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Natural language object retrieval is a highly useful yet challenging task for robots in human-centric environments. Previous work has primarily focused on commands specifying the desired object’s type such as “scissors” and/or visual attributes such as “red,” thus limiting the robot to only known object classes. We develop a model to retrieve objects based on descriptions of their usage. The model takes in a language command containing a verb, for example “Hand me something to cut,” and RGB images of candidate objects; and outputs the object that best satisfies the task specified by the verb. Our model directly predicts an object’s appearance from the object’s use specified by a verb phrase, without needing an object’s class label. Based on contextual information present in the language commands, our model can generalize to unseen object classes and unknown nouns in the commands. Our model correctly selects objects out of sets of five candidates to fulfill natural language commands, and achieves a mean reciprocal rank of 77.4% on a held-out test set of unseen ImageNet object classes and 69.1% on unseen object classes and unknown nouns. Our model also achieves a mean reciprocal rank of 71.8% on unseen YCB object classes, which have a different image distribution from ImageNet. We demonstrate our model on a KUKA LBR iiwa robot arm, enabling the robot to retrieve objects based on natural language descriptions of their usage (Video recordings of the robot demonstrations can be found at https://youtu.be/WMAdGhMmXEQ ). We also present a new dataset of 655 verb-object pairs denoting object usage over 50 verbs and 216 object classes (The dataset and code for the project can be found at https://github.com/Thaonguyen3095/affordance-language ).

Purpose This study aims to offer a conceptualization of sales transformation, a phenomenon that is redefining the role of salespeople and the nature of Business-to-Business (B2B) relationships while disrupting the selling logics across a variety of industries. Design/methodology/approach Through a two-stage approach, the authors propose and test a conceptual model of sales transformation. The authors conducted 20 interviews and two focus groups with sales directors and managers. The authors then surveyed directors, executives and managers in the sales area (n = 190) and tested a reflective–formative hierarchical model using partial least squares structural equation modeling (PLS-SEM). Findings Sales transformation is a multidimensional construct that includes four higher-order dimensions, namely, people, digitalization, integration and acceleration, and 16 sub-dimensions. These dimensions simultaneously contribute to the sales transformation phenomenon that is conceptualized as a systemic process. This study also offers a measurement tool to assess the degree of sales transformation and enhance the value generated through sales. Originality/value Although many companies are facing challenges stemming from the process of sales transformation, most studies have only focused on micro-aspects of this transformation. This study provides a holistic view of sales transformation aimed at understanding the complexity of this phenomenon by adopting a macro-level perspective on the different dimensions that contribute to its occurrence and development.

The sales function is experiencing a process of transformation developing across different industries and company types. This transformation redefines the role of salespeople and organizations within the broader service ecosystem by introducing new technological applications and enhancing relationships with customers, internal and external stakeholders. As many companies are facing challenges related to sales transformation, this phenomenon requires further investigation from a practical and theoretical standpoint. This paper proposes a theoretical framework to understand the nature and the dimensions contributing to sales transformation. Based on thirty in-depth interviews and two focus groups, the study identifies four dimensions of sales transformation (1) People, (2) Digitalization, (3) Integration, (4) Acceleration and discusses fifteen factors driving this phenomenon. The study offers insights on relevant factors for successfully implement sales transformation within companies and enhance the value generated through the sales function.

The 14th edition of the Workshop on Recent Issues in Bioanalysis (14th WRIB) was held virtually on June 15-29, 2020 with an attendance of over 1000 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations, and regulatory agencies worldwide. The 14th WRIB included three Main Workshops, seven Specialized Workshops that together spanned 11 days in order to allow exhaustive and thorough coverage of all major issues in bioanalysis, biomarkers, immunogenicity, gene therapy and vaccine. Moreover, a comprehensive vaccine assays track; an enhanced cytometry track and updated Industry/Regulators consensus on BMV of biotherapeutics by LCMS were special features in 2020. As in previous years, this year's WRIB continued to gather a wide diversity of international industry opinion leaders and regulatory authority experts working on both small and large molecules to facilitate sharing and discussions focused on improving quality, increasing regulatory compliance and achieving scientific excellence on bioanalytical issues. This 2020 White Paper encompasses recommendations emerging from the extensive discussions held during the workshop and is aimed to provide the Global Bioanalytical Community with key information and practical solutions on topics and issues addressed, in an effort to enable advances in scientific excellence, improved quality and better regulatory compliance. Due to its length, the 2020 edition of this comprehensive White Paper has been divided into three parts for editorial reasons. This publication (Part 3) covers the recommendations on Vaccine, Gene/Cell Therapy, NAb Harmonization and Immunogenicity). Part 1 (Innovation in Small Molecules, Hybrid LBA/LCMS & Regulated Bioanalysis), Part 2A (BAV, PK LBA, Flow Cytometry Validation and Cytometry Innovation) and Part 2B (Regulatory Input) are published in volume 13 of Bioanalysis, issues 4 and 5 (2020), respectively.

Different fluid compositions have been considered as heat transfer fluids (HTF) for concentrating solar power (CSP) applications. In linear focusing CSP systems synthetic oils are prevalently employed, more recently, the use of molten salt mixtures in linear focusing CSP systems has been proposed too. This paper presents a comparative assessment of thermal oils and five four nitrate/nitrite mixtures, among the ones mostly employed or proposed so far for CSP applications. The typical medium-size CSP plant (50 MWe) operating with synthetic oil as HTF and the “solar salt” as TES was considered as a benchmark. In the first part of the paper, physical properties and operation ranges of different HTFs are reviewed, corrosion and environmental issues are highlighted too. Besides an extensive review of HTFs based on data available from the open literature, the authors report their own obtained experimental data needed to thoroughly compare different solutions. In the second part of the paper, the impact of the different HTF options on the design and operation of CSP plants are analyzed from techno-economic perspectives.

The production of electric energy from solar radiation is nowadays one of the most investigated and developed “carbon free” technology. A throughout investigation of the ceramics most commonly used as heat transfer fluids and/or heat storage materials for concentrating solar power systems (i.e. alkaline and heart alkaline nitrate/nitrite mixtures) is here reported. The study stems by the need to base materials selection on an accurate and critical knowledge of all their characteristics, including their thermophysical, environmental compatibility, and economic features. At this purpose, a rating criterion have been established, to readily show the advantages and disadvantages of each material, and to highlight which characteristics of the examined materials need to be further investigated and improved. Nitrate/nitrite mixtures have also been compared with other ceramics used for thermal storage, such as solid fillers, liquid metals, other salt mixtures, or phase change materials.

