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1. MTS image analyzer: a software tool to identify mesial temporal sclerosis in MRI images

Author

Castillo, D., Macas, J., Samaniego, R., Jiménez, Y., Díaz, P., Rodríguez-Álvarez, M. J., and Lakshminarayanan, Vasudevan

Subjects
medicine.medical_specialty, Neurology, Computer science, Image processing, Epilepsy, Software, Region of interest, medicine, 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades, Software system, Texture features, Hippocampal sclerosis, business.industry, Pattern recognition, 3D ROI, medicine.disease, Hippocampal volume, Texture analysis, Brain MRI, Computer-aided diagnosis, Artificial intelligence, Mesial temporal sclerosis, MATEMATICA APLICADA, business
Abstract

[EN] Epilepsy is a chronic neurological disorder that causes unprovoked and recurrent seizures which according to WHO affects approximately 50 million people worldwide. Functional magnetic resonance images (MRI) help to identify certain affected areas of the brain, namely, the gliosis and hippocampal volume loss. These losses cause complex epilepsy, and is known as hippocampal sclerosis or Mesial Temporal Sclerosis (MTS). This work presents the development of a Computer Aided Diagnosis CAD system software package) that can be used to identify the characteristics and patterns of MTS from brain magnetic resonance images. The image processing techniques involve texture analysis, statistical features, evaluation of the 3D Region of interest (ROI), and threshold analysis. The software allows the automatic evaluation of the degeneration of hippocampal structures, hippocampal volume and signal intensity. We will describe and demonstrate the software (which can currently be accessed on GitHub). It is expected that this tool will be useful in new neurology/radiology specialists and can serve as a secondary diagnosis. However, it is necessary to validate the software system qualitatively and quantitatively in order to get more effectiveness and efficiency in a real-world clinical application.

Published
2021
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2. Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study

