshall, E., Roul, H., Selinger-Leneman, H., Potard, V., Benveniste, O., Breton, G., Lupin, C., Bourzam, E., Girard, P. M., Fonquernie, L., Valin, N., Lefebvre, B., Sebire, M., Pialoux, G., Lebrette, M. G., Tibaut, P., Adda, A., Hamidi, M., Cadranel, J., Lavole, A., Parrot, A., Bouchaud, O., Vignier, N., Mechai, F., Makhlouf, S., Honore, P., Bergmann, J. F., Delcey, V., Lopes, A., Sellier, P., Parrinello, M., Oksenhendler, E., Gerard, L., Molina, J. M., Rozenbaum, W., Denis, B., De Castro, N., Lascoux, C., Yazdanpanah, Y., Lariven, S., Joly, V., Rioux, C., Poupard, M., Taverne, B., Sutton, L., Masse, V., Genet, P., Wifaq, B., Gerbe, J., Grefe, S., Dupont, C., Freire Maresca, A., Reimann, E., Bloch, M., Meier, F., Mortier, E., Zeng, F., Montoya, B., Perronne, C., Mathez, D., Marigot-Outtandy, D., Berthe, H., Greder Belan, A., Terby, A., Godin Collet, C., Marque Juillet, S., Ruquet, M., Roussin-Bretagne, S., Colardelle, P., Granier, F., Laurichesse, J. J., Perronne, V., Akpan, T., Marcou, M., Daneluzzi, V., Veyssier-Belot, C., Masson, H., Welker, Y., Brazille, P., Kahn, J. E., Zucman, D., Majerholc, C., Fourn, E., Bornarel, D., Chambrin, V., Kansau, I., Raho-Moussa, M., Lelievre, J. D., Saidani, M., Chesnel, C., Dumont, C., Vittecoq, D., Derradji, O., Bolliot, C., Goujard, C., Teicher, E., Mole, M., Bourdic, K., Salmon, D., Le Jeunne, C., Guet, P., Pietri, M. P., Pannier Metzger, E., Marcou, V., Loulergue, P., Dupin, N., Morini, J. P., Deleuze, J., Gerhardt, P., Chanal, J., Weiss, L., Lucas, M. L., Jung, C., Ptak, M., Viard, J. P., Ghosn, J., Gazalet, P., Cros, A., Maignan, A., Lortholary, O., Rouzaud, C., Touam, F., Benhadj, K., Consigny, P. H., Bossi, P., Gergely, A., Cessot, G., Durand, F., Beck-Wirth, G., Michel, C., Benomar, M., Rey, D., Partisani, M., Cheneau, C., Batard, M. L., Fischer, P., Leclercq, P., Blanc, M., Morand, P., Epaulard, O., Signori-Schmuck, A., Laurichesse, H., Jacomet, C., Vidal, M., Coban, D., Casanova, S., Fresard, A., Guglielminotti, C., Botelho-Nevers, E., Brunon-Gagneux, A., Ronat, V., Verdon, R., Dargere, S., Haustraete, E., Feret, P., Goubin, P., Chavanet, P., Fillion, A., Croisier, D., Gohier, S., Arvieux, C., Souala, F., Chapplain, J. M., Ratajczak, M., Rohan, J., Faller, J. P., Ruyer, O., Gendrin, V., Toko, L., Chirouze, C., Hustache-Mathieu, L., Faucher, J. F., Proust, A., Magy-Bertrand, N., Gil, H., Meaux-Ruault, N., Sotto, A., Rouanet, I., Mauboussin, J. M., Doncesco, R., Jacques, G., May, T., Rabaud, C., Andre, M., Delestan, M., Bouillon, M. P., Bani-Sadr, F., Rouger, C., Berger, J. L., Nguyen, Y., Marchou, B., Delobel, P., Martin Blondel, G., Cuzin, L., Biezunski, N., Alric, L., Bonnet, D., Guivarch, M., Palacin, A., Payssan, V., Ajana, F., Meybeck, A., Viget, N., Pugliese, P., Roger, P. M., Rosenthal, E., Durant, J., Cua, E., Naqvi, A., Perbost, I., Risso, K., Quinsat, D., Raphael, St., Del Giudice, P., Dides, P. Y., Sambuc, R., Antolini-Bouvenot, M. S., Druart, P., Meddeb, L., Ravaux, I., Menard, A., Tomei, C., Dhiver, C., Moreau, J., Mokhtari, S., Soavi, M. J., Tomas, V., Bregigeon, S., Faucher, O., Obry-Roguet, V., Ritleng, A. S., Petit, N., Bartoli, C., Ruiz, J. M., Blanc, D., Allegre, T., Sordage, M., Riou, J. M., Faudon, C., Slama, B., Zerazhi, H., Boulat, O., Chebrek, S., Beyrne, M., Granet Brunello, P., Pellissier, L., Bonnabel, D., Cohen Valensi, R., Mouchet, B., Mboungou, G., Lafeuillade, A., Hope-Rapp, E., Hittinger, G., Philip, G., Lambry, V., Raf, F., Allavena, C., Hall, N., Reliquet, V., Chidiac, C., Ferry, T., Perpoint, T., Miailhes, P., Boibieux, A., Livrozet, J. 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E., Gorgolas, M., Svedhem-Johansson, V., Flamholc, L., Gisslen, M., Hejdeman, B., Norgren, H., Wendahl, S., European Centre for Disease Prevention and Control (ECDC), Esser, Stefan (Beitragende*r), Schenk-Westkamp, Pia (Herausgeber*in), Vourli G., Noori T., Pharris A., Porter K., Axelsson M., Begovac J., Cazein F., Costagliola D., Cowan S., Croxford S., Monforte A.D., Delpech V., Diaz A., Girardi E., Gunsenheimer-Bartmeyer B., Hernando V., Leierer G., Lot F., Nunez O., Obel N., Op de Coul E., Paraskeva D., Patrinos S., Reiss P., Schmid D., Sonnerborg A., Suligoi B., Supervie V., van Sighem A., Zangerle R., Touloumi G., Egle A., Kanatschnig M., Ollinger A., Rieger A., Schmied B., Wallner E., Dewasurendra D., Gisinger M., Kitchen M., Plattner A., Rieser E., Sarcletti M., Greil R., Schachner M., Skocic M., Muller M., Aichwalder R., Chromy D., Grabmeier-Pfstershammer K., Skoll M., Touzeau V., Cichon P., Wolf-Nussmuller S., Laferl H., Zoufaly A., Genger-Hackl C., Kapper A., Schneeberger T., 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Adda A., Hamidi M., Cadranel J., Lavole A., Parrot A., Bouchaud O., Vignier N., Mechai F., Makhlouf S., Honore P., Bergmann J.F., Delcey V., Lopes A., Sellier P., Parrinello M., Oksenhendler E., Gerard L., Molina J.M., Rozenbaum W., Denis B., De Castro N., Lascoux C., Yazdanpanah Y., Lariven S., Joly V., Rioux C., Poupard M., Taverne B., Sutton L., Masse V., Genet P., Wifaq B., Gerbe J., Grefe S., Dupont C., Freire Maresca A., Reimann E., Bloch M., Meier F., Mortier E., Zeng F., Montoya B., Perronne C., Mathez D., Marigot-Outtandy D., Berthe H., Greder Belan A., Terby A., Godin Collet C., Marque Juillet S., Ruquet M., Roussin-Bretagne S., Colardelle P., Granier F., Laurichesse J.J., Perronne V., Akpan T., Marcou M., Daneluzzi V., Veyssier-Belot C., Masson H., Welker Y., Brazille P., Kahn J.E., Zucman D., Majerholc C., Fourn E., Bornarel D., Chambrin V., Kansau I., Raho-Moussa M., Lelievre J.D., Saidani M., Chesnel C., Dumont C., Vittecoq D., Derradji O., Bolliot C., Goujard C., Teicher E., Mole M., Bourdic K., Salmon D., Le Jeunne C., Guet P., Pietri M.P., Pannier Metzger E., Marcou V., Loulergue P., Dupin N., Morini J.P., Deleuze J., Gerhardt P., Chanal J., Weiss L., Lucas M.L., Jung C., Ptak M., Viard J.P., Ghosn J., Gazalet P., Cros A., Maignan A., Lortholary O., Rouzaud C., Touam F., Benhadj K., Consigny P.H., Bossi P., Gergely A., Cessot G., Durand F., Beck-Wirth G., Michel C., Benomar M., Rey D., Partisani M., Cheneau C., Batard M.L., Fischer P., Leclercq P., Blanc M., Morand P., Epaulard O., Signori-Schmuck A., Laurichesse H., Jacomet C., Vidal M., Coban D., Casanova S., Fresard A., Guglielminotti C., Botelho-Nevers E., Brunon-Gagneux A., Ronat V., Verdon R., Dargere S., Haustraete E., Feret P., Goubin P., Chavanet P., Fillion A., Croisier D., Gohier S., Arvieux C., Souala F., Chapplain J.M., Ratajczak M., Rohan J., Faller J.P., Ruyer O., Gendrin V., Toko L., Chirouze C., Hustache-Mathieu L., Faucher J.F., Proust A., Magy-Bertrand N., Gil H., Meaux-Ruault N., Sotto A., Rouanet I., Mauboussin J.M., Doncesco R., Jacques G., May T., Rabaud C., Andre M., Delestan M., Bouillon M.P., Bani-Sadr F., Rouger C., Berger J.L., Nguyen Y., Marchou B., Delobel P., Martin Blondel G., Cuzin L., Biezunski N., Alric L., Bonnet D., Guivarch M., Palacin A., Payssan V., Ajana F., Meybeck A., Viget N., Pugliese P., Roger P.M., Rosenthal E., Durant J., Cua E., Naqvi A., Perbost I., Risso K., Quinsat D., Raphael St., Del Giudice P., Dides P.Y., Sambuc R., Antolini-Bouvenot M.S., Druart P., Meddeb L., Ravaux I., Menard A., Tomei C., Dhiver C., Moreau J., Mokhtari S., Soavi M.J., Tomas V., Bregigeon S., Faucher O., Obry-Roguet V., Ritleng A.S., Petit N., Bartoli C., Ruiz J.M., Blanc D., Allegre T., Sordage M., Riou J.M., Faudon C., Slama B., Zerazhi H., Boulat O., Chebrek S., Beyrne M., Granet Brunello P., Pellissier L., Bonnabel D., Cohen Valensi R., Mouchet B., Mboungou G., Lafeuillade A., Hope-Rapp E., Hittinger G., Philip G., Lambry V., Raf F., Allavena C., Hall N., Reliquet V., Chidiac C., Ferry T., Perpoint T., Miailhes P., Boibieux A., Livrozet J.M., Makhlouf D., Brunel F., Chiarello P., Hoen B., Lamaury I., Fabre I., Samar K., Duvallon E., Clavel C., Stegmann S., Walter V., Adriouch L., Huber F., Vanticlke V., Couppie P., Abel S., Pierre-Francois S., Ricaud C., Rodet R., Wartel G., Sautron C., Poubeau P., Borgherini G., Camuset G., Arasteh K., Kowohl Vivantes S., Schurmann D., Warncke Charite M., Rockstroh J., Wasmuth J., Hass S., Jensen B.O., Feind C., Esser S., Schenk-Westkamp P., Haberl A., Stephan C., Plettenberg A., Kuhlendahl F., Adam A., Weitner L., Schewe K., Goey H., Fenske S., Buhk T., Stellbrink H.J., Hofmann C., Hansen S., Degen O., Heuer M., Stoll M., Gerschmann S., Horst H., Trautmann S., Gillor D., Bogner J., Sonntag B., Salzberger B., Fritzsche C., Adamis G., Antoniadou A., Chini M., Chrysos G., Gikas A., Gogos H.A., Katsarou O., Lazanas M., Metallidis S., Panagopoulos P., Paparizos V., Papastamopoulos V., Paraskevis D., Psychogiou M., Sambatakou H., Sipsas N.V., Pantazis N., Papadopoulos A., Nitsotolis T., Xylomenos G., Marangos M.N., Kouramba A., Kontos A., Lioni A., Tsachouridou O., Kourkounti S., Ganitis A., Barbounakis E., d'Arminio Monforte A., Antinori A., Andreoni M., Castagna A., Castelli F., Cauda R., Di Perri G., Galli M., Iardino R., Ippolito G., Lazzarin A., Marchetti G.C., Rezza G., von Schloesser F., Viale P., Ceccherini-Silberstein F., Cozzi-Lepri A., Lo Caputo S., Mussini C., Puoti M., Perno C.F., Bai F., Balotta C., Bandera A., Bonora S., Borderi M., Calcagno A., Capetti A., Capobianchi M.R., Cicalini S., Cingolani A., Cinque P., Di Biagio A., Gianotti N., Gori A., Guaraldi G., Lapadula G., Lichtner M., Madeddu G., Maggiolo F., Marchetti G., Monno L., Nozza S., Pinnetti C., Quiros Roldan E., Rossotti R., Rusconi S., Santoro M.M., Saracino A., Sarmati L., Fanti I., Galli L., Lorenzini P., Rodano A., Macchia M., Tavelli A., Carletti F., Carrara S., Di Caro A., Graziano S., Petroni F., Prota G., Trufa S., Giacometti A., Costantini A., Barocci V., Angarano G., Milano E., Suardi C., Donati V., Verucchi G., Castelnuovo F., Minardi C., Menzaghi B., Abeli C., Cacopardo B., Celesia B., Vecchiet J., Falasca K., Pan A., Lorenzotti S., Sighinolf L., Segala D., Blanc P., Vichi F., Cassola G., Viscoli C., Alessandrini A., Bobbio N., Mazzarello G., Fondaco L., Bonfanti P., Molteni C., Chiodera A., Milini P., Nunnari G., Pellicano G., Rizzardini G., Cannizzo E.S., Moioli M.C., Piolini R., Bernacchia D., Salpietro S., Tincati C., Puzzolante C., Migliorino C., Sangiovanni V., Borgia G., Esposito V., Di Flumeri G., Gentile I., Rizzo V., Cattelan A.M., Marinello S., Cascio A., Trizzino M., Francisci D., Schiaroli E., Parruti G., Sozio F., Magnani G., Ursitti M.A., Cristaudo A., Vullo V., Acinapura R., Moschese D., Capozzi M., Mondi A., Rivano Capparuccia M., Iaiani G., Latini A., Gagliardini R., Plazzi M.M., De Girolamo G., Vergori A., Cecchetto M., Viviani F., De Vito A., Rossetti B., Montagnani F., Franco A., Fontana Del Vecchio R., Di Giuli C., Caramello P., Orofno G.C., Sciandra M., Bassetti M., Londero A., Manfrin V., Battagin G., Starnini G., Ialungo A., van der Valk M., Geerlings S.E., Goorhuis A., Hovius J.W., Lempkes B., Nellen F.J.B., van der Poll T., Prins J.M., van Vugt M., Wiersinga W.J., Wit F.W.M.N., van Duinen M., van Eden J., Hazenberg A., van Hes A.M.H., Pijnappel F.J.J., Smalhout S.Y., Weijsenfeld A.M., Jurriaans S., Back N.K.T., Zaaijer H.L., Berkhout B., Cornelissen M.T.E., Schinkel C.J., Wolthers K.C., Peters E.J.G., van Agtmael M.A., Bomers M., Sigalof K.C.E., Heitmuller M., Laan L.M., Ang C.W., van Houdt R., Jonges M., van Prehn J., Kuijpers T.W., Pajkrt D., Scherpbier H.J., de Boer C., van der Plas A., van den Berge M., Stegeman A., Baas S., Hage de Loof L., Wintermans B., Veenemans J., Pronk M.J.H., Ammerlaan H.S.M., de Munnik E.S., Jansz A.R., Tjhie J., Wegdam M.C.A., Deiman B., Scharnhorst V., van Eeden A., Brokking W., Elsenburg 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Pedreira J.D., Galera C., Albendin H., Iborra A., Campillo M.A., Vidal A., Amador C., Pasquau F., Ena J., Benito C., Fenoll V., Mohamed-Balghata M.O., Gomez M.A., Alberto de Zarraga M., Rivas M.E., Gorgolas M., Svedhem-Johansson V., Flamholc L., Gisslen M., Hejdeman B., Norgren H., Wendahl S., Global Health, Infectious diseases, AII - Infectious diseases, APH - Aging & Later Life, ANS - Neuroinfection & -inflammation, Internal medicine, Medical Microbiology and Infection Prevention, AMS - Rehabilitation & Development, VU University medical center, Amsterdam Gastroenterology Endocrinology Metabolism, Pediatric surgery, Neurology, Amsterdam Neuroscience - Neurodegeneration, Pulmonary medicine, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Ethics, Law & Medical humanities, APH - Quality of Care, ACS - Pulmonary hypertension & thrombosis, Amsterdam Neuroscience - Neuroinfection & -inflammation, Amsterdam Reproduction & Development (AR&D), APH - Societal Participation & Health, Pediatrics, HAL-SU, Gestionnaire, National and Kapodistrian University of Athens (NKUA), University College of London [London] (UCL), Public Health Agency of Sweden, University of Zagreb, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Statens Serum Institut [Copenhagen], Public Health England [London], Università degli Studi di Milano = University of Milan (UNIMI), Instituto de Salud Carlos III [Madrid] (ISC), Istituto Nazionale di Malattie Infettive 'Lazzaro Spallanzani' (INMI), Robert Koch Institute [Berlin] (RKI), Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), University of Copenhagen = Københavns Universitet (UCPH), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Hellenic Center for Disease Control and Prevention, Amsterdam UMC - Amsterdam University Medical Center, Austrian Agency for Health and Food Safety (AGES), Department of Infectious Diseases, Institution of Medicine, Karolinska University Hospital and Karolinska Institutet, Istituto Superiore di Sanita [Rome], Stichting HIV Monitoring [Amsterdam], Universiteit van Amsterdam (UvA), University of Athens Medical School [Athens], Vourli, G, Noori, T, Pharris, A, Porter, K, Axelsson, M, Begovac, J, Cazein, F, Costagliola, D, Cowan, S, Croxford, S, Monforte, A, Delpech, V, Diaz, A, Girardi, E, Gunsenheimer-Bartmeyer, B, Hernando, V, Leierer, G, Lot, F, Nunez, O, Obel, N, Op