Background While many studies focus on specific aspects of Unaccompanied Migrant Minors’ (UMMs) health, especially mental well-being, there is a lack of tools comprehensively assessing their needs. To fill this gap, we developed and validated a questionnaire to thoroughly assess unAccompaniEd miGrant mInorS’ physical, psychological, legal, spiritual, social and educational needs (AEGIS-Q). Methods This work consisted of three stages. The first one involved an extensive literature review. Given the results of the review, a first draft of the questionnaire was developed and submitted to a panel of experts for validation (Delphi method-second stage). During the third stage, the final version of the questionnaire was pilot-tested in a sample of 18 UMMs. Results The questionnaire, drafted based on the results of the review, consisted of sections covering personal data, migration profile, physical health needs and access to healthcare, psychological needs, legal needs, spiritual needs and educational and social needs of UMMs. After two Delphi rounds, the final version of the questionnaire, consisting of 83 questions, was structured. The pilot study had a response rate of 89–100%. We found substantial reliability for most of the sections in the questionnaire, including physical health (α=0.652), legal (α=0.781), and educational and social (α=0.614) needs. The questions regarding psychological needs had very high reliability (α=0.860). Conclusions The questionnaire offers a useful sharable tool to assess and monitor UMMs’ needs, helping the reception system to better know and meet their needs and implement the taking in charge.

The most fitting way to celebrate Joan Petersilia’s numerous advancements within the field of criminal justice is to deliberately practice the two most important lessons that perhaps best define he...

PurposeThis paper aims to deal with the concepts of “institutions” and “institutional logics” in the context of business-to-business (B2B) marketing systems and uses institutional theory as a framework to look at value co-creation.Design/methodology/approachBy integrating the literature on value co-creation, institutional theory and institutional entrepreneurship, the paper argues that the boundaries of B2B marketing systems are continuously reshaped through legitimation processes occurring through actors’ institutional work, thus making co-created value the only legitimate value.FindingsThe paper proposes a conceptual framework and furthers the conceptual development of value co-creation and augments the literature on service-dominant logic and the notion of co-created value by assuming a legitimacy-based B2B market systems perspective.Practical implicationsThis paper presents a number of propositions that serve to illustrate several managerial implications. These arise from organizations co-creating value by conforming to the various institutional logics that maximize their legitimacy.Originality/valueThe paper makes a contribution by developing a critical theoretical framework based on the application of institutional theoretical constructs/concepts (e.g. ceremonial conformity, decoupling, considerations of face, confidence and good faith).

Introduction Lymphangioma is an abnormal proliferation of lymphatic vessels. Isolated splenic lymphangioma (SL) is rare; in the last 30 years only 22 cases were reported in the literature. Diagnosis is difficult by the absence of typical symptoms and signs. SL is often asymptomatic and occasionally detected through radiological exams or, after the onset of a life-threatening complication, at surgery or pathological examination. Surgery represents the treatment of choice. Presentation of case A 22-year-old Caucasian male was admitted to the Emergency Department after a car accident, complaining of sudden onset, severe, left upper quadrant abdominal pain. Abdominal examination revealed mild abdominal distention and a severe abdominal pain on superficial and deep palpation of left upper abdominal quadrant with obvious muscle guarding and rebound tenderness. Abdominal computed tomography scan showed splenic rupture with hemoperitoneum. Laboratory tests reported severe anemia. The patient received blood transfusions and was taken emergently to the operating room for exploratory laparotomy, evacuation of hemoperitoneum and splenectomy. The postoperative course was uneventful, the patient was discharged on the 7th post-operative day. Diagnosis of microcystic SL was made at pathological examination. Discussion Post-traumatic splenic rupture may be favored by the presence of a unknown and asymptomatic isolated SL. Although different types of treatment of SL are reported in the literature, splenectomy represents the treatment of choice to avoid complications. Conclusion Isolated SL is difficult to diagnose and suspect because of lack of pathognomonic symptoms and specific diagnostic signs. It can be diagnosed after the onset of a life-threatening complication. Splenectomy is the preferable definitive treatment.

The 2019 13th Workshop on Recent Issues in Bioanalysis (WRIB) took place in New Orleans, LA, USA on April 1–5, 2019 with an attendance of over 1000 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide. WRIB was once again a 5-day, week-long event – a full immersion week of bioanalysis, biomarkers, immunogenicity and gene therapy. As usual, it was specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small- and large-molecule bioanalysis involving LCMS, hybrid LBA/LCMS, LBA cell-based/flow cytometry assays and qPCR approaches. This 2019 White Paper encompasses recommendations emerging from the extensive discussions held during the workshop and is aimed to provide the bioanalytical community with key information and practical solutions on topics and issues addressed, in an effort to enable advances in scientific excellence, improved quality and better regulatory compliance. Due to its length, the 2019 edition of this comprehensive White Paper has been divided into three parts for editorial reasons. This publication (Part 3) covers New Insights in Biomarker Assay Validation, Current & Effective Strategies for Critical Reagent Management, Flow Cytometry Validation in Drug Discovery & Development & CLSI H62, Interpretation of the 2019 FDA Immunogenicity Guidance and Gene Therapy Bioanalytical Challenges. Part 1 (Innovation in Small Molecules and Oligonucleotides & Mass Spectrometry Method Development Strategies for Large Molecule Bioanalysis) and Part 2 (Recommendations on the 2018 FDA BMV Guidance, 2019 ICH M10 BMV Draft Guideline and regulatory agencies' input on bioanalysis, biomarkers, immunogenicity and gene therapy) are published in volume 11 of Bioanalysis, issues 22 and 23 (2019), respectively.

Chemical systems for thermal energy storage are promising routes to overcome the issue of solar irradiation discontinuity, helping to improve the cost-effectiveness and dispatchability of this technology. The present work is concerned with the simulation of a configuration based on an indirect-packed bed heat exchanger, for which few experimental and modelling data are available about practical applications. Since air shows advantages both as a reactant and heat transfer fluid, the modelling was performed considering a redox oxide based system, and, for this purpose, it was considered a pelletized aluminum/manganese spinel. A symmetrical configuration was selected and the calculation was carried out considering a heat duty of 125 MWth and a storage period of 8 h. Firstly, the heat exchanger was sized considering the mass and energy balances for the discharging step, and, subsequently, air inlet temperature and mass flow were determined for the charging step. The system performances were then modelled as a function of the heat exchanger length and the charging and discharging time, by solving the relative 1D Navier-Stokes equations. Despite limitations in the global heat exchange efficiency, resulting in an oversize of the storage system, the results showed a good storage efficiency of about 0.7.