Author

Walsh S. L. F., Maher T. M., Kolb M., Poletti V., Nusser R., Richeldi L., Vancheri C., Wilsher M. L., Antoniou K. M., Behr J., Bendstrup E., Brown K., Calandriello L., Corte T. J., Cottin V., Crestani B., Flaherty K., Glaspole I., Grutters J., Inoue Y., Kokosi M., Kondoh Y., Kouranos V., Kreuter M., Johannson K., Judge E., Ley B., Margaritopoulos G., Martinez F. J., Molina-Molina M., Morais A., Nunes H., Raghu G., Ryerson C. J., Selman M., Spagnolo P., Taniguchi H., Tomassetti S., Valeyre D., Wijsenbeek M., Wuyts W., Hansell D., Wells A., Zhu P. S., Yuan Y., Yoshito Fukuda C., Yoshimatsu Y., Xaubet A., Wong A. M., White P., Westney G., West A., Wessendorf T., Waseda Y., Wang C., Vienna J. M., Videnovic Ivanov J., Vicens Zygmunt V., Venero Caceres M. C., Velasquez Pinto G., Veitch E., Vasakova M., Varone F., Varela B. E., Van Hal P., Van De Ven M., Van Der Lee I., Van Den Toorn L., Urrutia Gajate A., Urban J., Ugarte Fornell L. G., Tzouvelekis A., Twohig K., Turner A., Trujillo S., Triani A., Traila D., Torres V., Tomioka H., Tomii K., Tomic R., Toma C., Tokgoz Akyil F., Tobino K., Tobar R., Tiwari A., Tibana R., Tian X., Thillai M., Tham W., Teo F., Tekavec Trkanjec J., Teixeira P., Tarpey D., Tapias L., Tanizawa K., Tanino Y., Takada T., Tabaj G., Szolnoki E., Swarnakar R., Strambu I., Sterclova M., Spinks K., Soo C. I., Soltani A., Solanki S., Sobh E., Soares M. R., Smith J., Smith B., Slocum P., Slabbynck H., Sivokozov I., Shifren A., Shen S. M., Sharp C., Shanmuganathan A., Sebastiani A., Scarlata S., Savas R., Sasaki S., Santeliz J., Santana ANC., Sanchez R., Salinas M., Saito S., Ryan F., Royo Prats J. A., Rosi E., Rokadia H., Robles Perez A., Rivera Ortega P., Rio Ramirez M., Righetti S., Reichner C., Ravaglia C., Ratanawatkul P., Ramalingam V., Rajasekaran A., Radzikowska E., Ra S. W., Quadrelli S., Precerutti J., Prasad J., Popa D., Pizzalato S., Piotrowski W., Pineiro A., Piloni D., Peros Golubicic T., Perez R., Pereira C., Pereira B., Perch M., Patel N., Patel D., Papanikolaou I., Papakosta D., Panselinas E., Pang Y. K., Pandya P., Padrao E., Ozdemir Kumbasar O., Overbeek M. J., Otto Minasian A., O'Riordan D., Ora J., Oldham J., Okutan O., Ohshimo S., Oguzulgen I. K., Ogura T., O'Donnell T., O'Dochartaigh C., O'Beirne S., Novikova L., Novelli L., Noth I., Nogueira Mendes Neto N., Niroumand M., Nieto A., Neves A., Nambiar A., Nair S., Nadama R., Murtagh E., Mura M., Muller Quernheim J., Mukhopadhyay A., Mukherjee S., Morisset J., Moran O., Mooney J., Moller J., Mogulkoc N., Miyamoto A., Milenkovic B., Mette S., Mejia M., Mei F., Mazzei M., Matsuda T., Mason C., Martinez Frances M., Mannarino S., Mancuzo E., Malli F., Malhotra P., Maillo M., Maia J., Mahdavian M., Madsen F., Luckhardt T., Lucht W., Low S. Y., Lopez Miguel C. P., Lipchik R., Levy S., Levin K., Lee K. L., Lederer D., Lammi M. R., Kwan H. Y., Kukreja S., Kruavit A., Kotecki M., Kolilekas L., Knoop H., Kiyan E., Kishaba T., King Biggs M., Khor Y. H., Khan A., Khalil N., Kedia R., Kebba N., Kawano Dourado L., Kapitan K., Kan C. D., Kalyoncu A. F., Kalluri M., Kabasakal Y., Jyothula S., Juretschke M. A., Jovanovic D., Jonkers R., Jo H., Izumi S., Ishii H., Ikeda S., Ibrahim A., Hyldgaard C., Hunninghake G., Huie T., Hufton A., Hu X., Hseih W. C., Hoyos R., Hoyles R., Holguin Rodriguez O., Hogan M. P., Hodgson U., Hilkin Sogoloff H., Herrera E., Henry B. M., Hellemons M., Hecimovic A., Hayashi R., Hart S., Harari S., Haney S., Hambly N., Hakkim R., Gutierrez M., Gripaldo R., Gomez A., Goh N., Godoy R., Gilbert C., Giannarakis I., Gasparini S., Garcha P., Furtado S., Fois A., Flood Page P., Fletcher S., Fiss E., Figueroa Casas J., Figueroa Casas M., Fiddler C. A., Ferrara G., Fernandez Casares M., Felton C., Faverio P., Fabro A. T., Estrada A., Errhalt P., Enomoto N., Enghelmayer J. I., El Kersh K., Eiger G., Dubaniewicz A., Drakopanagiotakis F., Disayabutr S., Dijkstra A., Diaz Patino J. C., Diaz Castanon J. J., Dhooria S., Dhasmana D. J., De Rosa M., De Luca S., Delobbe A., Delgado D., Delgado C., De La Fuente I., De Kruif M., De Gier M., De Andrade J., Davidsen J. R., Daoud B., Dalhoff K., Cotera Solano J. V., Costa A. N., Coronel S., Confalonieri M., Conemans L., Comellas A., Colella S., Clemente S., Clark J., Ciuffreda M., Chung C. L., Chong S. G., Chirita D., Chen P. L., Chaudhuri N., Chambers D., Chalmers G., Chairman D., Chai G. T., Chacon Chaves R., Cetinsu V., Ceruti M., Ceballos Zuniga C. O., Castillo D., Carbone R. G., Caminati A., Callejas Gonzalez F. J., Butler M., Bustos C., Bukowczan M., Buendia I., Brunetti G., Brockway B., Bresser P., Breseghello J., Bouros D., Botero Zaccour J. A., Borzone G., Borie R., Blum H. C., Blank J., Biswas A., Bennett D., Benjamin M., Belaconi I. N., Beirne P., Beckert L., Bastiampillai S., Bascom R., Bartholmai B., Barros M., Ban AYL., Balestro E., Baldi B., Baddini Martinez J., Baburao A., Babu S., Averyanov A., Avdeev S., Athanazio R., Atahan E., Asuquo B., Assayag D., Antuni J., Antillon S., Anderson K. C., Anderson A., Alwani F., Altinisik G., Alsouofi N., Allam J. S., Al Jahdali H., Al Farttoosi A., Alfaro T., Al Busaidi N., Alavi Foumani A., Agreda Vedia M. G., Agarwal A., Afridi F., Adeyeye O. O., Adegunsoye A., Adamali H., Abedini A., Walsh, S. L. F., Maher, T. M., Kolb, M., Poletti, V., Nusser, R., Richeldi, L., Vancheri, C., Wilsher, M. L., Antoniou, K. M., Behr, J., Bendstrup, E., Brown, K., Calandriello, L., Corte, T. J., Cottin, V., Crestani, B., Flaherty, K., Glaspole, I., Grutters, J., Inoue, Y., Kokosi, M., Kondoh, Y., Kouranos, V., Kreuter, M., Johannson, K., Judge, E., Ley, B., Margaritopoulos, G., Martinez, F. J., Molina-Molina, M., Morais, A., Nunes, H., Raghu, G., Ryerson, C. J., Selman, M., Spagnolo, P., Taniguchi, H., Tomassetti, S., Valeyre, D., Wijsenbeek, M., Wuyts, W., Hansell, D., Wells, A., Zhu, P. S., Yuan, Y., Yoshito Fukuda, C., Yoshimatsu, Y., Xaubet, A., Wong, A. M., White, P., Westney, G., West, A., Wessendorf, T., Waseda, Y., Wang, C., Vienna, J. M., Videnovic Ivanov, J., Vicens Zygmunt, V., Venero Caceres, M. C., Velasquez Pinto, G., Veitch, E., Vasakova, M., Varone, F., Varela, B. E., Van Hal, P., Van De Ven, M., Van Der Lee, I., Van Den Toorn, L., Urrutia Gajate, A., Urban, J., Ugarte Fornell, L. G., Tzouvelekis, A., Twohig, K., Turner, A., Trujillo, S., Triani, A., Traila, D., Torres, V., Tomioka, H., Tomii, K., Tomic, R., Toma, C., Tokgoz Akyil, F., Tobino, K., Tobar, R., Tiwari, A., Tibana, R., Tian, X., Thillai, M., Tham, W., Teo, F., Tekavec Trkanjec, J., Teixeira, P., Tarpey, D., Tapias, L., Tanizawa, K., Tanino, Y., Takada, T., Tabaj, G., Szolnoki, E., Swarnakar, R., Strambu, I., Sterclova, M., Spinks, K., Soo, C. I., Soltani, A., Solanki, S., Sobh, E., Soares, M. R., Smith, J., Smith, B., Slocum, P., Slabbynck, H., Sivokozov, I., Shifren, A., Shen, S. M., Sharp, C., Shanmuganathan, A., Sebastiani, A., Scarlata, S., Savas, R., Sasaki, S., Santeliz, J., Santana, Anc., Sanchez, R., Salinas, M., Saito, S., Ryan, F., Royo Prats, J. A., Rosi, E., Rokadia, H., Robles Perez, A., Rivera Ortega, P., Rio Ramirez, M., Righetti, S., Reichner, C., Ravaglia, C., Ratanawatkul, P., Ramalingam, V., Rajasekaran, A., Radzikowska, E., Ra, S. W., Quadrelli, S., Precerutti, J., Prasad, J., Popa, D., Pizzalato, S., Piotrowski, W., Pineiro, A., Piloni, D., Peros Golubicic, T., Perez, R., Pereira, C., Pereira, B., Perch, M., Patel, N., Patel, D., Papanikolaou, I., Papakosta, D., Panselinas, E., Pang, Y. K., Pandya, P., Padrao, E., Ozdemir Kumbasar, O., Overbeek, M. J., Otto Minasian, A., O'Riordan, D., Ora, J., Oldham, J., Okutan, O., Ohshimo, S., Oguzulgen, I. K., Ogura, T., O'Donnell, T., O'Dochartaigh, C., O'Beirne, S., Novikova, L., Novelli, L., Noth, I., Nogueira Mendes Neto, N., Niroumand, M., Nieto, A., Neves, A., Nambiar, A., Nair, S., Nadama, R., Murtagh, E., Mura, M., Muller Quernheim, J., Mukhopadhyay, A., Mukherjee, S., Morisset, J., Moran, O., Mooney, J., Moller, J., Mogulkoc, N., Miyamoto, A., Milenkovic, B., Mette, S., Mejia, M., Mei, F., Mazzei, M., Matsuda, T., Mason, C., Martinez Frances, M., Mannarino, S., Mancuzo, E., Malli, F., Malhotra, P., Maillo, M., Maia, J., Mahdavian, M., Madsen, F., Luckhardt, T., Lucht, W., Low, S. Y., Lopez Miguel, C. P., Lipchik, R., Levy, S., Levin, K., Lee, K. L., Lederer, D., Lammi, M. R., Kwan, H. Y., Kukreja, S., Kruavit, A., Kotecki, M., Kolilekas, L., Knoop, H., Kiyan, E., Kishaba, T., King Biggs, M., Khor, Y. H., Khan, A., Khalil, N., Kedia, R., Kebba, N., Kawano Dourado, L., Kapitan, K., Kan, C. D., Kalyoncu, A. F., Kalluri, M., Kabasakal, Y., Jyothula, S., Juretschke, M. A., Jovanovic, D., Jonkers, R., Jo, H., Izumi, S., Ishii, H., Ikeda, S., Ibrahim, A., Hyldgaard, C., Hunninghake, G., Huie, T., Hufton, A., Hu, X., Hseih, W. C., Hoyos, R., Hoyles, R., Holguin Rodriguez, O., Hogan, M. P., Hodgson, U., Hilkin Sogoloff, H., Herrera, E., Henry, B. M., Hellemons, M., Hecimovic, A., Hayashi, R., Hart, S., Harari, S., Haney, S., Hambly, N., Hakkim, R., Gutierrez, M., Gripaldo, R., Gomez, A., Goh, N., Godoy, R., Gilbert, C., Giannarakis, I., Gasparini, S., Garcha, P., Furtado, S., Fois, A., Flood Page, P., Fletcher, S., Fiss, E., Figueroa Casas, J., Figueroa Casas, M., Fiddler, C. A., Ferrara, G., Fernandez Casares, M., Felton, C., Faverio, P., Fabro, A. T., Estrada, A., Errhalt, P., Enomoto, N., Enghelmayer, J. I., El Kersh, K., Eiger, G., Dubaniewicz, A., Drakopanagiotakis, F., Disayabutr, S., Dijkstra, A., Diaz Patino, J. C., Diaz Castanon, J. J., Dhooria, S., Dhasmana, D. J., De Rosa, M., De Luca, S., Delobbe, A., Delgado, D., Delgado, C., De La Fuente, I., De Kruif, M., De Gier, M., De Andrade, J., Davidsen, J. R., Daoud, B., Dalhoff, K., Cotera Solano, J. V., Costa, A. N., Coronel, S., Confalonieri, M., Conemans, L., Comellas, A., Colella, S., Clemente, S., Clark, J., Ciuffreda, M., Chung, C. L., Chong, S. G., Chirita, D., Chen, P. L., Chaudhuri, N., Chambers, D., Chalmers, G., Chairman, D., Chai, G. T., Chacon Chaves, R., Cetinsu, V., Ceruti, M., Ceballos Zuniga, C. O., Castillo, D., Carbone, R. G., Caminati, A., Callejas Gonzalez, F. J., Butler, M., Bustos, C., Bukowczan, M., Buendia, I., Brunetti, G., Brockway, B., Bresser, P., Breseghello, J., Bouros, D., Botero Zaccour, J. A., Borzone, G., Borie, R., Blum, H. C., Blank, J., Biswas, A., Bennett, D., Benjamin, M., Belaconi, I. N., Beirne, P., Beckert, L., Bastiampillai, S., Bascom, R., Bartholmai, B., Barros, M., Ban, Ayl., Balestro, E., Baldi, B., Baddini Martinez, J., Baburao, A., Babu, S., Averyanov, A., Avdeev, S., Athanazio, R., Atahan, E., Asuquo, B., Assayag, D., Antuni, J., Antillon, S., Anderson, K. C., Anderson, A., Alwani, F., Altinisik, G., Alsouofi, N., Allam, J. S., Al Jahdali, H., Al Farttoosi, A., Alfaro, T., Al Busaidi, N., Alavi Foumani, A., Agreda Vedia, M. G., Agarwal, A., Afridi, F., Adeyeye, O. O., Adegunsoye, A., Adamali, H., Abedini, A., National Institute for Health Research, British Lung Foundation, Walsh, S, Maher, T, Kolb, M, Poletti, V, Nusser, R, Richeldi, L, Vancheri, C, Wilsher, M, Antoniou, K, Behr, J, Bendstrup, E, Brown, K, Calandriello, L, Corte, T, Cottin, V, Crestani, B, Flaherty, K, Glaspole, I, Grutters, J, Inoue, Y, Kokosi, M, Kondoh, Y, Kouranos, V, Kreuter, M, Johannson, K, Judge, E, Ley, B, Margaritopoulos, G, Martinez, F, Molina-Molina, M, Morais, A, Nunes, H, Raghu, G, Ryerson, C, Selman, M, Spagnolo, P, Taniguchi, H, Tomassetti, S, Valeyre, D, Wijsenbeek, M, Wuyts, W, Hansell, D, Wells, A, Zhu, P, Yuan, Y, Yoshito Fukuda, C, Yoshimatsu, Y, Xaubet, A, Wong, A, White, P, Westney, G, West, A, Wessendorf, T, Waseda, Y, Wang, C, Vienna, J, Videnovic Ivanov, J, Vicens Zygmunt, V, Venero Caceres, M, Velasquez Pinto, G, Veitch, E, Vasakova, M, Varone, F, Varela, B, Van Hal, P, Van De Ven, M, Van Der Lee, I, Van Den Toorn, L, Urrutia Gajate, A, Urban, J, Ugarte Fornell, L, Tzouvelekis, A, Twohig, K, Turner, A, Trujillo, S, Triani, A, Traila, D, Torres, V, Tomioka, H, Tomii, K, Tomic, R, Toma, C, Tokgoz Akyil, F, Tobino, K, Tobar, R, Tiwari, A, Tibana, R, Tian, X, Thillai, M, Tham, W, Teo, F, Tekavec Trkanjec, J, Teixeira, P, Tarpey, D, Tapias, L, Tanizawa, K, Tanino, Y, Takada, T, Tabaj, G, Szolnoki, E, Swarnakar, R, Strambu, I, Sterclova, M, Spinks, K, Soo, C, Soltani, A, Solanki, S, Sobh, E, Soares, M, Smith, J, Smith, B, Slocum, P, Slabbynck, H, Sivokozov, I, Shifren, A, Shen, S, Sharp, C, Shanmuganathan, A, Sebastiani, A, Scarlata, S, Savas, R, Sasaki, S, Santeliz, J, Santana, A, Sanchez, R, Salinas, M, Saito, S, Ryan, F, Royo Prats, J, Rosi, E, Rokadia, H, Robles Perez, A, Rivera Ortega, P, Rio Ramirez, M, Righetti, S, Reichner, C, Ravaglia, C, Ratanawatkul, P, Ramalingam, V, Rajasekaran, A, Radzikowska, E, Ra, S, Quadrelli, S, Precerutti, J, Prasad, J, Popa, D, Pizzalato, S, Piotrowski, W, Pineiro, A, Piloni, D, Peros Golubicic, T, Perez, R, Pereira, C, Pereira, B, Perch, M, Patel, N, Patel, D, Papanikolaou, I, Papakosta, D, Panselinas, E, Pang, Y, Pandya, P, Padrao, E, Ozdemir Kumbasar, O, Overbeek, M, Otto Minasian, A, O'Riordan, D, Ora, J, Oldham, J, Okutan, O, Ohshimo, S, Oguzulgen, I, Ogura, T, O'Donnell, T, O'Dochartaigh, C, O'Beirne, S, Novikova, L, Novelli, L, Noth, I, Nogueira Mendes Neto, N, Niroumand, M, Nieto, A, Neves, A, Nambiar, A, Nair, S, Nadama, R, Murtagh, E, Mura, M, Muller Quernheim, J, Mukhopadhyay, A, Mukherjee, S, Morisset, J, Moran, O, Mooney, J, Moller, J, Mogulkoc, N, Miyamoto, A, Milenkovic, B, Mette, S, Mejia, M, Mei, F, Mazzei, M, Matsuda, T, Mason, C, Martinez Frances, M, Mannarino, S, Mancuzo, E, Malli, F, Malhotra, P, Maillo, M, Maia, J, Mahdavian, M, Madsen, F, Luckhardt, T, Lucht, W, Low, S, Lopez Miguel, C, Lipchik, R, Levy, S, Levin, K, Lee, K, Lederer, D, Lammi, M, Kwan, H, Kukreja, S, Kruavit, A, Kotecki, M, Kolilekas, L, Knoop, H, Kiyan, E, Kishaba, T, King Biggs, M, Khor, Y, Khan, A, Khalil, N, Kedia, R, Kebba, N, Kawano Dourado, L, Kapitan, K, Kan, C, Kalyoncu, A, Kalluri, M, Kabasakal, Y, Jyothula, S, Juretschke, M, Jovanovic, D, Jonkers, R, Jo, H, Izumi, S, Ishii, H, Ikeda, S, Ibrahim, A, Hyldgaard, C, Hunninghake, G, Huie, T, Hufton, A, Hu, X, Hseih, W, Hoyos, R, Hoyles, R, Holguin Rodriguez, O, Hogan, M, Hodgson, U, Hilkin Sogoloff, H, Herrera, E, Henry, B, Hellemons, M, Hecimovic, A, Hayashi, R, Hart, S, Harari, S, Haney, S, Hambly, N, Hakkim, R, Gutierrez, M, Gripaldo, R, Gomez, A, Goh, N, Godoy, R, Gilbert, C, Giannarakis, I, Gasparini, S, Garcha, P, Furtado, S, Fois, A, Flood Page, P, Fletcher, S, Fiss, E, Figueroa Casas, J, Figueroa Casas, M, Fiddler, C, Ferrara, G, Fernandez Casares, M, Felton, C, Faverio, P, Fabro, A, Estrada, A, Errhalt, P, Enomoto, N, Enghelmayer, J, El Kersh, K, Eiger, G, Dubaniewicz, A, Drakopanagiotakis, F, Disayabutr, S, Dijkstra, A, Diaz Patino, J, Diaz Castanon, J, Dhooria, S, Dhasmana, D, De Rosa, M, De Luca, S, Delobbe, A, Delgado, D, Delgado, C, De La Fuente, I, De Kruif, M, De Gier, M, De Andrade, J, Davidsen, J, Daoud, B, Dalhoff, K, Cotera Solano, J, Costa, A, Coronel, S, Confalonieri, M, Conemans, L, Comellas, A, Colella, S, Clemente, S, Clark, J, Ciuffreda, M, Chung, C, Chong, S, Chirita, D, Chen, P, Chaudhuri, N, Chambers, D, Chalmers, G, Chairman, D, Chai, G, Chacon Chaves, R, Cetinsu, V, Ceruti, M, Ceballos Zuniga, C, Castillo, D, Carbone, R, Caminati, A, Callejas Gonzalez, F, Butler, M, Bustos, C, Bukowczan, M, Buendia, I, Brunetti, G, Brockway, B, Bresser, P, Breseghello, J, Bouros, D, Botero Zaccour, J, Borzone, G, Borie, R, Blum, H, Blank, J, Biswas, A, Bennett, D, Benjamin, M, Belaconi, I, Beirne, P, Beckert, L, Bastiampillai, S, Bascom, R, Bartholmai, B, Barros, M, Ban, A, Balestro, E, Baldi, B, Baddini Martinez, J, Baburao, A, Babu, S, Averyanov, A, Avdeev, S, Athanazio, R, Atahan, E, Asuquo, B, Assayag, D, Antuni, J, Antillon, S, Anderson, K, Anderson, A, Alwani, F, Altinisik, G, Alsouofi, N, Allam, J, Al Jahdali, H, Al Farttoosi, A, Alfaro, T, Al Busaidi, N, Alavi Foumani, A, Agreda Vedia, M, Agarwal, A, Afridi, F, Adeyeye, O, Adegunsoye, A, Adamali, H, Abedini, A, and Pulmonary Medicine

