Search

Background: Catheter-related bladder discomfort (CRBD) has been observed in many patients undergoing a urethral catheterization. CRBD may be so severe that the patients require additional analgesics. Muscarinic receptors are involved in the mechanism of CRBD. The aim of this study is to determine the effects of the antimuscarinic properties of atropine, which is frequently used in current practice on CRBD, by comparing it with sugammadex which has no antimuscarinic effects. Methods: Sixty patients selected for transurethral resection due to bladder tumors were randomized into 2 groups: an atropine group and a sugammadex group, with no antimuscarinic effect. The patients were given rocuronium (0.6 mg/kg) as a neuromuscular-blocker. In addition to the frequency and severity of CRBD postoperatively at 0, 1, 6, 12, and 24 hours, postoperative numeric rating scale (NRS) scores, and postoperative nausea and vomiting were examined. Results: The incidence of CRBD was significantly lower in the atropine group in all postoperative measurements. The score was found to be significantly lower in the atropine group when NRS measurements were performed at all time periods (P < 0.01). There was no difference between the groups in terms of nausea and vomiting (P > 0.05). Conclusions: Atropine is a cheap, easy-to-access, safe-to-use drug for reducing CRBD symptoms, without any observed adverse effects. Since it not only reduces CRBD symptoms but also has a positive effect on postoperative pain, it can be used safely to increase patient comfort in patients receiving general anesthesia and a urinary catheter. WOS:000522786000010 2-s2.0-85089625537 PubMed: 32235018

Today, with the rapid development of technology, various methods are being developed for computer assisted diagnostic systems. Computer assisted diagnostic systems allow an objective assessment and help physicians to diagnose. Pulmonary sounds are effective signals in the diagnosis of Chronic Obstructive Pulmonary Disease (COPD). In this study, multichannel respiratory sounds obtained by auscultation method were analyzed and the effect of auscultation points on nonlinear classifiers was investigated. In computerized analysis, EWT (Empirical Wavelet Transform) method was applied to 12-channel lung sounds which obtained from different auscultation points. Then, statistical properties based on extracted frequency components were calculated. COPD and healthy lung sounds were classified using nonlinear classifiers for each channel. At the end of the study, the effects of channels on classifiers were compared.

AKMESE, OMER FARUK/0000-0002-5877-0177; Erbay, Hasan/0000-0002-7555-541X WOS: 000531591600001 PubMed: 32377437 Acute appendicitis is one of the most common emergency diseases in general surgery clinics. It is more common, especially between the ages of 10 and 30 years. Additionally, approximately 7% of the entire population is diagnosed with acute appendicitis at some time in their lives and requires surgery. The study aims to develop an easy, fast, and accurate estimation method for early acute appendicitis diagnosis using machine learning algorithms. Retrospective clinical records were analyzed with predictive data mining models. The predictive success of the models obtained by various machine learning algorithms was compared. A total of 595 clinical records were used in the study, including 348 males (58.49%) and 247 females (41.51%). It was found that the gradient boosted trees algorithm achieves the best success with an accurate prediction success of 95.31%. In this study, an estimation method based on machine learning was developed to identify individuals with acute appendicitis. It is thought that this method will benefit patients with signs of appendicitis, especially in emergency departments in hospitals.