Thermal energy storage technology with Phase Change Materials (PCM) is an attractive option to optimise energy resources and to recover and promote excess heat. The phase change behaviour of PCM requires advanced research to understand and better control the thermal energy storage using PCM, which is a crucial step to develop a powerful latent storage system. This paper aims to analyse the multiphysics phenomena of three regenerator configurations, horizontal case and two injection direction of Heat Transfer Fluid (HTF): top and bottom in vertical case. The study is done for the charge and discharge cycles of the solid-solid and solid-liquid phase transitions of PCM. First, the temperature dependence of the thermal and physical properties of paraffin as PCM is characterised. Second, an experimental study of an annular latent storage system was carried out. Also, an experimental mesh method was introduced to compare the energy behaviour of the three cases. Third, a numerical analysis of the experimental storage unit with low thermal diffusion is performed. The experimental results are confronted with the numerical results obtained with ANSYS Fluent and COMSOL Multiphysics commercial software. Last, the three configurations are compared to a reference case without gravitational field. The results show that specific mechanisms control the thermal and energetic behaviour of the regenerator. Furthermore, several parameters, such as storage density, distribution of energy storage rate in the different regenerator components (PCM, HTF, and heat exchanger), were analysed. Altogether, the results supply important information to understand the dynamics of passive storage systems.

Objective Italy is facing the COVID‐19 outbreak with an abrupt reorganization of its national health‐system, in order to augment care provision to symptomatic patients. The sudden shift of personnel and resources towards COVID‐19 care has led to the reduction of surgery, with possible severe drawbacks. The aim of the study is to describe the trend in surgical volume in urology, in Italy. Materials and Methods Thirty‐three urological units with physicians affiliated to the AGILE consortium were involved in a survey. Urologists were asked to report the amount of surgical elective procedures week‐by‐week, from the beginning of the emergency to the following month. Results The 33 hospitals involved in the study account, globally, for 22,945 beds and are distributed in 13/20 Italian regions. Before the outbreak, the involved urology units performed an overall amount of 1,213 procedures per week, half of which were oncological. One month later, the amount of surgery declined by 78%. Lombardy, the first region with positive‐cases, experienced a 94% reduction. The decrease in oncological and non‐oncological surgical activity was 35,9% and 89%, respectively. The trend of the decline showed a delay of roughly 2 weeks for the other regions. Conclusion Italy, the country with the highest fatality rate from COVID‐19, is experiencing a sudden decline in surgical activity. It is inversely related to the increase in COVID‐19 care, with potential harm particularly in the oncological field. The Italian experience can be helpful for future surgical pre‐planning in other countries not so hardly hit by the disease yet.

Purpose of review Concussion is a complex injury that may present as a variety of clinical profiles, which can overlap and reinforce one another. This review summarizes the medical management of patients with concussion and persistent post-concussive symptoms (PPCS). Recent findings Management of concussion and PPCS relies on identifying underlying symptom generators. Treatment options include sub-symptom threshold aerobic exercise, cervical physical therapy, vestibular therapy, vision therapy, cognitive rehabilitation, cognitive behavioral therapy, pharmacological management, or a combination of treatments. Evidence-based treatments have emerged to treat post-concussion symptom generators for sport-related concussion and for patients with PPCS.

Purpose of review Concussion produces a variety of signs and symptoms. Most patients recover within 2-4 weeks, but a significant minority experiences persistent post-concussive symptoms (PPCS), some of which may be from associated cervical or persistent neurologic sub-system (e.g., vestibular) dysfunction. This review provides evidence-based information for a pertinent history and physical examination of patients with concussion. Recent findings The differential diagnosis of PPCS is based on the mechanism of injury, a thorough medical history and concussion-pertinent neurological and cervical physical examinations. The concussion physical examination focuses on elements of autonomic function, oculomotor and vestibular function, and the cervical spine. Abnormalities identified on physical examination can inform specific forms of rehabilitation to help speed recovery. Emerging data show that there are specific symptom generators after concussion that can be identified by a thorough history, a pertinent physical examination, and adjunct tests when indicated.

The selection of a proper heat transfer (HTF) and storage (HSM) material is a key parameter in the design of a CSP system, especially in the employment of parabolic trough concentrating solar power plants (CSP). The use of nitrates as HTF, alternatively to thermal oils, can increase the CSP efficiency and several mixtures have been proposed at this aim. The most employed molten nitrate salt is the so called “solar salt” that presents several advantages but also a relative high liquidus temperature point of 238 °C. The use, either as HTF or HSM, of a low melting mixtures is currently considered a promising alternative to decrease the investment cost and improve the manageability of CSP plants. In this work, a low melting fluid was selected, composed of calcium, sodium and potassium nitrate, and proposed to be used both as HTF and HSM in a direct and active storage system. The electric LCOEs was calculated for a medium size (50 MWe) plant located at the Priolo Gargallo site (Sicily-Italy). In order to evaluate the obtained outcome, the identical procedure was carried out considering the same size and location, and the “solar salt” and a thermal oil as heat transfer fluids, with the former as storage medium. The comparison between the results show that there is a clear, although limited, economic benefit in using the ternary mixture.

Purpose: The coronavirus disease 2019 (COVID-19) pandemic has put a substantial burden on the Italian healthcare system, resulting in the restructuring of hospitals to care for COVID-19 patients. However, this has likely impacted access to care for patients experiencing other conditions. We aimed to quantify the impact of COVID-19 on access to care for patients with urgent/emergent urological conditions throughout Italy. Materials and Methods: A questionnaire was sent to 33 urological units in the AGILE consortium, asking clinicians to report on the number of urgent/emergent urological patients seen and/or undergoing surgery over a 3-week period during the peak of the COVID-19 outbreak and a reference week prior to the outbreak. ANOVA and linear regression models were used to quantify these changes. Results: Data from 27 urological centres in Italy showed a decrease from 956 patients/week seen just prior to the outbreak to 291 patients/week seen by the end of the study period. There was a difference in the number of patients with urgent/emergent urological disease seen within/during the different weeks (all p values < 0.05). A significant decrease in the number of patients presenting with haematuria, urinary retention, urinary tract infection, scrotal pain, renal colic, or trauma and urgent/emergent cases that required surgery was reported (all p values < 0.05). Conclusion: In Italy, during the COVID-19 outbreak there has been a decrease in patients seeking help for urgent/emergent urological conditions. Restructuring of hospitals and clinics is mandatory to cope with the COVID-19 pandemic; however, the healthcare system should continue to provide adequate levels of care also to patients with other conditions.