Subjects
Male, Pediatrics, International Cooperation, Respiratory System, Hospitals, University, Idiopathic pulmonary fibrosis, 0302 clinical medicine, Cohen's kappa, Diagnosis, UK, 030212 general & internal medicine, Medical diagnosis, Referral and Consultation, Pulmonologists, Idiopathic Pulmonary Fibrosi, Interstitial lung disease, 11 Medical And Health Sciences, Middle Aged, respiratory system, Prognosis, Hospitals, humanities, Dimensional Measurement Accuracy, Clinical Competence, Diagnosis, Differential, Diagnostic Techniques, Respiratory System, Female, Humans, Idiopathic Pulmonary Fibrosis, Quality of Health Care, Reproducibility of Results, Human, Cohort study, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Prognosi, education, MEDLINE, Reproducibility of Result, INTERSTITIAL PNEUMONIA, Interstitial Lung Diseases, 03 medical and health sciences, Internal medicine, PARENCHYMAL LUNG-DISEASE, MANAGEMENT, medicine, Idiopathic pulmonary fibrosis, diagnosis, Pulmonologist, University, business.industry, MORTALITY, Original Articles, medicine.disease, respiratory tract diseases, Diagnostic Techniques, IPF Project Consortium, 030228 respiratory system, Differential, INTEROBSERVER AGREEMENT, UPDATE, COOPERAÇÃO INTERNACIONAL, Differential diagnosis, business
Abstract

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (κw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the C-index. A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (κw=0.65, IQR 0.53–0.72, p20 years of experience (C-index=0.72, IQR 0.0–0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70–0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72–0.75). Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts., Academic status, access to MDT meetings and clinician experience predict accuracy of a clinical diagnosis of IPF http://ow.ly/k43W30cTMg1

Published
2017
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3. Validation of multidisciplinary diagnosis in IPF

Author

Castillo, D., Walsh, S., Hansell, D. M., Vasakova, M., Cottin, Vincent, Altinisik, G., Palmucci, S., Sterclova, M., Harari, S., Richeldi, L., Vancheri, C., Wells, A. U., group, Erice Ild working, Infections Virales et Pathologie Comparée - UMR 754 (IVPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL)

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Validation study, Humans, Idiopathic Pulmonary Fibrosis/*diagnosis, Patient Care Team, Practice Guidelines as Topic, Reproducibility of Results, [SDV]Life Sciences [q-bio], Respiratory System, Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO, Critical Care Medicine, 03 medical and health sciences, 0302 clinical medicine, Multidisciplinary approach, medicine, Disease Exacerbation, 030212 general & internal medicine, Intensive care medicine, Patient care team, Fibrosing alveolitis, business.industry, Idiopathic Pulmonary Fibrosis, Clinical Practice, 030228 respiratory system, Clinical competence, Consensus development, business
Published
2018
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4. Grosor de Íntima-Media Carotídea en Niños Sanos por Técnica Ecográfica Computarizada