Objective: Urinary system stone disease is a very common health problem that affects 2 to 3% of people and causes serious complications when it is not treated. The prevalence of renal stones has been increasing worldwide and surgical methods have changed over time. However, there is no comprehensive bibliometric analysis of the retrograde intrarenal surgery (RIRS) method in the literature. This study aimed to conduct a bibliometric analysis of all articles regarding RIRS published between 1980 and 2019. Materials and Methods: The literature search was performed using only the following keywords: “RIRS” and “flexible ureterorenoscopy/flexible ureteroscopy”, in the “title” part of the search. Using this search method, all the articles published between 1980 and 2019 on this topic were accessed and downloaded from the Web of Science database, and the articles were analyzed using bibliometric methods. Results: Totally, 1378 publications were found as a result of the literature search, of which 619 were articles. We noted that there has been a rapid increase in the number of publications, especially from the year 2011. Turkiye was found to be the most productive country with regard to RIRS. The journals that contributed most to the literature were: Journal of Endourology, Urology, Journal of Urology, Urolithiasis, and World Journal of Urology. Conclusion: One of the notable findings of this study is that Turkiye is among the world countries that produced the highest number of publications with regard to this topic and that the hospitals where this technique is used the most are located in Turkiye. Amaç: Üriner sistem taş hastalığı, insanların %2 ila 3’ünü etkileyen ve tedavi edilmediğinde ciddi sorunlara neden olan çok yaygın bir sağlık sorunudur. Renal taşların prevalansı dünya çapında artmaktadır ve cerrahi yöntemler zaman içinde değişmiştir. Bununla birlikte, literatürde retrograd intrarenal cerrahi (RIRC) yönteminin kapsamlı bir bibliyometrik analizi yer almamaktadır. Bu çalışma 1980 ve 2019 yılları arasında yayınlanan RIRC ile ilgili tüm makalelerin bibliyometrik analizini yapmayı amaçlamaktadır. Gereç ve Yöntem: Literatür taraması sadece aramanın “başlık” kısmında “RIRC” ve “esnek üreterorenoskopi/esnek üreteroskopi” anahtar kelimeleri kullanılarak yapıldı. Bu arama yöntemi kullanılarak 1980-2019 yılları arasında bu konu hakkında yayınlanan tüm makalelere erişildi ve Web of Science veritabanından indirildi. Makaleler bibliometrik yöntemler kullanılarak analiz edildi. Bulgular: Literatür taraması sonucunda toplam 1378 yayın bulundu. Bu yayınlardan 619’u makaleydi. Özellikle 2011 yılından bu yana yayın sayısında hızlı bir artış olmuştur. Türkiye’nin RIRS konusunda en verimli ülke olduğu tespit edildi. Literatüre en fazla katkıda bulunan dergiler Journal of Endourology, Urology, Journal of Urology, Urolithiasis, and World Journal of Urology olarak bulundu. Sonuç: Bu çalışmanın dikkate değer bulgularından biri de Türkiye’nin bu konuda en fazla sayıda yayın yapan dünya ülkeleri arasında olması ve bu tekniğin en çok kullanıldığı hastanelerin Türkiye’de bulunmasıdır. WOS:000561681300005

BackgroundDespite the increasing number of publications on celiac disease, there is a lack of studies that made a holistic bibliometric evaluation of the studies on this topic.AimsThe purpose of this study is to analyze the publications about celiac disease by using bibliometric methods and this way to demonstrate the celiac disease-related trends, top effective articles, journals, and international collaborations between the countries and institutions.MethodsAll articles published between 1980 and 2018 on celiac disease were downloaded from Web of Science and analyzed with bibliometric methods. The correlations between economic development and publication productivity of the countries were investigated with Spearman's rank correlation coefficient. Linear regression analysis was used to estimate the number of publications and citations.ResultsThe literature review showed that there were 6545 articles about celiac disease published between the years 1980 and 2018. The top productive country that produced most publications about celiac disease was the Italy. The most prolific journals were the Journal of Pediatric Gastroenterology and Nutrition and Scandinavian Journal of Gastroenterology. There was a moderate positive significant correlation between the number of publications and gross domestic product (r=0.639, p