Chemical storage systems are a promising innovative route to overcome the issue of the solar irradiation storage, resulting as cost effective and with high energy density. A main problem with these kinds of materials is to design a synthesis method for preparing stable reactive structures, presenting at the same time a high volumetric charging/discharging enthalpy. At this purpose, a size controlled spinel was produced, characterized and investigated regarding its thermophysical and kinetics properties. The obtained powder presents an average diameter between 100 and 200 µm and an energy density of 133 J/g and an experimental test was carried out to verify the spinel morphology stability under thermal cycles. The specific heat is similar to other structured chemical storage system and makes the spinel feasible to be used also as sensible accumulation medium. Despite the relatively high particles size, and the expected small exposed reactive area, the charging, and especially discharging reaction rates resulted particularly favourable and comparable with the reported behaviour of micrometric powders. The particularly simple preparation method plus the cost effectiveness of the precursors leads to a quite convenient expected cost for the storage material, absolutely similar to commercially available accumulation systems.

The possibility of storing solar thermal energy to decouple electricity production from the availability of the solar resource is a key factor in development of concentrating solar power (CSP) technologies. In this context, a challenging perspective is the storage of solar energy on a seasonal basis through thermochemical storage (TCS) systems, as well as the use of excess summer solar energy for stabilizing the annual electricity production, thus increasing the capacity factor of the CSP plant. In this paper, we report the experimental characterization of a material initially developed within the context of CO2 capture technologies, namely calcium oxide supported on mayenite, which in previous investigations shown good sorption capacity and substantial cycling stability. The objective of this new experimental campaign is to test the performance of this material when adopted for thermochemical storage purposes. The tests confirmed that the material, synthesized through a SolGel method, remains stable over long term cycling, with a carbonation conversion higher than 80%. Furthermore, no physical/chemical interaction of the mayenite support with CO2 was observed, confirming its inertia and suitability for TCS purposes.

This article advances a conceptualization of service innovation as socially constructed through resource integration and sensemaking. By developing this view, the current study goes beyond an outcome perspective, to include the collective nature of service innovation and the role of the social context in affecting the service innovation process. Actors enact and perform service innovation through two approaches, one that is more concerted and another that emerges in some way. Each approach is characterized by distinct resource integration processes, in which the boundary objects (artifacts, discourses, and places) play specific roles. They act as bridge-makers that connect actors, thereby fostering resource integration and shared meanings.

Data-flow programming is the computational model of choice for a large class of application domains, such as, real-time data processing, robotics platforms, and big-data analytics. Traditionally, dataflows are deployed and executed within well-defined system boundaries, such as robots, radars, or data-centers. These boundaries however are expected to blur with the advent of Edge Computing, which provides a multi-tier infrastructure spanning from the cloud to the things and enables for the distribution of applications across this continuum. In this paper we make a step towards the design of an Edge-native data-flow by mixing technologies coming from both worlds: ERDOS, a novel data-flow framework, and Eclipse Zenoh, a Named-Data-Networking built for the Edge Computing. More specifically, we (i) investigate how ERDOS can be expanded to cover Edge deployments by leveraging Zenoh, (ii) analyze the advantages provided by this integration, and (iii) evaluate the performance of a Zenoh-powered ERDOS. Our results show that ERDOS experiences a higher throughput and bounded latency when operating over Zenoh. Moreover, Zenoh enhances ERDOS with full location transparency, allowing developers and system designers to focus on the logic of their application as opposed to the topology deployment. Finally, our integration of Zenoh and ERDOS is available as open source at https://github.com/atolab/erdos-on-zenoh.

Edge computing has established itself as the foundation for next-generation mobile networks, IT infrastructure, and industrial systems thanks to promised low network latency, computation offloading, and data locality. These properties empower key use-cases like Industry 4.0, Vehicular Communication, and the Internet of Things. Nowadays implementation of Edge computing is based on extensions to available Cloud computing software tools. While this approach accelerates adoption, it hinders the deployment of the aforementioned use-cases that requires an infrastructure largely more decentralized than Cloud data centers, notably in the far-Edge of the network. In this context, this work aims at (i) analyzing the differences between Cloud and Edge infrastructures, (ii) analyzing the architecture adopted by the most prominent open-source Edge computing solutions, and (iii) evaluating those solutions in terms of scalability and service instantiation time in a medium-size far Edge system. Results show that mainstream Edge solutions require powerful centralized controllers and always-on connectivity, making them unsuitable for highly decentralized scenarios in the far-Edge where stable and high-bandwidth links are not ubiquitous., This work has been partially funded by the H2020 collaborative Europe/Taiwan research project 5G-DIVE (grant no. 859881) and by the H2020 European collaborative research project DAEMON (grant no. 101017109).

Nonuniversal use of facial protection during endoscopy may place endoscopists at risk of exposure to blood and body fluids; however, the frequency of exposure is unknown.A prospective 6-month study of 4 gastroenterologists using a face shield during endoscopy was undertaken. The face shield was swabbed in a standardized fashion before and at the end of the session. Controls included pre- and post-swabs of face shields placed on the (1) endoscopy suite wall, (2) remote patient intake bay wall, and (3) after deliberate contamination with a colonoscope immediately after colonoscopy. The swabs were cultured for 48 hours, and growth was reported as no growth or by number of colony-forming units (CFUs). The groups were compared for +CFU rate and CFU number.A total of 1100 procedures were performed in 239 endoscopy sessions. The +CFU rate in the pre-endoscopy groups (2%-4.8%, not significant) was significantly lower than the postendoscopist face shield (45.8%, P .001) and endoscopy suite wall groups (21.4%, P .001), respectively. Using a cut-off of15 CFUs as an indicator of definite exposure, the occurrence rate was 5.6 per 100 half days of endoscopy to the endoscopist's face and 3.4 per 100 half days of endoscopy 6 feet away.This is the first study to quantify the rate of unrecognized exposure to the endoscopist's face to potentially infectious biologic samples during endoscopy (5.6/100 days of endoscopy). This exposure may result in transmission of infectious diseases. As such, we recommend the use of universal facial protection during GI endoscopy.

The interactional, interdependent, and dynamic nature of value co-creation has made value management in business relationships a particularly challenging issue for both academicians and practitioners. In addition, studies on this topic have mostly focused on managing value co-creation in isolation from the wider relational context without completely capturing the influence of other value processes on value co-creation. This paper examines the broader picture of value co-creation management by providing a model based on interlinked value processes, namely, value communication, value appropriation, value measurement, and value representation. We adopted a qualitative approach based on 86 interviews with managers of both customer and supplier companies, which operated in different industries. Results showed that the management of value co-creation implies considering complex patterns of interconnections with other value processes. In particular, the study will shed light on the centrality of value appropriation to co-create value and on the importance of value representation to coordinate ideas and enable future co-creation opportunities.