Author

Catalina Le Roy O, Catalina Bagés M, Anibal Espinoza G, and Carlos Castillo D

Subjects
Percentile, business.industry, Ultrasound, Abdominal circumference, Normal values, medicine.disease, Vascular endothelium, Pediatrics, Perinatology and Child Health, cardiovascular system, medicine, cardiovascular diseases, Metabolic syndrome, Nuclear medicine, business, Body mass index, Target organ
Abstract

Introduction: Vascular endothelium is a target organ in metabolic syndrome. Ultrasound measurement of intimae-media thickness (IMT) is used in adults to predict cardiovascular risk, but normal values in children are unknown. Objective: To describe arterial intima-media thickness in healthy children, by means of an ultrasonographic technique and a specific software. Subjects and Methods: Seventy-four healthy children, 39 males, ages 5-15 y.o., body mass index (BMI) 10-85 percentile were selected from an upper-middle socioeconomic background. Subjects were grouped by age. Three measurements were carried out to each subject at the middle third of the right common carotid for maximal intima-media thickness using a Phillips iU22 ultrasound system; a 12-5 MHz lineal transducer and QLAB advanced quantification software, which includes a specific program for automated IMT measurements, were used. Weight, stature, BMI, and abdominal circumference were registered. Results: No significant differences in the IMT values according to age or gender were found. Median IMT was 0.41 mm (0.40-0.56 mm); 5 children presented IMT 0.50-0.56 mm (> 75th percentile). The median IMT for those children with abdominal circumference < 50th percentile was the same for those over 50th percentile (0.41 mm). Conclusions: Measurements of carotid intima-media thickness for healthy Chilean children were found to be in the expected range, in relation with adult known values.

Published
2011
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5. Desafíos Emergentes en la Nutrición del Adolescente

Author

M. LUISA AGUIRRE C, CARLOS CASTILLO D, and CATALINA LE ROY O

Subjects
Gerontology, Calorie, business.industry, Addiction, media_common.quotation_subject, Social change, Physical activity, Increased risk, Pediatrics, Perinatology and Child Health, Nutritional behavior, Medicine, Eating behavior, business, Autonomy, media_common
Abstract

Adolescence is a dynamic period of the life cycle, with significant physical, psychological and social changes, leading to autonomy and independence in eating behaviors. During this time, there is an increased risk in nutritional behavior, including excessive intake of calories, increased consumption of fat, cholesterol, and simple carbohydrates, and nutrient deficiencies such as calcium. In addition, other behaviors are at risk, including disorganized mealtimes, eating outside the home, and the onset of eating behavior disorders and addictions (caffeine, alcohol). It is necessary to develop preventive educational programs including physical activity among adolescents, to promote healthy behaviors into adulthood. Significant literatee in Chile and South America is reviewed.

Published
2010
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6. Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: protocol for DIET-HD, a prospective multinational cohort study

Author

Palmer, Sc, Ruospo, M, Campbell, Kl, Garcia Larsen, V, Saglimbene, V, Natale, P, Gargano, L, Craig, Jc, Johnson, Dw, Tonelli, M, Knight, J, Bednarek Skublewska, A, Celia, E, Del Castillo, D, Dulawa, J, Ecder, T, Fabricius, E, Frazão, Jm, Gelfman, R, Hoischen, Sh, Schön, S, Stroumza, P, Timofte, D, Török, M, Hegbrant, J, Wollheim, C, Frantzen, L, Strippoli, Gf, Raña, S, Serrano, M, Claros, S, Arias, M, Petracci, L, Arana, M, De Rosa, P, Gutierrez, A, Simon, M, Vergara, V, Tosi, M, Cernadas, M, Vilamajó, I, Gravac, D, Paulón, M, Penayo, L, Carrizo, G, Ghiani, M, Perez, G, Da Cruz, O, Galarce, D, Gravielle, M, Vescovo, E, Paparone, R, Mato Mira, C, Mojico, E, Hermida, O, Florio, D, Yucoswky, M, Labonia, W, Rubio, D, Di Napoli, G, Fernandez, A, Altman, H, Rodriguez, J, Serrano, S, Valle, G, Lobos, M, Acosta, V, Corpacci, G, Jofre, M, Gianoni, L, Chiesura, G, Capdevila, M, Montenegro, J, Bequi, J, Dayer, J, Gómez, A, Calderón, C, Abrego, E, Cechín, C, García, J, Corral, J, Natiello, M, Coronel, A, Muñiz, M, Muñiz, V, Bonelli, A, Sanchez, F, Maestre, S, Olivera, S, Camargo, M, Avalos, V, Geandet, E, Canteli, M, Escobar, A, Sena, E, Tirado, S, Peñalba, A, Neme, G, Cisneros, M, Oliszewski, R, Nascar, V, Daud, M, Mansilla, S, Paredes Álvarez, A, Gamín, L, Arijón, M, Coombes, M, Zapata, M, Boriceanu, C, Lankester, M, Poignet, Jl, Saingra, Y, Indreies, M, Santini, J, Amar, M, Robert, A, Bouvier, P, Merzouk, T, Villemain, F, Pajot, A, Tollis, F, Brahim Bounab, M, Benmoussa, A, Albitar, S, Guimont, Mc, Ciobotaru, P, Guerin, A, Diaconita, M, Shh, Saupe, J, Ullmann, I, Grosser, S, Kunow, J, Grueger, S, Bischoff, D, Benders, J, Worch, P, Pfab, T, Kamin, N, Roesch, M, Albert, K, Csaszar, I, Kiss, E, Kosa, D, Orosz, A, Redl, J, Kovacs, L, Varga, E, Szabo, M, Magyar, K, Zajko, E, Bereczki, A, Csikos, J, Kerekes, E, Mike, A, Steiner, K, Nemeth, E, Tolnai, K, Toth, A, Vinczene, J, Szummer, S, Tanyi, E, Szilvia, M, Murgo, Am, Sanfilippo, N, Dambrosio, N, Saturno, C, Matera, G, Benevento, M, Greco, V, di Leo, G, Papagni, S, Alicino, F, Marangelli, A, Pedone, F, Cagnazzo, Av, Antinoro, R, Sambati, Ml, Donatelli, C, Ranieri, F, Torsello, F, Steri, P, Riccardi, C, Flammini, A, Moscardelli, L, Boccia, E, Mantuano, M, Di Toro Mammarella, R, Meconizzi, M, Fichera, R, D'Angelo, A, Latassa, G, Molino, A, Fici, M, Lupo, Antonio, Montalto, G, Messina, S, Capostagno, C, Randazzo, G, Pagano, S, Marino, G, Rallo, D, Maniscalco, A, Trovato, Om, Strano, C, Failla, A, Bua, A, Campo, S, Nasisi, P, Salerno, A, Laudani, S, Grippaldi, F, Bertino, D, Di Benedetto, Dv, Puglisi, A, Chiarenza, S, Lentini Deuscit, M, Incardona, Cm, Scuto, G, Todaro, C, Dino, A, Novello, D, Coco, A, Bocheńska Nowacka, E, Jaroszyński, A, Drabik, J, Wypych Birecka, M, Daniewska, D, Drobisz, M, Doskocz, K, Wyrwicz Zielińska, G, Kosicki, A, Ślizień, Ws, Rutkowski, P, Arentowicz, S, Dzimira, S, Grabowska, M, Ostrowski, J, Całka, A, Grzegorczyk, T, Dżugan, W, Mazur, M, Myślicki, M, Piechowska, M, Kozicka, D, Mira, Ar, Martins, V, Velez, B, Pinheiro, T, Agapi, E, Ardelean, Cl, Baidog, A, Bako, G, Barb, M, Blaga, A, Bodurian, E, Bumbea, V, Dragan, E, Dumitrache, D, Florescu, L, Havasi, N, Hint, S, Ilies, R, Mandita, Ag, Marian, Ri, Medrihan, Sl, Mitea, L, Mitea, S, Mocanu, R, Moro, Dc, Nitu, M, Popa, Ml, Popa, M, Railean, E, Scuturdean, Ar, Szentendrey, K, Teodoru, Cl, Varga, A, Bernat, A, De la Torre, B, Lopez, A, Martin, J, Cuesta, G, Rodriguez, Rm, Ros, F, Garcia, M, Orero, E, Ros, E, Goch, J, Katzarski, Ks, Wulcan, A, Akbiber, H, Arslan, H, Bicen, L, Buyukkiraz, A, Celik, R, Dogan, Is, Erkalkan, S, Ertas, A, Hark, U, Iravul, E, Karakaya, M, Mengu, K, Ongun, S, Ozkan, Z, Ozlu, A, Ozveren, N, Sifil, Hm, Sonmez Turksoz, N, and Yilmaz, Z.

