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Background Oral rehabilitation of atrophic maxillae features high complexity, for which there are several therapeutic modalities reported on scientific literature. Zygomatic implant placement is a viable option that features low morbidity and allows immediate prosthetic loading. The purpose of the present study was to determine the methodological quality of systematic reviews that assessed the effectiveness of zygomatic implants placed in atrophic maxillae. Material and Methods Searches were conducted on Medline via Pubmed, LILACS, Dare Cochrane, Scopus, and Sigle via Open Grey up to June 2019. Results Seven systematic reviews were eligible for Overview and comprised a total of 2313 patients, 4812 zygomatic implants, and a 96,72% success rate. Common surgical complications, in decreasing order, were: maxillary sinusitis, peri-implant mucositis, prosthetic fracture, and infections. Methodological quality was assessed using the AMSTAR 2 tool, which revealed that six systematic reviews showed critically low methodological quality and one review was assessed as of low methodological quality. Conclusions Zygomatic implants seem to be an adequate option for atrophic maxilla rehabilitation, however, new studies with a higher methodological rigor are needed to provide more reliable results to professionals and patients undergoing this modality of oral rehabilitation. Key words:Zygomatic Implants, dental Implants, complications, oral rehabilitation.

Fanconi Anemia (FA) is a syndrome associated with chromosomal fragility. Current laboratory tests to diagnose this disease are based on the scoring of chromosomal aberrations induced in peripheral blood lymphocytes by clastogenic chemical agents, mainly: diepoxybutane (DEB) or mitomycin C (MMC). This study evaluated an alternative test for the diagnosis of FA, in which ionizing radiation replaces DEB/MMC. Two groups were studied: normal and DEB-sensitive individuals. From each individual, samples of peripheral blood were irradiated using an electron linear accelerator. Following lymphocyte cultures, and slide preparation, metaphases were scored based on the same methodology for biological dosimetry, according to recommendations of the International Atomic Energy Agency. Our results emphasized a pattern of distribution of dicentrics, fragments, as well as abnormal chromosomal arrangements. The methodology of analysis here proposed permitted to distinguish normal from DEB-sensitive subjects.

This study aimed to evaluate the effect of pioglitazone on brown adipose tissue function and hypothalamic gliosis in humans. Brown adipose tissue and the hypothalamus are regarded as important potential pharmacological targets to metabolic diseases, and defining the impact of current therapies on their structure and/or function could provide therapeutic advance in this field. Six patients with type 2 diabetes were treated for 24 weeks with pioglitazone 30 mg/day as an add-on therapy. Brown adipose tissue glucose uptake and volume were determined using 18F-FDG PET/CT scans; hypothalamic gliosis was determined using MRI scans; blood was collected for hormone and biochemistry measurements. All tests were performed at inclusion and six months after pioglitazone introduction. Pioglitazone treatment led to a significant 3% body mass increase. There were neither changes in cold-induced brown adipose tissue glucose uptake and volume nor changes in hypothalamic gliosis. This is a proof-of-concept study that provides clinical evidence for a lack of action of a thiazolidinedione, pioglitazone, to promote homogeneous and measurable changes in brown adipose tissue volume and also in hypothalamic gliosis after 6 months of treatment.

Background Since implant placement on diabetic patients still is a controversial topic and systematic reviews are at the top of scientific evidence hierarchy, a thorough assessment of the methodological quality of these reviews must be performed to inform clinicians if their conclusions and recommendations can be followed on clinical practice. An overview of systematic reviews was performed with the purpose to assess the methodological quality of systematic reviews regarding dental implant placement on diabetic patients. In addition, we presented a synthesis of clinical outcomes about the focused theme. Material and Methods An online search was performed on MEDLINE via PubMed, EMBASE, DARE-Cochrane, Scopus, Web of Science, LILACS, and SIGLE via Open Grey. Searches were conducted from database inception to May 2018. Systematic review articles with or without meta-analysis about the placement of dental implants on diabetic patients were included. Exclusion criteria were: articles whose primary outcome was not the survival/success rate of dental implants on diabetic patients; studies that do not relate the survival/success rate of dental implants with diabetes; duplicated papers. Methodological quality assessment was performed with AMSTAR. A descriptive synthesis of clinical outcomes was performed. Results We identified 1.661 initial hits and eight articles were selected for overview (kappa=0.83; strong agreement). Six studies presented moderate methodological quality and two showed high methodological quality. Implant survival rate ranged from 31.8% to 100% and data from four meta-analysis showed that diabetes does not affect implant survival rate. On the other hand, data from two meta-analysis for marginal bone loss showed that diabetes statistically affects this outcome. Conclusions Two of the eight included studies presented high methodological quality and their meta-analysis showed that implant placement on diabetic patients does not affect implant survival rate and statistically affects marginal bone loss. However, clinicians must be aware that marginal bone loss values were not clinically relevant and may not be safe to follow the conclusions and recommendations of these studies. Key words:Dental implants, diabetes, systematic review, meta-analysis, survival rate.

Summary The giant pre-salt Bacalhau field is located in the Santos Basin, and is the first pre-salt greenfield development by an international oil company (IOC) in Brazil. Bacalhau is a complex, overpressured field with high quality carbonate reservoirs with light oil belonging to the Barra Velha Formation. This work presents the story from the appraisal to development of the production of the field that will be a future cornerstone of Equinor daily production.