Robots must reason about pushing and grasping in order to engage in flexible manipulation in cluttered environments. Earlier works on learning pushing and grasping only consider each operation in isolation or are limited to top-down grasping and bin-picking. We train a robot to learn joint planar pushing and 6-degree-of-freedom (6-DoF) grasping policies by self-supervision. Two separate deep neural networks are trained to map from 3D visual observations to actions with a Q-learning framework. With collaborative pushes and expanded grasping action space, our system can deal with cluttered scenes with a wide variety of objects (e.g. grasping a plate from the side after pushing away surrounding obstacles). We compare our system to the state-of-the-art baseline model VPG [1] in simulation and outperform it with 10% higher action efficiency and 20% higher grasp success rate. We then demonstrate our system on a KUKA LBR iiwa arm with a Robotiq 3-finger gripper.

Background and Aims Indole-3-acetic acid (IAA, also called auxin) is a protein-bound indolic uremic toxin deriving from tryptophan metabolism by the intestinal bacteria. Previous studies have shown that increased IAA is associated with enhanced tissue factor synthesis in endothelial and peripheral blood mononuclear cells, oxidative stress and endothelial inflammation with resulting higher risk of thrombotic events and both cardiovascular and all-cause mortality. An emerging biomarker of cardiovascular disease is the monocyte to high-density lipoprotein (HDL) ratio (MHR). Its prognostic value is related to the ability of monocytes to release several cytokines involved in inflammation and atherogenesis and to the protective role of HDL through removal of cholesterol from peripheral tissues and suppression of both monocyte progenitor cell proliferation and differentiation and monocyte activation. In this single-centre cross-sectional observational study, we investigated the potential association of IAA with MHR and other markers of cardiovascular risk in a cohort of patients with CKD and evaluated the effect of a single midweek dialysis session with AFB (Acetate-free Biofiltration) technique on IAA serum concentrations. Method We enrolled 61 non-dialysis CKD adult patients and 6 dialysis patients treated with AFB technique. IAA levels were measured using an enzyme-linked immunosorbent assay (ELISA) kit (Cat. number abx150354; Abbexa Ltd, Cambridge, UK). Post-dialysis IAA levels were corrected for haemoconcentration. Results In the whole cohort of 67 patients, IAA was directly related to creatinine (ρ = 0.247; P = 0.0441), potassium (r = 0.2871; P = 0.0185), Ca x P product (ρ = 0.256; P = 0.0365) and MHR (ρ = 0.321; P = 0.0082). After adjustment for creatinine, the correlation between IAA and potassium became not significant (r = 0.1968; P = 0.1133). Stratifying patients according to the history of cardiovascular disease, in the 40 patients with previous cardiovascular events IAA levels correlated significantly with uric acid (r = 0.3952; P = 0.0116) and MHR (ρ = 0.380; P = 0.0157). In the remaining 27 patients without history of cardiovascular disease, IAA only correlated with potassium (r = 0.3912; P=0.0481) and, though borderline significantly, with creatinine (ρ = 0.349; P = 0.0805). To assess whether IAA would independently predict MHR values, we evaluated potential correlations of MHR with risk factors for cardiovascular disease. MHR was related with fibrinogen (ρ = 0.426; P = 0.0010), arterial hypertension (ρ = 0.274; P = 0.0251), C-reactive protein (ρ = 0.332; P = 0.0061), gender (ρ = -0.375; P = 0.0017; 0 = male, 1 = female), and CKD stage (ρ = 0.260; P = 0.0337). A multiple regression analysis identified IAA as an independent predictor of MHR. Lastly, IAA levels were higher in dialysis patients compared to non-dialysis CKD patients (97.44 ± 21.58 versus 65.08 ± 24.38 ng/ml respectively; P = 0.0026) and it was significantly removed by a single AFB session (97.44 ± 21.58 versus 54.59 ± 21.74 ng/ml; P = 0.0028) with a reduction ratio of 43.80 ± 17.47%. Conclusion This study shows a statistically significant association between IAA and MHR. Based on previous experimental studies, such relationship could be explained by the activation of the transcription factor aryl hydrocarbon receptor. Indeed, IAA is a potent ligand of aryl hydrocarbon receptor and the latter has proinflammatory and proatherogenic activities and can reduce HDL levels. Moreover, AFB efficiently removes IAA during a single dialysis session. Prospective studies with appropriate sample size and sufficiently long period of observation are required to evaluate if decreasing IAA levels, through targeted therapeutic strategies in non dialysis CKD patients or by optimization of dialysis techniques and prescriptions in patients receiving renal replacement therapy, may reduce MHR levels and cardiovascular events and improve clinical outcomes and survival.

Cancer is a global major public health problem, particularly in Western countries, where it represents the second leading cause of death after cardiovascular disease. Malnutrition is common in cancer patients and differs from starvation-related malnutrition, as it results from a combination of anorexia and metabolic dysregulation, caused by the tumor itself or by its treatment, and causing cachexia. Cancer-associated malnutrition can lead to several negative consequences, including poor prognosis, reduced survival, increased therapy toxicity, reduced tolerance and compliance to treatments, and diminished response to antineoplastic drugs. Guidelines issued by the Ministry of Health in 2017, the most recent ESPEN guidelines and the PreMiO study highlighted an inadequate nutritional support in cancer patients since their first visit, and recommended an optimization of the quality of life of cancer patients in each stage of the disease, also through specific nutritional interventions by multidisciplinary teams. Based on the evidences summarized above, a survey has been carried out on a sample of 300 Italian hospital medical oncologists to evaluate their level of awareness and perception of cancer-related malnutrition and their proposals to implement effective strategies to improve nutritional care in the setting of hospital oncology departments in Italy. The survey results indicate that, despite high levels of awareness among Italian oncologists, malnutrition in cancer patients remains, at least in part, an unmet medical need, and additional efforts are necessary in terms of increased training and hiring of personnel, and of creation of organizational pathways aimed at treatment optimization based on available evidences.