de Coul, E, Paraskeva, D, Patrinos, S, Reiss, P, Schmid, D, Sonnerborg, A, Suligoi, B, Supervie, V, van Sighem, A, Zangerle, R, Touloumi, G, Egle, A, Kanatschnig, M, Ollinger, A, Rieger, A, Schmied, B, Wallner, E, Dewasurendra, D, Gisinger, M, Kitchen, M, Plattner, A, Rieser, E, Sarcletti, 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Leclercq, S, Lievre, L, Marshall, E, Roul, H, Selinger-Leneman, H, Potard, V, Benveniste, O, Breton, G, Lupin, C, Bourzam, E, Girard, P, Fonquernie, L, Valin, N, Lefebvre, B, Sebire, M, Pialoux, G, Lebrette, M, Tibaut, P, Adda, A, Hamidi, M, Cadranel, J, Lavole, A, Parrot, A, Bouchaud, O, Vignier, N, Mechai, F, Makhlouf, S, Honore, P, Bergmann, J, Delcey, V, Lopes, A, Sellier, P, Parrinello, M, Oksenhendler, E, Gerard, L, Molina, J, Rozenbaum, W, Denis, B, De Castro, N, Lascoux, C, Yazdanpanah, Y, Lariven, S, Joly, V, Rioux, C, Poupard, M, Taverne, B, Sutton, L, Masse, V, Genet, P, Wifaq, B, Gerbe, J, Grefe, S, Dupont, C, Freire Maresca, A, Reimann, E, Bloch, M, Meier, F, Mortier, E, Zeng, F, Montoya, B, Perronne, C, Mathez, D, Marigot-Outtandy, D, Berthe, H, Greder Belan, A, Terby, A, Godin Collet, C, Marque Juillet, S, Ruquet, M, Roussin-Bretagne, S, Colardelle, P, Granier, F, Laurichesse, J, Perronne, V, Akpan, T, Marcou, M, Daneluzzi, V, Veyssier-Belot, C, Masson, H, Welker, Y, Brazille, P, Kahn, J, Zucman, D, Majerholc, C, Fourn, E, Bornarel, D, Chambrin, V, Kansau, I, Raho-Moussa, M, Lelievre, J, Saidani, M, Chesnel, C, Dumont, C, Vittecoq, D, Derradji, O, Bolliot, C, Goujard, C, Teicher, E, Mole, M, Bourdic, K, Salmon, D, Le Jeunne, C, Guet, P, Pietri, M, Pannier Metzger, E, Marcou, V, Loulergue, P, Dupin, N, Morini, J, Deleuze, J, Gerhardt, P, Chanal, J, Weiss, L, Lucas, M, Jung, C, Ptak, M, Viard, J, Ghosn, J, Gazalet, P, Cros, A, Maignan, A, Lortholary, O, Rouzaud, C, Touam, F, Benhadj, K, Consigny, P, Bossi, P, Gergely, A, Cessot, G, Durand, F, Beck-Wirth, G, Michel, C, Benomar, M, Rey, D, Partisani, M, Cheneau, C, Batard, M, Fischer, P, Leclercq, P, Blanc, M, Morand, P, Epaulard, O, Signori-Schmuck, A, Laurichesse, H, Jacomet, C, Vidal, M, Coban, D, Casanova, S, Fresard, A, Guglielminotti, C, Botelho-Nevers, E, Brunon-Gagneux, A, Ronat, V, Verdon, R, Dargere, S, Haustraete, E, Feret, P, Goubin, P, Chavanet, P, Fillion, A, Croisier, D, Gohier, S, 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A, Sarmati, L, Fanti, I, Galli, L, Lorenzini, P, Rodano, A, Macchia, M, Tavelli, A, Carletti, F, Carrara, S, Di Caro, A, Graziano, S, Petroni, F, Prota, G, Trufa, S, Giacometti, A, Costantini, A, Barocci, V, Angarano, G, Milano, E, Suardi, C, Donati, V, Verucchi, G, Castelnuovo, F, Minardi, C, Menzaghi, B, Abeli, C, Cacopardo, B, Celesia, B, Vecchiet, J, Falasca, K, Pan, A, Lorenzotti, S, Sighinolf, L, Segala, D, Blanc, P, Vichi, F, Cassola, G, Viscoli, C, Alessandrini, A, Bobbio, N, Mazzarello, G, Fondaco, L, Bonfanti, P, Molteni, C, Chiodera, A, Milini, P, Nunnari, G, Pellicano, G, Rizzardini, G, Cannizzo, E, Moioli, M, Piolini, R, Bernacchia, D, Salpietro, S, Tincati, C, Puzzolante, C, Migliorino, C, Sangiovanni, V, Borgia, G, Esposito, V, Di Flumeri, G, Gentile, I, Rizzo, V, Cattelan, A, Marinello, S, Cascio, A, Trizzino, M, Francisci, D, Schiaroli, E, Parruti, G, Sozio, F, Magnani, G, Ursitti, M, Cristaudo, A, Vullo, V, Acinapura, R, Moschese, D, Capozzi, M, Mondi, A, Rivano Capparuccia, M, Iaiani, G, Latini, A, Gagliardini, R, Plazzi, M, De Girolamo, G, Vergori, A, Cecchetto, M, Viviani, F, De Vito, A, Rossetti, B, Montagnani, F, Franco, A, Fontana Del Vecchio, R, Di Giuli, C, Caramello, P, Orofno, G, Sciandra, M, Bassetti, M, Londero, A, Manfrin, V, Battagin, G, Starnini, G, Ialungo, A, van der Valk, M, Geerlings, S, Goorhuis, A, Hovius, J, Lempkes, B, Nellen, F, van der Poll, T, Prins, J, van Vugt, M, Wiersinga, W, Wit, F, van Duinen, M, van Eden, J, Hazenberg, A, van Hes, A, Pijnappel, F, Smalhout, S, Weijsenfeld, A, Jurriaans, S, Back, N, Zaaijer, H, Berkhout, B, Cornelissen, M, Schinkel, C, Wolthers, K, Peters, E, van Agtmael, M, Bomers, M, Sigalof, K, Heitmuller, M, Laan, L, Ang, C, van Houdt, R, Jonges, M, van Prehn, J, Kuijpers, T, Pajkrt, D, Scherpbier, H, de Boer, C, van der Plas, A, van den Berge, M, Stegeman, A, Baas, S, Hage de Loof, L, Wintermans, B, Veenemans, J, Pronk, M, Ammerlaan, H, de Munnik, E, Jansz, A, Tjhie, J, Wegdam, M, Deiman, B, Scharnhorst, V, van Eeden, A, Brokking, W, Elsenburg, L, Nobel, H, Damen, M, van Kasteren, M, Berrevoets, M, Brouwer, A, Adams, A, de Kruijf-Van de Wiel, B, Keelan-Pfaf, S, van der Ven, B, Buiting, A, Murck, J, Versteeg, D, de Vries-Sluijs, T, Bax, H, van Gorp, E, Nouwen, J, Rijnders, B, Schurink, C, Verbon, A, de Jong-Peltenburg, N, Bassant, N, van Beek, J, Vriesde, M, van Zonneveld, L, van den Berg-Cameron, H, de Groot, J, Boucher, C, Koopmans, M, van Kampen, J, Fraaij, P, van Rossum, A, Vermont, C, van der Knaap, L, Visser, E, Branger, J, Douma, R, Duijf-Van de Ven, C, Schippers, E, van Nieuwkoop, C, van IJperen, J, Geilings, J, van der Hut, G, van Burgel, N, Leyten, E, Gelinck, L, Mollema, F, Davids-Veldhuis, S, Wildenbeest, G, Heikens, E, Groeneveld, P, Bouwhuis, J, Lammers, A, Kraan, S, van Hulzen, A, Kruiper, M, van der Bliek, G, Bor, P, Bloembergen, P, Wolfagen, M, Ruijs, G, Kroon, F, de Boer, M, Scheper, H, Jolink, H, Dorama, W, van Holten, N, Claas, E, Wessels, E, den Hollander, J, El Moussaoui, R, Pogany, K, Kastelijns, M, Smit, J, Smit, E, Struik-Kalkman, D, Tearno, C, van Niekerk, T, Pontesilli, O, Lowe, S, Oude Lashof, A, Posthouwer, D, Ackens, R, Burgers, K, Schippers, J, Weijenberg-Maes, B, van Loo, I, Havenith, T, Weijer, S, van Vonderen, M, Kampschreur, L, Faber, S, Steeman-Bouma, R, Weel, J, Kootstra, G, Delsing, C, van der Burg-Van de Plas, M, Heins, H, Kortmann, W, van Twillert, G, Renckens, R, Ruiter-Pronk, D, van Truijen-Oud, F, Cohen Stuart, J, Jansen, E, Hoogewerf, M, Rozemeijer, W, van der Reijden, W, Sinnige, J, Brinkman, K, van den Berk, G, Blok, W, Frissen, P, Lettinga, K, Schouten, W, Veenstra, J, Vrouenraets, S, Brouwer, C, Geerders, G, Hoeksema, K, Kleene, M, Knapen, M, van der Meche, I, Mulder-Seeleman, E, Toonen, A, Wijnands, S, Kwa, D, van Crevel, R, van Aerde, K, Doferhof, A, Henriet, S, ter Hofstede, H, Hoogerwerf, J, Keuter, M, Richel, O, Albers, M, Grintjes-Huisman, K, de Haan, M, Marneef, M, Strik-Albers, R, Rahamat-Langendoen, J, Stelma, F, Burger, D, Gisolf, E, Hassing, R, Claassen, M, ter Beest, G, van Bentum, P, Langebeek, N, Tiemessen, R, Swanink, C, van Lelyveld, S, Soetekouw, R, van der Prijt, L, van der Swaluw, J, Bermon, N, Jansen, R, Herpers, B, Veenendaal, D, Verhagen, D, Lauw, F, van Broekhuizen, M, van Wijk, M, Bierman, W, Bakker, M, Kleinnijenhuis, J, Kloeze, E, Middel, A, Scholvinck, E, Stienstra, Y, Verhage, A, Wouthuyzen-Bakker, K, Boonstra, A, de Groot-De Jonge, H, van der Meulen, P, de Weerd, D, Niesters, H, van Leer-Buter, C, Knoester, M, Hoepelman, A, Arends, J, Barth, R, Bruns, A, Ellerbroek, P, Mudrikova, T, Oosterheert, J, de Regt, M, Schadd, E, van Zoelen, M, Aarsman, K, Grifoen-Van Santen, B, de Kroon, I, van Rooijen, C, van Berkel, M, Schuurman, R, Verduyn-Lunel, F, Wensing, A, Bont, L, Geelen, S, Loefen, Y, Wolfs, T, Nauta, N, Zaheri, S, Boyd, A, Bezemer, D, Smit, C, Hillebregt, M, de Jong, A, Woudstra, T, Bergsma, D, Meijering, R, van de Sande, L, Rutkens, T, van der Vliet, S, de Groot, L, van den Akker, M, Bakker, Y, El Berkaoui, A, Bezemer, M, Bretin, N, Djoechro, E, Geerlinks, J, Kruijne, E, Lodewijk, C, Lucas, E, van der Meer, R, Munjishvili, L, Paling, F, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Schoorl, M, Schnorr, P, Tuijn, E, Veenenberg, L, Witte, E, Tuk, B, Moreno, S, del Amo, J, Dalmau, D, Navarro, M, Gonzalez, M, Blanco, J, Garcia, F, Rubio, R, Iribarren, J, Gutierrez, F, Vidal, F, Berenguer, J, Gonzalez, J, Sobrino, P, Alejos, B, Alvarez, D, Jarrin, I, Moreno, C, Munoz-Fernandez, M, Garcia-Merino, I, Rico, C, de la Fuente, J, Torre, A, Portilla, J, Merino, E, Reus, S, Boix, V, Giner, L, Gadea, C, Portilla, I, Pampliega, M, Diez, M, Rodriguez, J, Sanchez-Paya, J, Podzamczer, D, Imaz, E, Van Den Eyncle, E, Di Yacovo, S, Sumoy, M, Gomez, J, Hernandez, J, Aleman, M, Alonso, M, Hernandez, M, Diaz-Flores, F, Garcia, D, Pelazas, R, Asensi, V, Valle, E, Carton, J, Perez, V, Molina, M, Garcia, J, Carrera, E, Pulido, F, Bisbal, O, Matarranz, M, Lagarde, M, Rubio-Martin, R, Hernando, A, Bermejo, L, Dominguez, L, Arrizabalaga, J, Aramburu, M, Camino, X, Rodriguez-Arrondo, F, von Wichmann, M, Tome, L, Goenaga, M, Bustinduy, M, Galparsoro, H, Ibarguren, M, Aguado, M, Umerez, M, Masia, M, Lopez, C, Padilla, S, Navarro, A, Montolio, F, Robledano, C, Colome, J, Adsuar, A, Pascual, R, Carlos, F, Martinez, M, Fernandez, M, Garcia, E, Muga, R, Tor, J, Sanvisens, A, Bernaldo de Quiros Lopez, J, Miralles, P, Gutierrez, I, Ramirez, M, Padilla, B, Gijon, P, Carrero, A, Aldamiz-Echevarria, T, Tejerina, F, Parras, F, Balsalobre, P, Diez, C, Peraire, J, Vilades, C, Veloso, S, Vargas, M, Lopez-Dupla, M, Olona, M, Aguilar, A, Sirvent, J, Alba, V, Calavia, O, Montero, M, Lacruz, J, Blanes, M, Calabuig, E, Cuellar, S, Lopez, J, Salavert, M, de la Serna, I, Arribas, J, Montes, M, Pena, J, Arribas, B, Castro, J, Zamora, J, Perez, I, Estebanez, M, Garcia, S, Diaz, M, Alcariz, N, Mingorance, J, Montero, D, Gonzalez, A, Isabel de Jose, M, de los Santos, I, Sanz, J, Salas, A, Sarria, C, Berrocal, A, Garcia-Fraile, L, Oteo, J, Ibarra, V, Metola, L, Sanz, M, Perez-Martinez, L, Pascual, A, Ramos, C, Arazo, P, Gil, D, Jaen, A, Cairo, M, Irigoyen, D, Jordano, Q, Xercavins, M, Martinez-Lacasa, J, Velli, P, Font, R, Sanmarti, M, Ibanez, L, Rivero, M, Casado, M, Diaz, J, Uriz, J, Reparaz, J, Irigoyen, C, Arraiza, M, Segura, F, Amengual, M, Navarro, G, Sala, M, Cervantes, M, Pineda, V, Segura, V, Anton, E, Nogueras, M, Casado, J, Dronda, F, Moreno, A, Elias, M, Lopez, D, Gutierrez, C, Madrid, N, Lamas, A, Marti, P, de Diaz, A, Serrrano, S, Donat, L, Cano, A, Bernal, E, Munoz, A, Pena, A, Munoz, L, Parra, J, Alvarez, M, Chueca, N, Guillot, V, Vinuesa, D, Fernandez, J, Del Romero, J, Rodriguez, C, Puerta, T, Carrio, J, Vera, M, Ballesteros, J, Domingo, P, Sambeat, M, Lamarca, K, Mateo, G, Gutierrez, M, Fernandez, I, Antela, A, Losada, E, Riera, M, Penaranda, M, Leyes, M, Ribas, M, Campins, A, Vidal, C, Gil, L, Fanjul, F, Marinescu, C, Ribera, E, Santos, J, Marquez, M, Viciana, I, Palacios, R, Gonzalez, C, Viciana, P, Leal, M, Lopez-Cortes, L, Espinosa, N, Munoz, J, Zubero, M, Baraia-Etxaburu, J, Ibarra, S, Ferrero, O, Lopez de Munain, J, Camara, M, Lopez, I, de la Pena, M, Suarez-Garcia, I, Malmierca, E, Olalla, J, del Arco, A, de la Torre, J, Prada, J, Caracuel, Z, Lopez-Lirola, A, Lozano, A, Fernandez, E, Martinez, O, Vera, F, Martinez, L, Alcaraz, B, Jimeno, A, Poveda, E, Pernas, B, Mena, A, Grandal, M, Castro, A, Pedreira, J, Galera, C, Albendin, H, Iborra, A, Campillo, M, Vidal, A, Amador, C, Pasquau, F, Ena, J, Benito, C, Fenoll, V, Mohamed-Balghata, M, Gomez, M, Alberto de Zarraga, M, Rivas, M, Gorgolas, M, Svedhem-Johansson, V, Flamholc, L, Gisslen, M, Hejdeman, B, Norgren, H, and Wendahl, S
Subjects: Male, 0301 basic medicine, Psychological intervention, Human immunodeficiency virus (HIV), Medizin, Continuum of care, Europe, HIV infection, Key population, Sex, Anti-Retroviral Agents, Continuity of Patient Care, European Union, HIV, Humans, HIV Infections, medicine.disease_cause, key population, 0302 clinical medicine, HIV Infection, 030212 general & internal medicine, Men having sex with men, media_common, education.field_of_study, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Transmission (medicine), Infectious Diseases, AcademicSubjects/MED00290, HIV infection, continuum of care, sex, key population, Europe, Microbiology (medical), Population, Socio-culturale, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), SDG 3 - Good Health and Well-being, medicine, media_common.cataloged_instance, European union, education, Pandemics, continuum of care, sex, business.industry, SARS-CoV-2, COVID-19, medicine.disease, 030112 virology, Major Articles and Commentaries, Anti-Retroviral Agent, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Demography
Abstract: Background High uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV) transmission and related mortality; however, gaps in care exist. We aimed to construct the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. To estimate progress toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 target, we compared 2016 to 2013 estimates for the same countries, representing 73% of the population in the region. Methods A CoC with the following 4 stages was constructed: number of people living with HIV (PLHIV); proportion of PLHIV diagnosed; proportion of those diagnosed who ever initiated ART; and proportion of those ever treated who achieved viral suppression at their last visit. Results We estimated that 87% of PLHIV were diagnosed; 92% of those diagnosed had ever initiated ART; and 91% of those ever on ART, or 73% of all PLHIV, were virally suppressed. Corresponding figures for men having sex with men were: 86%, 93%, 93%, 74%; for people who inject drugs: 94%, 88%, 85%, 70%; and for heterosexuals: 86%, 92%, 91%, 72%. The proportion suppressed of all PLHIV ranged from 59% to 86% across countries. Conclusions The EU is close to the 90-90-90 target and achieved the UNAIDS target of 73% of all PLHIV virally suppressed, significant progress since 2013 when 60% of all PLHIV were virally suppressed. Strengthening of testing programs and treatment support, along with prevention interventions, are needed to achieve HIV epidemic control., Standardized definitions were used to estimate a 4-stage continuum of human immunodeficiency virus (HIV) care in 11 European Union (EU) countries in 2016. The EU is close to the 90-90-90 target, with the main challenge being the percentage of undiagnosed infections.
Published: 2020