Subjects
Adult, Male, medicine.medical_specialty, Pediatrics, Adolescent, Turkey, medicine.medical_treatment, Argentina, NUTRITION & DIETETICS, Nutritional Status, Infections, Young Adult, Informed consent, Renal Dialysis, Cause of Death, Fatty Acids, Omega-6, Epidemiology, Fatty Acids, Omega-3, medicine, Protocol, Humans, EPIDEMIOLOGY, Social determinants of health, hemodialysis, Prospective Studies, Prospective cohort study, Dialysis, Renal Medicine, business.industry, Other Research Radboud Institute for Health Sciences [Radboudumc 0], General Medicine, medicine.disease, Europe, Hospitalization, Cardiovascular Diseases, Food, Research Design, Emergency medicine, Kidney Failure, Chronic, Female, Hemodialysis, business, Energy Intake, Kidney disease, Cohort study
Abstract

Contains fulltext : 153534.pdf (Publisher’s version ) (Open Access) INTRODUCTION: Adults with end-stage kidney disease (ESKD) treated with haemodialysis experience mortality of between 15% and 20% each year. Effective interventions that improve health outcomes for long-term dialysis patients remain unproven. Novel and testable determinants of health in dialysis are needed. Nutrition and dietary patterns are potential factors influencing health in other health settings that warrant exploration in multinational studies in men and women treated with dialysis. We report the protocol of the "DIETary intake, death and hospitalisation in adults with end-stage kidney disease treated with HaemoDialysis (DIET-HD) study," a multinational prospective cohort study. DIET-HD will describe associations of nutrition and dietary patterns with major health outcomes for adults treated with dialysis in several countries. METHODS AND ANALYSIS: DIET-HD will recruit approximately 10,000 adults who have ESKD treated by clinics administered by a single dialysis provider in Argentina, France, Germany, Hungary, Italy, Poland, Portugal, Romania, Spain, Sweden and Turkey. Recruitment will take place between March 2014 and June 2015. The study has currently recruited 8000 participants who have completed baseline data. Nutritional intake and dietary patterns will be measured using the Global Allergy and Asthma European Network (GA(2)LEN) food frequency questionnaire. The primary dietary exposures will be n-3 and n-6 polyunsaturated fatty acid consumption. The primary outcome will be cardiovascular mortality and secondary outcomes will be all-cause mortality, infection-related mortality and hospitalisation. ETHICS AND DISSEMINATION: The study is approved by the relevant Ethics Committees in participating countries. All participants will provide written informed consent and be free to withdraw their data at any time. The findings of the study will be disseminated through peer-reviewed journals, conference presentations and to participants via regular newsletters. We expect that the DIET-HD study will inform large pragmatic trials of nutrition or dietary interventions in the setting of advanced kidney disease.

Published
2015

7. COLGAJO BILOBULADO EN EPITELIOMAS BASOCELULARES NASALES

Author

Paulo Castillo D, Mathias Yagnam D, Antonio Troncoso R, Marcelo Feres W, Patricio Fuentes F, and David Coronel F

Subjects
medicine.medical_specialty, Epithelioma, business.industry, Anatomy, medicine.disease, Surgery, Colgajo bilobulado, medicine.anatomical_structure, epitelioma basocelular nasal, Bilobed flap, otorhinolaryngologic diseases, medicine, business, Nose
Abstract

Objetivo: La nariz es el área corporal con mayor incidencia de epiteliomas basocelulares y la reparación de los defectos secundarios a su resección, puede ser un desafío. El objetivo es presentar nuestra experiencia en la reparación de defectos nasales, empleando colgajos bilobulados. Material y Método: Se realizó una revisión retrospectiva de 10 pacientes con epiteliomas basocelulares nasales en que empleamos este colgajo. Resultados: En todos los pacientes el colgajo bilobulado permitió la reparación del defecto, con la propia piel nasal y sin complicaciones. Conclusiones: Consideramos al colgajo bilobulado como una excelente técnica para la reparación de defectos nasales de mediano tamaño, secundarios a la resección de epiteliomas basocelulares.

Published
2014

8. Programa de prevención y control de las enfermedades respiratorias agudas de la infancia en Santiago, Chile

Author

Salomé Sánchez C, Carlos Castillo D, Patricia Navarrete M, and Leonardo Véjar M

Subjects
medicine.medical_specialty, education.field_of_study, lcsh:Arctic medicine. Tropical medicine, Poverty, business.industry, lcsh:RC955-962, lcsh:Public aspects of medicine, Population, lcsh:R, Public Health, Environmental and Occupational Health, lcsh:Medicine, lcsh:RA1-1270, medicine.disease, Malnutrition, Pneumonia, Health facility, Health care, Emergency medicine, medicine, Health education, business, education, Cause of death
Abstract

With the decline in Chile of deaths from diarrhea and malnutrition pneumonia has become the leading cause of death among small children. The Southeastern Metropolitan Health Service one of 26 government health services in Chile has doubled its coverage to over a million inhabitants over the past decade as a result of immigration. Much of this population lives in poverty or extreme poverty. Health care is provided in 16 urban and 8 rural posts and in 1 general hospital. A primary care program to control early childhood pneumonia was initiated in the health zone in 1989. Its specific objectives were to reduce mortality form pneumonia among infants and children under 5 years old reduce pneumonia deaths occurring in the home increase hospitalization of children with severe respiratory infections and improve treatment for acute respiratory infections in homes and health centers. Records of acute respiratory infections in the health area for 1990-94 were examined and information from various sources on the pneumonia deaths was reviewed. A series of workshops was organized in each health facility and presented to all health personnel including doctors nurses and auxiliaries. The training stressed warning signs the concept of focusing attention on groups at risk and access to the health system. Each facility had a room called the short-term hospitalization room equipped with cots oxygen respirators and aerosol bronchodilators. Each center referred its most serious cases to the hospital treated less severe cases and provided education on respiratory infections to family members of patients in risk groups and to the community at large. In the first 5 years pneumonia mortality among children aged under 5 in the health area declined from 69.4 to 37.7 per 100000. The number of children under 1 year of age who died of acute respiratory infections declined from 73 to 43 corresponding to a reduction from 3.2 to 1.7 per 1000. The 1994 cost of the program was estimated at US$223834.

Published
1998

9. EL ZINC EN LA SALUD HUMANA -1

Author

Doricela Diazgranados, Carlos Castillo D, and Daniel López de Romaña

Subjects
intervenciones, deficiencia, Nutrition and Dietetics, business.industry, zinc, chemistry.chemical_element, Zinc, Human health, chemistry, salud, Environmental health, homeostasis, Medicine, business, Food Science
Abstract

El zinc es un catión divalente con múltiples funciones en el cuerpo humano. La absorción de zinc ocurre en el intestino delgado y es junto con la excreción de zinc vía heces, los puntos de control de la homeostasis de zinc. El zinc es un nutriente esencial con un rol específico en más de 300 enzimas, las cuales participan en todas las reacciones bioquímicas importantes del cuerpo humano. Por ende, el estado de zinc tiene un efecto directo en el crecimiento, el desarrollo neurológico y de comportamiento y en el sistema inmune. El diagnóstico de deficiencia de zinc en individuos no es posible pues aun no existe un marcador lo suficientemente sensible. Sin embargo, el zinc sérico es aceptable para evaluar a poblaciones. Finalmente, se pueden usar las estrategias de suplementación, fortificación y/o modificación alimentaria para controlar y/o prevenir la deficiencia de zinc.

Published
2010
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10. Short Bowel Syndrome

Author

Jesús Rebollo G, Teresa Young A, Sylvia Ibáñez T, Daniel Abumohor D, Verónica Mann B, Carlos Castillo D, Elisa Aguila G, Silvia Guardia B, Angel Fuentes Z, Marcelo Ducheylard R, Guillermo Correia D, Abdallah Harún M, Carolina Laguna N, and Pedro Herskovic L

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Immunology, medicine, Short bowel syndrome, medicine.disease, business, Gastroenterology
Published
2008
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11. EVALUACIÓN DEL APOYO NUTRICIONAL A PACIENTES PEDIÁTRICOS GRAVES

Author

Jessica Osorio E, Carlos Castillo D, and M. Adela Godoy R

Subjects
Gynecology, severe illnesses, medicine.medical_specialty, Nutrition and Dietetics, business.industry, nutritional support, malnutrition, malnutrición, Nutrient intake, apoyo nutricional, children, enfermedad grave, medicine, business, Ingesta alimentaria, niños, Food Science
Abstract

Introducción: Los niños gravemente enfermos presentan mayor riesgo de malnutrición, de complicaciones y de estadías más prolongadas. Objetivo: Evaluar el estado nutricional y el apoyo nutricional entregado a niños hospitalizados en una unidad de cuidados intermedios. Sujetos y método: Se estudiaron 123 niños, ingresados consecutivamente a un Hospital de Santiago. La evaluación nutricional se realizó al ingreso y al 5º día. La ingesta alimentaria se evaluó por pesaje de alimentos. Resultados: 46% de los niños presentó malnutrición por déficit, 10% déficit nutricional agudo, 11% sobrepeso u obesidad y 33 % estado nutricional normal. El 20% de los niños cubría sus requerimientos energéticos, de estos 33% se encontraba con alimentación enteral, 42% por vía oral y 21% mixta (oral más enteral). Entre los niños que cubrieron menos del 100% de sus requerimientos, 19% sólo recibían soluciones glucosadas vía intravenosa. La ingesta proteica promedio fue 1,1 ± 0,7 g/kg peso, lo que equivale a un P% de 8,9 ± 3,3. Conclusiones: Un porcentaje bajo de los niños ingresados a una unidad de cuidados intermedios cubren sus requerimientos energéticos (20%) y proteicos (32%). Los mejores aportes lo lograron aquellos niños con alimentación enteral o alimentación mixta Introduction: Children admitted to a Hospital due to severe illnesses have an increased risk of wasting, complications and of prolonged stays at the hospital. Objective: To evaluate the nutritional status and the nutritional support provided to children with severe non-critical illnesses during their stay at a pediatric hospital. Subjects and method: One hundred and twenty three children consecutively admitted to a Pediatric Department of a public hospital were followed up during their stay. A nutritional assessment was prospectively performed on admission and after 5 days. The nutrient intakes were evaluated by direct observation and weighing the foods administered and rejected by children. Results: Malnutrition was found in 46% of children, including 10% of wasting, 11% overweight and 33% with a normal nutritional status. Twenty percent of children covered their energy requirements with enteral feeding, 42% with oral feedings and 21% with oral plus enteral feeding. Among those who partially covered their energy requirements, 19% received only intravenous glucose solutions. Mean protein intake was 1.1 ± 0.7 g/Kg (P%= 8.9 ± 3,3). Conclusions: A low proportion of children hospitalized due to severe non-critical illnesses cover their energy and protein requirements. More adequate energy intakes were provided by enteral feedings alone or by oral and enteral feedings