Digital technologies automating marketing and sales activities are rapidly spreading. The adoption of Sales & Marketing Automation (S&MA) systems allows companies to improve their marketing campaigns, track their customers’ journey and generate real-time insights to respond to customers more efficiently and effectively. The Covid-19 pandemic has further increased the importance of S&MA as customers have massively shifted towards digital channels to interact with businesses and purchase products and services. In this paper, we investigate how S&MA generates value for companies in the post-Covid-19 scenario, adopting the perspective of the buyer organization. Based on insights generated through a qualitative and quantitative research, we propose a conceptual model explaining the value drivers of S&MA in terms of benefits and sacrifices. Our research highlights that a mere focus on the technological side of these platforms limits the assessment of value generation as it is crucial to also consider customer-centric, operational and integration-based value drivers. By segmenting the S&MA value perceptions of different companies, this research also provides guidelines to develop, promote and implement S&MA solutions for buyers and vendors operating in B2B.

BACKGROUND: Palbociclib plus endocrine therapy (ET) is the standard treatment for hormone receptor-positive and human epidermal growth factor receptor 2-negative, metastatic breast cancer (MBC). However, its efficacy has not been compared with that of chemotherapy in a phase III trial. PATIENTS AND METHODS: PEARL is a multicentre, phase III randomised study in which patients with aromatase inhibitors (AIs)-resistant MBC were included in two consecutive cohorts. In cohort 1 (C1), patients were randomised 1:1 to palbociclib plus exemestane or capecitabine. On discovering new evidence about oestrogen receptor-1 (ESR1) mutations inducing resistance to AIs, the trial was amended to include cohort 2 (C2), in which patients were randomised 1:1 between palbociclib plus fulvestrant and capecitabine. The stratification criteria were disease site, prior sensitivity to ET, prior chemotherapy for MBC, and country of origin. Co-primary endpoints were progression-free survival (PFS) in C2 and in wild-type ESR1 patients (C1+C2). ESR1 hotspot mutations were analysed in baseline circulating tumour DNA. RESULTS: From March-2014 to July-2018, 296 and 305 patients were included in C1 and C2, respectively. Palbociclib plus ET was not superior to capecitabine in both C2 (median PFS: 7.5 vs. 10.0 months; adjusted hazard ratio [aHR]: 1.13; 95% confidence Interval [CI]: 0.85-1.50) and wild-type ESR1 patients (median PFS: 8.0 vs. 10.6 months; aHR: 1.11; 95% CI: 0.87-1.41). The most frequent grade 3-4 toxicities with palbociclib plus exemestane, palbociclib plus fulvestrant, and capecitabine were neutropenia (57.4%, 55.7% and 5.5%), hand/foot syndrome (0%, 0% and 23.5%), and diarrhoea (1.3%, 1.3% and 7.6%). Palbociclib plus ET offered better quality of life (aHR for time to deterioration of global health status: 0.67; 95% CI: 0.53-0.85). CONCLUSIONS: There was no statistical superiority of palbociclib plus ET over capecitabine with respect to PFS in MBC patients resistant to AIs. Palbociclib plus ET showed a better safety profile and improved quality of life.

BACKGROUND: The PEARL study showed that palbociclib plus endocrine therapy (palbociclib/ET) was not superior to capecitabine in improving progression-free survival in postmenopausal patients with metastatic breast cancer resistant to aromatase inhibitors, but was better tolerated. This analysis compared patient-reported outcomes. PATIENTS AND METHODS: The PEARL quality of life (QoL) population comprised 537 patients, 268 randomised to palbociclib/ET (exemestane or fulvestrant) and 269 to capecitabine. Patients completed the European Organisation for Research and Treatment of Cancer QLQ-C30 and QLQ-BR23and EQ-5D-3L questionnaires. Changes from the baseline and time to deterioration (TTD) were analysed using linear mixed-effect and stratified Cox regression models, respectively. RESULTS: Questionnaire completion rate was high and similar between treatment arms. Significant differences were observed in the mean change in global health status (GHS)/QoL scores from the baseline to cycle 3 (2.9 for palbociclib/ET vs. -2.1 for capecitabine (95% confidence interval [CI], 1.4-8.6; P=0.007). The median TTD in GHS/QoL was 8.3 months for palbociclib/ET versus 5.3 months for capecitabine (adjusted hazard ratio, 0.70; 95% CI, 0.55-0.89; P=0.003). Similar improvements for palbociclib/ET were also seen for other scales as physical, role, cognitive, social functioning, fatigue, nausea/vomitingand appetite loss. No differences were observed between the treatment arms in change from the baseline in any item of the EQ-5D-L3 questionnaire as per the overall index score and visual analogue scale. CONCLUSION: Patients receiving palbociclib/ET experienced a significant delay in deterioration of GHS/QoL and several functional and symptom scales compared with capecitabine, providing additional evidence that palbociclib/ET is better tolerated. TRIAL REGISTRATION NUMBER: NCT02028507 (ClinTrials.gov). EUDRACT STUDY NUMBER: 2013-003170-27.

Background: Numerous surveys have been performed to determine the competence and the confidence of residents. However, there is no data available on the condition of Italian residents in urology. Objective: To investigate the status of training among Italian residents in urology regarding scientific activity and surgical exposure. Design, setting, and participants: A web-based survey that included 445 residents from all of the 25 Italian Residency Programmes was conducted between September 2015 and November 2015. Outcome measurements and statistical analysis: The main outcomes were represented by scientific activity, involvement in surgical procedures, and overall satisfaction. Results and limitations: In total, 324 out of 445 (72.8%) residents completed the survey. Overall, 104 (32%) residents had not published any scientific manuscripts, 148 (46%) published ≤5, 38 (12%) ≤10, 26 (8%) ≤15, four (1%) ≤20, and four (1%) >20 manuscripts, respectively. We did not observe any differences when residents were stratified by sex (p = 0.5). Stent positioning (45.7%), extracorporeal shock wave lithotripsy (30.9%), transurethral resection of bladder tumor (33.0%), hydrocelectomy (24.7%), varicocelectomy (17%), ureterolithotripsy (14.5%), and orchiectomy (12.3%) were the surgical procedures more frequently performed by residents. Overall, 272 residents (84%) expressed a good satisfaction for urology specialty, while 178 (54.9%) expressed a good satisfaction for their own residency programme. We observed a statistically decreased trend for good satisfaction for urology specialty according to the postgraduate year (p = 0.02). Conclusions: Italian Urology Residency Programmes feature some heavy limitations regarding scientific activity and surgical exposure. Nonetheless, satisfaction rate for urology specialty remains high. Further improvements in Residency Programmes should be made in order to align our schools to others that are actually more challenging. Patient summary: In this web-based survey, Italian residents in urology showed limited scientific productivity and low involvement in surgical procedures. Satisfaction for urology specialty remains high, demonstrating continuous interest in this field of study from residents. Italian Residency Programs in urology shows some limitation regarding scientific productivity and surgical activity. Resident involvement in many urological procedures still remains low and there is a risk in providing the near future urologists with no expertise.