27. Spatial Analysis of the Mode of Management and Conflicts of Use of Water Resources in the Watershed of the Lobo River in Nibehibe (Central-Western Côte d'Ivoire)

Author: Yao Affoue Berthe, Koita Mahamadou, Toure Fanraban Fabrice, Diarra Ali, Koua Tano Jean Jacques, and Konan-Waidhet Arthur Brice
Subjects: Water resources, Watershed, Geography, business.industry, Integrated water resources management, Water supply, Cote d ivoire, Water resource management, business
Abstract: Water is an indispensable resource for all activities developed by man. Water resources are indispensable for the survival of the populations of the Lobo watershed in Nibéhibé. They offer many multidimensional services. Around these important resources, social actors have different ways of perceiving them. This is why their management comes up against a difference in logic and action on the part of the different stakeholders. Thus, it must be noted that there is a crystallization of social relations between the different groups of actors involved and this is based on conflicts of use and the intensity of water scarcity. The objective of this study is to show the relationship between management mode and conflicts of use of water resources in the Lobo watershed in Nibéhibé. To achieve this objective, the methodology was based on the triptych documentary research, interview and questionnaire survey. The documentary research consisted in defining the contours of the subject in order to better understand it. Then, the interviews carried out with the actors of the water sector in the Lobo basin made it possible to collect information on the perception and the mode of management of the water resources in the basin. Finally, using the simple random selection method without discount and the use of a statistical equation, a sample of 384 households spread over the entire catchment area served as the basis for our surveys. Population surveys, combined with spatially referenced data under a GIS, have made it possible to map the spatial distribution of water supply sites on the one hand, and the spatial distribution of water-related conflict types on the other. The results show that the population has a wide variety of water supply sources. Moreover, the current management mode is either liberal (or private) or participatory (or community-based) depending on the type of water resource (surface or groundwater) and on the perception of the actors with regard to water. Thus, the different uses generate conflicts that are perceived between cultural actors (indigenous) and economic actors such as SODECI (Water Distribution Company in Côte d'Ivoire) and fishermen (non-indigenous). There are also conflicts between women, which can be summarized as disputes over water points and distrust between different communities. An integrated management of water resources in this watershed would therefore be beneficial to all stakeholders.
Published: 2020