Methods for image data stream classification need to update their model constantly and many of these perform this in a supervised way. However, these studies evaluate the performance of their methods assuming that all labels will be available immediately after classification, which is not consistent with various real-world application scenarios. This article proposes a new evaluation method for image data stream classifiers that allows for the exploration of different issues present in real-world applications, such as the emergence of new classes, the evolution of existing classes, and delayed image labels after classification. Through an analysis of the experimental results, we verified that the proposed evaluation method allowed the identification of the issues that most impact the accuracy of the image classifier, indicating a need to direct efforts in carrying out future works to develop strategies to mitigate these issues.

Hyperspectral images (HIs) are characterized by a higher spectral resolution than other images and have applications in various fields, to wit, medicine, agriculture, mining, among others. Segmentation can be obtained from the pixel classification and it is a powerful tool for object identification. Notwithstanding, the problems of the curse of dimensionality and the demand for computational resources occur due to the number of bands. Techniques that reduce dimensionality, such as genetic algorithms, are promising, but they cannot assure a balance between conflicting objectives such as improving classification and reducing the number of bands. Multiobjective band selection can be applied to search for tradeoff solutions that have this balance. Therefore, in this manuscript, we propose a novel method called Incorporated Decision-Marker-based multiobjective band selection (IDMMoBS) that tries to find tradeoff solutions using spectral and spatial information. In the experiments, the IDMMoBS reduced the number of bands between 85.4 and 85.8 percent of the total and it outperformed the majority of other methods compared in this criterion. For the pixel classification, the IDMMoBS presented better results than all compared cases taking into account all evaluated metrics using SVM classifier. Accordingly, the IDMMoBS is suitable for band selection.

The use of prestress for the structural strengthening of timber elements is not new and has been used before to increase the load capacity and ductility of timber beams. The work presented herein a...

Cutaneous T-cell lymphomas are rare, generally incurable, and associated with reduced quality of life. Present systemic therapies rarely provide reliable and durable responses. We aimed to assess efficacy and safety of brentuximab vedotin versus conventional therapy for previously treated patients with CD30-positive cutaneous T-cell lymphomas.In this international, open-label, randomised, phase 3, multicentre trial, we enrolled adult patients with CD30-positive mycosis fungoides or primary cutaneous anaplastic large-cell lymphoma who had been previously treated. Patients were enrolled across 52 centres in 13 countries. Patients were randomly assigned (1:1) centrally by an interactive voice and web response system to receive intravenous brentuximab vedotin 1·8 mg/kg once every 3 weeks, for up to 16 3-week cycles, or physician's choice (oral methotrexate 5-50 mg once per week or oral bexarotene 300 mg/mBetween Aug 13, 2012, and July 31, 2015, 131 patients were enrolled and randomly assigned to a group (66 to brentuximab vedotin and 65 to physician's choice), with 128 analysed in the intention-to-treat population (64 in each group). At a median follow-up of 22·9 months (95% CI 18·4-26·1), the proportion of patients achieving an objective global response lasting at least 4 months was 56·3% (36 of 64 patients) with brentuximab vedotin versus 12·5% (eight of 64) with physician's choice, resulting in a between-group difference of 43·8% (95% CI 29·1-58·4; p0·0001). Grade 3-4 adverse events were reported in 27 (41%) of 66 patients in the brentuximab vedotin group and 29 (47%) of 62 patients in the physician's choice group. Peripheral neuropathy was seen in 44 (67%) of 66 patients in the brentuximab vedotin group (n=21 grade 2, n=6 grade 3) and four (6%) of 62 patients in the physician's choice group. One of the four on-treatment deaths was deemed by the investigator to be treatment-related in the brentuximab vedotin group; no on-treatment deaths were reported in the physician's choice group.Significant improvement in objective response lasting at least 4 months was seen with brentuximab vedotin versus physician's choice of methotrexate or bexarotene.Millennium Pharmaceuticals Inc (a wholly owned subsidiary of Takeda Pharmaceutical Company Ltd), Seattle Genetics Inc.

The activity of brown/beige adipose tissue (B/BAT) is inversely proportional to body adiposity. Studies have shown that obese subjects submitted to distinct approaches aimed at reducing body mass present an increase of B/BAT activation. However, it is unknown if this beneficial effect of body mass reduction applies to patients with type 2 diabetes mellitus. In this study, we evaluated the impact of massive body mass reduction obtained as a consequence of bariatric surgery in the cold-induced activation of B/BAT in obese non-diabetic (OND) and obese diabetic (OD) subjects. This is an observational study. Fourteen OND, 14 OD and 11 subjects were included in the study. All obese subjects were submitted to Roux-in-Y gastric bypass and measurements were performed before and 8 months after surgery. B/BAT was evaluated by (18F)-FDG-PET/CT scan and determination of signature transcript expression in specimens obtained in biopsies. Before surgery, mean B/BAT activity and the expression of signature transcripts were similar between OND and OD groups. Eight months after surgery, body mass reduction was similar between the obese groups. Nevertheless, the activity of B/BAT was increased in OND and unchanged in OD subjects. This effect was correlated with a more pronounced improvement of insulin resistance, as evaluated by the hyperinsulinemic, euglycemic clamp, in OND subjects as compared with OD subjects. Body mass reduction has a more efficient effect to induce the activation of B/BAT in non-diabetic than in diabetic subjects. This effect is accompanied by more pronounced insulin sensitivity and serine 473 phosphorylation of Akt in B/BAT of non-diabetic than in diabetic subjects.