Amaç: Yoğun bakım hastalarında beslenme büyük bir öneme sahiptir. Hastaların yeterli beslenme desteği alması iyileşme oranlarını artırdığı gibi mortalite ve morbiditeyi de düşürmektedir. Bu çalışmanın amacı hastaların yoğun bakımda beslenme desteği aldığında, hedeflenen kaloriye ulaşmasına engel olan faktörlerini ortaya koymak, varsa beslenme intoleransı ve yetersizliğinin mortalite ve morbitide üzerine etkilerini belirlemektir. Gereç ve Yöntemler: Eylül 2017- Eylül 2018 tarihleri arasında yoğun bakım ünitesine kabul edilen 18 yaş üstü 80 hastanın dâhil edildiği prospektif gözlemsel bir araştırmadır. Seksen hastanın 13’üne sadece parenteral destek verildiğinden çalışma dışı bırakıldı. Hastalar enteral yolla ilk 4 gün hedeflenen kalorinin %50 ve fazlasını alamayan (Grup 1) ve alan (Grup 2) olarak ikiye ayrıldı. Hastaların yaş cinsiyet, boy, kilo, APACHE II, SOFA, Glaskow skorları, yatış nedeni, vazopressör desteği, beslenme desteği, bulantı-kusma, reflü, diyare varlığı, dört günlük kalori ihtiyacına erişimi, solunum desteği, bası yarası, diyaliz gereksinimi, dört günlük kaloriye erişim yolu, ülser proflaksisi, yatış süresi ve mortalite kayıt altına alındı. Bulgular: Grup 1 (n=30) hastada, hedef kaloriye enteral yol ile ulaşılamazken Grup 2 (n=37) hastada enteral beslenmenin yeterli olduğu görüldü. Gruplar arasında yaş, cinsiyet, boy, kilo, VKİ, APACHE II, SOFA ve Glaskow skorları arasında fark olmadığı tespit edildi. Hastaların %80.5 (n=54) mekanik ventilatör desteği, %12.9 (n=7) trakeostomi ile destek aldığı görüldü. Mekanik ventilatör desteği almayan hastalarda %19.5 (n=13) hastanın noninvaziv ventilatasyon desteği aldığı görüldü. Solunum desteği açısından gruplar arasında anlamlı fark saptanmadı. Hastaların kültürde üreme, vazopressör desteği, mortalite ve yatış süresi açısından anlamlı fark saptanmadı. Sonuç: Hastaların iyileşme sürecine katkıda bulunmak için beslenme büyük önem arz eder. Bu çalışmada da enteral beslenmenin, beslenme intoleransı ve yetersizliğine yol açmayacak şekilde hastanın gereksinimi olan enerji ihtiyacına ek morbidite eklemeden ulaşmasına yardımcı olduğu görülmüştür. Beslenme intoleransı hakkında yapılan çalışmalarda mortalite ile ilişkilendirilse de çalışmanın sonuçlarında mortalite ve yoğun bakım yatış süreleri ile beslenme intoleransı arasında ilişki bulunmamıştır. Objective: Nutrition is of great importance in intensive care patients. Adequate nutritional support increases recovery rates while decreasing mortality/morbidity. The aim of this study was to identify the factors that prevent patients from reaching the targeted calories when they receive nutritional support and to demonstrate the effects of nutritional intolerance/insufficiency on mortality and morbidity. Material and Methods: This is an observational study involving 80 patients over the age of 18 who were admitted to the intensive care unit between September 2017-September 2018. Thirteen of the 80 patients were excluded from the study because only parenteral support was given. Patients were divided into two groups as the patients who did not receive 50%or more of the targeted calories for the first 4 days by enteral pathway (Group 1) and patients who did (Group 2). Demographic data, Apache II, SOFA, Glasgow scores, reason for admission, vasopressor /nutritional support, nausea-vomiting, reflux, diarrhea, the accession to four day calorie needs and access path, respiratory support, dialysis requirement, ulcer prophylaxis and mortality of the patients were recorded. Results: In Group1 (n=30), the target calories could not be reached by the enteral way, while enteral nutrition was sufficient in Group 2 (n=37). There was no difference between the groups in demographic data. Also, 80.5% (n=54) of the patients received ventilator support and 12.9% (n=7) tracheostomy support. There was no significant difference between the groups in terms of respiratory support, bacterial culture, vasopressor support, mortality and length of hospitalization. Conclusion: Nutrition is of great importance for healing. It was observed that enteral nutrition helps to reach the need for energy without adding additional morbidity in a way that does not lead to nutritional intolerance/insufficiency. Although it is associated with mortality in studies on nutritional intolerance, there was no relationship of nutritional intolerance with mortality and intensive care hospitalization.

