Prostate cancer is reported mainly in men. Based on global cancer statics, it is in the second position compared with other cancers in men. Men below 65 years with mutation in BRCA-2 gene and history of urinary tract infection are more susceptible to prostate cancer. The current treatment includes surgery, radiation therapy, anticancer drugs, hormone therapy, etc. But these led the patients toward infertility. The unique properties in terms of size, surface characteristics, shape, and nanoparticle open a new wave in prostate cancer therapy. Nanoparticle carrier systems can be developed either from natural or synthetic origin. The natural compounds are frequently used for nanoparticle preparation because they are innoxious and did not produce any immune response. Nanoparticle systems that are commonly used include liposomes, polymeric nanoparticles, micelles, dendrimers, carbon-based nanoparticles, etc. The potential of nanoparticle systems provides advanced drug delivery in prostate cancer management.