Background Myofibroblasts (MF) and angiogenesis are important factors in the development and expansion of cystic lesions, where these cells secrete growth factors and proteases, stimulating angiogenesis, matrix deposition and cell migration, affecting the growth of these periapicopathies. The present study aimed to evaluate the immunohistochemical expression of CD34 and α-SMA in radicular cysts (RC) and residual radicular cysts (RRC), with the purpose of contributing to a better understanding of the expansion and progression of these periapical lesions. Material and Methods The present study os a descriptive, quantitative and comparative analysis of positive CD34 and α-SMA immunohistochemical expressions in 30 RC and 30 RRC specimens. α-SMA expression was evaluated in the fibrous capsule of the lesions, at 100x magnification below the epithelial lining. A total of 10 higher immunostaining fields were selected and subsequently, positive cells were quantified at 400x magnification, averaged per field. Regarding the angiogenic index, immuno-labeled microvessel counts for the anti-CD34 antibody were performed in 10 fields at 200x magnification. Results Statistically significant differences regarding α-SMA immunostaining were observed (p = 0.035), as well as a correlation between α-SMA versus CD34 (p = 0.004) in RRC. However, the angiogenic index obtained by immunostaining for CD34 indicated no statistical difference between lesions. Intense inflammatory infiltrates were predominant in RC, while mild and moderate degrees were more commonly observed in RRC (p

RESUMO Objetivos: Comparar a evolução do perfil nutricional de pacientes submetidos ao bypass gástrico em Y de Roux (BGYR) e ao Sleeve, em hospitais dos setores público e privado da Saúde de Pernambuco. Método: O estudo incluiu pacientes submetidos à cirurgia bariátrica nos setores público e privado de saúde de Pernambuco no período de 2008 a 2016. Foram avaliados dados antropométricos e bioquímicos (Hemoglobina, Vitamina B12, Ferro e Ferritina) no período pré-operatório e com 3, 6 e 12 meses de pós-operatório. Resultados: Não foram registradas diferenças significativas entre os pacientes internados nos dois setores da Saúde no tocante às variáveis: níveis hemoglobina, anemia por deficiência de ferro e vitamina B12 em nenhuma das avaliações e conforme o tipo de cirurgia. Entre os pacientes submetidos ao BGYR, os níveis de ferro sérico foram significativamente menores nos pacientes do setor privado da Saúde apenas na primeira avaliação. Baixos níveis de ferritina sérica foram observados na segunda avaliação, sendo os pacientes do setor privado os que apresentaram menores valores. O sucesso cirúrgico foi significativamente maior no grupo que realizou o BGYR na rede privada. Conclusões: Com um seguimento de 12 meses pós-cirurgia bariátrica, não foi observada diferença estatisticamente significante no que diz respeito às deficiências de micronutrientes entre pacientes usuários dos setores público e privado de Saúde. ABSTRACT Purpose: To compare the nutritional status follow up of patients who underwent Roux-en-Y gastric bypass (BGYR) and Sleeve gastrectomy (SG) in hospitals of the private and public health systems, in Pernambuco. Methods: This study included patients who underwent bariatric surgery in the public and private health systems, in Pernambuco, from 2008 to 2016. Anthropometric and biochemical (hemoglobin, B12, iron and ferritin) data were evaluated in the preoperative period and at 3, 6 and 12 months after the operation. Results: There were no significant difference between patients seen at the two health systems regarding the levels of hemoglobin, iron, anemia and vitamin B12. Patients who underwent the RYGB, presented with iron deficiency which was significantly lower for those in the private system, but only at the 3 month evaluation. Low levels of ferritin were observed at the 6 month evaluation, and patients in the private health system presented with the highest ferritin deficiency. The rate of surgical success was significantly higher in those patients undergoing the RYGB at the private system. Conclusions: After a 12-month bariatric surgery follow-up, there was no statistically significant difference regarding micronutrient deficiency between patients followed up at the private and public health systems.

Public mobility is a major concern for big cities, but even more complex if the main transport relies on public buses, such as Sao Paulo. Despite recent improvements, bus service quality is still below expectations. A survey-based analysis investigates the main issues and evaluates possible differences based on social-demographic aspects.

Spinal cord stimulation (SCS) has been used for the treatment of chronic pain for nearly five decades. With a high degree of efficacy and a low incidence of adverse events, it is now considered to be a suitable therapeutic alternative in most guidelines. Experimental studies suggest that SCS may also be used as a therapy for motor and gait dysfunction in parkinsonian states. The most common and disabling gait dysfunction in patients with Parkinson's disease (PD) is freezing of gait (FoG). We review the evolution of SCS for gait disorders from bench to bedside and discuss potential mechanisms of action, neural substrates, and clinical outcomes.