28. [18F]FDG-PET or PET/CT in the evaluation of pelvic and para-aortic lymph nodes in patients with locally advanced cervical cancer: A systematic review of the literature

Author: Judit A. Adam, Berthe L. F. van Eck-Smit, Constantijne H. Mom, Jaap Stoker, Shandra Bipat, Pascal R. van Diepen, Radiology and Nuclear Medicine, CCA -Cancer Center Amsterdam, CCA - Imaging and biomarkers, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
Subjects: 0301 basic medicine, medicine.medical_specialty, Locally advanced, Histopathology, 03 medical and health sciences, 0302 clinical medicine, Locally advanced cervical cancer (LACC), Medicine, In patient, Lymph node, Cervical cancer, PET-CT, 2-deoxy-2-[ F]fluoro-D-glucose ([ F]FDG), business.industry, Positron emission computed tomography (PET/CT), Obstetrics and Gynecology, medicine.disease, Confidence interval, 030104 developmental biology, Standard error, medicine.anatomical_structure, Sensitivity and specificity, Oncology, 030220 oncology & carcinogenesis, business, Nuclear medicine
Abstract: Purpose: Imaging is essential in detecting lymph node metastases for radiotherapy treatment planning in locally advanced cervical cancer (LACC). There are not many data on the performance of [ 18F]FDG-PET(CT) in showing lymph node metastases in LACC. We pooled sensitivity and specificity of [ 18F]FDG-PET(CT) for detecting pelvic and/or para-aortic lymph node metastases in patients with LACC. Also, the positive and negative posttest probabilities at high and low levels of prevalence were determined. Methods: MEDLINE and EMBASE searches were performed and quality characteristics assessed. Logit-sensitivity and logit-specificity estimates with corresponding standard errors were calculated. Summary estimates of sensitivity and specificity with corresponding 95% confidence intervals (CIs) were calculated by anti-logit transformation. Positive and negative likelihood ratios (LRs) were calculated from the mean logit-sensitivity and mean logit-specificity and the corresponding standard errors. The posttest probabilities were determined by Bayesian approach. Results: Twelve studies were included with a total of 778 patients aged 10–85 years. For pelvic nodes, summary estimates of sensitivity, specificity, LR+ and LR- were: 0.88 (95%CI: 0.40–0.99), 0.93 (95%CI: 0.85–0.97), 11.90 (95%CI: 5.32–26.62) and 0.13 (95%CI: 0.01–1.08). At the lowest prevalence of 0.15 the positive predictive value (PPV) and negative predictive value (NPV) were 0.68 and 0.98, at the highest prevalence of 0.65, 0.96 and 0.81. For the para-aortic nodes, the summary estimates of sensitivity, specificity LR+ and LR- were: 0.40 (95%CI: 0.18–0.66), 0.93 (95%CI: 0.91–0.95), 6.08 (95%CI: 2.90–12.78) and 0.64 (95%CI: 0.42–0.99), respectively. At the lowest prevalence of 0.17 the PPV and NPV were 0.55 and 0.88, at the highest prevalence of 0.50, 0.86 and 0.61. Conclusion: The PPV and NPV of [ 18F]FDG-PET(CT) showing lymph node metastases in patients with LACC improves with higher prevalence. Prevalence and predictive values should be taken into account when determining therapeutic strategies based on [ 18F]FDG-PET(CT).
Published: 2020

29. Grade 2 acute GVHD is a factor of good prognosis in patients receiving peripheral blood stem cells haplo-transplant with post-transplant cyclophosphamide

Author: Steven Le Gouill, Ana Berceanu, A. Dormoy, Patrice Chevallier, Yohan Desbrosses, Caroline Malugani, Céline Bressollette, Berthe-Marie Imbert, Benoit Tessoulin, Thomas Gastinne, Eric Deconinck, Beatrice Mahe, Nicolas Blin, Philippe Moreau, Thierry Guillaume, Marie C. Béné, Marion Eveillard, Sophie Vantyghem, Amandine Le Bourgeois, Alix Duquesne, Etienne Daguindau, Yannick Le Bris, Alice Garnier, Cyrille Touzeau, Viviane Dubruille, Anne Lok, and Pierre Peterlin
Subjects: Adult, Male, medicine.medical_specialty, Transplantation Conditioning, Post transplant cyclophosphamide, Graft vs Host Disease, Peripheral Blood Stem Cells, Gastroenterology, 030218 nuclear medicine & medical imaging, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Immune system, immune system diseases, Internal medicine, Acute graft versus host disease, medicine, Humans, Clofarabine, Radiology, Nuclear Medicine and imaging, In patient, Cyclophosphamide, Aged, Retrospective Studies, business.industry, Hematopoietic Stem Cell Transplantation, Hematology, General Medicine, Middle Aged, Prognosis, Peripheral blood, surgical procedures, operative, Oncology, 030220 oncology & carcinogenesis, Female, Good prognosis, business, medicine.drug
Abstract: The impact of acute graft versus host disease (GVHD) on survivals for patients receiving a haploidentical allogeneic stem-cell transplant (Allo-SCT) with peripheral blood stem-cells (PBSC) complemented by post-transplant cyclophosphamide (PTCY) is ill-known.This retrospective study included 131 patients who received a PBSC haplograft in order to precise the impact of acute GVHD on outcomes. There were 78 males and 53 females and the median age for the whole cohort was 59 years (range: 20-71). Thirty-five patients were allografted for a lymphoid disease and 96 for a myeloid malignancy, including 67 patients with acute myeloid leukemia (AML).The cumulative incidence (CI) of day 100 grade 2-4 and 3-4 acute GVHD was 43.4 + 4.6% and 16.7 + 3.4%, respectively. The 2-year CI of moderate/severe chronic GVHD was 10.1 + 2.8%. The only factor affecting the occurrence of GVHD was GVHD prophylaxis. Indeed, CI of day 100 grade 2-4 (but not grade 3-4) acute GVHD was significantly reduced when adding anti-thymoglobulin (ATG) to PTCY. However, in multivariate analysis, grade 2 acute GVHD was significantly associated with better disease-free (HR: 0.36; 95%CI: 0.19-0.69,Acute grade 2 GVHD is a factor of good prognosis after PBSC haplotransplant with PTCY. Further and larger studies are needed to clarify the complex question of GVHD prophylaxis in the setting of haplo-transplant, especially that of combining ATG and PTCY.
Published: 2020

30. ANALYSIS AND REAL-TIME VISUALIZATION OF GEO-SPATIAL DATA USING XDASH: APPLICATION TO FLAIR PROJECT

Author: A. El Feki, G. Berthe, M. Ben Gaid, and V. Rouchon
Subjects: Software visualization, lcsh:Applied optics. Photonics, business.industry, Computer science, lcsh:T, Real-time computing, lcsh:TA1501-1820, Context (language use), Gas emissions, lcsh:Technology, Methane, Visualization, Weather station, chemistry.chemical_compound, Data visualization, Data acquisition, Software, chemistry, lcsh:TA1-2040, Greenhouse gas, Global Positioning System, business, lcsh:Engineering (General). Civil engineering (General)
Abstract: The reduction of atmospheric greenhouse gas emissions is a major challenge. In this context, each natural or industrial release such as methane (CH4), carbon dioxide (CO2) has to be monitored, localized and quantified. IFP Energies nouvelles (IFPEN) is developing a mobile measurement system called Flair car whose purpose is the detection of different abnormal gas emissions. Flair car system incorporates various gas sensors, including a weather station and GPS (Global Positioning System) module, mounted on a plugin hybrid electric vehicle. This enables the real-time monitoring and the recording of geo-time-stamped gas concentration measurements. Flair map corresponds to the on board real-time visualization software.Flair map development required two important challenges: a quick and agile software modification capability together with a real-time display of measurements on maps. In order to meet these two challenges, we adopted a software rapid-prototyping approach based on the xDash tool. In this paper, our proposed real-time data visualisation approach is first introduced. Then, the rapid-prototyping development methodology which resulted in the Flair map software is described. Finally, two main operational usages of Flair map are illustrated. The first involves real-time visualization aboard the car of the maps representing data acquisition from gas concentration sensors. The second shows the a-posteriori analysis of measurement campaigns for the purpose of methane anomalies study.
Published: 2020

