1. Establishing a reproductive biorepository for basic and translational research: experience developing the reproductive subjects registry and sample repository
- Author
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Erica E. Marsh, Dee E. Fenner, Samantha B. Schon, Min Xu, Kun Yang, Nicholas Raja, Jayne Reynolds, and Heather Cameron
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,Reproductive care ,Uterine tissue ,Reproductive medicine ,Translational research ,Sample (statistics) ,Tissue Banks ,Specimen Handling ,Translational Research, Biomedical ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Genetics ,Humans ,Medicine ,Registries ,Genetics (clinical) ,Aged ,Aged, 80 and over ,030219 obstetrics & reproductive medicine ,business.industry ,Reproduction ,Obstetrics and Gynecology ,Subject Characteristics ,General Medicine ,Middle Aged ,Precision medicine ,Reproductive Physiology and Disease ,030104 developmental biology ,Biorepository ,Reproductive Medicine ,Family medicine ,Female ,business ,Developmental Biology - Abstract
PURPOSE: To report experience designing and establishing a reproductive registry and sample biorepository and to describe initial subject characteristics and biospecimens. METHODS: Beginning in December 2017, patients presenting for reproductive care at the University of Michigan were approached for study enrollment. Following consent, subjects completed detailed reproductive and health questionnaires. A variety of reproductive specimens and tissues were collected and processed for multiple downstream applications. RESULTS: Subject enrollment began in December of 2017. There are currently 1798 subjects enrolled. Female participants report a variety of reproductive disorders. Available samples include semen, sperm, follicular fluid, granulosa cells, immature oocytes, ovarian and uterine tissue, and blood samples. CONCLUSION: We report the successful establishment of a reproductive registry and sample biorepository. Furthermore, we describe methods for collection and storage of a variety of reproductive tissue processed for multiple downstream translational applications.
- Published
- 2021