BACKGROUND/OBJECTIVES: Hypothalamic neurons play a major role in the control of body mass. Obese subjects present radiologic signs of gliosis in the hypothalamus, which may reflect the damage or loss of neurons involved in whole-body energy homeostasis. It is currently unknown if hypothalamic gliosis (1) differs between obese nondiabetic (ND) and obese diabetic subjects (T2D) or (2) is modified by extensive body mass reduction via Roux-n-Y gastric bypass (RYGB). SUBJECTS/METHODS: Fifty-five subjects (all female) including lean controls (CT; n = 13), ND (n = 28), and T2D (n = 14) completed at least one study visit. Subjects underwent anthropometrics and a multi-echo MRI sequence to measure mean bilateral T2 relaxation time in the mediobasal hypothalamus (MBH) and two reference regions (amygdala and putamen). The obese groups underwent RYGB and were re-evaluated 9 months later. Analyses were by linear mixed models. RESULTS: Analyses of T2 relaxation time at baseline showed a group by region interaction only in the MBH (P < 0.0001). T2D had longer T2 relaxation times compared to either CT or ND groups. To examine the effects of RYGB on hypothalamic gliosis a three-way (group by region by time) mixed effects model adjusted for age was executed. Group by region (P < 0.0001) and region by time (P = 0.0005) interactions were significant. There was a reduction in MBH relaxation time by RYGB, and, although the T2D group still had higher T2 relaxation time overall compared to the ND group, the T2D group had significantly lower T2 relaxation time after surgery and the ND group showed a trend. The degree of reduction in MBH T2 relaxation time by RYGB was unrelated to clinical outcomes. CONCLUSION: T2 relaxation times, a marker of hypothalamic gliosis, are higher in obese women with T2D and are reduced by RYGB-induced weight loss.

Background Alveolar infection is known as a risk factor for implant failure. Current meta-analysis on the theme could not prove statistically that immediate dental implants placed into infected sites have a higher risk of failure than immediate dental implants placed into non-infected sites. The purpose of this meta-analysis was to determine the effectiveness of immediate dental implants placed into infected versus non-infected sites. Material and Methods Seven databases were sought by two reviewers. Randomized or non-randomized clinical trials that compared the placement of dental implants into infected versus non-infected sites were eligible for the study. Exclusion criteria were: papers in which the survival rate was not the primary outcome; papers without a control group; studies with less than one year of follow-up; studies whose patients did not receive antibiotic therapy; studies with medically compromised patients; duplicated papers. Risk of bias assessment was performed with the Cochrane Collaboration tool. Results Of the 3.253 initial hits, 8 studies were included in both qualitative and quantitative synthesis (kappa=0.90; very good agreement). Forest plot for implant failure showed that immediate implants placed into infected sites presented a statistically significant risk of failure that is almost 3 times higher than when placed into non-infected sites (risk ratio= 2.99; 95% confidence interval: 1.04, 8.56; p= 0.04; 935 implants; i2= 0%). Peri-implant outcomes showed no statistical difference. Conclusions Immediate dental implants placed into infected sites presented a statistically significant higher risk of failure than immediate dental implants placed into non-infected sites. Peri-implant outcomes were not statistically affected in this intervention. Key words:Dental implants, infection, tooth socket, systematic review, immediate placement.

Background It is of great value to develop valid instruments to estimate food consumption; for this purpose, the triads method has been applied in validation studies of dietary intake to evaluate the correlation between three measurements [food frequency questionnaire (FFQ), reference method and biomarker]. The main aim of the present study was to validate a FFQ for Brazilian adults by means of the method of triads by estimating the ingestion of total fatty acids based on the level of saturation. Methods The present study enrolled 152 Brazilian adults of both sexes, who were residents in the city of Vicosa, Brazil. The ingestion of total saturated, monounsaturated, polyunsaturated, trans, linoleic and linolenic fatty acids was assessed by means of a FFQ, two food records, and biomarkers, which were detected by gas chromatography. The validation coefficients were calculated using the method of triads and concordance was determined by Kappa statistics. Results The FFQ was considered an adequate dietary method, because, based on the validation coefficients, it estimates the intake of total fat (0.84), as well as linolenic (0.90) and linoleic acids (0.31). A high concordance rate was confirmed for all nutrients assessed by the FFQ and food records. Regarding the biomarkers, linolenic acid and linoleic acid presented greater concordance. Conclusions According to the validation coefficients, the FFQ precisely estimated total fat, linolenic acid and linoleic acid contents.

As with mostprevious studies on the prevalence of metabolicsyndrome (MetS) in systemic lupus erythematosus(SLE), in which the prevalence varies greatly, itwas found to be always greater than in non-lupus patients. MetS, a bundle of cardiovascular risk factors, is highly prevalent and associated with increased rate of cardiovascular events and death. Apart from these risk factors, MetS is closely correlated with inflammation. Not only are they related to each other, but the inflammatory burst also precedes the MetS. Was evaluated the influence of SLICC criteria and other disease-specific factors in the presentation of MetS. In order to evaluate these factors, It was conducted a cross-sectional pilot study with 59 women with SLE according to the American College Rheumatology (ACR) criteria at the rheumatology out patient clinic. Individuals with SLE had a higher prevalence of MetS (30.5%) than controls (20.5%), as shown previously. Despite this higher prevalence, there was no si-nificant association between the presence of SLE and whether individuals had MetS or not(p¼0.117). Via a binary logistic regression, was evaluated the chance of specific factors associated with SLE predicting the presence of MetS. No significant association was detected between MetS and any SLE specific factors.