31. Access to health care for people with disabilities in rural Malawi: what are the barriers?

Author: Josephine A. K. Harrison, Stefanie Gregorius, Berthe Stenberg, Tim Marshall, Rachael Thomson, Hastings T Banda, and Grace Bongololo Mbera
Subjects: Adult, Male, Rural Population, Gerontology, medicine.medical_specialty, Malawi, wa_395, Health Services Accessibility, wa_20_5, 26bc6fb8, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Epidemiology, Health care, medicine, Humans, Disabled Persons, Rural, 030212 general & internal medicine, f0e481db, Qualitative Research, Disability, business.industry, Public health, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, wb_300, Outreach, Socioeconomic Factors, Impairment, Community health, Health care access, Female, Thematic analysis, Biostatistics, In-depth interviews, business, 030217 neurology & neurosurgery, Barriers, Research Article, Qualitative research
Abstract: Background People with disabilities experience significant health inequalities. In Malawi, where most individuals live in low-income rural settings, many of these inequalities are exacerbated by restricted access to health care services. This qualitative study explores the barriers to health care access experienced by individuals with a mobility or sensory impairment, or both, living in rural villages in Dowa district, central Malawi. In addition, the impact of a chronic lung condition, alongside a mobility or sensory impairment, on health care accessibility is explored. Methods Using data from survey responses obtained through the Research for Equity And Community Health (REACH) Trust’s randomised control trial in Malawi, 12 adult participants, with scores of either 3 or 4 in the Washington Group Short Set (WGSS) questions, were recruited. The WGSS questions concern a person’s ability in core functional domains (including seeing, hearing and moving), and a score of 3 indicates ‘a lot of difficulty’ whilst 4 means ‘cannot do at all’. People with cognitive impairments were not included in this study. All who were selected for the study participated in an individual in-depth interview and full recordings of these were then transcribed and translated. Results Through thematic analysis of the transcripts, three main barriers to timely and adequate health care were identified: 1) Cost of transport, drugs and services, 2) Insufficient health care resources, and 3) Dependence on others. Attitudinal factors were explored and, whilst unfavourable health seeking behaviour was found to act as an access barrier for some participants, community and health care workers’ attitudes towards disability were not reported to influence health care accessibility in this study. Conclusions This study finds that health care access for people with disabilities in rural Malawi is hindered by closely interconnected financial, practical and social barriers. There is a clear requirement for policy makers to consider the challenges identified here, and in similar studies, and to address them through improved social security systems and health system infrastructure, including outreach services, in a drive for equitable health care access and provision.
Published: 2020

32. Comparison of the ablation rates, fissures and fragments produced with 150 µm and 272 µm laser fibers with superpulsed thulium fiber laser: an in vitro study

Author: Olivier Traxer, Nicolas Kogane, Laurent Berthe, Pierre Lapouge, F. Panthier, Steeve Doizi, and Catherine Chaussain
Subjects: business.industry, Urology, medicine.medical_treatment, 030232 urology & nephrology, chemistry.chemical_element, Lithotripsy, Ablation, Laser, law.invention, 03 medical and health sciences, 0302 clinical medicine, Thulium, chemistry, Optical microscope, law, 030220 oncology & carcinogenesis, Fiber laser, medicine, Holmium, business, Lasing threshold, Biomedical engineering
Abstract: Holmium:YAG(Ho:YAG) is currently the standard for lithotripsy. Superpulsed Thulium Fiber Laser(TFL) has been evaluated as an alternative for lithotripsy, using laser fibers with core-diameters(CDF) down to 50 µm and additional available settings suitable for “dusting” technique. This in-vitro study compared ablation rates, fissures and fragments’ size with 150µmCDF or 272µmCDF with different laser settings using TFL and Ho:YAG. 150CDF and 272CDF were compared using three settings for TFL “fine dusting”(FD:0.15 J/100 Hz); “dusting”(D:0.5 J/30 Hz); “fragmentation”(Fr:1 J/15 Hz) and Ho:YAG(D and Fr). An experimental setup consisting of immerged 10 mm cubes of artificial hard(H) or soft(S) stone phantoms was used with a 20 s’ lasing time and a spiral trajectory, in contact mode. Fragments (acquired through sieves) and stones were observed under optical microscopy before three-dimensional scanning to measure fragments and fissures(DOF) mean diameters and ablation volumes. Ablation volumes in with 150CDF-TFL and 272CDF-TFL were higher than those for 272CDF-Ho:YAG in both “dusting” (twofold and threefold) and “fragmentation”(1,5-fold and twofold). “Fine dusting” ablation rates with 150CDF-TFL and 272CDF-TFL were respectively at least 1,5-fold and twofold higher than those for 272CDF-Ho:YAG in “dusting”. 150CDF produced significantly smaller DOF than 272CDF in all settings against S and H except in fragmentation. 150CDF produced lower fragments’ diameter than 272CDF in all settings except dusting. These preliminary studies demonstrate that at equal settings and CDF, TFL ablation rates are at least two-fold higher than those with Ho:YAG. 150CDF produces smaller fissures and fragments (that meets the definition of “dusting” lithotripsy) than 272CDF and higher ablation volumes than Ho:YAG.
Published: 2020

33. Heart failure after treatment for breast cancer

Author: Fran Duane, Carolyn W. Taylor, Michael Hauptmann, Caroline M. Seynaeve, Berthe M.P. Aleman, Sarah C. Darby, Naomi B. Boekel, Flora E. van Leeuwen, Gabe S. Sonke, Jourik A. Gietema, Angela H.E.M. Maas, Michael Schaapveld, Maartje J. Hooning, Judy N. Jacobse, Medical Oncology, Guided Treatment in Optimal Selected Cancer Patients (GUTS), and Damage and Repair in Cancer Development and Cancer Treatment (DARE)
Subjects: Oncology, Cancer Research, medicine.medical_treatment, TRASTUZUMAB, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], 030204 cardiovascular system & hematology, Anthracycline, Rate ratio, 0302 clinical medicine, Breast cancer, ADJUVANT CHEMOTHERAPY, Interquartile range, Trastuzumab, Anthracyclines, Radiation dose-response, Mastectomy, RISK, NCCTG N9831, Middle Aged, Radiation dose–response, Focus on Cardio‐oncology, CARDIOVASCULAR-DISEASE, Female, Cardiology and Cardiovascular Medicine, After treatment, medicine.drug, Research Article, RADIOTHERAPY, Adult, medicine.medical_specialty, Breast Neoplasms, Heart failure, ANTHRACYCLINE CARDIOTOXICITY, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Chemotherapy, business.industry, medicine.disease, Radiation therapy, Case-Control Studies, OLDER WOMEN, RADIATION, business, FOLLOW-UP
Abstract: Background: We aimed to develop dose–response relationships for heart failure (HF) following radiation and anthracyclines in breast cancer treatment, and to assess HF associations with trastuzumab and endocrine therapies. Methods and Results: A case–control study was performed within a cohort of breast cancer survivors treated during 1980–2009. Cases (n = 102) had HF as first cardiovascular diagnosis and were matched 1:3 on age and date of diagnosis. Individual cardiac radiation doses were estimated, and anthracycline doses and use of trastuzumab and endocrine therapy were abstracted from oncology notes. For HF cases who received radiotherapy, the estimated median mean heart dose (MHD) was 6.8 Gy [interquartile range (IQR) 0.9–13.7]. MHD was not associated with HF risk overall [excess rate ratio (ERR) = 1%/Gy, 95% confidence interval (CI) −2 to 10]. In patients treated with anthracyclines, exposure of ≥20% of the heart to ≥20 Gy was associated with a rate ratio of 5.7 (95% CI 1.7–21.7) compared to Conclusions: In absence of anthracyclines, breast cancer radiotherapy was not associated with increased HF risk. Strongly elevated HF risks were observed after treatment with anthracyclines and also after treatment with trastuzumab. The benefits of these systemic treatments usually exceed the risks of HF, but our results emphasize the need to support ongoing efforts to evaluate preventative strategies.
Published: 2020

34. Prognosis of acute coronary syndromes after radiotherapy for breast cancer

Author: Judy N. Jacobse, Maartje J. Hooning, Ilonca Vaartjes, Berthe M.P. Aleman, Lynnly Y. Boekel, Emiel J. Th. Rutgers, Josefien Buddeke, Angela H.E.M. Maas, Michael Schaapveld, Gabe S. Sonke, Caroline M. Seynaeve, Margreet H.A. Baaijens, Flora E. van Leeuwen, Nicola S. Russell, Naomi B. Boekel, Medical Oncology, and Radiation Oncology
Subjects: medicine.medical_specialty, medicine.medical_treatment, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Breast Neoplasms, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, Risk Factors, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Cumulative incidence, Myocardial infarction, Breast, Acute Coronary Syndrome, Aged, Proportional Hazards Models, business.industry, Hazard ratio, Confounding, Hematology, medicine.disease, Prognosis, Confidence interval, Radiation therapy, Oncology, 030220 oncology & carcinogenesis, Cohort, business
Abstract: Breast cancer patients treated with radiotherapy are at increased risk of subsequent acute coronary syndromes (ACS). We aimed to study if radiotherapy also influences the prognosis of these ACS.We included all 398 patients diagnosed with ACS following radiotherapy from our hospital-based cohort of early breast cancer patients aged71 years, treated 1970-2009. Cardiovascular disease incidence and cause of death were acquired through questionnaires to general practitioners and cardiologists. Internal mammary chain (IMC) irradiation delivers the highest heart doses in breast cancer radiotherapy. Hence, we compared ACS prognosis between patients treated with/without IMC-irradiation. ACS prognosis was assessed through cardiac death, death due to ACS and cardiovascular disease incidence, using multivariable Cox proportional hazard models and by estimating cumulative incidence.In total, 62% of patients with ACS had received IMC-irradiation and 38% did not (median age at ACS diagnosis, 67 years). Median time between breast cancer and ACS was 15 years. After ACS, ten-year cumulative risk of cardiac death was 35% for patients who had IMC-irradiation (95% confidence interval [95%CI] 29-41) compared to 24% (95%CI 17-31) for patients without IMC-irradiation (p = 0.04). After correction for confounders, IMC-irradiation remained associated with a less favourable prognosis of ACS compared to no IMC-irradiation (hazard ratio cardiac death = 1.7, 95%CI 1.1-2.5).Our results suggest that radiotherapy, in case of substantial heart doses,may worsen ACS prognosis. This is an important, novel finding that may impact upon the risk-based care for breast cancer survivors with ACS.
Published: 2020

35. E-tourism in developing and underdeveloped countries: Case of Cameroon

Author: Idriss Thierry Tchamy, Berthe Cyrielle Maloum Koubikat, Joseph Ateba, and Jonathan Tchamy
Subjects: 0301 basic medicine, Economic growth, Energy resources, 030106 microbiology, Developing country, 03 medical and health sciences, 030104 developmental biology, Strategic partnership, Information and Communications Technology, Social media, Business, China, Developed country, Tourism
Abstract: Tourism is a fragmented yet most popular sector worldwide. The involvement of ICT and social media in a tourism sector is now very popular in developed countries, meanwhile developing countries are still struggling on the implementation of the e-tourism in their respectively countries. The aim of this study is to provide an understanding of the related concepts and research foundation on E-tourism, and make an overview of E-tourism in several developing countries, then compare Cameroon’s E-tourism industry performances with China’s industry follow by the investigation of the major determinants of E-tourism adoption in Cameroon and recommendations for better E-tourism development in developing and underdeveloped countries like Cameroon. Differences between China and Cameroon are: cultural difference and environment differences. Opportunities between China and Cameroon are: creation of job opportunities and development of infrastructures that would benefit the tourism industry under the belt and road initiative. It is found that China’s presence in Africa is very important ,also China has shown a growing interest in open up new markets and investments opportunities and accessing the energy resources of Africa in return it has offers credits opportunities, development assistance as well as strategic partnerships with African governments and they are equally interested in collaborating with Cameroon as they look for new businesses opportunities and ways to boost regime stability specially by developing the tourism industry.
Published: 2020