This study aims to investigate the relationship between individuals' attitudes about acceptance of aesthetic surgery (e.g. rhinoplasty, autoplasty, blepharoplasty, and mammaplasty) and some of the worship practices in Islamic religion such as performing prayer, fasting, and going to pilgrimage. Although many people think that aesthetic surgery is inappropriate in Islamic religion, no studies in the literature were found to have investigated this issue. This study collected data through a questionnaire administered to 96 patients who applied to our Plastic Surgery Clinic and underwent various surgical operations and 96 patients who were recommended plastic surgery but rejected to have one; the questionnaire aimed to identify the participants' frequency of religious worship practices and appropriateness of aesthetic surgery to their beliefs. The participants responded on the frequency of religious worship levels according to the options in the questionnaire. The Acceptance of Cosmetic Surgery Scale was utilized in order to identify their attitudes towards aesthetic surgery. Levels of performing prayers, fasting, and going to pilgrimage in the groups that accepted surgery and in the groups that rejected surgery were significantly different (p < 0.001, p = 0.008, p < 0.001). In two different groups, the Acceptance of Aesthetic Surgery Scale scores were significantly different within the prayer groups and fasting groups (p < 0.001, p < 0.001, p = 0.001, p < 0.001). While the group that accepted surgery indicated no significant differences between those who thought about going to pilgrimage and who did not (p = 0.650), there was a significant difference in the group that rejected surgery (p < 0.001). While 14.6% of the participants in the group that accepted surgery considered aesthetic surgery a sin, this proportion was 56.3% in the group that rejected surgery, and this difference was significant (p < 0.001). In both surgery groups, there were differences in the scale scores of those who considered aesthetic surgery a sin and those who did not (p < 0.001, p < 0.001). There was a significant relationship between worship practices, one of the biggest indicators of the level of belief in Islamic religion, and aesthetic surgery attitudes. However, despite the fact that belief levels affect the decision of having an operation in plastic surgery, in case of serious health problems, the decision of having an operation becomes more important religious beliefs. WOS:000522841400014 2-s2.0-85064245472 PubMed: 30701424

There is an increasing interest in the effects of preoperative anxiety on the course and outcomes of surgical treatments and also in the studies about the anxiety-decreasing interventions. The present study aims to identify the relationship between the preoperative anxiety level of the individuals prior to aesthetic surgery operations such as nose, ear, eyelid, and mammoplasty and religious rituals such as performing prayers, fasting, and going to pilgrimage. The frequency of performing the religious rituals was identified through a questionnaire. The questionnaire included questions about the religious rituals such as performing prayers, going to a pilgrimage, and fasting as well as questions about sociodemographic features such as gender, age, and education level of the patients. Preoperative anxiety level was measured using the Anxiety Specific to Surgery Questionnaire. The nonparametric Mann-Whitney U test was used for the scale score comparisons of the two independent groups. The scale score comparisons of more than two groups were performed using the Kruskal-Wallis test. The relationships between age and scale scores were analyzed using the Spearman's correlation coefficient. The study involved 117 patients who were planned to undergo an aesthetic surgery operation. The scale scores were significantly different according to the pilgrimage groups (p = 0.004). The scale scores were significantly different according to the level of fasting (p = 0.022). No significant differences were found between the scales scores of the groups who reported the frequency of performing prayer as never, sometimes or five times (p = 0.515). In conclusion, the present study found that Muslim people who performed religious rituals more often experienced less preoperative anxiety levels in plastic surgeries, which indicates that the belief level is an effective factor in preoperative anxiety levels. The findings of the present study indicate that patients' beliefs and worship practices should be taken into consideration by doctors, operating room personnel, and even all health workers in order to decrease the anxiety levels of patients who will undergo surgery. WOS:000519150900038 2-s2.0-85067008916 PubMed: 31172393