Published
2007

12. Alimentación parenteral: Factores ambientales y químicos asociados a su estabilidad

Author

Carlos Castillo D, Daisy Miranda C, and Saturnino de Pablo

Subjects
prescription, Pediatrics, medicine.medical_specialty, pediatrics, business.industry, condiciones ambientales, Pediatría, Direct observation, parenteral nutrition, recomendaciones, estabilidad, stability, Parenteral nutrition, Alimentación parenteral, recommendations, Pediatrics, Perinatology and Child Health, Medicine, In patient, Pediatric unit, Medical prescription, business, environment
Abstract

Introducción: La alimentación parenteral (ALPAR) es muy usada en Pediatría en enfermos que no pueden recibir los aportes nutricionales requeridos por vía digestiva. Sin embargo, tiene riesgos de alteraciones físico-químicas y con ello, de complicaciones en el paciente. Objetivos: Comparar las prescripciones de ALPAR en Servicios de Pediatría y neonatología de 2 hospitales, en cuanto a las recomendaciones nutricionales y características de su administración en relación a las normas nacionales; describir el impacto de algunos factores ambientales que pueden afectar su estabilidad. Pacientes y Métodos: Se seleccionaron al azar 99 ALPAR aportadas a enfermos hospitalizados en Unidades Pediátricas y Neonatales de dos Hospitales públicos de Santiago, evaluándose su forma de administración e insumos utilizados por 24 horas. Se constataron algunas características fisicoquímicas: modificaciones en aspecto (observación directa), cambios de pH (pHmetro) y las temperaturas medioambientales por 24 h en forma continua mediante termómetro ambiental. Resultados: Las prescripciones de las ALPAR se ajustaron a las recomendaciones nutricionales. Hubo una variabilidad en los insumos usados en la administración de la ALPAR según Unidad y Hospital. Se observó mayores temperaturas ambientales en las Unidades de Neonatología (28,1 ± 1,7 ºC) en comparación a Pediatría (26,5 ± 1,4 ºC), sin una evidente asociación con alteraciones de su estabilidad. Conclusiones: Las ALPAR en hospitales públicos cumplen con los requerimientos nutricionales pediátricos; pero no existe uniformidad en la forma de administrarlas. Se requiere mejorar las guías nacionales respecto a su organización general, insumos utilizados y precauciones en cuanto a condiciones ambientales Background: Parenteral nutrition (PN) is widely used in Pediatrics, specially in patients who cannot be fed enterally. However, PN has been associated with an increase risk of physicochemical alterations and clinical complications in patients. Objectives: Compare national PN prescription in relation to international recommendations for children and evaluate the influence of some environmental conditions that may affect its stability. Method: 99 PN administered during 24 h, were randomly selected among those delivered to children hospitalized in Pediatric and Neonatal Units in Hospital San Borja Arriarán and Dr. Luis Calvo Mackenna at Santiago-Chile. The nutrients provided in relation to recommendations, changes in appearance (direct observation), changes in pH (pHmeter) and 24-hr environmental temperatures were evaluated. Results: PN prescriptions were in accordance with nutritional recommendations. Wide variations in materials used for PN were observed in each Hospital and Pediatric Unit. Furthermore, environmental temperatures were greater in the Neonatal Units (28,1 ± 1,7 ºC) than in the Pediatric Units (26,5 ± 1,4 ºC), with no evident association with PN unstability. Conclusions: Parenteral nutrition in public hospitals fulfil the nutrient recommendations. There is no uniformity among Pediatric Hospitals and Units regarding materials used for PN administration. Improvements in national clinical guidelines for parenteral nutrition are required, especially in relation to materials and environmental conditions

Published
2007

13. Basic food basket, food pyramid and nutritional recommendations for chilean children

Author

Ximena Díaz Sm, Carlos Castillo D, Sonia Olivares C, Francisco Moraga M, Daniela Neri D, and María Jesús Rebollo G

Subjects
recomendaciones de nutrientes, business.industry, nutritional recommendations, Food pyramid, Food basket, Food consumption, Canasta básica de alimentos, Nutrient intake, Zinc intake, Age and gender, food pyramid, pirámide alimentaria, children, Pediatrics, Perinatology and Child Health, Medicine, Food science, business, Basic food basket, niños
Abstract

La canasta básica de alimentos (CBA) se elaboró para evaluar pobreza a nivel nacional, ajustada para cubrir los requerimientos de energía (E) y proteínas de la población. Las guías alimentarias y la pirámide alimentaria (PA) son instrumentos educativos, representando el ideal de consumo. No se conoce la relación entre ambos instrumentos. Objetivo: Analizar el consumo de nutrientes de preescolares (PE) y escolares (ES) de una familia chilena urbana representativa, de acuerdo a la CBA urbana y compararla con las recomendaciones internacionales y con la PA chilena. Métodos: Se analizó la información base de la CBA (MIDEPLAN) y de la PA chilena; se asumió una familia con 2 hijos (4 y 10 años), una estimación de consumo proporcional de la canasta según recomendaciones de E y una frecuencia de consumo semanal para los grupos de alimentos por esta familia tipo. Resultados: El consumo de E fue 125% para el PE y 91% para el ES de los estándares FAO/OMS 2002; el consumo de proteínas de alto valor biológico fue bajo comparado con la recomendación: PE: 76% y ES: 42%. El porcentaje de E de la canasta como grasas, estuvo de acuerdo a lo recomendado: 21%, con 7% de grasa saturada. La adecuación del consumo de Ca fue 31% para el PE y 29% para el ES; en Zn alcanzó al 76% para PE y 73% para ES. Conclusiones: La CBA chilena presenta deficiencias en aportes de proteínas de alto valor biológico, Ca y Zn; la PA chilena está excedida en proteínas y deficiente en Zn, ambas comparadas con las recomendaciones internacionales; se justifica reanalizar ambos instrumentos The basic food basket (BFB) has been developed to evaluate poverty and patterns of food consumption in many countries, including Chile. Different alternatives, like food pyramid (FP), have been proposed as guidelines for nutritional education. The relationship between both tools is unknown. Objective: To analyze the nutrient intake of children belonging to low-income Chilean families according to the BFB, in order to compare it with nutritional recommendations and Chilean FP. Methods: Information included in the CBA (MIDEPLAN) and Chilean BFB was analyzed. A family with 2 children (4 and 10 years-old) was studied in their feeding based on the BFB. We assume a proportional rate of intake according to normal energy (E) requirements by age and gender. The standard for nutrients consumption were those of FAO-WHO 2002 for energy and protein and WHO 1996 for zinc. Results: The E consumption with the BFB was 125% for preschool (PS) and 91% for school children (SC) of recommendations. High quality protein consumption was 76% in PS and 42% in SC children. Energy provided by fats was similar in terms of recommendations (21% with 7% saturated fats). The intake of calcium was 31% for PS and 29% for SC; zinc intake was 76% for PS and 73% for SC, all compared to WHO 1996 recommendations. Conclusions: BFB does not provide adequate amounts of protein, calcium and zinc. Chilean FP for children exceeds in proteins and contains few zinc. The analysis of both tools is recommended

Published
2006

14. Anisakiasis en un lactante

Author

Virginia Martínez C, Carlos Castillo D, and Francisco Ossandón C

Subjects
medicine.medical_specialty, biology, Crying, business.industry, invaginación intestinal, Lumen (anatomy), biology.organism_classification, digestive system, Anisakis, Gastroenterology, Appendix, medicine.anatomical_structure, Internal medicine, Pediatrics, Perinatology and Child Health, Epidemiology, anisakiasis, medicine, parasitosis, intestinal intusucception, medicine.symptom, business, Recent onset, Pathological
Abstract

on el objetivo de revisar la importancia epidemiológica para el ser humano del parásito Anisakiasis, se presenta el caso de un lactante de 7 meses de edad quien presenta en forma brusca crisis prolongada de llanto. Acude a una Unidad de emergencia donde es intervenido quirúrgicamente debido a una invaginación ileo-ileal. Se desinvagina por vía laparoscópica y se aprovecha de extraer el apéndice cecal; éste muestra en el análisis anátomo-patológico un parásito desvitalizado, correspondiente a un anisakis, se discuten aspectos epidemiológicos y de prevención de esta enfermedad. Anisakiasis in a 7 month old infant We report the case of a 7 month old infant who presented in Emergencies with episodes of protracted crying of recent onset. He underwent laparoscopic examination, which revealed an ileo-ileal intusucception. A reduction was performed and the caecal appendix removed. The pathological finding was the presence of an anisakis in the appendicular lumen. The epidemiological implications of this fish parasite in humans is discussed

Published
2003

15. Contaminación microbiana de fórmulas enterales de uso hospitalario

Author

Karen Ridermann S., Juan Kehr S., Loriana Castillo D., Waldo Aranda Ch, Blanca Morales V., and Mónica Campano B.