36. Clinicopathological features and risk factors for developing colorectal neoplasia in Hodgkin's lymphoma survivors

Author: Richard W.M. van der Maazen, Manon C.W. Spaander, Michael Schaapveld, Leon M G Moons, Flora E. van Leeuwen, Jan de Boer, Cecile P.M. Janus, Petur Snaebjornsson, Pieternella J. Lugtenburg, Tanya M. Bisseling, Evelien Dekker, Ernst J. Kuipers, Monique E. van Leerdam, Judith M. Roesink, Lisanne S. Rigter, Beatriz Carvalho, Berbel L. M. Ykema, Eefke Petersen, Berthe M.P. Aleman, Gerrit A. Meijer, Wieke H. M. Verbeek, Gastroenterology and Hepatology, CCA - Cancer Treatment and Quality of Life, Amsterdam Gastroenterology Endocrinology Metabolism, Gastroenterology & Hepatology, and Hematology
Subjects: Adult, medicine.medical_specialty, Colorectal cancer, DNA mismatch repair, Colonoscopy, Procarbazine, Asymptomatic, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Risk Factors, colonoscopy, Internal medicine, medicine, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], Humans, cancer survivors, Radiology, Nuclear Medicine and imaging, Survivors, medicine.diagnostic_test, Hodgkin's lymphoma, business.industry, Odds ratio, Middle Aged, colorectal neoplasms, medicine.disease, Hodgkin Disease, Dysplasia, 030220 oncology & carcinogenesis, Cohort, 030211 gastroenterology & hepatology, medicine.symptom, business, medicine.drug, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Abstract: Contains fulltext : 249566.pdf (Publisher’s version ) (Open Access) BACKGROUND: Hodgkin's lymphoma (HL) survivors treated with abdominal radiotherapy and/or procarbazine have an increased risk of developing colorectal neoplasia. AIMS: We evaluated the clinicopathological characteristics and risk factors for developing (advanced) neoplasia (AN) in HL survivors. METHODS: In all, 101 HL survivors (median age 51 years, median age of HL diagnosis 25 years) underwent colonoscopy and 350 neoplasia and 44 AN (classified as advanced adenomas/serrated lesions or colorectal cancer), mostly right-sided, were detected, as published previously. An average-risk asymptomatic cohort who underwent screening colonoscopy were controls (median age 60 years). Clinicopathological characteristics of AN were evaluated in both groups. Mismatch repair (MMR) status was assessed using immunohistochemistry (MLH1/MSH2/MSH6/PMS2). Logistic regression analysis was performed to evaluate the risk factors for AN in HL survivors, including age at HL diagnosis and interval between HL and colonoscopy. RESULTS: In 101 colonoscopies in HL survivors, AN was primarily classified based on polyp size ≥10 mm, whereas (high-grade)dysplasia was more often seen in AN in controls. An interval between HL diagnosis and colonoscopy >26 years was associated with more AN compared with an interval of
Published: 2022

37. Évaluation de la mise en œuvre de la stratégie de gratuité des actes et des médicaments dans le district sanitaire de Bourem au Mali en 2014

Author: I Berthé, B Sanogo, T Diall, O Berthe, B Sidibé, M Berthé, AN Koné, and M Diabate
Subjects: Medical services, business.industry, medicine, Economic shortage, Retrospective cohort study, Christian ministry, Monitoring and evaluation, Medical emergency, medicine.disease, business, Test (assessment)
Abstract: Introduction : Instaurée dans les régions du nord par la lettre circulaire n°0700 / MS-SG du Ministère de la santé, en date du 21 mai 2012, la politique de gratuité des actes et médicaments fait suite à la crise sécuritaire que le Mali a connu en 2012. Sa mise en œuvre dans le district sanitaire de Bourem a été confrontée à des difficultés d'où son évaluation. Matériel et méthodes : Une étude rétrospective a permis de collecter les données des rapports de 2011 et 2014 suivi d'un entretien avec les usagers / acteurs de la mise en œuvre soit 455 participants. Ces données ont permis de comparer certains indicateurs des périodes de 2011 et de 2014 avec un test de khi-deux d'une part et d'analyser celle de 2014 d'autre part. Résultats : Nous avions trouvé que les indicateurs de consultation médicale et prénatale premier contact de 2014 étaient meilleurs comparés à ceux de 2011. Le taux de rupture des médicaments du panier commun était élevé en 2014, soit 45% contre un taux national de 20% pour la même année. Sur l'ensemble des usagers enquêtés, 65,5% trouvaient que la gratuité de la consultation curative était effective et 56,9% trouvaient que celle des médicaments l'était aussi. Conclusion : Au terme de l'étude, cette politique a été jugée peu satisfaisante par les agents de santé et les maires, par contre la majorité des usagers (81,9%) et des ASACO (76,9%) trouvait qu'elle doit continuer. Le suivi- évaluation est indispensable pour la réussite de cette politique.
Published: 2019

38. Etude comparative des infections du site opératoire : césarienne systématique versus césarienne itérative au centre de sante de référence de la commune V du district de Bamako/Mali

Author: Issa Konaté, D Goita, Ibrahim Teguete, O Oulale, Sounkalo Dao, Ba Berthe, O Koné, Saoudatou Tall, Youssouf Traore, Dramane Sogoba, Soumana Oumar Traoré, A Samaké, S. Doumbia, and Mamadou Traoré
Subjects: Gynecology, Bamako, medicine.medical_specialty, business.industry, Mean age, Amoxicillin, medicine.disease, Microbiology, infection, QR1-502, site_opératoire, Risk class, Césarienne, Antibiotic therapy, Surgical site, medicine, Chi-square test, Medicine, Maternal death, Antibiotic prophylaxis, business, medicine.drug
Abstract: Introduction : L'objectif était de déterminer la fréquence, les aspects cliniques et thérapeutiques des infections du site opératoire (ISO) chez les césariennes itératives (utérus cicatriciels) versus césariennes systématiques (utérus sains). Matériel et méthode : Etude rétrospective et comparative du 1er janvier 2013 au 31 décembre 2017. Tous les cas de césariennes itératives et systématiques avec infections du site opératoire ont été inclus. L'analyse des données a été effectuée sur le logiciel SPSS. Le khi2 avec un seuil significatif de p < 0,05 a été utilisé. Résultats : Au total sur 10281 césariennes, 4318 étaient itératives et 5923 systématiques. Les infections du site opératoire ont été retrouvées chez 540(5,25%) dont 180 itératives et 360 systématiques (p=0,0000). L'âge moyen était de 26 ans. Conformément aux politiques, normes et procédures en vigueur au Mali, toutes les patientes césarisées ont été soumises à une antibioprophylaxie systématique à base d'Amoxicilline. La suppuration superficielle a été retrouvée chez 115(64%) utérus cicatriciels contre 192(53,33%) utérus sains (p=0,019). 170(94,44%) utérus cicatriciels et 304(84,44%) utérus sains étaient de la classe II de risque d'Altemeier avec p=0,000. 170(94,44%) utérus cicatriciels et 304(84,44%) utérus sains avaient le score zéro de NNISS. Staphylocoques sp et Escherichia coli ont été isolés respectivement dans 31,44%(77) et 16,94%(53). L'antibiothérapie était adaptée à l'antibiogramme. La durée moyenne d'hospitalisation était de 17,5 jours. Aucun décès maternel n'a été enregistré liés aux ISO. Conclusion : les ISO post césariennes restent élevées en commune V de Bamako.
Published: 2019

39. GPUCorrel: A GPU accelerated Digital Image Correlation software written in Python

Author: Pauline Lecomte-Grosbras, Jean-François Witz, Victor Couty, Mathias Brieu, E. Deletombe, Julien Berthe, Laboratoire de Mécanique, Multiphysique, Multiéchelle - UMR 9013 (LaMcube), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), DMAS, ONERA [Lille], ONERA, and California State University [Los Angeles] (CAL STATE LA)
Subjects: Digital image correlation, Computer science, Computation, GPU, CUDA, 02 engineering and technology, Mechanics, 01 natural sciences, Field (computer science), Strain, 010309 optics, QA76.75-76.765, DIC, [SPI]Engineering Sciences [physics], Software, 0203 mechanical engineering, Computer graphics (images), Digital Image Correlation, 0103 physical sciences, [CHIM]Chemical Sciences, Computer software, Projection (set theory), computer.programming_language, [PHYS]Physics [physics], Experimental mechanics, Measurement, business.industry, Python (programming language), Base (topology), Computer Science Applications, 020303 mechanical engineering & transports, business, computer, Python
Abstract: International audience; This article presents an open-source Integrated Digital Image Correlation (I-DIC) software written in Python using CUDA-enabled GPUs designed to run at high (1-100 Hz) frequency. The field computation is performed using a global approach and the result is a projection of the real field in a user-defined base of fields. This software can be used in many applications and one use in experimental mechanics is demonstrated by driving a bi-axial tensile test on a cruciform specimen.
Published: 2021

40. Laser interaction in a water tank configuration: Higher confinement breakdown threshold and greater generated pressures for laser shock peening

Author: Yann Rouchausse, Olivier Castelnau, Alexandre Rondepierre, Laurent Berthe, Olivier Casagrande, Laurent Videau, Laboratoire Procédés et Ingénierie en Mécanique et Matériaux (PIMM), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Thales LAS France, Laboratoire Matière sous Conditions Extrêmes (LMCE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, and ANR-18-CE08-0026,ForgeLaser,Traitement par Choc laser pour surfaces claustrées(2018)
Subjects: Materials science, Plasmas [Sciences de l'ingénieur], Biomedical Engineering, Atmospheric-pressure plasma, 02 engineering and technology, Sciences de l'ingénieur, 01 natural sciences, law.invention, [SPI]Engineering Sciences [physics], Optics, law, Ionization, 0103 physical sciences, Electronic, Atomic and molecular physics, Optical and Magnetic Materials, Laser-induced plasma, Instrumentation, 010302 applied physics, Water breakdown, business.industry, [SPI.PLASMA]Engineering Sciences [physics]/Plasmas, Pulse duration, Peening, Plasma, VISAR analysis, 021001 nanoscience & nanotechnology, Laser, water tank configuration, Pressure record, Atomic and Molecular Physics, and Optics, Avalanche breakdown, Electronic, Optical and Magnetic Materials, Shock (mechanics), plasma breakdown, 0210 nano-technology, business, Laser shock application
Abstract: International audience; The authors present a new configuration for laser-induced plasmas in confined regimes for a 10 ns-range laser pulse in the green wavelength (532 nm) that repulses the breakdown threshold above 20 GW/cm2 compared to 8 GW/cm2 as generally indicated in previous works. Using this new configuration, pressures above 12 GPa have been reached for the first time in confined regimes. This can enlarge the range of appli-cations of laser shock such as the range of treatable materials (very high strength materials) or facilities’ costs since neither vacuum nor heavy laser systems will be needed to reach these levels of pressure. The proposed configuration mainly consists of the usage of a water tank. Hence, a great thickness of water is used instead of the extensively used thin water layer. Therefore, the water breakdown plasma will not ini-tiate at the surface of the water, as the laser beam is still not focused there. Instead, it will occur in the depth of the water. In that case, the breakdown threshold value is increased as either the avalanche breakdown or the multiphoton ionization may start at higher laser intensities than at the air/water interface. The authors experimentally demonstrated this new breakdown threshold with the measurement of transmit-ted intensity, transmitted pulse duration, and the indirect measurement of the plasma pressure. Multiple shots (laser shock treatment) were also performed, and the specimen surface deformation was measured, leading to the same conclusion.
Published: 2021

41. Macrolide-associated ototoxicity: A cross-sectional and longitudinal study to assess the association of macrolide use with tinnitus and hearing loss