OBJECTIVE To determine the outcomes of retrograde intrarenal surgery (RIRS) and its complications in both young and elderly patients. STUDY DESIGN An observational study. PLACE AND DURATION OF STUDY Departments of Urology, University of Health Sciences, Ankara Research and Training Hospital, Ankara, and Corum Hitit University, Corum, Turkey from April 2019 to January 2020. METHODOLOGY Patients with kidney stones up to 3 cm in maximal diameter on computarised tomography (CT) scan, were divided into two groups according to age (

Ozkan, Aysegul Taylan/0000-0001-8421-3625; AKMESE, Omer Faruk/0000-0002-5877-0177 WOS:000546977100010 PubMed: 32284264 Background: The global prevalence of allergic diseases has increased dramatically in recent years and are now recognized as significant chronic diseases worldwide. One of the most important allergens that causes allergic diseases is house dust mites. Objective: This study aims to present a bibliometric overview of research published on dust mites between 1980 and 2018. Methods: Articles published from 1980 to 2018 were analyzed using bibliometric methods. The keywords ?Dust mite*,? and ? Dermatophagoides ? were used in the Web of Science (WoS). Simple linear regression analysis was used to estimate the number of future publications on this subject. Results: A total of 4742 publications were found, 2552 (53.8%) of them were articles. Most of the articles were on subjects related to immunology (1274; 49.9%) and allergy (1229; 48.1%). Clinical and Experimental Allergy (222; 8.7%) was the journal with the most publications. The USA was the country that most contributed to the literature with 461 (18.1%) articles. The countries producing the most publications on this subject were developed countries. The most active author was W.R. Thomas (66; 2.5%). The most productive institution was the University of Western Australia (91; 3.6%). The most cited article was published in the New England Journal of Medicine .Conclusion: According to the findings, developed countries were the most productive in publishing on house dust mites. By planning multinational research rather than regional studies, it may be suggested that researchers in underdeveloped or developing countries could also-conduct more research on this subject.(C) 2019 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.

The purpose of this study is to make a holistic summary of the articles published in the field of Legal Medicine/Forensic Science through bibliometric methods, determine the top cited publications in the field, and to determine the most active journals and especially trend topics. The articles published in the field of Legal Medicine between the years 1975 and 2018 were downloaded from the Web of Science index and were analyzed using bibliometric methods. The correlations between the number of publications of the countries and the Gross Domestic Product (GDP), and the Gross Domestic Product per capita (GDP PPP) values was analyzed using the Spearman's correlation coefficient. The number of articles to be published in the field of Legal Medicine between the years 2019 and 2022 was estimated with linear regression analysis. The results showed that there were totally 38845 articles published in the field of Legal Medicine. Regression analysis results indicate that it will exceed 2500 publications after 2022. The most productive countries in the field of Legal Medicine were the USA (12.448, 32.045%). A high correlation was found between legal medicine publication productivity and GDP and GDP PPP (r = 0.726, p < 0.001; r = 0.703, p < 0.001). As for the collaboration between countries, analysis results showed that the network web indicated the most important factor as the geographical location. This study will provide important information to a forensic scientist (a doctor, academic, and practitioner). WOS:000514552200016 2-s2.0-85074725797 PubMed: 31733463