Subjects
business.industry, Enteral feeds, Microbiological quality, Fecal coliform, Animal science, Microbiological contamination, Pediatrics, Perinatology and Child Health, microbiological contamination, Ready to use, Medicine, Contaminación Microbiana, Enteral formulas, enteral feeds, Nutricion enteral, business, Nutritional science, Nutrición Enteral
Abstract

Objetivo: Determinar la calidad microbiológica de dos fórmulas enterales (FE): ADN® polvo (P) y ADN® líquido (L) listo para utilizar. Método: en 4 hospitales de Santiago se realizó recuento de mesófilas (Me), coliformes totales (CT) y coliformes fecales (CF) en un total de 144 muestras de FE, obtenidas a los tiempos 0, 2, 4, 6, 10, 24 y 48 horas. Los estándares de calidad microbiológica (ECM) utilizados al tiempo cero fueron: < 102 UFC/ml de Me y ausencia de CT, y a los restantes tiempos: < 103 UFC/ml de Me; < 10 UFC/ml de CT y ausencia de CF. Resultados: Los porcentajes de cumplimiento de los ECM de ADN®-P para Me fueron: 42%, 75%, 50%, 33% y 25%, y para CT fueron: 83%, 91,5%, 83%, 75% y 42% al tiempo 0, 2, 4, 6 y 10 horas respectivamente. El cumplimiento de los ECM de ADN®-L para Me fue 100% al tiempo 0, 2, 4 y 6 horas, 92% a las 10 horas; para CT fue de 100% en todos los tiempos evaluados. El recuento de CT fue significativamente superior en las muestras de ADN®-P desde las cuatro horas en adelante. El ADN® -L abierto y refrigerado a 4° C cumplió con los ECM hasta las 48 horas de estudio. Conclusiones: La mayor adhesión de las FE de ADN®-L a los ECM sugieren privilegiar su uso. Las FE de ADN®-P y de ADN®-L pueden estar colgadas a temperatura ambiente hasta por 4 y 10 horas respectivamente. La conservación de cajas Tetra Pak de ADN®-L abiertas y refrigeradas a 4° C permite su uso hasta las 48 horas Objective: to determine the microbiological quality of 2 ready to use enteral formulas ADN powder (P) and ADN liquid (L). Methods: the study was carried out in 4 hospitals in Santiago. 144 samples were cultured at time 0 preparation), 2, 4, 6, 8 and 10 hours after preparation. At 24 and 48 hours samples were taken from L kept at 4° C. Counts of mesophils (Me), total coliforms (TC) and faecal coliforms (FC) were measured. The microbial quality standards (MQS) were at time 0 < 1 x 102 UFC/ml of Me and no TC, at time 2,4,6,8 and 10 hours, < 1 x 103 UFC/ml of Me, < 10 UFC/ml TC and no FC. Results: the average that fulfilled MQS criteria for P at times 0, 2, 4, 6, 8, 10 hours were; Me: 42%, 75%, 50%, 33% and 25%. For CT 83%, 91.5%, 83%, 75% and 42%. For L at times 0,2,4,6 and 8 hours 100% and at 10 hours 92% for Me, for TC 100% at any time. After 4 hours the difference between the TC of P and L was significant (p < 0.05). Conclusions: L fulfills the MQS criteria better than P. Ready to use formulas should be used as a first option. The maximum storage time for L is 10 hours at room temperature, whereas this is 4 hours for Tetra Pak P. L can be opened and stored at 4° C and used during the first 48 hours

Published
2002
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16. Crecimiento postnatal inicial de lactantes prematuros nacidos en Chillán, de acuerdo a residencia urbana o rural

Author

M. Angélica González S. and Carlos Castillo D.

Subjects
Low income, prematuro, medicine.medical_specialty, business.industry, postnatal growth, crecimiento postnatal, residencia rural, residence urban, residence rural, residencia urbana, Pediatrics, Perinatology and Child Health, medicine, Residence, preterm infants, Neonatology, Postnatal growth, business, Demography
Abstract

Se estudió la asociación entre la residencia rural o urbana y el crecimiento inicial de lactantes nacidos pretérmino (AEG) en el Hospital Herminda Martín de Chillán, Chile. Se estudiaron prospectivamente hasta los 4 meses de vida, 80 lactantes nacidos entre enero y septiembre de 1995 (35 urbano y 45 rural), con peso de nacimiento < 2 500 g y edad gestacional 2000 g rural infants from low income homes showed a lower length gain than the urban infants (12.7 vs. 15.4 cm p < 0.01). We conclude that the rural preterm babies born at the Hospital Herminda Martin in Chillán have a decreased postnatal growth than the urban infants in the first four months of age

Published
2001
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17. Prevalencia de Streptococcus pneumoniae resistente a penicilina en niños que asisten a jardines infantiles en Santiago

Author

Ignacio Bravo P, Valeria Prado J, Jaime Inostroza S, EIsa Cabrera J, Rosa Bustos V, Olivia Trucco A, Loriana Castillo D., and Raúl Teran R

Subjects
Antibiotic resistance, abuso, business.industry, Pediatrics, Perinatology and Child Health, Medicine, castigo físico, business, niñez, maltrato, violencia familiar, Microbiology
Abstract

e good to mcnitore antimicrobial resistance and oreva'en? sero'ypes. To desc'"beprevalence o~ resistant isolates of S. pneumoniae among children attending day ca'e centers and their most prevalentserotyoes, samples o~ nasopharyngeal secretions were obtained a-d cultured in sheep blooc cgar with o' withoutgentamicin 5 (ig/rri a' 37° C in c 5% CO

Published
1996
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18. Experiencia nacional en el manejo del síndrome de intestino corto en niños

Author

Sylvia Ibáñez T, Abdallah Harún M, Marcelo Ducheylard R, Jesús Rebollo G, Teresa Young A, Daniel Abumohor D, Carlos Castillo D, Elisa Aguila G, Angel Fuentes Z, Silvia Guardia B, Guillermo Correia D, Verónica Mann B, Pedro Herskovic L, and Carolina Laguna N

Subjects
Gynecology, medicine.medical_specialty, business.industry, Pediatrics, Perinatology and Child Health, intestino corto, alimentación parenteral, Medicine, Gestation, Chronological age, business, Short bowel syndrome, medicine.disease, Surgery
Abstract

o delineate IOCQ. causes, management and short term (first vO days after intestinal resectio") .-esjlts, a ret-rospective cclaborative study en pediatnc cases of short bowel syndrome after intestinal sjrgerv seen from year 1989throughout 1995 at six s'ate end one private chilean hospitals was done. Fourteen parents wi'n smell bowel remnantsshorter than 50% of normclly expected for gestational or chronological age were ava.lable for review. T^eir hitialdiseases were "ntestinal atresa (n = 6), necrolizing enterocclitis [n = 5) and intestinal volvu us [r = 3). Bowel resectionwas done mainly along the neo-atcl period Most patients had been prematurely born infante 1107 14) and 10 we

Published
1996

19. Alimentación enteral precoz en lactantes con infección respiratoria baja

Author

Francisco Lagrutta S and Carlos Castillo D

Subjects
alimentación enteral, Pediatrics, medicine.medical_specialty, Respiratory rate, Respiratory tract infections, business.industry, lactantes, Enteral administration, Infant nutrition disorder, apoyo nutricional, Parenteral nutrition, Respiratory failure, Infecciones respiratorias bajas, Anesthesia, Pediatrics, Perinatology and Child Health, Salbutamol, Medicine, Respiratory system, business, medicine.drug
Abstract

A decrease in food intake during the acute phase of lower respiratory tract infections may affect the course of illness. To determine if enteral feeding improves the clinical course of lower respiratory infections (LRI) we studied 42 infants (2 to 12 months of age) with LRI which were given antibiotics and salbutamol therapy based on clinical and X-ray findings. On admission to the hospital patients were randomly allocated to group A (fed by nasogastric tube as intermittent bolus); group B (infants fed by continuous drip via nasogastric tube) and group C (subjects fed ad-libitum by the oral route). Feedings consisted of powdered whole cow's milk formula, reconstituted to 7.5% (W/V), with added sucrose 5% and maltodextrin 5% (77 kcal/dl). Energy intake in group A increased from 69 to 110 kcal.kg.day; in group B, from 68 to 114 kcal.kg.day, and in group C, from 55 to 109 kcal.kg.day (ANOVA, p < 0.005 for the first three days). Infants of groups A and B had shorter hospital stays than C (8.7 and 8.4 vs. 9.8 days, ANOVA, p < 0.02) and a faster improvement of respiratory failure index (4.1 and 3.8 vs. 5.5. days, p < 0.001). Groups A and B also showed greater decrease in their heart rates (mean 170 down to 134 beats/min) than group C patients (169 down to 142 beats/min), p < 0.01 at discharge from the hospital. No differences were noted in trends of respiratory rate, weight/length, albuminemia, C-reactive protein, erythro-sedimentation rate or glycemia. No adverse effects of nasogastric tube feeding were observed.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1991
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20. Recuperation nutritional de lactantes con cardiopatia congenita y desnutricion severa, con una dieta hipercalorica