Author: M. Arfan Ikram, Berthe C Oosterloo, Nelly F Ly, André Goedegebure, Anna Vanoverschelde, Lies Lahousse, Bruno H. Stricker, Epidemiology, and Otorhinolaryngology and Head and Neck Surgery
Subjects: Microbiology (medical), Longitudinal study, medicine.medical_specialty, Hearing loss, Population, AZITHROMYCIN, PROGRESSION, Logistic regression, Tinnitus, 03 medical and health sciences, Rotterdam Study, 0302 clinical medicine, ERYTHROMYCIN, Ototoxicity, SDG 3 - Good Health and Well-being, Internal medicine, AGING POPULATION, Medicine and Health Sciences, medicine, otorhinolaryngologic diseases, AcademicSubjects/MED00740, Humans, Pharmacology (medical), Longitudinal Studies, 030212 general & internal medicine, Hearing Loss, education, Original Research, RISK, Pharmacology, education.field_of_study, Absolute threshold of hearing, business.industry, IMPAIRMENT, medicine.disease, PREVALENCE, Anti-Bacterial Agents, AcademicSubjects/MED00290, Cross-Sectional Studies, Infectious Diseases, Macrolides, medicine.symptom, AcademicSubjects/MED00230, business, 030217 neurology & neurosurgery
Abstract: Background Macrolides are widely prescribed antibiotics for many different indications. However, there are concerns about adverse effects such as ototoxicity. Objectives To investigate whether macrolide use is associated with tinnitus and hearing loss in the general population. Methods Cross-sectional (n = 4286) and longitudinal (n = 636) analyses were performed within the population-based Rotterdam Study. We investigated with multivariable logistic regression models the association between macrolides and tinnitus, and with multivariable linear regression models the association between macrolides and two different hearing thresholds (both ears, averaged over 0.25, 0.5, 1, 2, 4 and 8 kHz and 2, 4 and 8 kHz). Both regression models were adjusted for age, sex, systolic blood pressure, alcohol, smoking, BMI, diabetes, education level, estimated glomerular filtration rate and other ototoxic or tinnitus-generating drugs. Cumulative exposure to macrolides was categorized according to the number of dispensed DDDs and duration of action. Results In the fully adjusted model, ever use of macrolides was associated with a 25% higher likelihood of prevalent tinnitus (OR = 1.25; 95% CI 1.07–1.46). This association was more prominent in participants with a cumulative dose of more than 14 DDDs and among users of intermediate- or long-acting macrolides. Macrolide use in between both assessments was associated with more than a 2-fold increased risk on incident tinnitus. No general association between macrolides and hearing loss was observed. A borderline significant higher hearing threshold in very recent users (≤3 weeks) was found. Conclusions Macrolide use was significantly associated with both prevalent and incident tinnitus. Macrolide-associated tinnitus was likely cumulative dose-dependent.
Published: 2021

42. Safety and antibody response after one and/or two doses of BNT162b2 Anti‐SARS‐CoV‐2 mRNA vaccine in patients treated by CAR T cells therapy

Author: Anne Lok, Pierre Peterlin, Viviane Dubruille, Steven Le Gouill, Sophie Vanthygem, Marianne Coste-Burel, Patrice Chevallier, Benoit Tessoulin, Berthe-Marie Imbert, Marie C. Béné, Nicolas Blin, Philippe Moreau, Thomas Drumel, Alice Garnier, Thierry Guillaume, Amandine Le Bourgeois, Beatrice Mahe, Maxime Jullien, Thomas Gastinne, Cyrille Touzeau, Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Immunobiology of Human αβ and γδ T Cells and Immunotherapeutic Applications (CRCINA-ÉQUIPE 1), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Bernardo, Elizabeth, Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), and Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)
Subjects: Male, Antibodies, Viral, Immunotherapy, Adoptive, Immunogenicity, Vaccine, 0302 clinical medicine, vaccine, Antineoplastic Combined Chemotherapy Protocols, Medicine, CAR‐T cells, 030212 general & internal medicine, Antigens, Viral, ComputingMilieux_MISCELLANEOUS, Receptors, Chimeric Antigen, Lymphoma, Non-Hodgkin, Vaccination, Hematopoietic Stem Cell Transplantation, Hematology, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, SARS-CoV-2 mRNA, Combined Modality Therapy, 3. Good health, 030220 oncology & carcinogenesis, Spike Glycoprotein, Coronavirus, Female, Car t cells, COVID 19, Adult, 2019-20 coronavirus outbreak, Fever, Coronavirus disease 2019 (COVID-19), CAR-T cells, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunization, Secondary, Receptors, Antigen, T-Cell, Pain, [SDV.CAN]Life Sciences [q-bio]/Cancer, SARS‐CoV‐2 mRNA, Immunocompromised Host, Young Adult, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Correspondence, Humans, In patient, BNT162 Vaccine, Aged, Biological Products, Messenger RNA, SARS-CoV-2, business.industry, COVID-19, Virology, Antibody response, Immunoglobulin G, BNT162b2, business
Abstract: International audience; No abstract available
Published: 2021

43. Tinnitus and Its Central Correlates: A Neuroimaging Study in a Large Aging Population

Author: Meike W. Vernooij, M. Arfan Ikram, Gennady V. Roshchupkin, Robert J. Baatenburg de Jong, André Goedegebure, Pauline H. Croll, Berthe C Oosterloo, Otorhinolaryngology and Head and Neck Surgery, Radiology & Nuclear Medicine, and Epidemiology
Subjects: Male, Aging, medicine.medical_specialty, Hearing loss, Population, Neuroimaging, Audiology, White matter, Tinnitus, Speech and Hearing, Rotterdam Study, Magnetic resonance imaging of the brain, medicine, otorhinolaryngologic diseases, Humans, Gray Matter, education, Aged, education.field_of_study, medicine.diagnostic_test, business.industry, Brain, Magnetic Resonance Imaging, White Matter, Confidence interval, medicine.anatomical_structure, Otorhinolaryngology, Female, medicine.symptom, business
Abstract: Objectives: To elucidate the association between tinnitus and brain tissue volumes and white matter microstructural integrity. Design: Two thousand six hundred sixteen participants (mean age, 65.7 years [SD: 7.5 years]; 53.9% female) of the population-based Rotterdam Study underwent tinnitus assessment (2011 to 2014) and magnetic resonance imaging of the brain (2011 to 2014). Associations between tinnitus (present versus absent) and total, gray, and white matter volume and global white matter microstructure were assessed using multivariable linear regression models adjusting for demographic factors, cardiovascular risk factors, depressive symptoms, Mini-Mental State Examination score, and hearing loss. Finally, potential regional gray matter density and white matter microstructural volume differences were assessed on a voxel-based level again using multivariable linear regression. Results: Participants with tinnitus (21.8%) had significantly larger brain tissue volumes (difference in SD, 0.09; 95% confidence interval, 0.06 to 0.13), driven by larger white matter volumes (difference, 0.12; 95% confidence interval, 0.04 to 0.21) independent of hearing loss. There was no association between tinnitus and gray matter volumes nor with global white matter microstructure. On a lobar level, tinnitus was associated with larger white matter volumes in each lobe, not with gray matter volume. Voxel-based results did not show regional specificity. Conclusions: We found that tinnitus in older adults was associated with larger brain tissue volumes, driven by larger white matter volumes, independent of age, and hearing loss. Based on these results, it may be hypothesized that tinnitus potentially has a neurodevelopmental origin in earlier life independent of aging processes.
Published: 2021

44. Novel Confinement Possibility for Laser Shock: Use of Flexible Polymer Confinement at 1064 nm Wavelength

Author: M. Ayad, Yann Rouchausse, Corentin Le Bras, Alexandre Rondepierre, Stéphane Valadon, Laurent Berthe, Matthieu Gervais, Laboratoire Procédés et Ingénierie en Mécanique et Matériaux (PIMM), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM), Airbus Operation S.A.S., Airbus [France], and Thales LAS France
Subjects: Finite element method, Materials science, Polymers, Water flow, finite element method, 02 engineering and technology, Sciences de l'ingénieur, 01 natural sciences, Velocity interferometer system for any reflector, law.invention, polymer confinement, VISAR measurement, [SPI]Engineering Sciences [physics], law, 0103 physical sciences, General Materials Science, Laser shock peening, polymers, 010302 applied physics, Mining engineering. Metallurgy, business.industry, Metals and Alloys, TN1-997, Peening, 021001 nanoscience & nanotechnology, Laser, Characterization (materials science), Shock (mechanics), Wavelength, laser shock peening, Optoelectronics, Polymer confinement, 0210 nano-technology, business
Abstract: International audience; Through the years, laser shock peening became a treatment of choice in the aerospace industry to prolong the life of certain critical pieces. Water flow is commonly used as a confinement to improve the process capability but some applications cannot allow for water presence in the area of interest. In a previous article, an alternative to the water confinement was presented, a flexible polymer confinement was used and demonstrated the production of pressures equivalent to the water configuration treatment. However, laser parameters have been restricted to a wavelength in the visible range at 532 nm. In this paper, the study is extended to 1064 nm which is commonly used in LSP applications and with two different pulse durations. A 1064 nm near infra-red laser is used to do pressure characterization of shots with polymer confinement through Velocity Interferometer System for Any Reflector (VISAR) measurements coupled with Finite Element Modelling on Abaqus software. The results show that the pressures produced by the confinement is slightly lower with the 1064 nm wavelength, similar to what is observed with the classic water confined regime when switching from 532 nm to a near infra-red wavelength. Nevertheless, the high level of pressure produced by laser shock under the polymer confinement configuration allows for the treatment of common types of metal alloys used in the aerospace industry. Although the use of such a confinement has yet to be applicable to peening setups, it has already uses in some single shot configurations such as LasAT where it allows the avoidance of the water flow optimization.
Published: 2021

45. Demographic and Clinical Characteristics Associated With Severity, Clinical Outcomes, and Mortality of COVID-19 Infection in Gabon

Author: Avelin Fobang Aghokeng, Pascal Pineau, Berthe Amélie Iroungou, Laurette Guignali Mangouka, Farrel Nzigou Boucka, Jean Raymond Nzenze, Pamela Moussavou-Boundzanga, Berthold Bivigou-Mboumba, Judicaël Obame-Nkoghe, Romain Tchoua, Augustin Mouinga-Ondémé, Centre International de Recherches Médicales de Franceville (CIRMF), Service de Médecine Interne, Hôpital d'Instruction des Armées Omar Bongo Ondimba, Université des Sciences et Techniques de Masuku [Franceville, Gabon] (USTM), Agence Gabonaise d'Etudes et d'Observations Spatiales, Génétique et évolution des maladies infectieuses (GEMI), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Service de Réanimation, Hôpital d'Instruction des Armées Omar Bongo Ondimba, Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by the Gabonese government (Prof Tchoua and Prof Nzenze)., We are grateful to all patients involved in this study. We also acknowledge Remi Charlebois, MS (GSSHealth), for attentive review of the manuscript. He was not paid for this contribution., Pineau, Pascal, Université des Sciences et Techniques de Masuku (USTM), and Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC)
Subjects: Adult, Male, Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Cross-sectional study, Central china, Severity of Illness Index, Risk Factors, Interquartile range, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Diabetes mellitus, Severity of illness, parasitic diseases, Diabetes Mellitus, Medicine, Humans, Gabon, Risk factor, Pandemics, Developing Countries, Demography, Original Investigation, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, business.industry, SARS-CoV-2, Mortality rate, Research, Age Factors, COVID-19, General Medicine, Middle Aged, medicine.disease, Online Only, Cross-Sectional Studies, Infectious Diseases, Africa, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, business
Abstract: This cross-sectional study describes the clinical characteristics and outcomes of patients with COVID-19 infection in Gabon from March to June 2020., Key Points Question What were the epidemiologic and clinical aspects of patients with COVID-19 infection in the Armed Forces Hospital in Libreville, Gabon, from March to June 2020? Findings In this cross-sectional study of 837 patients with COVID-19 in Gabon, 63% had no symptoms. Severity of disease and mortality were associated with advanced age and advanced stage of lung damage. Meaning Findings from this observational study provide preliminary data for use in future epidemiologic studies of COVID-19 in Gabon., Importance Since the emergence of COVID-19 in central China, sub-Saharan African countries, with the exception of South Africa, have been relatively spared during the COVID-19 pandemic. Consequently, few descriptive studies from this region are available. Objective To describe the clinical characteristics and outcomes of patients with COVID-19 infection in Gabon, from March to June 2020. Design, Setting, and Participants A single-center, cross-sectional study of 837 patients with COVID-19 was conducted from March to June 2020 in the Armed Forces Hospital in Libreville, Gabon. Main Outcomes and Measures Demographic and clinical characteristics and imaging findings of hospitalized patients with COVID-19. Results Of the 837 patients enrolled, 572 (68.3%) were men, and 264 (31.5%) were women (male to female ratio, 2:1); the median (interquartile range [IQR]) age was 35 (30-45) years (mean [SD] age, 38.0 [12.2] years. The mortality rate associated with COVID-19 was low (1.4%). Of these 837 patients, 524 (62.6%) were categorized as having no symptoms, 282 (33.7%) as having mild symptoms, and 31 (3.7%) as having severe symptoms. Patients with severe symptoms were older (mean [SD] age, 46.1 [14.7] years) than patients with mild symptoms (mean [SD] age, 41.3 [12.5] years) and those with no symptoms (mean [SD] age, 35.7 [11.3] years) (Kruskal-Wallis χ22 = 53.5; P
Published: 2021

