1. Increased risk of metabolic dysfunction in children conceived by assisted reproductive technology
- Author
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Jingmei Hu, Min Zhao, Bo Xi, Kuona Hu, Yingying Qin, Mei Fang, Lili Yang, Zi-Jiang Chen, Yongzhi Cao, Li You, Linlin Cui, Mingming Wang, Wang Shui, Liu Yang, Jinlong Ma, Chuanwei Ma, Wei Zhou, and Jun Zhang
- Subjects
Adult ,Blood Glucose ,Male ,0301 basic medicine ,Infertility ,Reproductive Techniques, Assisted ,Apolipoprotein B ,Offspring ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Physiology ,030209 endocrinology & metabolism ,Fertilization in Vitro ,Carotid Intima-Media Thickness ,Intracytoplasmic sperm injection ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Internal Medicine ,Humans ,Insulin ,Medicine ,Sperm Injections, Intracytoplasmic ,Child ,Apolipoproteins A ,In vitro fertilisation ,Assisted reproductive technology ,biology ,business.industry ,Anthropometry ,medicine.disease ,030104 developmental biology ,Case-Control Studies ,Prenatal Exposure Delayed Effects ,biology.protein ,Female ,Insulin Resistance ,business ,Maternal Age - Abstract
Assisted reproductive technology (ART) is the most widely used treatment for infertility and has resulted in millions of births worldwide. The safety of the offspring has been of the utmost concern. Previous studies suggested an increase in metabolic disorders in offspring later in life. The aim of the present study was to investigate metabolic changes at age 6–10 years in offspring conceived as a result of in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI). A total of 380 children born from IVF/ICSI and a matched control group of 380 naturally conceived children, all aged 6–10 years, were recruited. Anthropometric measures, ultrasound and serum tests were performed for body mass, glucose metabolism and lipid profiles, and examination of vasculature structure. The children conceived by ART showed significantly higher fasting blood glucose and serum insulin levels and HOMA-IR (adjusted β [95% CI]: fasting blood glucose 0.49 [0.42, 0.55]; loge-transformed insulin 0.28 [0.20, 0.35]; loge-transformed HOMA-IR 0.38 [0.30, 0.46]), as well as a lower HOMA-B and serum apolipoprotein A (ApoA) levels (adjusted β [95% CI]: loge-transformed HOMA-B −0.19 [−0.27, −0.11]; ApoA −0.17 [−0.21, −0.13]), when compared with the control group. Furthermore, the ultrasound scan indicated elevated carotid intima–media thickness in children conceived by ART (β 0.13 [95% CI 0.12, 0.13]). Children conceived by IVF/ICSI have a less favourable glucose and cardiovascular metabolic profile in childhood when compared with naturally conceived children. The underlying mechanisms and potential long-term consequences need to be elucidated in future studies.
- Published
- 2020