Author

Maria Soledad Las Heras M, Carlos Castillo D, Pía Rosati R, Verónica Marín B, and Cecilia Rivera C

Subjects
Pediatrics, medicine.medical_specialty, Heart disease, business.industry, Follow up studies, Retrospective cohort study, Milk formula, Mean age, medicine.disease, congenital heart disease, malformaciones cardiacas, Malnutrition, nutrition, dieta hipercalorica, nutricion, Pediatrics, Perinatology and Child Health, Medicine, medicine.symptom, diet, business, Corn starch, Weight gain
Abstract

Protein-energy malnutrition is commonly observed in infants with congenital heart disease (CHD). The effect of a hypercaloric formula on nutritional recovery was evaluated in malnourished infants with congenital heart diseases. We retrospectively studied 30 infants (mean age 9 months, range 2 to 21) with CHD along 60 to 90 days in a closed nutritional recovery center. All patients were fed a hypercaloric whole cow's milk formula with sucrose, butter oil and corn starch (1.29 kcal.ml). Mean daily energy intake was 220 +/- 19.8 kcal.kg body weight.day. Mean weight gain was 2.7 g.kg.day. No effect of cyanosis, cardiac failure, degree of malnutrition or number of illness-free days was observed on nutritional recovery. Patients older than 9 months had significantly greater weight gain than younger infants. Those infants with worse CHD and severe intercurrent illnesses had the worst nutritional recovery. We suggest that a hypercaloric formula induces good nutritional weight gain infants with severe congenital heart disease.

Published
1990
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21. Manejo nutricional de la glucogenosis

Author

Carlos Castillo D and Francisco Lagrutta

Subjects
medicine.medical_specialty, glucogenosis, business.industry, hipoglicemia, Hypoglycemic episodes, Disease, almidón de maíz, medicine.disease, Gastroenterology, Dietary treatment, Internal medicine, tratamiento dietetico, Pediatrics, Perinatology and Child Health, medicine, Normal growth, Glycogen storage disease, Hepatic biopsy, Medical nutrition therapy, business, Corn starch
Abstract

Three cases of glycogenosis are presented. They were recognized by clinical evidence and hepatic biopsy specimens. Dietary treatment with a normocaloric diet and raw corn starch every 6 hours was given. In cases 1 and 2 hepatic size returned to normal and they showed an initial catch up growth without signs of renal disease or other complications. Case 3 showed persistent hepatomegaly, normal growth pattern and no hypoglycemic episodes independently of nutritional management. These cases represent our initial experience on nutritional intervention in glycogenosis, even though enzymatic tests were not done, which are considered essential for optimal diagnosis and nutritional therapy of glycogen storage disease.

Published
1990
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23. Discondrosteosis de Leri-Weill

Author

Santiago Muzzo B, Raquel Burrows A, and Carlos Castillo D

Subjects
malformación de Madelung, medicine.anatomical_structure, Forearm, business.industry, Pediatrics, Perinatology and Child Health, Síndrome de Leri-Waill, Medicine, Dwarfism, Anatomy, Wrist, discondroteosis, business, medicine.disease
Published
1985
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24. SITUACIÓN ACTUAL Y PLANTEAMIENTOS FUTUROS PARA LA INVESTIGACIÓN DE MARKETING EN ESPAÑA

Author

Gázquez Abad, J. C. and Jiménez Castillo, D.

Subjects
Marketing, Investigación, Congreso, Áreas temáticas, Revisión., Business, HF5001-6182
Abstract

El marketing ha evolucionado notablemente como disciplina científica en España a lo largo de los últimos años. El presente trabajo trata de poner de manifiesto qué ha caracterizado esta evolución en las dos últimas décadas, y cuál es su estado actual. Para ello, y junto a una comparativa de los principales trabajos de revisión de la investigación en marketing en nuestro país desarrollados hasta el momento, se analiza el contenido de las ocho últimas ediciones del principal congreso sobre marketing de los que se celebran en España, el Encuentro de Profesores Universitarios de Marketing. El objetivo último de este trabajo consiste en extender el conocimiento sobre la investigación de marketing en España, analizando aspectos tales como el grado de concentración/especialización de los trabajos presentados, la autoría de los mismos, su evolución a lo largo de las ediciones celebradas, etc.

Published
2009

25. Maritime networks of Africa and Asia

Author

César Ducruet, Kenmei Tsubota, EconomiX, Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS), Parisnanterre, EconomiX, Géographie-cités (GC (UMR_8504)), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Olukoju A., and Castillo D.

Subjects
050210 logistics & transportation, Focus (computing), business.industry, 05 social sciences, 0211 other engineering and technologies, COUV, Containerization, 021107 urban & regional planning, 02 engineering and technology, Minor (academic), International trade, PARIS team, [SHS.GEO]Humanities and Social Sciences/Geography, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Globalization, Geography, 0502 economics and business, Container (abstract data type), [No keyword available], business, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, Decolonization, ComputingMilieux_MISCELLANEOUS
Abstract

This chapter explores the long-term evolution of the maritime networks of African continent with focus on Asia. Starting from the observation of historical trade statistics, we confirm that the major trading partner of Africa have always been European countries. Then, we explore the historical trends of minor intercontinental trade with America, Asia and Oceania. We find that particularly after the decolonialization of African countries, the diversifications in direction of trade have been progressed and that the share of non-European and non-intra-African trade has been increasing. Furthermore, with utilizing a unique data of container vessel movements from 1977 to 2016, we extensively show the changing and increasing connectivity of Africa and Asia.

Published
2020

26. Antacid therapy in idiopathic pulmonary fibrosis: more questions than answers?

Author

Claudia Valenzuela, Jan C. Grutters, David M. Hansell, Sebastiano Alfio Torrisi, Wim Wuyts, Nunzio Crimi, Maria Molina-Molina, Athol U. Wells, Benjamin Bondue, Andreas Guenther, Simon L.F. Walsh, Harold R. Collard, Raphael Borie, Thomas Geiser, Irina Strâmbu, Goksel Altinisik, Nathan Hambly, Martina Sterclova, Nesrin Mogulkoc, Marlies S. Wijsenbeek, Jack Gauldie, Martina Vasakova, Michael Kreuter, Sergio Harari, Elisabeth Bendstrup, Kevin K. Brown, Vincent Cottin, Venerino Poletti, Philippe Camus, Michael P. Keane, Luca Richeldi, Brett Ley, Claudia Ravaglia, Stefano Palmucci, Toby M. Maher, Eliza Tsitoura, Antje Prasse, Diego Castillo, Paola Rottoli, Carlo Albera, Kerri A. Johannson, Fabrizio Luppi, Aryeh Fischer, Paolo Spagnolo, Mark Jones, Carlo Vancheri, Katerina M. Antoniou, Giovanni Ferrara, Johannson, K, Strâmbu, I, Ravaglia, C, Grutters, J, Valenzuela, C, Mogulkoc, N, Luppi, F, Richeldi, L, Wells, A, Vancheri, C, Kreuter, M, Albera, C, Antoniou, K, Altinisik, G, Bendstrup, E, Bondue, B, Borie, R, Brown, K, Camus, P, Castillo, D, Collard, H, Cottin, V, Crimi, N, Ferrara, G, Fischer, A, Gauldie, J, Geiser, T, Guenther, A, Hambly, N, Hansell, D, Harari, S, Jones, M, Keane, M, Ley, B, Maher, T, Molina-Molina, M, Palmucci, S, Poletti, V, Prasse, A, Rottoli, P, Spagnolo, P, Sterclova, M, Torrisi, S, Tsitoura, E, Vasakova, M, Walsh, S, Wijsenbeek, M, and Wuyts, W

Subjects
Parenchymal lung disease, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Proton Pump Inhibitor, MEDLINE, Histamine H2 Antagonist, Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO, Severity of Illness Index, 03 medical and health sciences, Idiopathic pulmonary fibrosis, 0302 clinical medicine, Antacid therapy, Risk Factors, Antacids, Disease Progression, Gastroesophageal Reflux, Histamine H2 Antagonists, Humans, Idiopathic Pulmonary Fibrosis, Practice Guidelines as Topic, Proton Pump Inhibitors, Severity of illness, medicine, Antacid, 030212 general & internal medicine, Intensive care medicine, business.industry, Risk Factor, Disease progression, Idiopathic Pulmonary Fibrosi, Guideline, respiratory system, medicine.disease, respiratory tract diseases, 030228 respiratory system, Physical therapy, Position paper, business, Human
Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive parenchymal lung disease of complex cause. Gastro-oesophageal reflux (GER) and microaspiration have been proposed as risk factors for the development and progression of IPF, but robust definitive data are few. A recent international guideline conditionally recommended the use of antacid therapy (proton pump inhibitors or histamine-2-receptor antagonists) for patients with IPF, in the absence of oesophageal reflux or symptoms. In this Position Paper, we summarise the literature addressing the association between GER and IPF, and also identify future research priorities that could clarify this issue. We shed light on the process through which the guideline recommendation was achieved and aim to contextualise the recommendation for providers caring for patients with IPF.

Published
2017

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