46. Sensitivity, Specificity, and Public-Health Utility of Clinical Case Definitions Based on the Signs and Symptoms of Cholera in Africa

Author: Atek Kagirita, Godfrey Bwire, Guy Mutombo Ndongala, Daouda Coulibaly, Cynthia Semá Baltazar, Adèle Kacou N’douba, Martin A. Mengel, Lamine Koivogui, Abiba Banla Kere, Johara Nadri, Elibariki R. Mwakapeje, Sakoba Keita, José Paulo Langa, Berthe Miwanda, Berthe Marie Njanpop-Lafourcade, Bradford D. Gessner, Delphine Sauvageot, Dadja Essoya Landoh, and Jacob L. Mwambeta
Subjects: Adult, Diarrhea, Male, medicine.medical_specialty, Adolescent, 030231 tropical medicine, medicine.disease_cause, Sensitivity and Specificity, Disease Outbreaks, Feces, Young Adult, 03 medical and health sciences, 0302 clinical medicine, food, Cholera, Virology, Internal medicine, Positive predicative value, medicine, Humans, 030212 general & internal medicine, Child, Vibrio cholerae, business.industry, Public health, Infant, Outbreak, Articles, Gold standard (test), Middle Aged, Rice water, medicine.disease, food.food, Infectious Diseases, Child, Preschool, Africa, Epidemiological Monitoring, Female, Parasitology, Public Health, Symptom Assessment, medicine.symptom, business
Abstract: During 2014, Africa reported more than half of the global suspected cholera cases. Based on the data collected from seven countries in the African Cholera Surveillance Network (Africhol), we assessed the sensitivity, specificity, and positive and negative predictive values of clinical cholera case definitions, including that recommended by the World Health Organization (WHO) using culture confirmation as the gold standard. The study was designed to assess results in real-world field situations in settings with recent cholera outbreaks or endemicity. From June 2011 to July 2015, a total of 5,084 persons with suspected cholera were tested for Vibrio cholerae in seven different countries of which 35.7% had culture confirmation. For all countries combined, the WHO case definition had a sensitivity = 92.7%, specificity = 8.1%, positive predictive value = 36.1%, and negative predictive value = 66.6%. Adding dehydration, vomiting, or rice water stools to the case definition could increase the specificity without a substantial decrease in sensitivity. Future studies could further refine our findings primarily by using more sensitive methods for cholera confirmation.
Published: 2018

47. Demographics and outcomes of laboratory-confirmed COVID-19 cases during the first epidemic wave in Senegal

Author: Diop Sa, Martin Martinot, Adama Berthe, Agbogbenkou Tevi Déla-dem Lawson, Fulgence Abdou Faye, Madoky Maguette Diop, Papa Alassane Diaw, Christian Kempf, and Mamour Dieng
Subjects: Adult, Male, Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Demographics, Disease, Asymptomatic, Article, law.invention, law, Quarantine, Case fatality rate, medicine, Humans, Epidemics, Retrospective Studies, business.industry, SARS-CoV-2, Incidence (epidemiology), Incidence, Asymptomatic infection, COVID-19, Retrospective cohort study, Senegal, Infectious Diseases, Female, medicine.symptom, business, Laboratories
Abstract: Background Few studies have focused on the effects of COVID-19 on African populations. During the first epidemic wave in Senegal (May 1 to July 31, 2020), COVID-19 cases were isolated in treatment centers of epidemics (TCEs). We described the demographics and outcomes of COVID-19 cases in TCEs. Patients and methods All cases with laboratory-confirmed COVID-19 in Thies medical region of Senegal were included. Results COVID-19 was confirmed in 600 cases. Median age of cases (men: 357, 59.5%; women: 243, 40.5%) was 34.0 years. The incidence was 12 per 100,000 inhabitants per month. Overall, 46 (7.7%) cases had a severe or critical form of the disease, and nine of them died. Of 455 cases quarantined in non-hospital TCEs, 340 (74.7%) had no symptom and 115 (25.3%) had mild or moderate symptoms. Conclusion In this African retrospective cohort, COVID-19 cases were young and mostly asymptomatic with a low case fatality rate.
Published: 2021

48. Single-Electron Tunneling PbS/InP Heterostructure Nanoplatelets for Synaptic Operations

Author: Louis Biadala, Maxime Berthe, Y. Lambert, Jin Ho Kim, Jimmy Xu, Richard M. Osgood, Gilles Patriarche, Bruno Grandidier, Paulo F. Jarschel, Physique - IEMN (PHYSIQUE - IEMN), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Plateforme de Caractérisation Multi-Physiques - IEMN (PCMP - IEMN), National Renewable Energy Laboratory (NREL), Centre de Nanosciences et de Nanotechnologies (C2N), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), support from NSF CMMI 1530547, AFOSR FA9550-19-1-0355, and ARO W911NF-14-2-0075. European Community’s H2020 Program (grant no. PITN-GA-2016-722176, 'Indeed' Project),EQUIPEX programs Excelsior (grant no. ANR-11-EQPX-0015)Tempos (grant no. ANR-10-EQPX-0050), and the RENATECH network. We are grateful to D. Pavlidis and G. Dambrine for initiating and enabling the France–USA collaborations. We thank X. Wallart for the XPS analysis., Renatech Network, PCMP PCP, ANR-11-EQPX-0015,Excelsior,Centre expérimental pour l'étude des propriétés des nanodispositifs dans un large spectre du DC au moyen Infra-rouge.(2011), and European Project: 722176,H2020, H2020-MSCA-ITN-2016,INDEED(2017)
Subjects: 0303 health sciences, Materials science, Fabrication, business.industry, Scanning tunneling spectroscopy, Heterojunction, 02 engineering and technology, 021001 nanoscience & nanotechnology, Epitaxy, 7. Clean energy, 03 medical and health sciences, [SPI]Engineering Sciences [physics], Neuromorphic engineering, Scalability, Optoelectronics, General Materials Science, 0210 nano-technology, business, Nanoscopic scale, Quantum tunnelling, 030304 developmental biology
Abstract: International audience; Power consumption, thermal management, and wiring challenge of the binary serial architecture drive the search for alternative paradigms to computing. Of special interest is neuromorphic computing, in which materials and device structures are designed to mimic neuronal functionalities with energy-efficient non-linear responses and both short- and long-term plasticities. In this work, we explore and report on the enabling potential of single-electron tunneling (SET) in PbS nanoplatelets epitaxially grown in the liquid phase on InP, which present these key features. By extrapolating the experimental data in the SET regime, we predict and model synaptic operations. The low-energy (
Published: 2021

49. Characteristics and outcomes of patients with laboratory-confirmed COVID-19 during the first wave in Senegal

Author: Adama Berthe, Agbogbenkou Tevi Déla-dem Lawson, Mamour Dieng, Fulgence Abdou Faye, Martin Martinot, Madoky Maguette Diop, Diop Sa, Christian Kempf, and Papa Alassane Diaw
Subjects: Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Medicine, business
Abstract: BackgroundFew studies have focused on the effects of coronavirus disease 2019 (COVID-19) on African populations. During the first wave (May 1, 2020 to July 31, 2020), all patients with laboratory-confirmed COVID-19 in the Thiès medical region of Senegal were isolated in two types of treatment centers of epidemics (TCEs): hospitals (hTCEs) or out-of-hospital TCE (oTCEs). We have described the demographic characteristics and outcomes of patients in TCEs.MethodsResultsA total 600 cases of COVID-19 were diagnosed. The median age of the patients was 34.0 years; 357 (59.5%) were men and 243 (40.5%) were women. The incidence of reverse transcriptase polymerase chain reaction (RT-PCR)–positive findings of COVID-19 was 12 per 100,000 inhabitants per month. Forty-six (7.7%) patients with severe or critical disease and 99 (16.5%) patients with high-risk conditions and nonsevere disease were hospitalized in hTCEs; 455 (75.8%) patients were quarantined in the oTCEs. In hTCEs, the severely ill patients had a median age of 68 (range, 52–88) years and were older than both the less ill patients in the hTCEs (median age, 45 years; range, 7–78 years; p < 0.0001) and the patients in oTCEs (median age, 30 years; range, 1–86 years; p < 0.0001). Nine patients (7 men, 2 women) died (median age, 73 years; range, 52–88 years); thus the total case fatality rate was 1.5%. Of the patients quarantined in the oTCEs, 340 (74.7%) had no symptoms, and 115 (25.3%) had mild or moderate symptoms; only 2 (0.4%) developed severe disease during the follow-up period. ConclusionIn this retrospective cohort, patients were young (median age, 34.0 years) and mostly asymptomatic (67.8%); the overall fatality rate was low at 1.5%.
Published: 2021

50. Seroprevalence of Cysticercosis among Epileptic Patients Attending Neurological Units in the Urban Area of Abidjan

Author: Man-Koumba Soumahoro, Berthe Assi, Mireille Nowakowski, Jihen Melki, Mamadou Camara, Gildas Boris Tazemda-Kuitsouc, Ronan Jambou, Yves Landry Kangah, Constance Yapo-Ehounoud, Jacques Bellalou, and T. Sonan
Subjects: Microbiology (medical), Pediatrics, medicine.medical_specialty, Neurology, QH301-705.5, Microbiology, Article, Serology, Epilepsy, Virology, Taenia solium, medicine, Seroprevalence, In patient, Family history, Biology (General), seroprevalence, business.industry, cysticercosis, Cysticercosis, medicine.disease, medicine.drug_formulation_ingredient, epilepsy, business, urban area, Cote d’Ivoire
Abstract: Cysticercosis is one of the main causes of secondary epilepsy in sub-Saharan Africa. To estimate the seroprevalence of cysticercosis among epileptic patients, we conducted a cross-sectional study of patients attending neurology consultation in Abidjan, Côte d’Ivoire. Methods: Patients’ socio-demographic and lifestyle data were collected as well as blood samples for serological testing using ELISA and Western blot based on IgG antibodies detection. For qualitative variables comparison, Chi2 or Fisher tests were used, a Student’s t-test was used to compare quantitative variables. A multivariate logistic regression model was fit to identify risks factors. Results: Among 403 epileptic patients included in the study, 55.3% were male, the median age was 16.9 years, 77% lived in Abidjan, 26.5% were workers. Most patients included in the study had tonic-clonic seizures (80%), and 11.2% had focal deficit signs. The seroprevalence of cysticercosis was 6.0%. The risk was higher in patients over 30 years old (aOR = 5.1 (1.3–20.0)) than in patients under 16. The risk was also considerably high in patients who reported epileptics in the family (aOR = 5 (1.7–14.6)). The risk was three-fold less in females than in males. Conclusions: This study highlighted the exposure of epileptic patients to Taenia solium larvae in an urban area. The risk of positive serology was increased with age, male gender, and family history of epilepsy.
Published: 2021

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