Aim: Endometrial polyps are frequently associated with abnormal uterine bleeding. The kispeptin family is one of the peptides that play a role in reproductive functions and whose expression varies in various uterine pathologies. The aim of the study was to determine the relationship between serum Kisspeptin levels and endometrial polyps in women with premenopausal status.Material and Methods: The blood was collected prior to endometrial sampling from women admitted to the hospital due to abnormal uterine bleeding. According to the pathology results, patients were identified as polyp group (n=38) (endometrial polyps) and control group (n=50) (normal endometrial findings). Kisspeptin-54 levels were determined by ELISA method from serum obtained from venous blood. Results: There were no difference was found between the patients’ age, body mass index, gravida, para, abortus and the number of living children were compared (p>0.05). There was no statistically significant difference between the groups in terms of follicle stimulating hormone, luteinizing hormone and thyroid stimulating hormone values (p>0.05). Plasma kisspeptin (1.84±0.93 ng/dL and 1.32±0.47 ng/dL, p= 0.008) and estradiol (90.34±13.02 pg/mL and 81.75±12.36 pg/mL, p=0.002) levels were significantly higher in the polyp group than in the control group. After the Receiver Operating Characteristic (ROC) analysis the area under the curve (AUC) was 1.26 (p= 0.08), (95% CI, 0.550-0.782). The sensitivity value was 0.684 (0.512-0.819), the specificity was 0.620 (0.471-0.750).Conclusion: The serum Kisspeptin-54 and estradiol levels were found higher in patients with endometrial polyps.Keywords: Abnormal uterine bleeding; endometrial polyps; kisspeptin.

Objective This study aims to compare breast volume changes and other anthropometric measurements by using before and after breast reduction pictures of women who underwent breast reduction operation in Plastic and Reconstructive Surgery clinic and by performing measurements from the anatomic points indicated in the literature. Background Landmarks (previously identified as anatomic points) that show the success of breast reduction operation are not sufficient. Anthropometric points and their identification are of great importance for choosing the landmarks and identifying the statistical approaches to be used. Methods A total of 40 women were measured breast anthropometric measurements in pre-and post-operative breast reduction surgery changes by a photographic technique using Image J programme from the anatomical points determined in the literature. Comparison of right and left breast anthropometric measurements before and after the operation was performed using the paired t test or Wilcoxon signed rank test. The intraclass correlation coefficient (ICC) and Bland-Altman plots were used to determine the agreement between each pair of measurements. Results There was a statistically significant agreement between all the measurements (p

Aim: Fertility preservation (FP) has become an important issue for both women and men, due to oncological therapies, gonadotoxic treatments, surgeries, and infertility. The aim of this study is to investigate the publications related to FP, identify the top effective countries and journals, top productive researchers, and trend topics. Material and Methods: The data of this study were obtained using the Thomson Reuters WoS (Thomson Reuters, New York, NY, USA) database, separately for females and males. In the bibliometric analysis, ‘fertility preservation’ was used as a keyword. VOSviewer (Version 1.6.6) was utilized for bibliometric network visualizations. SPSS was used for the statistical analyses (Version 22.0)Results: Analysis results of the keywords used for men indicated 817 publications and for females indicated 2531 publications totally. The United States of America (USA) was the top country for the publications about both genders. The top three research fields for both genders were Obstetrics and Gynecology, Reproductive Biology, and Oncology. The journals that contributed to the literature most were Fertility and Sterility and Human Reproduction respectively in both gender categories. The correlation between the number of total fertility preservation articles and total cancers,Gross Domestic Product-World Bank (GDP-WB), Gross Domestic Product-International Monetary Fund (GDP-IMF), Human Development Index (HDI), and Internet Users (IU) was significant (r=0.482, p=0.017; r=0.609, p0.001; r=0.620, p0.001; r=0.365, p=0.043; r=0.479, p=0.006). Conclusion: It has been determined that researches on the protection of the fertility of cancer patients and infertile patients have increased from past to present. Also, it is observed that the economies of countries have an active role in research productivity.Keywords: Bibliometrics; fertility preservation; female; male.