The aim of this randomized controlled study was to verify the impact of a 12-weeks muscular endurance (ME) training of high repetitions (i. e., 15–30) with 2 different periodization models on body composition, maximal strength, muscular endurance and cardiorespiratory fitness. Twenty eight sedentary women aged 20–35 years were randomly assigned to: control (CON) (n=8), linear periodization (LP) (n=10) and daily undulating periodization (DUP) (n=10). LP and DUP models significantly improved body composition, maximal strength and ME. However, no significant changes were detected for cardiorespiratory fitness. LP showed a higher body fat loss ( − 12.73%) compared to DUP ( − 9.93%) (p=0.049), and systematically higher effect sizes (ES) when compared with DUP for maximal strength and cardiorespiratory fitness parameters (e. g. ES=0.53 for ventilatory threshold). In contrast, DUP exhibited a significantly (p=0.002) greater ME gain (129.43%) compared to LP (70.72%) in bench press, and greater ES in all exercises. It may be suggested that LP performed with a high number of repetitions may be considered an appropriate periodization model for untrained young women that would likely lead to the improvement of body composition and maximum strength performance, whereas DUP is more effective for the development of ME.

O objetivo deste trabalho foi analisar o efeito do exercício físico regular no controle glicêmico em indivíduos diabéticos tipo 2, tratados e não-tratados com insulina, em pessoas da região do Vale do Itajaí, SC, com idades entre 45 e 75 anos. Foram realizados testes de glicemia jejum (GJ), hemoglobina glicosilada (HbA1) e glicemia capilar nos clientes da Unicardio/HSC e nos participantes da Associação dos Diabéticos de Blumenau (n= 33), onde estes passaram por um programa de exercício físico de 10 semanas, após as quais os participantes da amostra foram reavaliados. Foi avaliado também: perfil lipídico, pressão arterial, freqüência cardíaca de repouso e índice de massa corporal. Os instrumentos utilizados foram: o exame de sangue em jejum para avaliação laboratorial e a glicemia capilar. Para análise estatística utilizou-se o teste "t" de Student e a reta ajustada de mínimos quadrados, pela regressão linear. Obteve-se os seguintes resultados: glicemia capilar média pré-teste = 179mg/dL e pós-teste= 148mg/dL; HbA1 média pré-teste = 9,5% e pós-teste = 8,5%; GJ média pré-teste= 164,8mg/dL e pós-teste= 156,4mg/dL. Estes resultados permitem concluir que o exercício físico é de grande importância no controle glicêmico do indivíduo diabético tipo 2, tratado ou não-tratado com insulina, diminuindo a glicemia e a HbA1.

DM type 1 (T1D) incidence is increasing around 3% every year and represents risks for maternal and fetal health. The objective of this study was to explore the effects of diabetes on fetus liver cells in non-obese diabetic (NOD) mice. Hyperglycemic NOD (HNOD), normoglycemic NOD (NNOD) and BALB/c females were used for mating, and the fetus livers were collected at 19.5 gestation day (gd). HNOD group had reduced fetal weight (989.5±68.32 vs 1290±57.39 mg BALB/c, P−1, PPPPPP

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:18:37Z No. of bitstreams: 1 WOS000207598500116.pdf: 88785 bytes, checksum: aab6d6cc80f7774e328dc79f5eb6d0ee (MD5) Made available in DSpace on 2014-02-26T17:18:37Z (GMT). No. of bitstreams: 1 WOS000207598500116.pdf: 88785 bytes, checksum: aab6d6cc80f7774e328dc79f5eb6d0ee (MD5) Previous issue date: 2007-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:27:06Z No. of bitstreams: 1 WOS000207598500116.pdf: 88785 bytes, checksum: aab6d6cc80f7774e328dc79f5eb6d0ee (MD5) Made available in DSpace on 2014-05-20T15:27:06Z (GMT). No. of bitstreams: 1 WOS000207598500116.pdf: 88785 bytes, checksum: aab6d6cc80f7774e328dc79f5eb6d0ee (MD5) Previous issue date: 2007-01-01 Twenty eight Mediterranean buffaloes bulls were scanned with real-time ultrasound (RTU), slaughtered, and fabricated into retail cuts to determine the potential for ultrasound measures to predict carcass retail yield. Ultrasound measures of fat thickness, ribeye area and rump fat thickness were recorded three to five days prior to slaughter. Carcass measurements were taken, and one side of each carcass was fabricated into retail cuts. Stepwise regression analysis was used to compare possible models for prediction of either kilograms or percent retail product from carcass mesaurements and ultrasound measures. Results indicate that possible prediction models for percent or kilograms of retail products using RTU measures were similar in their predictive power and accuracy when compared to models derived from carcass measurements. Both fat thickness and ribeye area were over-predicted when measured ultrasonically compared to measurements taken on the carcass in the cooler. The mean absolute differences for both traits are larger than the mean differences, indicating that some images were interpreted to be larger and some smaller than actual carcass measurements. Ultrasound measurements of REA and FT had positive correlations with carcass measures of the same traits (r=.96 for REA and r=.99 for FT). Standard errors of prediction currently are being used as the standard to certify ultrasound technicians for accuracy. Regression equations using live weight (LW), rib eye area (REAU) and subcutaneous fat thickness (FTU) between 12(th) and 13 (th) ribs and also over the biceps femoris muscle (FTP8) by ultrasound explained 95% of the variation in the hot carcass weight when measure immediately before slaughter. São Paulo State Univ, Sch Vet Med & Anim Sci, Dept Anim Prod, BR-18618000 Botucatu, SP, Brazil São Paulo State Univ, Sch Vet Med & Anim Sci, Dept Anim Prod, BR-18618000 Botucatu, SP, Brazil

Permutations play an important role in the field of data security, representing a substantial contribution to increase the diffusion of the encryption process and many cryptosystems make use of them . However, in general, the literature on the subject reports very few results concerning those aspects of a permutation that make it atractive for cryptographic purposes. In this paper the subject is considered and, in the search for cryptographically strong permutations to be used in private or public cryptosystems, the problem of counting the number of permutations of degree n that fix i elements is approached.