Introduction: COVID-19 outbreak represented an unprecedented event that led to a redefinition of health care systems worldwide The impact of the emergency required a deviation of the care toward the assistance to COVID-19 patients, with reduction of resources for elective activities, including surgery We aim to report the decrease of urological surgical activity during the first weeks from the beginning of the pandemic, aiming to highlight the prioritization we applied to select patients for surgery Materials and methods: Thirty-three urological units with physicians affiliated to the AGILE group were involved in a survey Urologists were asked to report the amount of surgical elective procedures week- by-week, from the beginning of the emergency to the following month The type of surgery (oncologic, for urolithiasis, for benign prostate obstruction, other) was assessed as well Results: The 33 hospitals involved in the study account, globally, for 22,945 beds and are distributed in 13/20 Italian regions Before the outbreak, the involved urology units performed an overall amount of 1,213 procedures per week, half of which were oncological By the 20 of March, the amount of surgery declined by 78% Lombardy, the first region with positive-cases, experienced a 94% reduction The decrease in oncological and non- oncological surgical activity was 35,9% and 89%, respectively Among non-oncological procedures, stone surgery declined by 35,9% as well, whereas BPH and minor urological procedures completely dropped Reassessing for surgical activity on 20, April, a slight trend toward surgical restoration (+11%) started to appear Conclusions: Italy, the country with the highest fatality rate from COVID-19, had experienced a sudden decline in surgical activity;by the end of April, a current trend toward restoration of surgery started to appear Criteria for prioritization were consistent with an urgent/ emergent principle, with trauma, tumours and septic conditions being the ones prioritized The Italian experience can be helpful for future surgical pre-planning in other countries or pandemic settings Smart Communications (SC1–SC28) Andrology

Natural language object retrieval is a highly useful yet challenging task for robots in human-centric environments. Previous work has primarily focused on commands specifying the desired object's type such as "scissors" and/or visual attributes such as "red," thus limiting the robot to only known object classes. We develop a model to retrieve objects based on descriptions of their usage. The model takes in a language command containing a verb, for example "Hand me something to cut," and RGB images of candidate objects and selects the object that best satisfies the task specified by the verb. Our model directly predicts an object's appearance from the object's use specified by a verb phrase. We do not need to explicitly specify an object's class label. Our approach allows us to predict high level concepts like an object's utility based on the language query. Based on contextual information present in the language commands, our model can generalize to unseen object classes and unknown nouns in the commands. Our model correctly selects objects out of sets of five candidates to fulfill natural language commands, and achieves an average accuracy of 62.3% on a held-out test set of unseen ImageNet object classes and 53.0% on unseen object classes and unknown nouns. Our model also achieves an average accuracy of 54.7% on unseen YCB object classes, which have a different image distribution from ImageNet objects. We demonstrate our model on a KUKA LBR iiwa robot arm, enabling the robot to retrieve objects based on natural language descriptions of their usage. We also present a new dataset of 655 verb-object pairs denoting object usage over 50 verbs and 216 object classes.

Background: Melatoninergic agents are known to reduce intraocular pressure (IOP). The present study was performed to evaluate the effect of nanomicellar formulations of melatoninergic agents on IOP in the rat. Methods: Tonometry was used to measure IOP in eyes instilled with melatonin or agomelatine. Ocular hypertension was induced by the injection of methylcellulose in the anterior chamber. Results: Melatonin formulated in nanomicelles had a longer lasting hypotonizing effect on IOP with respect to melatonin in saline. Nanomicellar formulations of melatonin and agomelatine, either alone or in combination, had lowering effects that did not depend on their concentration or their combination, which, however, resulted in an increased duration of the hypotonizing effect. The duration of the lowering effect was further increased by the addition of lipoic acid. Conclusions: We demonstrated the effective hypotonizing activity of melatonin and agomelatine in combination with lipoic acid. Although results in animals cannot be directly translated to humans, the possibility of developing novel therapeutical approaches for patients suffering from hypertensive glaucoma should be considered.

BACKGROUND: We evaluated the safety and immunogenicity of liquid and lyophilized formulations of an investigational trivalent group B streptococcus (GBS) vaccine in non-pregnant women and assessed the formulations' equivalence in terms of serotype-specific immune response. METHODS: This phase II, randomized, comparative, observer-blind trial enrolled healthy non-pregnant women 18-40 years of age. Women received a single dose of fully liquid (n = 529) or lyophilized (n = 521) trivalent GBS vaccine on day 1. Safety assessments were performed up to day 181 (study termination). Serotype Ia/Ib/III-specific immunoglobulin G (IgG) antibodies were measured in sera from women on day 1 (pre-vaccination) and day 31. Equivalence between the two formulations was demonstrated if the two-sided 95% confidence interval (CI) for the ratio (liquid/lyophilized) of the geometric mean concentrations (GMCs) on day 31 was contained in a (0.5, 2.0) interval for each serotype. RESULTS: Solicited and unsolicited adverse events were reported at similar rates for both formulations. Serious adverse events were reported for six (1.1%) liquid GBS and nine (1.7%) lyophilized GBS vaccinated women, none of which were considered related to vaccination or fatal. On day 31, serotype-specific IgG concentrations were 8-16-fold higher than on day 1 in both groups. Equivalence of the liquid to the lyophilized formulation 30 days post-vaccination was demonstrated as the 95% CIs of the GMC ratios were within the pre-specified interval for the three serotypes: GMC ratios were 1.02 (95% CI: 0.79, 1.32) for serotype Ia, 0.93 (0.71, 1.21) for serotype Ib and 0.99 (0.76, 1.30) for serotype III. CONCLUSIONS: Both formulations of the investigational trivalent GBS vaccine had favorable safety profiles and induced similar GBS serotype-specific antibody concentrations. This study demonstrated that the fully liquid formulation was equivalent to the lyophilized formulation in healthy non-pregnant women in terms of immunogenicity for all three serotypes. CLINICAL TRIALS REGISTRATION: NCT02270944. ispartof: VACCINE vol:38 issue:16 pages:3227-3234 ispartof: location:Netherlands status: published

Objective The aim of the paper is to review the current information relating to the diagnosis and treatment of hepatitis C virus (HCV) infection in pregnant women and children, particularly those infected by mother-to-child transmission. Study Design A review of published literature was performed to identify relevant articles published between January 2015 and March 2019 on: HCV infection in pregnant woman, mother-to child-transmission of HCV and HCV infection in pediatrics. The results of the evaluation of the different studies were summarized in two sections describing separately the screening and effective treatments in pregnant women and children. Results The rate of mother-to-child transmission of HCV is approximately 5%. HCV infection is strongly associated with cholestasis and preterm birth. Prenatal diagnosis of hepatitis C virus has a dual benefit for mother and child. Perinatally infected children develop cirrhosis in earlier age than those who acquire HCV as adolescents. Pregnant women with cirrhosis have a higher risk of poor maternal and neonatal outcomes than those without cirrhosis. Conclusion To improve public health, universal screening of pregnant women for HCV infection should be performed. Early identification of women and children with HCV infection is important to enable them to be included in assessment and/or treatment programs.