Purpose: Many noninvasive tests have been studied for the diagnosis and determining the liver fibrosis score. In this study, we aimed to research the correlation of platelet parameters and stage of liver fibrosis in patients with chronic hepatitis B (CHB). Materials and Methods: A total of 140 biopsy-proven naive CHB cases were included in the study. HBV-DNA level, liver enzymes and function tests, white blood cell count, platelet parametres, hemoglobin, histological activity index (HAI) and other routine biochemical parameters were tested. Patients were divided into two groups as F0-2 and F3-6 with Ishak scoring system according to the severity of liver fibrosis. Results: There was no significant difference between the groups F0-2 and F3-6 in terms of, platelet (PLT), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT). There was a significant difference between these two groups for HAI, aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), age and lymphocyte (LYM) parameters. The formulation of (AST x Age x LYM) / ?PLT)which was formed from many different combinations, was investigated in order to be used in predicting the liver fibrosis stage. Conclusion: Although our new index is more sensitivitythan other noninvasive scoring systems, it is needed to have a larger sample size in patients with severe stage liver fibrosis in order to be used safely as a noninvasive marker. Amaç: Karaciğer fibrozis tanı ve skorunun belirlenmesi için birçok noninvaziv test çalışılmıştır. Bu çalışmada, kronik hepatit B (KHB) olan hastalarda platelet parametrelerinin ve karaciğer fibrozisin evresi arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya toplam 140 biyopsi ile kanıtlanmış naiv KHB olgusu dahiledildi. HBV-DNA düzeyi, karaciğer enzimleri ve fonksiyon testleri, beyaz kan hücresi sayısı, platelet parametreleri, hemoglobin, histolojik aktivite indeksi (HAI) ve diğer rutin biyokimyasal parametreler test edildi. Karaciğer biyopsi örnekleri modifiye Ishak skorlama sistemi kullanılarak incelendi. Hastalar karaciğer fibrosis şiddetine göre modifiye İshak puanlama sistemi ile F0-2 ve F3-6 olarak iki gruba ayrıldı. Bulgular: F0-2 ve F3-6 grupları arasında platelet (PLT), ortalama platelet hacmi (MPV), platelet dağılım genişliği (PDW) ve platelecrit (PCT) açısından anlamlı fark yoktu. Bu iki grup arasında HAİ, aspartat transaminaz (AST), gama glutamil transaminaz (GGT), yaş ve lenfosit parametreleri açısından anlamlı fark vardı. Karaciğer fibrozis evresini tahmin etmede kullanılmak üzere birçok farklı kombinasyondan oluşan (AST x Yaş x Lenfosit) /?PLT) formülasyonu araştırıldı. Sonuç: Yeni indeksimiz diğer noninvaziv skorlama sistemlerine göre daha sensitivitesi yüksek olmakla birlikte noninvaziv belirteç olarak güvenle kullanılabilmesi için ileri karaciğer fibrozis düzeyine sahip olan hastaların daha fazla olduğu, daha geniş örneklem büyüklüğüne sahip çalışmalara ihtiyaç vardır. WOS:000500930300002

Aim: The aim of this study was to develop a new web-based R Shiny package that calculates propensity score using many algorithms such as logistic regression, machine learning, and performs matching analysis with balance evaluation. In addition, it was aimed to explain the process of matching analysis on a real data set by comparing the number of live births between those with methylenetetrahydrofolate reductase (MTHFR) homozygous mutations and those without mutations in women hospitalized due to abortion in the gynecology and obstetrics clinic. Material and Methods: The web-based application was developed using R shiny. The “matchIt” library was used for matching analysis and PS prediction. The “cobalt” library was used to evaluate balance and generate plots. Results: The abortion variable, which was statistically significantly different in the groups before matching (p=0.010), was similar in the groups after matching (p=0.743). In addition, when the descriptive statistics and p values of the other variables were examined, it was seen that almost full balance was achieved after matching and the confounder variables were similar distributed in groups. After matching analysis, it was determined that the result variable “livebirths” did not show statistically significant difference in the groups (p=0.864). Conclusion: In this study, we developed an interactive web application for matching analysis based on propensity score. It is thought that this application will facilitate the studies of the researchers.