The city of Rio de Janeiro will host the 2016 Olympic and Paralympics Games. Several improvements are being planned for the city in order to prepare it for the so called Rio 2016 event. This sequence of developments will be decided by a Local Committee and many people enthusiastic to participate should contribute by sending ideas and actually collaborate in the planning process. To assist this huge task force, our paper intends to use decision support systems techniques and cognitive means through different approaches in order to aid large groups in their discussions, their alternatives generation and all group choosing process. This work presents a semantic search method in the LaSca system for the MUTIRO project, which explores the coordination in a Large Scale decision support system. The importance of a locale semantic search comparing to a classical search method is that most contributors are not formal and well behaved in language structure, using lots of slang and alternative means of communication. As Brazil is a continental country it created several local ways of communications that vary from place to place creating additional difficulties for a search tool. A smart thesaurus must be constructed through semi-automatic means and a search engine should be crated to allow feasible searches by the users. The main task of this project is to help groups interested in the Rio 2016 success taking into account socioeconomic and geographical aspects.

The purpose of the present study was to compare the effects of a program of resistance training in water-based exercises (RWE) with those of a program without resistance control in water-based exercises (WEs). Twenty-seven women (aged 60-74 years) were randomly assigned to the RWE group (n = 10), WE group (n = 10), or nontraining control (CON) group (n = 7). The RWE and WE groups trained classes with aerobic exercises and localized muscular resistance exercises for 50 minutes, twice a week for 12 weeks. For the RWE group, the program included 4 mesocycles of 3 weeks-respectively, 4 sets of 15 repetitions, 4 sets of 12 repetitions, 5 sets of 10 repetitions, and 5 sets of 8 repetitions-of shoulder horizontal flexion exercise at maximum speed, with the use of resistive equipment. For the WE group, the training was not periodized, and the resistance in the localized muscular exercises was not controlled. One repetition maximum (1RM) was measured on a pectoral fly machine at baseline and after the training period. The level of significance adopted was p ≤ 0.05. The results showed that the only significant increase in 1RM (10.89%, p < 0.001) occurred in the RWE group after training. In conclusion, these findings suggest that WEs with emphasis on resistance training in a periodized program can efficiently increase maximum strength in elderly women. Thus, it is suggested that the strategies used in WE programs be modified to offer suitable stimuli for the development of strength.

This paper describes a collaborative tool, ARARA (Artifacts and Requirements Awareness Reinforcement Agents), that provides awareness in Software Development Process (SDP). Ontologies support this application for they are used by project team members when preparing the artifacts, propagating the concepts through them, and used by agents as knowledge base to retrieve information, tag the artifacts, detect changes, and search for linked artifacts that may be affected by a change on a previous artifact. This collaborative tool can improve team members awareness automatically no matter where they are geographically working, once agents are responsible for tracking and notifying requirements, or any other changes, to team members, including consequent candidates for modifications.

Com uma área irrigada aproximada de 710.500 ha no Brasil, é possível estimar um consumo anual de 1928 GWh nos sistemas de irrigação por pivô central instalados. Considerando-se a necessidade de otimização da produção agrícola irrigada são analisadas, neste trabalho, as energias dissipadas nas tubulações de sucção, adutora, linha lateral, aspersão e proposta uma equação para determinar a potência útil de um sistema de irrigação por pivô central. Três sistemas pivô central do Assentamento Itamarati I, instalados em Ponta Porã, MS, foram avaliados e medidas de eficiência energética foram simuladas visando determinar uma configuração economicamente viável ao longo da vida útil do equipamento. Os sistemas foram caracterizados quanto ao aproveitamento da energia e a eficiência energética na irrigação média aumentou de 14,9 para 25,9%, possibilitando a redução de R$118.800 por ano em 7.200 ha, o equivalente a 11% das despesas anuais com energia elétrica de toda a propriedade. With an irrigated area of approximately 710,500 ha in Brazil, it is possible to estimate an annual electricity consumption of 1,928 GWh per year due to center pivot systems. Considering the need of optimization of the irrigated agricultural production, the energies that are dissipated in the suction pipes, water supply, lateral lines and sprinkler systems are analyzed in this study and an equation is proposed to determine the useful power of center pivot irrigation systems. Three center pivot systems located in Itamarati I (a Government settlement for the landless in the city of Ponta Porã, State of Mato Grosso do Sul, Brazil) were evaluated and measures of energetic efficiency were simulated in order to determine a viable economic configuration to meet the life span of the equipment. The systems were characterized by the energy use and results show that the average irrigation energetic efficiency may be raised from 14.9 to 25.9% leading to a possible reduction of R$ 118,800 per year over 7,200 ha, equivalent to 11% of the yearly expenses with electricity of the whole area.