HCV (Hepatitis C Virus) decreases Health-Related Quality of Life with detriments to physical, mental and social health domains. Interferon and Ribavirin treatment is associated with depression and anxiety that further impairs HRQoL (Health- Related Quality of Life). IFN-free (interferon-free) regimes (Direct Acting Antivirals, DAAs) are safe and highly effective drugs, with improvement also of HRQoL and related Psychological Well-Being. Our aim is to describe how the latest generation IFN-free treatment can change quality of life and related Psychological Well-Being in Italian Chronic Hepatitis C/Cirrhosis affected patients. SF-36v2 (Short Form Health Survey is a 36-item, patient-reported survey of patient health) – HQLQv2 (Hepatitis Quality of Life Questionnaire) was administered at two time points: baseline (n=72) and 12 weeks after the end of therapy [n=72, SVR=72 - Sustained Virologic Response (SVR)]. Patients with chronic HCV undergoing DAAs treatment from two Italian centers were enrolled. The overall average of the answers is configured for most of the domains that make up the questionnaire, with scores above 50. The quality of life of this sample is very close to the average of the US population, with a minimum average score of 45.9 for the Role Emotional scale and an average maximum score of 56.4 for the Vitality scale. Both are significant results from statistical analysis. It seems that DAAs treatment therapy does not affect but improves the general quality and psychological state of adult patients with Chronic HCV infection.

Purpose The purpose of this paper is to examine the role of proto-institutions that are new institutional subsystems that subsequently affect the current institutional arrangements in the evolution of service ecosystems. Design/methodology/approach To shed light on the mode of action of proto-institutions, the authors investigate the changes of three service ecosystems in Italy: the health care ecosystem, the food-supply ecosystem and the urban mobility ecosystem. Findings First, the paper elucidates how changes of service ecosystems are triggered by megatrends that are external to specific service ecosystems. Second, the study empirically shows how service ecosystems and their institutional settings change through the establishment of proto-institutions. Originality/value Responding to recent calls to investigate in more detail how actors challenge dominant social patterns and to conduct research to better understand how changes at the level of individual actors may lead to shifts within overall service ecosystems, this paper is one of the first to empirically study the relationships between phenomena that are external to service ecosystems, the emergence of proto-institutions and the resulting changes of institutional arrangements.

Background Recent biotechnological advancements have allowed for the adoption of Lactococcus lactis, a typical component of starter cultures used in food industry, as the host for the production of food-grade recombinant targets. Among several advantages, L. lactis has the important feature of growing on lactose, the main carbohydrate in milk and a majoritarian component of dairy wastes, such as cheese whey. Results We have used recombinant L. lactis NZ9000 carrying the nisin inducible pNZ8148 vector to produce MNEI, a small sweet protein derived from monellin, with potential for food industry applications as a high intensity sweetener. We have been able to sustain this production using a medium based on the cheese whey from the production of ricotta cheese, with minimal pre-treatment of the waste. As a proof of concept, we have also tested these conditions for the production of MMP-9, a protein that had been previously successfully obtained from L. lactis cultures in standard growth conditions. Conclusions Other than presenting a new system for the recombinant production of MNEI, more compliant with its potential applications in food industry, our results introduce a strategy to valorize dairy effluents through the synthesis of high added value recombinant proteins. Interestingly, the possibility of using this whey-derived medium relied greatly on the choice of the appropriate codon usage for the target gene. In fact, when a gene optimized for L. lactis was used, the production of MNEI proceeded with good yields. On the other hand, when an E. coli optimized gene was employed, protein synthesis was greatly reduced, to the point of being completely abated in the cheese whey-based medium. The production of MMP-9 was comparable to what observed in the reference conditions. Electronic supplementary material The online version of this article (10.1186/s12934-018-0974-z) contains supplementary material, which is available to authorized users.

The utility of police consolidation, and in particular police contracting of services, has received widespread attention in academic and practitioner circles. However, the bulk of empirical research centers on potential fiduciary benefits; only limited scholarship has explored the possibility that changes in police services may correspond with differences in crimes solved and offenses observed. To address this gap, we examine consolidation in police services in a historically high crime, disadvantaged urban setting (Compton, California), which began contracting with the Los Angeles County Sheriff’s Department (LACSD) after the closure of Compton Police Department in 2000. Independent samples difference in means tests are used to examine variations in crime clearance rates prior to and following the transition in Compton. Group-based trajectory analysis combined with difference-in-difference regression estimation is used to assess changes in criminal offenses while minimizing selection differences in comparison settings. With the exception of homicide, clearance rates for six Part I crimes experienced statistically significant improvements in Compton’s post-contractual period. Additionally, while the vast majority of Part I offenses remained stable during the transition to LACSD policing, burglary crime rates experienced a statistically significant and sustained decline, net of controls. A primary concern with police contracting centers on a lack of local police control, disconnect between local needs and actual services provided, and the potential for backlash related to a reduction in the quality of police services. Our findings from Compton suggest that contracting with a well-resourced agency experienced in police consolidation has the ability to maintain and, in some circumstances, improve the quality of law enforcement services.

Many scholars have recognized the negative consequences that arise from establishing and developing business relationships. Such consequences are also known as the dark side of business relationships. It has been stated that the dark side of business relationships limits value co-creation, if not destroying value entirely. At any rate, its wider effects on value processes beyond value co-creation still remain underinvestigated, with scant empirical evidence to date. This study aims to shed light on the implications of the dark side of business relationships for five value processes - namely, value co-creation, communication, measurement, appropriation, representation -. The empirical research analyzes 32 interviews with business-tobusiness managers in customer and supplier firms. Results from the study show that all value processes present a dark side and that their effects are interconnected. It thus also highlights the need for systematic and coordinated managerial actions aimed at managing such effects.