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:18:38Z No. of bitstreams: 1 WOS000207598500117.pdf: 125578 bytes, checksum: f23784509b5145151384822b66dac65a (MD5) Made available in DSpace on 2014-02-26T17:18:38Z (GMT). No. of bitstreams: 1 WOS000207598500117.pdf: 125578 bytes, checksum: f23784509b5145151384822b66dac65a (MD5) Previous issue date: 2007-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:27:07Z No. of bitstreams: 1 WOS000207598500117.pdf: 125578 bytes, checksum: f23784509b5145151384822b66dac65a (MD5) Made available in DSpace on 2014-05-20T15:27:07Z (GMT). No. of bitstreams: 1 WOS000207598500117.pdf: 125578 bytes, checksum: f23784509b5145151384822b66dac65a (MD5) Previous issue date: 2007-01-01 The objective of this work was to estimate the correlations among measurements taken in vivo with ultrasound equipment with some carcass traits measured after slaughter. Twenty eight Mediterranean bulls, with average shrunk body weight of 330 kg and 14 months of age, were fed by 120 days with high concentrate diets. The shrunk body weight, the ribeye area (REAU), the back fat thickness (FTU) over the Longissimus dorsi muscle between 12(a) and 13(a) ribs and rump fat (EGP8U), were measured at 28 days intervals. Real-time ultrasound equipment Piemedical Scanner 200 VET, with 18 cm linear array transducer was utilized. After the slaughter, the hot carcass weight (PCQ) and the kidney, pelvic and inguinal fat (GRPI) were weighted and the dressing percentage (DP) calculated. After 24 hours of cooling the ribeye area (REAC), backfat thickness (FTC) and rump fat (EGP8C) were measured. Both the REAC, FTC and EGP8C were underestimated by ultrasound measurements. The Pearson correlation coefficients for ribeye area, backfat thickness and rump fat measured in the carcass and with ultrasound, were 0.96, 0.99 and 0.91, respectively. The coefficient between DP and REAU was 0.47; 0.45 between DP and REAC, 0.56 between DP and FTU and 0.58 between DP and FTC. DP presented a 0.59 correlation coefficient with EGP8U. The Spearman correlation was estimated between REAU and REAC, FTU and FTC, EGP8U and EGP8C, and the values were 0.96, 0.99 and 0.91,respectively. The ultrasound measures could be used to estimate carcass traits in buffaloes with good accuracy. São Paulo State Univ, Sch Vet Med & Anim Sci, Dept Anim Prod, BR-18618000 Botucatu, SP, Brazil São Paulo State Univ, Sch Vet Med & Anim Sci, Dept Anim Prod, BR-18618000 Botucatu, SP, Brazil

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:01:24Z No. of bitstreams: 1 S0103-97332005000500018.pdf: 337371 bytes, checksum: da5044942f87106ca26045ba80096949 (MD5) Made available in DSpace on 2013-08-22T19:01:24Z (GMT). No. of bitstreams: 1 S0103-97332005000500018.pdf: 337371 bytes, checksum: da5044942f87106ca26045ba80096949 (MD5) Previous issue date: 2005-09-01 Made available in DSpace on 2013-09-30T20:01:22Z (GMT). No. of bitstreams: 2 S0103-97332005000500018.pdf: 337371 bytes, checksum: da5044942f87106ca26045ba80096949 (MD5) S0103-97332005000500018.pdf.txt: 15077 bytes, checksum: 4a10673e211fc850308c062a589c121f (MD5) Previous issue date: 2005-09-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:15:43Z No. of bitstreams: 2 S0103-97332005000500018.pdf: 337371 bytes, checksum: da5044942f87106ca26045ba80096949 (MD5) S0103-97332005000500018.pdf.txt: 15077 bytes, checksum: 4a10673e211fc850308c062a589c121f (MD5) Made available in DSpace on 2014-05-20T15:15:43Z (GMT). No. of bitstreams: 2 S0103-97332005000500018.pdf: 337371 bytes, checksum: da5044942f87106ca26045ba80096949 (MD5) S0103-97332005000500018.pdf.txt: 15077 bytes, checksum: 4a10673e211fc850308c062a589c121f (MD5) Previous issue date: 2005-09-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Computed Tomography (CT) has made possible visualization of physical structures in the interior of an object in their real relative spatial position and orientation. Another important contribution of CT is to greatly improve abilities to distinguish regions with different gamma ray transmittance and to separate over-lying structures. The mathematical problem of CT imaging is that of estimating an image from its projections. In this work, the experimental setup was performed using the Mini Computerized Tomograph of Uniso (MTCU). This tomograph system operates with a gamma ray source of 241Am (photons of 60 KeV and 100 mCi of intensity) and a NaI(Tl) solid state detector. The system features translation and rotation scanning modes, a 100 mm effective field of view, 1 mm of spatial resolution and 5 % to 10 % of density resolution. The image reconstruction problem can be solved using two different algorithms: Algebraic Reconstruction Techniques (ART) or Discrete Filtered Backprojection (FBP). The three-dimensional image reconstruction method discussed in this work, involves obtaining two-dimensional (2D) gamma ray tomography images and then combining these images into a three-dimensional (3D) volume data. An opacity, shading and color is attributed to each volume element (voxel) and the resulting scene is projected in a picture plane to be display in a monitor. Our implementation was developed to be used with MTCU data and was based in the Ray casting volume rendering technique. The use of such technique for nondestructive evaluation is a powerful tool to enable a visual trip inside an object without physically opening or cutting it. Experimental and theoretical methods used are discussed and results of experiments using the 3D reconstruction techniques are presented. A particular use of this technique to study concrete properties, such as stones distributions, visualization of structural occurrences inside concrete samples is discussed. Universidade de Sorocaba Faculdade de Engenharia de Sorocaba Universidade Estadual Paulista Julio de Mesquita Filho Universidade Estadual Paulista Julio de Mesquita Filho

Objective: To assess right ventricular systolic function using indices derived from tricuspid annular motion, and to compare the results with right ventricular ejection fraction (RVEF) calculated from radionuclide angiography. Design: Pulsed Doppler echocardiography indices were obtained from 10 patients with a normal RVEF (group 1) and from 20 patients whose RVEF was less than 45% (group 2). Results: The patients in the two groups were similar in age, systolic blood pressure, and heart rate. There was a close correlation between the tricuspid annular motion derived indices (D wave integral (DWI), peak velocity of D wave (PVDW), and tricuspid plane systolic excursion (TPSE)) and RVEF ( r = 0.72, 0.82, and 0.79, respectively). DWI was significantly higher in group 1 than in group 2. PVDW discriminated adequately between individuals with abnormal and normal right ventricular ejection fraction. The sensitivity and specificity of tricuspid annular motion derived indices were very good. Conclusions: Indices derived from tricuspid annular motion appear to be important tools for assessing right ventricular systolic function.

BACKGROUND--The formation of coronary artery neointima experimentally induced in piglets after cardiac transplantation is related to an immune-inflammatory reaction associated with increased expression of T cells and inflammatory mediators (tumour necrosis factor alpha and interleukin 1 beta) and upregulation of fibronectin. In vivo blockade of tumour necrosis factor alpha in rabbits after cardiac transplantation results in reduced neointimal formation. The objective of this study was to investigate the hypothesis that coronary restenosis after atherectomy or percutaneous balloon angioplasty is associated with a similar inflammatory cascade initiated by mechanical injury. METHODS--Specimens taken at coronary atherectomy were analysed from 16 patients. Nine had had the procedure performed twice, firstly, to remove a primary lesion, and secondly, to remove a restenotic lesion. Seven had percutaneous balloon angioplasty after removal of restenotic tissue. Coronary atherectomy specimens were analysed by immunohistochemistry for the presence of T cells, macrophages, major histocompatibility complex II, interleukin 1 beta, tumour necrosis factor alpha, fibronectin, and the receptor for hyaluronan mediated motility. RESULTS--The groups were clinically and angiographically similar with equivalent lumens before and after atherectomy. Restenotic lesions had increased expression of tumour necrosis factor alpha and fibronectin compared with the primary lesions (P < 0.05 for both). There was also a trend towards a greater number of T cells and increased expression of interleukin 1 beta. CONCLUSIONS--Restenosis is associated with increased expression of tumour necrosis factor alpha and fibronectin, suggesting that an immune-inflammatory reaction probably contributes to neointimal formation and may represent a form of wound healing and repair secondary to mechanical injury.

e18067 Background: The combination of pemetrexed plus cisplatin (PC) was recently approved in the initial treatment of advanced stage non-small cell lung cancer (NSCLC). Studies reported comparable...

e15105 Background: Although metastatic and relapsed germ cell tumor (GCT) can be cured with conventional dose salvage chemotherapy (CDCT), 20% to 30% do not achieve durable complete response. High ...

A microprocessor controlled system, aimed at the training of cardiologists in the interpretation of phono and electrocardiogram signals, was developed and implemented. The system has two independent modules: the data acquisition module and the generation module. The data acquisition module allows the creation of digital files of ECG and standard cardiac sounds which are processed by a microcomputer and stored in an EPROM. By using these data files, the microprocessor generation module generates the standard signals allowing the user to choose the kind and shape of signal to be generated. These signals can then be visualized in a monitor or plotter and an audio output. The system allows the user to simulate typical heart disease signals at different frequencies and to change the standard signals by software.

The non-stimulated and endotoxin-stimulated qualitative nitroblue tetrazolium (NBT) test was carried out in children with protein-calorie malnutrition (kwashiorkor and marasmic kwashiorkor) before during and after a 30-day period nutritional recovery. The NBT test was done on admission and 1 2 and 4 weeks later. Most PCM children exhibited a significant increase in NBT-positive cells on admission when compared to the controls; few PCM children exhibited a decrease in NBT-positive cells with or without endotoxin stimulation. After 30 days of nutritional recovery the non-stimulated NBT test showed a fall in NBT-positive cells for the PCM group with results similar to those for the control group (well nourished children). No correlation was found between the results of the NBT test on admission and the incidence of infectious diseases. On the basis of these data a basic fault in the phagocytosis system is suggested to occur in some PCM children.

A typical case of hypertrophy of the columns of Bertin is presented, with special consideration given the importance of the selective renal arteriogram which is, in our experience, the only diagnostic procedure of accuracy. With this in mind we have avoided renal exploration. The embryogenic origin of this entity is reviewed.